Proteasome

ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.

Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and …

Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases …

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.

RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.

Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome …

Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing …

Proteasome-IN-1 is an inhibitor of proteasome.

KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 …

PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 …

LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases …

(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the …

DD1 is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.

MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site …

Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is …

VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 …

RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS …

PSI is a proteasome inhibitor.

MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The …

AOB2796 is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis …

MG-132 is a potent cell-permeable 26S proteasome inhibitor (IC50: 100 nM). It also inhibits calpain …

AZD7986 is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 …

UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 …

ONX-0914 is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive …

Celastrol is an effective proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome(IC50=2.5 …

PI-1840( IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome …

N-(4-fluorophenyl)benzo[d]thiazol-2-amine is a protein kinase inhibitor.

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat …

AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). …

Ixazomib citrate is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation …

Bortezomib (PS-341) is a potent 20S proteasome inhibitor (Ki: 0.6 nM, in a cell-free assay).

Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.

Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.

MUN57694 is an inhibitor of 26S proteasome.

(R)-MG-132 is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than …

TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S …

Epoxomicin is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of …

Oprozomib (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5(IC50=36 nM)/LMP7(IC50=82 nM), …

CEP-18770 is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). …

Carfilzomib is an irreversible proteasome inhibitor and antineoplastic agent that is used in treatment of …