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Stem Cell and Derivatives

Stem Cell and Derivatives

Stem cell inhibitors are compounds that specifically target signaling pathways and proteins involved in the maintenance, differentiation, and proliferation of stem cells. These inhibitors are crucial for understanding stem cell biology and for developing strategies to manipulate stem cells for therapeutic purposes, such as regenerative medicine and cancer treatment. By controlling stem cell fate, these inhibitors can help guide stem cell differentiation into specific cell types or prevent unwanted cell growth. At CymitQuimica, we offer a selection of high-quality stem cell inhibitors to support your research in stem cell biology, developmental biology, and regenerative medicine.

Subcategories of "Stem Cell and Derivatives"

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Found 693 products of "Stem Cell and Derivatives"

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  • Cenacitinib
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    Cenacitinib

    CAS:
    <p>Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.</p>
    Formula:C19H19F2N7O3
    Color and Shape:Solid
    Molecular weight:431.40

    Ref: TM-T201149

  • DAPM
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    DAPM

    CAS:
    <p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>
    Formula:C20H20F2N2O4
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:390.38

    Ref: TM-T86161

  • YLIU-4-105-1
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    YLIU-4-105-1

    CAS:
    <p>YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.</p>
    Formula:C32H34F3N7O2
    Color and Shape:Solid
    Molecular weight:605.65

    Ref: TM-T201176

  • LNK01004
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    LNK01004

    CAS:
    <p>LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.</p>
    Formula:C26H31N7O2
    Color and Shape:Solid
    Molecular weight:473.57

    Ref: TM-T205387

  • GSK-3β inhibitor 20
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    GSK-3β inhibitor 20

    CAS:
    <p>GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.</p>
    Formula:C22H21N5O2S
    Color and Shape:Solid
    Molecular weight:419.50

    Ref: TM-T200457

  • STAT3-IN-35
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    STAT3-IN-35

    CAS:
    <p>STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.</p>
    Formula:C21H23NO4
    Color and Shape:Solid
    Molecular weight:353.41

    Ref: TM-T200468

  • JAK3-IN-7
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    JAK3-IN-7

    CAS:
    <p>JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50&lt;0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after</p>
    Formula:C17H20N6O
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:324.38

    Ref: TM-T10009

  • AJI-100
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    AJI-100

    CAS:
    <p>AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).</p>
    Formula:C17H14FN5O
    Color and Shape:Solid
    Molecular weight:323.32

    Ref: TM-T200052

  • AZ-3
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    AZ-3

    CAS:
    <p>AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).</p>
    Formula:C20H28FN7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:385.48

    Ref: TM-T10424

  • JAK2-IN-11
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    JAK2-IN-11

    CAS:
    <p>JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.</p>
    Formula:C31H31F3N8O4
    Color and Shape:Solid
    Molecular weight:639.64

    Ref: TM-T201601

  • Aβ42-IN-1
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    Aβ42-IN-1

    CAS:
    <p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>
    Formula:C29H27ClN4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:499

    Ref: TM-T10211

  • CymitQuimica logo
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    BPN-15606 besylate

    <p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>
    Formula:C29H29FN6O4S
    Color and Shape:Solid
    Molecular weight:576.64

    Ref: TM-T64081

  • HDAC6-IN-9
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    HDAC6-IN-9

    CAS:
    <p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>
    Formula:C19H16N2O3
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:320.34

    Ref: TM-T60856

  • AJI-214
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    AJI-214

    CAS:
    <p>AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).</p>
    Formula:C17H13ClFN5O
    Color and Shape:Solid
    Molecular weight:357.77

    Ref: TM-T200387

  • JAK3 covalent inhibitor-1
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    JAK3 covalent inhibitor-1

    CAS:
    <p>JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and</p>
    Formula:C22H17FN6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.47

    Ref: TM-T11709

  • YAP/TAZ-TEAD-IN-2
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    YAP/TAZ-TEAD-IN-2

    <p>YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.</p>
    Formula:C19H20N2O3S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T201766

  • YAP/TAZ inhibitor-3
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    YAP/TAZ inhibitor-3

    CAS:
    <p>YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.</p>
    Formula:C21H18F3NO3
    Purity:99.63%
    Color and Shape:Solid
    Molecular weight:389.37

    Ref: TM-T87651

  • CP-352664
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    CP-352664

    CAS:
    <p>CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.</p>
    Formula:C18H18N4
    Color and Shape:Solid
    Molecular weight:290.36

    Ref: TM-T200202

  • TGFβ1-IN-1
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    TGFβ1-IN-1

    CAS:
    <p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>
    Formula:C22H24N2O3
    Purity:99.89% - 99.89%
    Color and Shape:Solid
    Molecular weight:364.438

    Ref: TM-T61389

  • JAK1-IN-16
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    JAK1-IN-16

    <p>JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.</p>
    Formula:C20H15ClF3N3OS
    Color and Shape:Solid
    Molecular weight:437.87

    Ref: TM-T201648