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Stem Cell and Derivatives

Stem Cell and Derivatives

Stem cell inhibitors are compounds that specifically target signaling pathways and proteins involved in the maintenance, differentiation, and proliferation of stem cells. These inhibitors are crucial for understanding stem cell biology and for developing strategies to manipulate stem cells for therapeutic purposes, such as regenerative medicine and cancer treatment. By controlling stem cell fate, these inhibitors can help guide stem cell differentiation into specific cell types or prevent unwanted cell growth. At CymitQuimica, we offer a selection of high-quality stem cell inhibitors to support your research in stem cell biology, developmental biology, and regenerative medicine.

Subcategories of "Stem Cell and Derivatives"

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Found 693 products of "Stem Cell and Derivatives"

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  • Tyk2-IN-3
    Targetmol
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    Tyk2-IN-3

    CAS:
    <p>Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).</p>
    Formula:C25H24N6O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:520.63

    Ref: TM-T13233

  • ROCK/HDAC-IN-1
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    ROCK/HDAC-IN-1

    <p>ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.</p>
    Formula:C19H22N4O3S
    Color and Shape:Solid
    Molecular weight:386.47

    Ref: TM-T201708

  • JAK1/TYK2-IN-4
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    JAK1/TYK2-IN-4

    CAS:
    <p>JAK1/TYK2-IN-4 serves as a dual inhibitor targeting both JAK and TYK2, displaying IC50 values of 39 nM and 21 nM, respectively. It is also orally bioavailable [1].</p>
    Formula:C17H23N7O
    Color and Shape:Solid
    Molecular weight:341.41

    Ref: TM-T86755

  • (Rac)-SAG
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    (Rac)-SAG

    CAS:
    <p>(Rac)-SAG, an isoform of SAG, is a potent Smoothened (Smo) receptor agonist (EC₅₀ = 3 nM; Kd = 59 nM) that activates the Hedgehog signaling pathway and counteracts Cyclopamine's inhibition of Smo [1] [2] [3].</p>
    Formula:C28H28ClN3OS
    Color and Shape:Solid
    Molecular weight:490.06

    Ref: TM-T85362

  • STAT3-IN-8
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    STAT3-IN-8

    CAS:
    <p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>
    Formula:C19H7F7N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:444.26

    Ref: TM-T71550

  • MGD-28
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    MGD-28

    CAS:
    <p>MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.</p>
    Formula:C33H34FN7O3
    Purity:99.39%
    Color and Shape:Solid
    Molecular weight:595.67

    Ref: TM-T201415

  • MYF-03-176
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    MYF-03-176

    CAS:
    <p>MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC₅₀ values of 47/32/71 nM. inhibits TEAD transcriptional activity and cancer cell growth, antitumour.</p>
    Formula:C19H18F4N4O2
    Color and Shape:Solid
    Molecular weight:410.37

    Ref: TM-T62074

  • JAK1-IN-9
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    JAK1-IN-9

    CAS:
    <p>JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM.</p>
    Formula:C16H13IN6
    Color and Shape:Solid
    Molecular weight:416.22

    Ref: TM-T62155

  • STAT3-IN-36
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    STAT3-IN-36

    CAS:
    <p>STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.</p>
    Formula:C30H24F2N2O9S2
    Color and Shape:Solid
    Molecular weight:658.65

    Ref: TM-T201706

  • PF-06263276
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    PF-06263276

    CAS:
    <p>PF-06263276 selectively inhibits pan-JAK with IC50: JAK1 (2.2 nM), JAK2 (23.1 nM), JAK3 (59.9 nM), TYK2 (29.7 nM).</p>
    Formula:C31H31FN8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:566.63

    Ref: TM-T16488

  • TYK2 ligand 2
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    TYK2 ligand 2

    CAS:
    <p>TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.</p>
    Formula:C24H20FN7O4
    Color and Shape:Solid
    Molecular weight:489.458

    Ref: TM-T206678

  • CDD-1431
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    CDD-1431

    CAS:
    <p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>
    Formula:C33H38N8O5S
    Color and Shape:Solid
    Molecular weight:658.77

    Ref: TM-T205082

  • dCK1α-2
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    dCK1α-2

    <p>dCK1α-2 is an orally effective CK1α molecular glue (Molecular Glue) degrader that targets p53 pathway-related targets. It demonstrates antitumor efficacy in mouse models by enhancing the expression of p53-related genes.</p>
    Formula:C24H24ClN5O4
    Color and Shape:Solid
    Molecular weight:481.93

    Ref: TM-T201857

  • iBFAR2
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    iBFAR2

    CAS:
    <p>iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.</p>
    Formula:C19H15F3N2O2
    Color and Shape:Solid
    Molecular weight:360.33

    Ref: TM-T204531

  • Milpecitinib
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    Milpecitinib

    CAS:
    <p>Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.</p>
    Formula:C20H20N4O2S
    Color and Shape:Solid
    Molecular weight:380.463

    Ref: TM-T205326

  • PF-06648671
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    PF-06648671

    CAS:
    <p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>
    Formula:C25H23ClF4N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.92

    Ref: TM-T24621

  • CymitQuimica logo
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    JAK-IN-19

    <p>JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).</p>
    Formula:C26H36FN5O2
    Color and Shape:Solid
    Molecular weight:469.59

    Ref: TM-T63026

  • M3686
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    M3686

    CAS:
    <p>M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.</p>
    Formula:C21H18F3N5O2
    Color and Shape:Solid
    Molecular weight:429.395

    Ref: TM-T205477

  • GDC-9918
    Targetmol
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    GDC-9918

    CAS:
    <p>GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.</p>
    Formula:C20H18F2N6O5S
    Color and Shape:Solid
    Molecular weight:492.46

    Ref: TM-T201178

  • Casein kinase 1δ-IN-13
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    Casein kinase 1δ-IN-13

    CAS:
    Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.
    Formula:C15H13N3O2S
    Color and Shape:Solid
    Molecular weight:299.35

    Ref: TM-T201094