Tyrosine Kinase/Adaptors
Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.
Subcategories of "Tyrosine Kinase/Adaptors"
- ALK(112 products)
- CSF-1R(42 products)
- EGFR(572 products)
- Ephrin Receptor(23 products)
- FLT(92 products)
- Fibroblast Growth Factor Receptor (FGFR)(169 products)
- HER(5 products)
- Hck(3 products)
- IGF-1R(88 products)
- PDGFR(126 products)
- PYK2(7 products)
- Src(79 products)
- TAM Receptor(32 products)
- Tie-2(20 products)
- Trk receptor(59 products)
- Tyrosine Kinases(26 products)
- VEGFR(268 products)
- c-Fms(108 products)
- c-Kit(101 products)
- c-Met/HGFR(128 products)
- c-RET(51 products)
Show 13 more subcategories
Found 1370 products of "Tyrosine Kinase/Adaptors"
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ONO-7475
CAS:<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Formula:C32H26N4O6Purity:98.74%Color and Shape:SolidMolecular weight:562.57GW788388
CAS:<p>GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.</p>Formula:C25H23N5O2Purity:98.03% - 99.58%Color and Shape:SolidMolecular weight:425.48PKI (5-24) Acetate(99534-03-9 free base)
<p>PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).</p>Formula:C96H152N32O33Purity:99.47%Color and Shape:SolidMolecular weight:2282.43AG1557
CAS:<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formula:C16H14IN3O2Purity:98.61% - 99.23%Color and Shape:SolidMolecular weight:407.21XL092
CAS:<p>XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.</p>Formula:C29H25FN4O5Purity:98.60%Color and Shape:SolidMolecular weight:528.53ML347
CAS:<p>ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.</p>Formula:C22H16N4OPurity:99.30% - ≥95%Color and Shape:SolidMolecular weight:352.39E-4031 dihydrochloride
CAS:<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Formula:C21H29Cl2N3O3SPurity:99.31% - 99.87%Color and Shape:SolidMolecular weight:474.44H3B-6527
CAS:<p>H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.</p>Formula:C29H34Cl2N8O4Purity:97.45%Color and Shape:SolidMolecular weight:629.54JNJ-38158471
CAS:<p>JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor, inhibits closely related tyrosine kinases such as Ret and Kit .</p>Formula:C15H17ClN6O3Purity:97.08%Color and Shape:SolidMolecular weight:364.79TX1-85-1
CAS:<p>TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.</p>Formula:C32H36N8O3Purity:98.12% - 98.12%Color and Shape:SolidMolecular weight:580.68TAS0728
CAS:<p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>Formula:C26H32N8O3Purity:97.78%Color and Shape:SolidMolecular weight:504.58Pyridostatin
CAS:<p>Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or</p>Formula:C31H32N8O5Purity:98%Color and Shape:SolidMolecular weight:596.64LM22A-4
CAS:<p>LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).</p>Formula:C15H21N3O6Purity:99.56%Color and Shape:SolidMolecular weight:339.34WRG-28
CAS:<p>WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)</p>Formula:C21H18N2O5SPurity:97.21%Color and Shape:SolidMolecular weight:410.44AD80
CAS:<p>AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.</p>Formula:C22H19F4N7OPurity:99.49% - 99.75%Color and Shape:SolidMolecular weight:473.43Tyrphostin B44, (+) enantiomer
CAS:<p>Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)</p>Formula:C18H16N2O3Purity:97.18%Color and Shape:SolidMolecular weight:308.33GSK1838705A
CAS:<p>GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.</p>Formula:C27H29FN8O3Purity:98.89% - >99.99%Color and Shape:SolidMolecular weight:532.57A 77-01
CAS:<p>A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.</p>Formula:C18H14N4Purity:98.82% - ≥95%Color and Shape:SolidMolecular weight:286.33Tolimidone
CAS:<p>Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.</p>Formula:C11H10N2O2Purity:99.85% - 99.85%Color and Shape:SolidMolecular weight:202.21Tyrphostin 23
CAS:<p>Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.</p>Formula:C10H6N2O2Purity:99.7% - 99.86%Color and Shape:Yellow-Tan SolidMolecular weight:186.17Ponatinib
CAS:<p>Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively</p>Formula:C29H27F3N6OPurity:98% - 99.60%Color and Shape:SolidMolecular weight:532.56BLU9931
CAS:<p>BLU9931 is the first selective small molecule inhibitor of FGFR4.</p>Formula:C26H22Cl2N4O3Purity:96.958% - 99.85%Color and Shape:SolidMolecular weight:509.38123C4
CAS:<p>123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4 (Ki=0.65 μM)[1].</p>Formula:C43H47ClN8O6Purity:98.94%Color and Shape:SolidMolecular weight:807.34Cediranib
CAS:<p>Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.</p>Formula:C25H27FN4O3Purity:97.21% - 99.94%Color and Shape:SolidMolecular weight:450.51Pamufetinib mesylate
CAS:<p>Pamufetinib mesylate (TAS-115 mesylate) is a VEGFR antagonist and c-Met inhibitor used in the study of cancer and respiratory diseases.</p>Formula:C28H27FN4O7S2Purity:98.91%Color and Shape:SolidMolecular weight:614.67CEP-40783
CAS:<p>CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).</p>Formula:C31H26F2N4O6Purity:99.76% - 99.84%Color and Shape:SolidMolecular weight:588.56NRC-2694
CAS:<p>NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.</p>Formula:C24H26N4O3Purity:99.90%Color and Shape:SolidMolecular weight:418.49R112
CAS:<p>R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.</p>Formula:C16H13FN4O2Purity:99.27% - 99.84%Color and Shape:SolidMolecular weight:312.3RepSox
CAS:<p>RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).</p>Formula:C17H13N5Purity:98.8% - 99.73%Color and Shape:SolidMolecular weight:287.32Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Formula:C25H26N6O2Purity:99.67%Color and Shape:SolidMolecular weight:442.51TPX-0046
CAS:<p>TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.</p>Formula:C21H21FN6O3Purity:99.95%Color and Shape:SolidMolecular weight:424.43Canertinib
CAS:<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Formula:C24H25ClFN5O3Purity:98% - >99.99%Color and Shape:White Or Similar To White Crystalline PowderMolecular weight:485.94Entrectinib
CAS:<p>Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.</p>Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Desmethyl Erlotinib hydrochloride
CAS:<p>Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.</p>Formula:C21H21N3O4·HClPurity:99.49%Color and Shape:SolidMolecular weight:415.87(E)-AG 99
CAS:<p>(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).</p>Formula:C10H8N2O3Purity:99.23%Color and Shape:SolidMolecular weight:204.18EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS:<p>EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)</p>Formula:C23H21N3O3Purity:99.55%Color and Shape:SolidMolecular weight:387.435'-Fluoroindirubinoxime
CAS:<p>5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).</p>Formula:C16H10FN3O2Purity:>99.99%Color and Shape:SolidMolecular weight:295.27JCN037
CAS:<p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>Formula:C16H11BrFN3O2Purity:99.5%Color and Shape:SolidMolecular weight:376.18ALK-IN-1
CAS:<p>ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.</p>Formula:C26H34ClN6O2PPurity:99.74% - 99.80%Color and Shape:SolidMolecular weight:529.01Fostamatinib Disodium
CAS:<p>Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.</p>Formula:C23H24FN6O9P·2NaPurity:96.13% - 99.09%Color and Shape:SolidMolecular weight:624.42FLT3-IN-2
CAS:<p>FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).</p>Formula:C21H16ClF3N4Purity:97.57% - 98.53%Color and Shape:SolidMolecular weight:416.83Rebastinib
CAS:<p>DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC,</p>Formula:C30H28FN7O3Purity:99.53% - 99.79%Color and Shape:SolidMolecular weight:553.59ASP5878
CAS:<p>ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.</p>Formula:C18H19F2N5O4Purity:99.8% - 99.89%Color and Shape:SolidMolecular weight:407.37Avapritinib
CAS:<p>Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases.Cost-effective and quality-assured.</p>Formula:C26H27FN10Purity:96.59% - 99.7%Color and Shape:SolidMolecular weight:498.56Bacitracin Zinc
CAS:<p>Bacitracin Zinc is a dephosphorylated disruptor of C55-isoprene pyrophosphate that inhibits Tyr cleavage in Met-enkephalin with an IC50 of 10 μM.</p>Formula:C66H101N17O16SZnPurity:63.98%Color and Shape:Light-Colored Free-Flowing PowdersMolecular weight:1486.07Naquotinib
CAS:<p>Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFR</p>Formula:C30H42N8O3Purity:97.49%Color and Shape:SolidMolecular weight:562.71lavendustin C
CAS:<p>lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.</p>Formula:C14H13NO5Purity:98.06%Color and Shape:Yellow To Tan PowderMolecular weight:275.26Futibatinib
CAS:<p>Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.</p>Formula:C22H22N6O3Purity:97.66% - 99.44%Color and Shape:SolidMolecular weight:418.45Dovitinib lactate hydrate
CAS:<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Formula:C24H27FN6O4Purity:99.82%Color and Shape:SolidMolecular weight:482.51Methyl 2,5-dihydroxycinnamate
CAS:<p>Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.</p>Formula:C10H10O4Purity:99.60%Color and Shape:CrystallineMolecular weight:194.18
