IGF-1R
IGF-1R inhibitors are compounds that specifically target and inhibit the Insulin-like Growth Factor 1 Receptor (IGF-1R), a receptor tyrosine kinase involved in cellular growth, development, and survival. IGF-1R signaling plays a significant role in cancer progression, making these inhibitors valuable in oncology research. At CymitQuimica, we offer IGF-1R inhibitors to support your research in cancer biology, endocrinology, and targeted therapy development.
Found 98 products of "IGF-1R"
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IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColor and Shape:Lyophilized PowderMolecular weight:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.HNMPA-(AM)3
CAS:HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。Formula:C20H23O10PPurity:97.22%Color and Shape:SolidMolecular weight:454.36AG1024
CAS:AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Formula:C14H13BrN2OPurity:98% - 99.37%Color and Shape:SolidMolecular weight:305.17NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Formula:C23H25ClN6O3Purity:98.07% - 98.78%Color and Shape:SolidMolecular weight:468.94Ref: TM-T1918
1mg46.00€2mg59.00€5mg96.00€10mg155.00€25mg250.00€50mg358.00€100mg537.00€1mL*10mM (DMSO)96.00€GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purity:98.89% - >99.99%Color and Shape:SolidMolecular weight:532.57NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFormula:C27H29N5OPurity:98.7% - 99.86%Color and Shape:SolidMolecular weight:439.55NVP-ADW742
CAS:NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-AblFormula:C28H31N5OPurity:96.14% - 98.70%Color and Shape:SolidMolecular weight:453.58NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Formula:C16H14BrNO5SPurity:99.64%Color and Shape:SolidMolecular weight:412.26Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formula:C42H70O12Purity:98% - 99.65%Color and Shape:SolidMolecular weight:767.00Ref: TM-T6S1487
1mg107.00€5mg251.00€10mg404.00€25mg665.00€50mg888.00€100mg1,251.00€1mL*10mM (DMSO)341.00€Insulin(cattle)
CAS:Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.Formula:C254H377N65O75S6Purity:98%Color and Shape:SolidMolecular weight:5733.49NBI-31772 hydrate
NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.Formula:C17H13NO8Color and Shape:SolidMolecular weight:372.82Linsitinib
CAS:OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.Formula:C26H23N5OPurity:99.71% - ≥95%Color and Shape:SolidMolecular weight:421.49AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13%Color and Shape:SolidMolecular weight:448.95AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H31N7O2Purity:97.07% - 99.75%Color and Shape:SolidMolecular weight:485.58MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurity:99.39%Color and Shape:SolidMolecular weight:293.3Ref: TM-T8773
1mg52.00€5mg92.00€10mg138.00€25mg245.00€50mg363.00€100mg515.00€200mg700.00€1mL*10mM (DMSO)103.00€BRD7552
CAS:BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.Formula:C33H33N3O15Purity:>99.99% - ≥98%Color and Shape:SolidMolecular weight:711.63Sari 59-801
CAS:Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Formula:C18H23N3O2Purity:99.92%Color and Shape:SolidMolecular weight:313.39Ref: TM-T34532
1mg34.00€5mg107.00€10mg167.00€25mg263.00€50mg366.00€100mg492.00€1mL*10mM (DMSO)108.00€Glymidine
CAS:Glycodiazine, a sulfadiazine derivative, reduces blood sugar by boosting insulin release and sensitivity.Formula:C13H15N3O4SColor and Shape:SolidMolecular weight:309.34GIP (1-30) amide, porcine acetate
GIP (1-30) amide, porcine is a GIP receptor agonist that stimulates insulin and mildly inhibits gastric acid.Formula:C164H249N41O49SPurity:98.50%Color and Shape:SolidMolecular weight:3611.04Glymidine sodium
CAS:Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.Formula:C13H14N3NaO4SPurity:98.19%Color and Shape:SolidMolecular weight:331.32PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Formula:C18H17Cl2N3O2Purity:99.86%Color and Shape:SolidMolecular weight:378.25Insulin (human)
CAS:Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood.Formula:C257H383N65O77S6Purity:97.32% - 99.99%Color and Shape:SolidMolecular weight:5807.57MSDC 0160
CAS:MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Formula:C19H18N2O4SPurity:98.11% - 99.53%Color and Shape:SolidMolecular weight:370.42Ref: TM-T2607
1mg34.00€2mg48.00€5mg73.00€10mg94.00€25mg145.00€50mg187.00€100mg333.00€1mL*10mM (DMSO)78.00€MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurity:98.53%Color and Shape:SolidMolecular weight:314.38XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg52.00€2mg73.00€5mg94.00€10mg141.00€25mg244.00€50mg371.00€100mg552.00€1mL*10mM (DMSO)104.00€Ceritinib dihydrochloride
CAS:Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.Formula:C28H38Cl3N5O3SPurity:99.85% - 99.99%Color and Shape:SolidMolecular weight:631.06Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formula:C28H36ClN5O3SPurity:98.52% - 99.77%Color and Shape:SolidMolecular weight:558.14Picropodophyllin
CAS:Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.Formula:C22H22O8Purity:98.38% - 99.83%Color and Shape:SolidMolecular weight:414.41Ref: TM-T6943
5mg64.00€10mg88.00€25mg170.00€50mg316.00€100mg535.00€500mg1,121.00€1mL*10mM (DMSO)69.00€BMS-536924
CAS:BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFormula:C25H26ClN5O3Purity:99.02%Color and Shape:SolidMolecular weight:479.96GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Formula:C44H47F2N9O5SPurity:98.2% - 99.76%Color and Shape:SolidMolecular weight:851.96Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Formula:C20H19N3O4Purity:98.54%Color and Shape:SolidMolecular weight:365.38Ref: TM-T11654
1mg42.00€5mg88.00€10mg124.00€25mg197.00€50mg293.00€100mg434.00€200mg622.00€1mL*10mM (DMSO)93.00€Dusigitumab
CAS:Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.
Purity:95% - 95%Color and Shape:LiquidS961
CAS:S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.Formula:C211H297N55O71S2Purity:98%Color and Shape:SolidMolecular weight:4804.13BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formula:C23H24FN9OPurity:99.69% - 99.94%Color and Shape:SolidMolecular weight:461.49Ref: TM-T2349
1mg50.00€2mg66.00€5mg90.00€10mg158.00€25mg310.00€50mg509.00€100mg732.00€1mL*10mM (DMSO)110.00€D-(+)-Sorbose
CAS:D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.Formula:C6H12O6Color and Shape:SolidMolecular weight:180.16KU14R
CAS:KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.Formula:C13H14N2OPurity:98%Color and Shape:White SolidMolecular weight:214.26AZ12253801
CAS:AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.Formula:C21H22N8OPurity:98%Color and Shape:SolidMolecular weight:402.45IMP2-IN-2
CAS:IMP2-IN-2: potent, selective IMP2 inhibitor; IC50s: 120.9 μM (RNA_A), 236.7 μM (RNA_B); used in cancer research.Formula:C22H19F3N2O3SColor and Shape:SolidMolecular weight:448.46BM-131246
CAS:BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.Formula:C22H20N2O4SPurity:>99.99%Color and Shape:SolidMolecular weight:408.47H-1356
CAS:H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.Formula:C55H88N14O15S2Color and Shape:SolidMolecular weight:1249.5Protonstatin-1
CAS:Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Formula:C8H5NO2S2Purity:99.77%Color and Shape:SolidMolecular weight:211.26Ref: TM-T71812
1mg90.00€5mg215.00€10mg313.00€25mg537.00€50mg713.00€100mg982.00€200mg1,333.00€1mL*10mM (DMSO)236.00€NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formula:C16H14BrNO5SPurity:98.06% - 99.72%Color and Shape:SolidMolecular weight:412.26I-OMe-Tyrphostin AG 538
CAS:I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Formula:C17H12INO5Purity:98.8%Color and Shape:SolidMolecular weight:437.19Ref: TM-T11593
1mg56.00€5mg119.00€10mg187.00€25mg432.00€50mg638.00€100mg908.00€500mg1,825.00€1mL*10mM (DMSO)131.00€NBI-6024
CAS:NBI-6024, an altered peptide ligand (APL), serves as an epitope for interferon-gamma-producing T helper lymphocytes associated with inflammation in patientsFormula:C66H112N20O21Color and Shape:SolidMolecular weight:1521.72BMS-695735
CAS:BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.Formula:C26H31ClFN7OColor and Shape:SolidMolecular weight:512.02Tyrphostin AG 538
CAS:Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.Formula:C16H11NO5Purity:98.75%Color and Shape:SoildMolecular weight:297.26IGF-1R inhibitor-4
CAS:IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.Formula:C13H15ClN4OColor and Shape:SolidMolecular weight:278.737AGL-2263
CAS:AGL-2263 is a blocker of insulin receptor (IR)Formula:C17H10N2O5Color and Shape:SolidMolecular weight:322.27
