Ubiquitination
Ubiquitination inhibitors are compounds that interfere with the process of ubiquitination, where proteins are tagged with ubiquitin molecules for degradation by the proteasome. These inhibitors are critical for studying protein turnover, signal transduction, and the regulation of various cellular processes. Ubiquitination plays a key role in many diseases, including cancer, neurodegenerative disorders, and immune system dysfunction. By modulating ubiquitination, these inhibitors can provide insights into the mechanisms of disease and open up new avenues for therapeutic intervention. At CymitQuimica, we offer a wide selection of high-quality ubiquitination inhibitors to support your research in cell biology, proteomics, and drug discovery.
Subcategories of "Ubiquitination"
Found 75 products of "Ubiquitination"
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WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Formula:C18H21Cl2N9S2Purity:98.46%Color and Shape:SolidMolecular weight:498.46Ref: TM-T13349
1mg46.00€2mg58.00€5mg87.00€10mg144.00€25mg283.00€50mg558.00€100mg797.00€500mg1,634.00€1mL*10mM (DMSO)97.00€NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Formula:C6H7N3O3Purity:97.72%Color and Shape:SolidMolecular weight:169.14TAS4464 hydrochloride
CAS:TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).Formula:C21H24ClFN6O6SPurity:98.61% - 98.96%Color and Shape:SolidMolecular weight:542.97Ref: TM-T13090
1mg66.00€5mg144.00€10mg227.00€25mg455.00€50mg753.00€100mg1,301.00€1mL*10mM (DMSO)167.00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formula:C30H37N3O4SPurity:99.93%Color and Shape:SolidMolecular weight:535.7Ref: TM-T12024
1mg43.00€5mg87.00€10mg144.00€25mg283.00€50mg454.00€100mg655.00€200mg934.00€1mL*10mM (DMSO)104.00€IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Formula:C19H23ClN2OPurity:98.94%Color and Shape:SolidMolecular weight:330.85Ref: TM-T15604
1mg35.00€5mg67.00€10mg115.00€25mg235.00€50mg378.00€100mg627.00€200mg875.00€1mL*10mM (DMSO)73.00€ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Formula:C21H23BrN6O5SPurity:99.32% - 99.82%Color and Shape:SolidMolecular weight:551.41Ref: TM-T16102
1mg87.00€2mg113.00€5mg177.00€10mg260.00€25mg409.00€50mg560.00€100mg800.00€1mL*10mM (DMSO)225.00€Rugonersen sodium
CAS:Rugonersen sodium is a locked nucleic acid (LNA)-modified antisense oligonucleotide (ASO) designed to reduce the silencing of ubiquitin protein ligase E3A (UBE3A). Angelman syndrome (AS) refers to a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, and Rugonersen has been studied for its potential use in the treatment of AS.Formula:C204H235N63Na19O109P19S19Molecular weight:6948.00Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Color and Shape:Odour SolidCbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Formula:C33H31F4N7OMolecular weight:617.25262UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C17H17ClN4O2Color and Shape:SolidMolecular weight:344.8UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C23H16ClN3O3SColor and Shape:SolidMolecular weight:449.91RNF5 agonist 1
CAS:RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.Formula:C22H18N4SColor and Shape:SolidMolecular weight:370.47dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Formula:C14H11ClN4OSPurity:98.48% - 99.41%Color and Shape:SolidMolecular weight:318.78Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Color and Shape:Odour SolidRef: TM-L8600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireUP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formula:C20H15ClN2O5SColor and Shape:SolidMolecular weight:430.86OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFormula:C22H17Cl2FN2O4Purity:99.92%Color and Shape:SolidMolecular weight:463.29Post-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Color and Shape:Odour SolidRef: TM-L1620
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireSAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Formula:C27H30ClN5O5S2Molecular weight:603.13769USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.
Formula:C19H20ClF3N4OSPurity:99.92%Color and Shape:SolidMolecular weight:444.9Cbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Formula:C27H27N5O3Molecular weight:469.21139MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formula:C29H29F3N2Color and Shape:SolidMolecular weight:462.55MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurity:99.39%Color and Shape:SolidMolecular weight:293.3Ref: TM-T8773
1mg52.00€5mg92.00€10mg138.00€25mg245.00€50mg363.00€100mg515.00€200mg700.00€1mL*10mM (DMSO)103.00€DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formula:C16H9N5OPurity:99.34%Color and Shape:SolidMolecular weight:287.28Ref: TM-T11112
1mg137.00€2mg188.00€5mg325.00€10mg465.00€25mg743.00€50mg1,035.00€100mg1,406.00€500mg2,802.00€1mL*10mM (DMSO)341.00€CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Formula:C23H27N3O4Purity:98.02% - 99.48%Color and Shape:SolidMolecular weight:409.48CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Formula:C24H23N5O2Purity:95.95% - 99.92%Color and Shape:SolidMolecular weight:413.47Ref: TM-T6796
1mg43.00€2mg56.00€5mg93.00€10mg130.00€25mg281.00€50mg444.00€100mg650.00€500mg1,369.00€1mL*10mM (DMSO)92.00€NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formula:C27H28N4O3S2Purity:99.05% - 99.85%Color and Shape:SolidMolecular weight:520.67ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Formula:C23H20N6OPurity:99.73% - >99.99%Color and Shape:SolidMolecular weight:396.44Ref: TM-T3535
1mg35.00€2mg50.00€5mg77.00€10mg105.00€25mg178.00€50mg295.00€100mg477.00€200mg677.00€1mL*10mM (DMSO)84.00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formula:C23H25ClN4OPurity:99.91% - 99.96%Color and Shape:SolidMolecular weight:408.92P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purity:97.9% - 99.64%Color and Shape:SolidMolecular weight:315.32WSB1 Degrader 1
CAS:WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Formula:C21H22N2O2Purity:98.57%Color and Shape:SolidMolecular weight:334.41VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purity:98.53% - 99.91%Color and Shape:SolidMolecular weight:469.39Ref: TM-T4067
1mg96.00€2mg155.00€5mg259.00€10mg406.00€25mg680.00€50mg938.00€100mg1,301.00€1mL*10mM (DMSO)265.00€ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formula:C23H24N6Purity:99.87% - 99.96%Color and Shape:SolidMolecular weight:384.48PR-619
CAS:PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Formula:C7H5N5S2Purity:97.25% - >99.99%Color and Shape:SolidMolecular weight:223.28Skp2 Inhibitor C1
CAS:Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Formula:C18H13BrN2O4S2Purity:97.36%Color and Shape:SolidMolecular weight:465.34Ref: TM-T4253
2mg34.00€5mg52.00€10mg85.00€25mg164.00€50mg264.00€100mg386.00€200mg537.00€1mL*10mM (DMSO)54.00€BC-1382
CAS:BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Formula:C23H29N3O5SPurity:99.15% - 99.94%Color and Shape:SolidMolecular weight:459.56Ref: TM-T8564
1mg81.00€5mg170.00€10mg250.00€25mg505.00€50mg730.00€100mg1,018.00€200mg1,369.00€1mL*10mM (DMSO)240.00€IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formula:C20H23N3O2Purity:99.3%Color and Shape:SolidMolecular weight:337.42Ref: TM-T9375
1mg50.00€5mg97.00€10mg160.00€25mg319.00€50mg449.00€100mg640.00€200mg893.00€1mL*10mM (DMSO)107.00€ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Formula:C23H24N4OPurity:98%Color and Shape:SolidMolecular weight:372.46COH000
CAS:COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Formula:C25H25NO5Purity:99.23%Color and Shape:SolidMolecular weight:419.47Ref: TM-T5199
1mg170.00€5mg371.00€10mg537.00€25mg964.00€50mg1,333.00€100mg1,882.00€1mL*10mM (DMSO)409.00€ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formula:C12H22ClN3OSPurity:99.3%Color and Shape:SolidMolecular weight:291.84Ref: TM-T8931L
5mg34.00€10mg50.00€25mg90.00€50mg138.00€100mg198.00€200mg296.00€500mg469.00€1mL*10mM (DMSO)34.00€LANOSTEROL
CAS:Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Formula:C30H50OPurity:97.99% - 99.67%Color and Shape:SolidMolecular weight:426.72GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formula:C28H19FN2O4Purity:97.67%Color and Shape:SolidMolecular weight:466.46Ref: TM-T25465
2mg35.00€5mg55.00€10mg87.00€25mg161.00€50mg245.00€100mg358.00€200mg520.00€1mL*10mM (DMSO)57.00€Subasumstat
CAS:Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Formula:C25H28ClN5O5S2Purity:97.02% - 98.22%Color and Shape:SolidMolecular weight:578.1DKM 2-93
CAS:DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Formula:C11H14ClNO3Purity:98.37% - 99.39%Color and Shape:SolidMolecular weight:243.69TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formula:C9H2Cl4O2Purity:99.34%Color and Shape:SolidMolecular weight:283.92BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFormula:C25H28N8Purity:98.66%Color and Shape:SolidMolecular weight:440.54Ref: TM-T14569
1mg87.00€5mg178.00€10mg260.00€25mg462.00€50mg655.00€100mg887.00€200mg1,198.00€1mL*10mM (DMSO)203.00€FX12
CAS:FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Formula:C10H8O4SMolecular weight:224.23Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFormula:C24H29ClN6O2Purity:98%Color and Shape:SolidMolecular weight:468.98DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Formula:C19H13BrClNO5SPurity:99.17%Color and Shape:SolidMolecular weight:482.73USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purity:99.37%Color and Shape:SolidMolecular weight:338.41CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].
Formula:C24H24N6OPurity:97.66%Color and Shape:SoildMolecular weight:412.49
