Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1483 products of "Autophagy"
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Enzalutamide
CAS:<p>Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP).</p>Formula:C21H16F4N4O2SPurity:99% - 99.93%Color and Shape:SolidMolecular weight:464.44Arctigenin
CAS:<p>(-)-Arctigenin ((-)-Arctigenin) is found in burdock.</p>Formula:C21H24O6Purity:98% - 99.51%Color and Shape:SolidMolecular weight:372.41PRIMA-1
CAS:PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.Formula:C9H15NO3Purity:99.22%Color and Shape:SolidMolecular weight:185.22Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Formula:C32H36N2O3Purity:98.87% - 99.61%Color and Shape:SolidMolecular weight:496.64GSK2656157
CAS:<p>GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.</p>Formula:C23H21FN6OPurity:98.59% - >99.99%Color and Shape:SolidMolecular weight:416.45PD-166866
CAS:PD-166866 is a selective FGFR tyrosine kinase inhibitor.Formula:C20H24N6O3Purity:98.29%Color and Shape:SolidMolecular weight:396.44ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formula:C12H22ClN3OSPurity:99.3%Color and Shape:SolidMolecular weight:291.84Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Formula:C23H27N7O3S2Purity:98.69% - 99.97%Color and Shape:SolidMolecular weight:513.64SF1670
CAS:SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.Formula:C19H17NO3Purity:98.25% - 98.54%Color and Shape:SolidMolecular weight:307.34Thiamet G
CAS:Thiamet G is a selective O-GlcNAcase inhibitor (Ki=20 nM). The role of O-GlcNAcase is to remove O-GlcNAc from the modified protein. High-Quality, Low-Cost!Formula:C9H16N2O4SPurity:99.06% - 99.98%Color and Shape:SolidMolecular weight:248.3Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Formula:C22H34O7Purity:98.83% - 99.96%Color and Shape:Less Crystalline Solid Colorless Crystalline SolidMolecular weight:410.506-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurity:98.75% - >99.99%Color and Shape:Odorless Or Almost Odorless Pale Yellow Crystalline PowderMolecular weight:167.19Calcineurin substrate acetate
<p>Calcineurin substrate acetate is from the regulatory RII subunit of cAMP-dependent protein kinase.</p>Formula:C94H154N28O31Purity:97.59%Color and Shape:SolidMolecular weight:2172.4Cinobufagin
CAS:<p>Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.</p>Formula:C26H34O6Purity:97.77% - 99.97%Color and Shape:SolidMolecular weight:442.54Fludrocortisone acetate
CAS:<p>Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and</p>Formula:C23H31FO6Purity:96.92% - 98.03%Color and Shape:Crystalline SolidMolecular weight:422.49Vinblastine sulfate
CAS:Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).Formula:C46H58N4O9·H2SO4Purity:97.81% - 99.82%Color and Shape:White PowderMolecular weight:909.06Tacrolimus
CAS:<p>Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein</p>Formula:C44H69NO12Purity:98% - 99.94%Color and Shape:White Or Off-White Crystalline PowderMolecular weight:804.02Brazilin
CAS:<p>1.</p>Formula:C16H14O5Purity:98% - 99.83%Color and Shape:SolidMolecular weight:286.28Glycycoumarin
CAS:Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.Formula:C21H20O6Purity:97.64% - 99.78%Color and Shape:SolidMolecular weight:368.38PTC-209
CAS:PTC-209 is a potent and selective BMI-1 inhibitor.Formula:C17H13Br2N5OSPurity:99.43% - 99.887%Color and Shape:SolidMolecular weight:495.19S29434
CAS:S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).Formula:C21H18N4O3Purity:99.92%Color and Shape:SolidMolecular weight:374.39PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Formula:C22H19BrF2N2O3Purity:97.90% - 98.27%Color and Shape:SolidMolecular weight:477.3Isradipine
CAS:Isradipine (PN 200-110), a dihydropyridine, is an antihypertensive calcium channel blocker that dilates arteries and reduces resistance.Formula:C19H21N3O5Purity:99.84% - 99.95%Color and Shape:Yellow SolidMolecular weight:371.39AM580
CAS:<p>AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )</p>Formula:C22H25NO3Purity:98% - 99.89%Color and Shape:SolidMolecular weight:351.44Bakuchiol
CAS:<p>Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.</p>Formula:C18H24OPurity:98.04% - 99.05%Color and Shape:Brownish Yellow Liquid ViscousMolecular weight:256.38IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Formula:C28H29N5OSPurity:98.76% - 99.61%Color and Shape:SolidMolecular weight:483.63NL-1
CAS:NL-1 is a mitoNEET inhibitor with antileukemic effect.Formula:C18H25NO3SPurity:98.64%Color and Shape:SolidMolecular weight:335.46JH-II-127
CAS:JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).Formula:C19H21ClN6O3Purity:98.32%Color and Shape:SolidMolecular weight:416.86Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Formula:C17H18N6Purity:99.4% - >99.99%Color and Shape:SolidMolecular weight:306.36Silibinin
CAS:Silibinin, main component in milk thistle, offers liver protection and shows anti-cancer potential in various human cells.Formula:C25H22O10Purity:97.98% - 98.37%Color and Shape:SolidMolecular weight:482.44Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59Regorafenib Hydrochloride
CAS:<p>Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.</p>Formula:C21H16Cl2F4N4O3Purity:99.56%Color and Shape:SolidMolecular weight:519.28Aloe emodin
CAS:<p>Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.</p>Formula:C15H10O5Purity:97.00%Color and Shape:Orange SolidMolecular weight:270.24GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFormula:C31H39N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:541.69LYN-1604 dihydrochloride
CAS:LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Formula:C33H45Cl4N3O2Purity:98.95% - 99.92%Color and Shape:SolidMolecular weight:657.54OSU-T315
CAS:OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Formula:C30H30F3N5OPurity:98.69%Color and Shape:SolidMolecular weight:533.59Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Formula:C14H19BCl2N2O4Purity:98% - 98.92%Color and Shape:SolidMolecular weight:361.03SBE13 Hydrochloride
CAS:SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.Formula:C24H28Cl2N2O4Purity:99.00% - ≥95%Color and Shape:SolidMolecular weight:479.4Oxyphenisatin acetate
CAS:<p>Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.</p>Formula:C24H19NO5Purity:98% - 99.35%Color and Shape:SolidMolecular weight:401.41Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Formula:C25H21N7O3Purity:93.28% - 98.3%Color and Shape:SolidMolecular weight:467.48Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formula:C31H37N5O3Purity:97.14% - 98.80%Color and Shape:SolidMolecular weight:527.66Veliparib dihydrochloride
CAS:<p>Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.</p>Formula:C13H18Cl2N4OPurity:98% - 99.81%Color and Shape:SolidMolecular weight:317.21Ambroxol hydrochloride
CAS:Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract.Formula:C13H18Br2N2O·HClPurity:99.70%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:414.56CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formula:C27H23FN4O4Purity:99.66%Color and Shape:SolidMolecular weight:486.49ZLN005
CAS:ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.Formula:C17H18N2Purity:98.59% - >99.99%Color and Shape:SolidMolecular weight:250.34TWS119
CAS:TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiationFormula:C18H14N4O2Purity:98.14% - 99.63%Color and Shape:SolidMolecular weight:318.33Rutin hydrate
CAS:Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.Formula:C27H32O17Purity:97.23%Color and Shape:SolidMolecular weight:628.53Liensinine diperchlorate
CAS:Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus.Formula:C37H44Cl2N2O14Purity:99.8% - ≥95%Color and Shape:SolidMolecular weight:811.67Bafilomycin A1
CAS:<p>Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible.</p>Formula:C35H58O9Purity:95.87% - 99.36%Color and Shape:SolidMolecular weight:622.83
