DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Found 84 products of "DUB"
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IU1-47
CAS:<p>IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。</p>Formula:C19H23ClN2OPurity:98.94%Color and Shape:SolidMolecular weight:330.85C527
CAS:<p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>Formula:C17H8FNO3Purity:97.22%Color and Shape:SolidMolecular weight:293.25HBX 19818
CAS:<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Formula:C25H28ClN3OPurity:97.71%Color and Shape:SolidMolecular weight:421.96MF-094
CAS:<p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>Formula:C30H37N3O4SPurity:99.93%Color and Shape:SolidMolecular weight:535.7Subquinocin
<p>Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.</p>Formula:C20H27N3O4SColor and Shape:SolidMolecular weight:405.17223UBD1031
<p>UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.</p>Color and Shape:Odour SolidUbiquitination Compound Library
<p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；</p>Color and Shape:Odour SolidBAY-728
<p>BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].</p>Formula:C24H28F3N5O2SColor and Shape:SolidMolecular weight:507.57OTUB1/USP8-IN-1 HCl
<p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>Formula:C22H17Cl2FN2O4Purity:99.92%Color and Shape:SolidMolecular weight:463.29GK13S
<p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>Formula:C21H22N6O2Color and Shape:SolidMolecular weight:390.44MS7131
<p>MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.</p>Color and Shape:Odour SolidUSP7-IN-16
CAS:<p>USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.</p>Formula:C43H45N7O6SColor and Shape:SolidMolecular weight:787.93USP7-IN-15
<p>USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.</p>Color and Shape:Odour SolidUSP8-IN-2
CAS:<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Formula:C19H20ClF3N4OSPurity:99.92%Color and Shape:SolidMolecular weight:444.9USP8-IN-3
CAS:<p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>Formula:C18H18F3N5O2SPurity:99.79%Color and Shape:SolidMolecular weight:425.43OTUB2-IN-1
<p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>Formula:C19H18N2O6S2Purity:98.19%Color and Shape:SolidMolecular weight:434.49JAMM protein inhibitor 2
CAS:<p>JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.</p>Formula:C21H26N2O2Purity:98.57%Color and Shape:SolidMolecular weight:338.44USP7-IN-10 hydrochloride
<p>USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39</p>Formula:C26H30Cl2N4O3SColor and Shape:SolidMolecular weight:549.51GK16S
<p>GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].</p>Formula:C11H15N3OColor and Shape:SoildMolecular weight:205.12151USP8-IN-1
CAS:<p>USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].</p>Formula:C18H21N5O3SPurity:99.07%Color and Shape:SoildMolecular weight:387.46STD1T
CAS:<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Formula:C19H19N3O4S2Purity:98.77%Color and Shape:SolidMolecular weight:417.5ML364
CAS:<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Formula:C24H18F3N3O3S2Purity:99.35% - >99.99%Color and Shape:SolidMolecular weight:517.54DUB-IN-3
CAS:<p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>Formula:C16H9N5OPurity:99.34%Color and Shape:SolidMolecular weight:287.28GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Formula:C20H18N4OPurity:98.64%Color and Shape:SolidMolecular weight:330.38IU1-248
CAS:<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Formula:C20H23N3O2Purity:99.3%Color and Shape:SolidMolecular weight:337.42GNE-6776
CAS:<p>GNE-6776 is a selective USP7 inhibitor.</p>Formula:C20H20N4O2Purity:96.59% - 98.2%Color and Shape:SolidMolecular weight:348.4P 22077
CAS:<p>P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.</p>Formula:C12H7F2NO3S2Purity:97.9% - 99.58%Color and Shape:SolidMolecular weight:315.32STAMBP-IN-1
CAS:<p>STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after</p>Formula:C27H28N4O4SPurity:99.64%Color and Shape:SolidMolecular weight:504.6EOAI3402143
CAS:<p>EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.</p>Formula:C25H28Cl2N4O3Purity:99.6%Color and Shape:SolidMolecular weight:503.42TCID
CAS:<p>TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.</p>Formula:C9H2Cl4O2Purity:99.34%Color and Shape:SolidMolecular weight:283.92USP25/28 inhibitor AZ1
CAS:<p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>Formula:C17H16BrF4NO2Purity:99.79% - 99.79%Color and Shape:SolidMolecular weight:422.21USP7-IN-8
CAS:<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Formula:C21H21N3O2Purity:99.31%Color and Shape:SolidMolecular weight:347.41XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Formula:C48H57ClN8O5Purity:98.75%Color and Shape:SolidMolecular weight:861.47USP7/USP47 inhibitor
CAS:<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Formula:C18H11Cl2N3O3S3Purity:98.5% - 98.71%Color and Shape:SolidMolecular weight:484.4ML-323
CAS:<p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>Formula:C23H24N6Purity:99.87% - 99.96%Color and Shape:SolidMolecular weight:384.48DUB-IN-1
CAS:<p>DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).</p>Formula:C20H11N5OPurity:98.33% - 98.96%Color and Shape:SolidMolecular weight:337.33VLX1570
CAS:<p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>Formula:C23H17F2N3O6Purity:98.53% - 99.91%Color and Shape:SolidMolecular weight:469.39P005091
CAS:<p>P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.</p>Formula:C12H7Cl2NO3S2Purity:99.53% - 99.87%Color and Shape:SolidMolecular weight:348.22NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Formula:C21H22ClNOPurity:99.74% - 99.88%Color and Shape:SolidMolecular weight:339.86DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Formula:C15H9N5OPurity:98.96%Color and Shape:SolidMolecular weight:275.26SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Formula:C17H9NO3Purity:98.44%Color and Shape:SolidMolecular weight:275.26USP1-IN-2
CAS:<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Formula:C26H22F4N6OPurity:99.69% - 99.88%Color and Shape:SolidMolecular weight:510.486BC-1471
CAS:<p>BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.</p>Formula:C27H32N4O4SPurity:99.98%Color and Shape:SolidMolecular weight:508.63POSH-IN-1
CAS:<p>POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide （e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.</p>Formula:C14H8FNO3SPurity:99.29%Color and Shape:SolidMolecular weight:289.28LCAHA
CAS:<p>LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.</p>Formula:C24H41NO3Color and Shape:SolidMolecular weight:391.59USP28-IN-3
CAS:<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formula:C23H20Cl2N2O3SPurity:99.92%Color and Shape:SolidMolecular weight:475.39USP28-IN-4
CAS:<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formula:C22H18Cl2N2O3SPurity:98.48%Color and Shape:SolidMolecular weight:461.368RK64
CAS:<p>8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .</p>Formula:C14H16N8O2SColor and Shape:SolidMolecular weight:360.4USP7-IN-4
CAS:<p>USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .</p>Formula:C29H34N6O3Purity:98.27% - 99.09%Color and Shape:SolidMolecular weight:514.62FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Formula:C27H28N6O5SPurity:98.76%Color and Shape:SolidMolecular weight:548.61
