PKA
Protein kinase A (PKA) is a key enzyme in the GPCR signaling cascade, activated by cyclic AMP (cAMP) in response to various extracellular signals. PKA regulates a wide range of cellular processes, including metabolism, gene expression, and cell growth. Dysregulation of PKA activity is associated with various diseases, including cancer, metabolic disorders, and cardiovascular conditions. PKA modulators are valuable tools in research aimed at understanding GPCR signaling pathways and developing new therapeutic strategies. At CymitQuimica, we provide a selection of high-quality PKA modulators to support your research in signal transduction, cellular regulation, and disease mechanisms.
Found 48 products of "PKA"
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MR-L2
CAS:<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>Formula:C19H16Cl3FN4OPurity:98.09% - 98.94%Color and Shape:SolidMolecular weight:441.71A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formula:C12H14Cl2N2O2SPurity:99.32%Color and Shape:SolidMolecular weight:321.22Bucladesine sodium
CAS:<p>Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.</p>Formula:C18H23N5NaO8PPurity:96.56% - 99.76%Color and Shape:White PowderMolecular weight:491.37JAK1/2/3 Inhibitor 1
CAS:<p>JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines</p>Formula:C6H2Cl2N2SPurity:99.32%Color and Shape:SolidMolecular weight:205.06Vasonatrin Peptide (VNP)
CAS:<p>Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activity</p>Formula:C123H198N36O36S3Purity:98%Color and Shape:SolidMolecular weight:2865.37Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37KT5720
CAS:<p>KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).</p>Formula:C32H31N3O5Purity:98%Color and Shape:SolidMolecular weight:537.61PKG inhibitor peptide
CAS:<p>PKG inhibitor; mimics H2B phosphorylation site; Ki=86mM; blocks synthetic substrates, not histone phosphorylation; stops PKA activity on histones.</p>Formula:C38H74N18O10Purity:98%Color and Shape:SolidMolecular weight:943.12PKI(5-24)
CAS:<p>High affinity PKA inhibitor (Ki = 2.3 nM).</p>Formula:C76H129N31O28Purity:98%Color and Shape:SolidMolecular weight:1925.057Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formula:C13H14N2O4S2Purity:98%Color and Shape:SolidMolecular weight:326.39Malantide
CAS:<p>Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.</p>Formula:C72H124N22O21Purity:98%Color and Shape:SolidMolecular weight:1633.89Calcineurin substrate
CAS:<p>Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase.</p>Formula:C92H150N28O29Purity:98%Color and Shape:SolidMolecular weight:2112.35CREBtide
CAS:<p>CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).</p>Formula:C73H129N29O19Purity:98%Color and Shape:SolidMolecular weight:1716.99Kemptide Phospho-Ser5
<p>Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).</p>Formula:C32H62N13O12PPurity:98%Color and Shape:SolidMolecular weight:851.89PKG Substrate
CAS:<p>PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).</p>Formula:C35H67N17O11Purity:98%Color and Shape:SolidMolecular weight:902.01Malantide TFA
<p>Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.</p>Formula:C74H125F3N22O23Color and Shape:SolidMolecular weight:1747.91H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS:<p>H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].</p>Formula:C31H58N14O9Color and Shape:SolidMolecular weight:770.88PKI (5-24),amide
CAS:<p>PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.</p>Formula:C94H149N33O30Color and Shape:SolidMolecular weight:2221.4STAD 2
CAS:<p>STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap</p>Formula:C102H182N24O22Color and Shape:SolidMolecular weight:2096.724Kemptide
CAS:<p>Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).</p>Formula:C32H61N13O9Purity:98%Color and Shape:SolidMolecular weight:771.91Kiss2 peptide acetate
<p>Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).</p>Formula:C63H84N16O12·xC2H4O2Color and Shape:SolidMolecular weight:1257.44 (free base)PKA-IN-1
CAS:<p>PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study</p>Formula:C13H11N3OPurity:97.52%Color and Shape:SolidMolecular weight:225.25AP-C2
CAS:<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Formula:C18H16N4SPurity:99.87%Color and Shape:SoildMolecular weight:320.41PKA/AKAP-IN-2
CAS:<p>PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.</p>Formula:C17H17NO3Purity:99.82%Color and Shape:SoildMolecular weight:283.32Aplithianines A
<p>Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM by</p>Purity:98%Color and Shape:Odour SolidDT-3 acetate
<p>DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.</p>Formula:C152H258N52O28S·xC2H4O2Color and Shape:SolidMolecular weight:3294.07 (free acid)CCG215022
CAS:<p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>Formula:C26H22FN7O3Purity:97.63% - 99.69%Color and Shape:SolidMolecular weight:499.5Metadoxine
CAS:<p>Metadoxine (Metadoxil) is a neurotransmitter stimulant.</p>Formula:C8H11NO3·C5H7NO3Purity:99.19%Color and Shape:Off-White PowderMolecular weight:298.29AT7867
CAS:<p>AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.</p>Formula:C20H20ClN3Purity:99.63%Color and Shape:SolidMolecular weight:337.85Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Formula:C13H15N3O2SPurity:99.44%Color and Shape:Pale Yellow Crystalline SolidMolecular weight:277.34Iso-H7 dihydrochloride
CAS:<p>Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.</p>Formula:C14H19Cl2N3O2SPurity:99.53%Color and Shape:White Crystalline SolidMolecular weight:364.29Bilobetin
CAS:<p>Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.</p>Formula:C31H20O10Purity:97.74% - 99.69%Color and Shape:SolidMolecular weight:552.48Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formula:C14H18ClN3O2SPurity:99.54% - ≥95%Color and Shape:White SolidMolecular weight:327.83PKG drug G1
CAS:<p>PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.</p>Formula:C13H11N3OSPurity:97.57% - 97.67%Color and Shape:SolidMolecular weight:257.31AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Formula:C17H16ClN3OPurity:98.04% - ≥95%Color and Shape:SolidMolecular weight:313.78H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Formula:C20H20BrN3O2S·2HClPurity:98.22% - >99.99%Color and Shape:SolidMolecular weight:519.28Staurosporine
CAS:<p>Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr</p>Formula:C28H26N4O3Purity:99.24% - 99.82%Color and Shape:Off-White PowderMolecular weight:466.538-Bromo-cAMP sodium salt
CAS:<p>8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.</p>Formula:C10H10BrN5NaO6PPurity:98% - 99.94%Color and Shape:Off-White PowderMolecular weight:430.08H-8 hydrochloride
CAS:<p>H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.</p>Formula:C12H17Cl2N3O2SPurity:99.93%Color and Shape:White To Off-White Crystalline SolidMolecular weight:338.256-Bn-cAMP
CAS:<p>6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.</p>Formula:C17H18N5O6PColor and Shape:SolidMolecular weight:419.338-Chloro-cAMP sodium
CAS:<p>8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.</p>Formula:C10H10ClN5NaO6PColor and Shape:SolidMolecular weight:385.638-MA-cAMP
CAS:<p>8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.</p>Formula:C11H15N6O6PColor and Shape:SolidMolecular weight:358.25BGC201531
CAS:<p>BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.</p>Formula:C26H28N2O6SPurity:98.51% - 99.33%Color and Shape:SolidMolecular weight:496.58Rp-cAMPS triethylammonium salt
CAS:<p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>Formula:C16H27N6O5PSPurity:98%Color and Shape:SolidMolecular weight:446.46FMP-API-1
CAS:<p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>Formula:C13H14N2O2Color and Shape:SolidMolecular weight:230.2628-Br-cGMP-AM
CAS:<p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>Formula:C13H15BrN5O9PColor and Shape:SolidMolecular weight:496.16PET-cGMP
CAS:<p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>Formula:C18H16N5O7PColor and Shape:SolidMolecular weight:445.323
