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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1026 products of "PI3K/Akt/mTOR Signaling"

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  • AMG319
    Targetmol
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    AMG319

    CAS:
    AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
    Formula:C21H16FN7
    Purity:98.9% - 99.24%
    Color and Shape:Crystalline Solid
    Molecular weight:385.4

    Ref: TM-T6757

  • (E)-AG 99
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    (E)-AG 99

    CAS:
    (E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
    Formula:C10H8N2O3
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:204.18

    Ref: TM-T5155

  • CP-724714
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    CP-724714

    CAS:
    <p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), &gt;640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>
    Formula:C27H27N5O3
    Purity:97.1% - 98.82%
    Color and Shape:Solid
    Molecular weight:469.54

    Ref: TM-T4014

  • PP 3
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    PP 3

    CAS:
    <p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>
    Formula:C11H9N5
    Purity:98.61%
    Color and Shape:Whit To Off-White Solid
    Molecular weight:211.22

    Ref: TM-T23176

  • Almonertinib
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    Almonertinib

    CAS:
    Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.
    Formula:C30H35N7O2
    Purity:99.99%
    Color and Shape:Solid
    Molecular weight:525.64

    Ref: TM-T5462

  • MOTS-c(Human) Acetate(1627580-64-6 free)
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    MOTS-c(Human) Acetate(1627580-64-6 free)

    <p>MOTS-c(Human) Acetate is a mitochondrial-derived peptide.</p>
    Formula:C103H156N28O24S2
    Purity:100%
    Color and Shape:Solid
    Molecular weight:2234.64

    Ref: TM-TP2312

  • Torin 2
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    Torin 2

    CAS:
    <p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>
    Formula:C24H15F3N4O
    Purity:98.31% - 99.32%
    Color and Shape:Solid
    Molecular weight:432.4

    Ref: TM-T6100

  • Dacomitinib
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    Dacomitinib

    CAS:
    <p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>
    Formula:C24H25ClFN5O2
    Purity:99.4% - 99.72%
    Color and Shape:Solid
    Molecular weight:469.94

    Ref: TM-T2483

  • 4-Chloro-2'-bromoacetophenone
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    4-Chloro-2'-bromoacetophenone

    CAS:
    4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).
    Formula:C8H6BrClO
    Purity:98.34% - 99.41%
    Color and Shape:White To Beige Solid
    Molecular weight:233.49

    Ref: TM-T8908

  • Theliatinib tartrate
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    Theliatinib tartrate

    CAS:
    Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.
    Formula:C29H32N6O8
    Color and Shape:Solid
    Molecular weight:592.6

    Ref: TM-T72431

  • Dacomitinib hydrate
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    Dacomitinib hydrate

    CAS:
    Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of
    Formula:C24H27ClFN5O3
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:487.96

    Ref: TM-T19965

  • PKD-IN-1 dihydrochloride (956121-30-5 free base)
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    PKD-IN-1 dihydrochloride (956121-30-5 free base)

    CAS:
    <p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>
    Formula:C18H21Cl3N4O
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:415.75

    Ref: TM-T8957L

  • SU5214
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    SU5214

    CAS:
    SU5214 is a modulator of tyrosine kinase signal transduction.
    Formula:C16H13NO2
    Purity:99.45% - 99.55%
    Color and Shape:Solid
    Molecular weight:251.28

    Ref: TM-T3569

  • TBB
    Targetmol
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    TBB

    CAS:
    <p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>
    Formula:C6HBr4N3
    Purity:98.51% - 99.45%
    Color and Shape:Off-White Solid
    Molecular weight:434.71

    Ref: TM-T2695

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.
    Formula:C23H25NO·HCl
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:367.91

    Ref: TM-T6145

  • Gefitinib-based PROTAC 3
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    Gefitinib-based PROTAC 3

    CAS:
    Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).
    Formula:C47H57ClFN7O8S
    Purity:97.29% - 98.25%
    Color and Shape:Solid
    Molecular weight:934.51

    Ref: TM-T5437

  • AMG 511
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    AMG 511

    CAS:
    <p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>
    Formula:C22H28FN9O3S
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:517.58

    Ref: TM-T14214

  • SB 216763
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    SB 216763

    CAS:
    SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).
    Formula:C19H12Cl2N2O2
    Purity:98.9% - 99.13%
    Color and Shape:Solid
    Molecular weight:371.22

    Ref: TM-T3077

  • Eganelisib
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    Eganelisib

    CAS:
    Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)
    Formula:C30H24N8O2
    Purity:98.92% - 99.28%
    Color and Shape:Solid
    Molecular weight:528.56

    Ref: TM-T5432

  • WZ4003
    Targetmol
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    WZ4003

    CAS:
    <p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>
    Formula:C25H29ClN6O3
    Purity:99.65% - >99.99%
    Color and Shape:Solid
    Molecular weight:496.99

    Ref: TM-T6291