Oligosaccharides

<p>Robinose is a flavonoid derivative that is used as a conditioning agent in animal health products. It has been shown to increase the efficacy of an antigen by enhancing the immune response. Robinose also has enzyme activities and has been shown to work synergistically with other flavonoids such as quercetin. In addition, it can be used as an analytical method for glycan structures. Robinose is typically produced from the hydrolysis of flavonol glycosides found in plants such as raspberries, blackberries, and blueberries. It can also be extracted from sugar beet molasses or sugar cane molasses.</p>

<p>Induces ulceration; used to model inflammatory bowel disease</p>

<p>Core antigen fragment in ABO blood group system</p>

<p>Produced from starch by transglycosylation-15 a-(1,4) linked glucose residues</p>

<p>5-O-(a-D-[6,6'-2H2]Glucopyranosyl)-D-fructopyranose is a custom synthesis carbohydrate that is an oligosaccharide. It is a saccharide with a general formula of C6H10O5. One of its modifications is methylation. This product has been fluorinated and modified with the click reaction to create a glycosylated sugar. 5-O-(a-D-[6,6'-2H2]Glucopyranosyl)-D-fructopyranose is not radioactive and has high purity. It is also a polysaccharide that contains glucose monomers that are linked by glycosidic bonds to form branched chains of 10 or more units. The product has an appearance of white powder, and it can be used as an additive for pharmaceuticals, food products, and cosmetics.</p>

<p>Isolated from ivory-nut mannan, Picea glauca and Pinus strobus glucomannans</p>

<p>α 1,4-glucononasaccharide derived from starch by hydrolysis and chromatography</p>

<p>Sialylfucosyllacto-N-tetraose is a human milk oligosaccharide (HMO) and is present in lower concentrations than 2′-fucosyllactose. Sialylfucosyllacto-N-tetraose contains both nitrogen and sialic acid in its chemical structure. It has been demostrated that sialylfucosyllacto-N-tetraose in the HMO pool acts as a prebiotic, protects against infections and inflammation, modulates the immune system, supports brain development, and reduces the risk of necrotizing enterocolitis (Wiciński, 2020).</p>

<p>Benzyl 4-O-(2,6-di-O-benzyl-b-D-galactopyranosyl)-2,3,6-tri-O-benzyl-D-glucopyranoside is a carbohydrate that belongs to the oligosaccharide class of saccharides. It is a synthetic compound with a CAS number (CAS No.: 128364-79-5) and a high purity. The carbohydrate has been synthesized by methylation, glycosylation, and click modification. Its chemical name is benzyl 4-[(2,6-di-[3'-O-(4,4'-dimethoxytrityl)butyldimethylsilyl]benzoyl)-a -D--galactopyranosyl]-2,3,6-[3'-O-(4',4''dimethoxytrityl)butyl]tri[3',5']</p>

<p>This is a custom synthesis, modification, and fluorination of a polysaccharide. The monosaccharide units are methylated and then modified with a click reaction. The saccharides are glycosylated with 2-O-a-D-mannopyranosyl moieties for the purpose of increasing their water solubility. This saccharide has been synthesized by the modification of an oligosaccharide that has been modified to include a hydroxyl group. The carbohydrate is complex and contains many different types of sugars including glucose, mannose, and galactose.</p>

<p>Produced from starch; white hygroscopic spray-dried powder; easily digestible</p>

<p>A functionalized carbohydrate that serves as a valuable precursor for the synthesis of complex glycoconjugates, oligosaccharides, and glycopolymers through reactions like glycosylation and click chemistry</p>

<p>Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. Neoagarodecaose is reported to have potential for novel cosmeceuticals.</p>

<p>4-O-(2-Acetamido-2-deoxy-[UL-13C6]glucopyranosyl)-D-ribitol is a custom synthesis of an oligosaccharide, monosaccharide, and polysaccharide. It is a high purity and CAS No. custom synthesis with a high degree of modification. This product has been synthesized by methylation and glycosylation for use in the study of the structure and function of complex carbohydrates. The fluorination was done to the saccharide to give it the desired properties for use in various applications.</p>

<p>Glucotetraose (C) is a custom-synthesized carbohydrate that is modified with fluorine, methylation, and click modification. It is a monosaccharide with an Oligosaccharide chain of saccharides. This product has a purity of 99.5%.</p>

<p>Unusual lactose sulphate isolated from canine milk (beagle-Canis familiaris), which does not appear to have previously been isolated from milk or other natural sources. The structure was established by 2D NMR spectroscopy and mass spectrometry.</p>

<p>Core antigen fragment in ABO blood group system</p>

<p>Sucralose, an artificial sweetener, was discovered in a research programme supported by Tate &amp; Lyle to halogenate sucrose. The majority of ingested sucralose is not broken down by the body, so it is noncaloric. In the European Union, it has been given the E number E955. Sucralose is about 320 to 1,000 times sweeter than sucrose, three times as sweet as both aspartame and acesulfame potassium, and twice as sweet as sodium saccharin.  It is stable under heat and over a broad range of pH conditions. Therefore, it can be used in baking or in products that require a long shelf life. The commercial success of sucralose-based products stems from its favorable comparison to other low-calorie sweeteners in terms of taste profile, stability, and safety.</p>

<p>Trehalulose is a sugar that is found in plants, animals, and fungi. It is a reaction product of glucose with the enzyme trehalase, which cleaves off two molecules of water to form one molecule of glucose and one molecule of trehalulose. Trehalulose has been shown to be an inhibitor of phosphofructokinase, an enzyme involved in glycolysis. This inhibition can be reversed by the addition of ATP or pyruvate kinase. Trehalulose also has been shown to inhibit the growth of cells by interfering with protein synthesis. Trehalulose may have biological functions including dietary uses as a replacement for sucrose or lactose due to its low calorie content and high level of sweetness.br&gt;br&gt; Trehalulose is structurally similar to sucrose because it has both a glucose part and a fructose part and it will react with hydrogen fluoride (HF) in dry weight reactions, forming trehalo-s</p>

<p>Galactooligosaccharides (GOS) have a sweetness of 30–60 % relative to sucrose. They have applications in a wide range of food products such as sweeteners, bulking agents, and sugar substitutes and are found in a range of product types including bread, ‘sports’ drinks, jams, fermented milk, confectionary and desserts. In Europe they are incorporated into infant formula foods.</p>

<p>Tumor associated antigen and target for the development of anti-cancer vaccines</p>

<p>Core antigen fragment in ABO blood group system</p>

<p>Monosialyl, monofucosyl-(1-2)-lacto-N-hexaose is a synthetic, fluorinated monosaccharide that is used to modify complex carbohydrates. It can be used for the synthesis of oligosaccharides and polysaccharides with a variety of sugar modifications. Monosialyl, monofucosyl-(1-2)-lacto-N-hexaose has the CAS Registry Number 111832-43-9.</p>

<p>A antigen pentasaccharide Type I I, possible use in antiviral development</p>

<p>4-O-{4-O-[[2,4-Di-O-acetyl-3-O-[2,4-di-O-(3,4,6-tri-O-acetyl-2-deoxy-2--phthalimido--bD--glucopyranosyl)-3,6--di--O--benzyl aDmannopyra nosyl]-6--O-[3,4--di--O--acetyl 2,6--di--O-(3,4,6--tri - O - acetyl 2 - deoxy 2 - phthalimido bDglucopyranosyl) aDmannopyranosyl] } is a synthetic complex carbohydrate. It is an oligosaccharide that can be used in glycosylation reactions. This carbohydrate has been custom synthesized and modified to include methyl groups. The CAS number for this compound is 9461642899.</p>

<p>This mixture contains some of the neutral and sialylated oligosaccharides found in human meconium.</p>

<p>Sialylated oligosaccharide with the ability to inhibit angiogenesis and tumour development by binding to the vascular endothelial growth factor receptor VEGFR-2. Moreover, sialylated N-glycans in intestinal epithelium of chickens were found to carry terminal sialylgalactose, which interacts with influenza viruses during early stages of infection.</p>

<p>4-O-(b-D-Glucopyranosyl)-b-D-thioglucopyranose is a methylated, saccharide. It is a polysaccharide that can be modified with Click chemistry to introduce a variety of modifications in order to make it more suitable for different applications. This compound may be glycosylated or fluorinated for use in pharmaceuticals, as well as have its carbohydrate content modified. 4-O-(b-D-Glucopyranosyl)-b-D-thioglucopyranose is used as a synthetic sugar and is CAS No. 97787-84-5.</p>

<p>Used for structural and conformational studies and as enzyme substrates</p>

<p>Heparin is a glycosaminoglycan which is a complex carbohydrate that contains repeating disaccharide units of glucosamine and N-acetylglucosamine. Heparin has been shown to inhibit the activity of bacterial enzymes involved in fibrinolysis, such as plasminogen activator inhibitor 1 (PAI-1), and may act as an anticoagulant. Heparin is often used as an anticoagulant in patients with thrombotic disorders, including deep vein thrombosis, pulmonary embolism, or heart attack. Heparin also acts as a cofactor for the activation of clotting factors II (thrombin), VII, IX, X, XI and XII. In addition, it inhibits the activation of factor XIII by preventing its conversion from its inactive form into active factor XIIIa. The molecular weight of heparin is approximately 10 kilodaltons (kDa) and it has a molecular formula</p>

<p>Glycyl-Oligosaccharidesmannose 5 is a high purity, custom synthesis sugar that is fluorinated and glycosylated. It is an oligosaccharide with a mannose backbone and a glycyl group attached to the first mannose. The methylation of the glycyl group on Glycyl-Oligosaccharidesmannose 5 can be modified to produce different derivatives. This carbohydrate has been synthesized and has CAS Number: 68149-46-1.</p>

<p>Non-reducing storage and transport sugar in woody plants; used as a sweetener</p>

<p>Carbohydrate moiety of globopentaosylceramide</p>

<p>3'-Sialyllactose-BSA binds to human serum albumin. It is used in the detection of tumour cells in blood samples, and has been shown to be sensitive for the detection of malignant cells in sera from patients with metastatic breast cancer. 3'-Sialyllactose-BSA can also be used as a probe for the identification of glycosphingolipids in animal tissues. The antibody's specificity for glycosphingolipids was demonstrated by its ability to bind selectively to glycosphingolipid-containing liposomes, but not lipid vesicles without glycosphingolipids.</p>

<p>4-Methoxyphenyl 4-O-(4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-3,6,2′,4′″triphosphate (4MPP) is a methylated saccharide. It can be modified with click chemistry and has been shown to inhibit the synthesis of glycogen in the liver. 4MPP is a high purity product that has been synthesized from naturally occurring carbohydrates. It is also fluorinated for use in research.</p>

<p>Galactosyllactose attenuated NF-κB inflammatory signaling in human intestinal epithelial cells and in human immature intestine. Thus, galactosyllactoses are strong anti-inflammatory agents in human colostrum and early milk, contributing to innate immune modulation. The potential clinical utility of galactosyllactose warrants investigation.</p>

<p>Benzyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a lectin that has been found to have agglutinin activity. Lectins are carbohydrate binding proteins that bind to glycoproteins and glycolipids. This protein has also been shown to be an antigen, which can stimulate the production of antibodies in the body.</p>

<p>It is one of the few clusters of differentiation that is not a protein and structurally contains a galactose moiety linked α to lactosylceramide. Defects in the enzyme α-galactosidase lead to the buildup of globotriaosylceramide, causing Fabry's disease. The pharmaceutical drug migalastat enhances the function of α-galactosidase and is used to treat Fabry's.  Globotriaosylceramide is also one of the targets of Shiga toxin, which is responsible for pathogenicity of enterohemorrhagic E. coli.</p>

<p>Xyloglucan is a non-cellulosic polysaccharide polymer that is important in plant cell walls. Xyloglucan nonasaccharide (XN) is a linear molecule with an average molecular weight of 10,000 Da and consists of xylose monomers. The XN molecule has a basic structure, which may be due to the presence of amino acid residues, although the exact function of these amino acids is not known. XN has been shown to inhibit colony-stimulating factor (CSF) production and induce CSF release in mouse bone marrow cells. This inhibition may be due to the binding of XN to the monoclonal antibody CD45R on the surface of mouse bone marrow cells.</p>

<p>Derived from pullulan using pullulanase</p>

<p>Key synthetic precursor for the synthesis of lacto-oligosaccharides</p>

<p>Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. Neoagarotetraose is reported to have potential for novel cosmeceuticals.</p>

<p>Glycyl-sialyllacto-N-tetraose b is a custom synthesis of an oligosaccharide consisting of four monosaccharides. The monosaccharides are glycyl, sialyllactose and two tetrasaccharides with the configuration of (1,4)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)-beta-D-glucopyranosyl-(1,4)-alpha-D-mannopyranosyl. Glycyl-sialyllacto-N-tetraose b is a high purity product that can be modified to contain fluorine atoms. This product has been shown to have methylation activity in Methylation reactions.</p>

<p>N2F N-Glycan is a custom synthesis, modification and fluorination product that contains a methylated monosaccharide and a saccharide. The saccharide is glycosylated with a complex carbohydrate, which is composed of many sugar molecules. This product can be used for the modification of proteins, peptides and nucleic acids. It can also be used to synthesize oligosaccharides or polysaccharides.</p>

<p>This product is a synthetic, high purity, and custom-synthesized molecule that belongs to the group of saccharide polymers. It is synthesized by methylation of 4-methoxyphenyl 4-O-[3-O-(2,3,4,6-O-acetyl-a-D-mannopyranosyl)-4,6-O-benzylidene-2-O-levulinoyl]-b-Dglucopyranoside and Click modification. This product has potent glycosylation activity with polysaccharides such as heparin and chondroitin sulfate. The synthesis of this product is completed through the use of a highly efficient and selective carbohydrate polymerization method.</p>

<p>Methyl 4-O-(a-D-galactopyranosyl)-a-D-galactopyranoside (M4G) is a disaccharide that is a residue of the plant indigo dye. M4G is found in plants like Indigofera tinctoria, which are used to produce indigo dye. It is also a glycoside of methyl 4-O-(β-D-galactopyranosyl)-β-D-galactopyranoside (M4GP).</p>

<p>This product is a complex carbohydrate that has been modified with fluorination, saccharide modification, and Oligosaccharide synthesis. The specific modifications on the carbohydrate are methylation, Click modification, and polysaccharide synthesis. This product has a CAS No. of _______ and is custom synthesized for _______. It is available in high purity and has an _____ monosaccharide composition.</p>

<p>b1-4 penta mannuronosaccharide-from alginate by enzyme or acid hydrolysis</p>

<p>2-Acetamido-4-O-{2-acetamido-4-O-[3-O-[2,4-di-O-(2-acetamido-2,6-dideoxyb -D-glucopyranosyl)-a,D -mannopyranosyl]-6-O-[2,6 -di(2 -acetamido)-b -D -glucopyranosyl]-b D mannopyranosyl]] b D mannopyranosyl} 2,6 dideoxy b D glucopyranosyl} 6 O-(a L fucopyranosyl)}</p>

<p>Used as enzyme substrates, analytical standards and for in vitro diagnostics</p>