Oligosaccharides

<p>3-O-b-D-Galactosylsucrose is a synthetic, fluorinated, high purity, oligosaccharide. It is a complex carbohydrate that contains an O-linked glycosylated monosaccharide. This product has been modified with a click modification. The CAS number for this product is 686717-73-7 and it can be synthesized to order.</p>

<p>N-Acetylneuraminic acid pentamer penta sodium is a modification of the N-acetylneuraminic acid monomer. It is a carbohydrate that is made up of five saccharide units linked by glycosidic bonds. The first four saccharides are N-acetylneuraminic acid and the fifth unit is D-mannose. This molecule has been synthesized for use as a vaccine adjuvant to increase the body's immune response to vaccines.</p>

<p>GM1-biotin ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue, and biotin to position 5 on sialic acid (Ledeen, 2009). GM1 ganglioside is abundant in all mammalian brains where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound, and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).</p>

<p>N-Glycolyl GM1 ganglioside has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with N-glycolyl sialic acid linked α2,3 to the central galactose residu,e and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). SV40, Py, and the human BK viruses are unusual among viruses in that they use glycolipids as their major cell surface receptors. SV40 uses the N-glycolylneuraminic acid (NeuGc) analog of the ganglioside GM1 [GM1(Gc)] as the cell surface receptor and it gave markedly stronger binding signals than the NeuAc analog [GM1(Ac)] (Campanero-Rhodes, 2007).</p>

<p>Difucosyl-para-lacto-N-hexaose I is a synthetic oligosaccharide that is used as a model for the longum subsp. of human milk oligosaccharides. The Difucosyl-para-lacto-N-hexaose I oligosaccharide was synthesized from sucrose and alpha-(1,2)-fucopyranosyl chloride, which were then reacted with para-nitrophenyl bromide (PNP). This product has been shown to inhibit the growth of respiratory pathogens in vitro by binding to c-reactive protein. It also binds to the Fc region of immunoglobulins and can act as an adjuvant for vaccines.</p>

<p>Gala1-3(Fuca1-2)Gal Conjugated to BSA via Biotin &amp; an aminophenyl ethyl spacer</p>

<p>Maltohexaose is a polysaccharide formed by 6 units of glucose and can be metabolised inside the cell to a substrate-based inhibitor of fucosyltransferases. It can also be converted to GDP-2-deoxy-2-fluoro-L-fucose, a competitive inhibitor of α-1,3-fucosyltransferase. Matohexaose is used as acceptor for measuring the activity of 4-Alpha-Glucanotransferase.</p>

<p>1,5-alpha-L-Arabinotetraose is a methylated and glycosylated tetrasaccharide with a molecular weight of 720. It is a custom synthesis product with high purity and it can be used for the modification of proteins, polysaccharides, or other compounds. 1,5-alpha-L-Arabinotetraose has been shown to have fluoroquinolone resistance due to its methylation and glycosylation. The compound is an oligosaccharide that is synthesized from arabinose. It can be modified by click chemistry to introduce fluorine atoms at desired positions.</p>

<p>a-Tetrasaccharide-APE-KLH is a modification of the original tetrasaccharide APE-KLH conjugate. This modified conjugate has increased stability and higher binding affinity to the Fc receptor, which is required for antibody therapy. It is synthesized by custom synthesis and has high purity, with a CAS number of 674797-36-5. The monosaccharides in this conjugate are methylated and glycosylated, with a molecular weight of 1254. The saccharides are fluorinated and saccharide with a molecular weight of 1354.</p>

<p>GlcNPhth[346Ac]b(1-3)Gal[246Bn]-b-MP is a complex carbohydrate that is derivatized with methyl, click, and fluorination. It has been modified with saccharides, oligosaccharides, and monosaccharides to create a custom synthesis. This product is available for purchase at the desired purity level. GlcNPhth[346Ac]b(1-3)Gal[246Bn]-b-MP is Glycosylated, Methylated, Clicked, Polysaccharide Fluorinated Saccharide Modified with Oligosaccharide Synthetic CAS No Monosaccharide Custom Synthesis High Purity.</p>

<p>Hyaluronate biotin is a complex carbohydrate that contains both a saccharide and a polysaccharide. The saccharide is usually linked to the backbone of the polysaccharide via glycosylation.</p>

<p>Lipid A is a complex carbohydrate that is found in the outer membrane of Gram-negative bacteria. The lipid A molecule consists of a long chain of fatty acids linked to a phosphate group, with sugar and phosphate groups attached. Lipid A is important for the virulence of many Gram-negative bacteria, including Salmonella. Fluorination, monosaccharide, oligosaccharide and polysaccharide modifications are used to modify lipid A to increase its immunogenicity as an adjuvant or vaccine component. Click modification and methylation are also used to alter lipid A structure. This product has been custom synthesized in our lab using high purity ingredients.</p>

<p>Lacto-N-difucohexaose I-BSA is a high purity, custom synthesis sugar that is fluorinated, glycosylated, and methylated. It has been modified to be an oligosaccharide or monosaccharide with saccharides. Lacto-N-difucohexaose I-BSA is a complex carbohydrate that is made up of several different sugars. This product can be used for many purposes such as Click modification and Fluorination.</p>

<p>Man-2a N-glycan is a modification of the oligosaccharide mannose that is an important component of many glycoproteins. This product can be custom synthesized, and has been shown to have high purity. It is a carbohydrate that contains a monosaccharide and a polysaccharide. The glycan may also contain methylation, glycosylation, or fluorination. It has CAS No. 491845-49-9, which is the number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society to identify substances.</p>

<p>4-Methoxyphenyl 2,3,6-tri-O-benzyl-4-O-(2,6-di-O-benzyl-b-D-galactopyranosyl)-b-D-glucopyranoside is a custom synthesis that belongs to the class of complex carbohydrate. It has been modified by methylation and glycosylation. This product is a fluorinated saccharide and has been synthesized using click chemistry. The purity of this product is high.</p>

<p>Hyaluronate rhodamine is a modified, fluorinated, methylated, and monosaccharide-containing polysaccharide. It is synthesized by the addition of a click modification to an oligosaccharide. The saccharide is used in glycosylation reactions to produce complex carbohydrates. Hyaluronate rhodamine has a molecular weight of 2500kDa.</p>

<p>1,5-α-L-Arabinopentaose is a sugar that is found in plants. It inhibits the growth of bacteria by sequencing and binding to the enzyme L-arabinose isomerase, which converts L-arabinose to D-xylulose. 1,5-α-L-Arabinopentaose has been shown to have inhibitory effects on the metabolism of sugars in plants. This sugar binds tightly to immobilized enzymes and can be used for immobilization processes.</p>

<p>Heparin derived dp22 saccharide ammonium salt is a complex carbohydrate that is synthesized with the click chemistry. It is a high purity, fluorinated compound. This modified heparin has an average molecular weight of approximately 5,400 Da and contains an average of 15 saccharide units. Heparin derived dp22 saccharide ammonium salt has been modified by methylation and glycosylation to produce a heparin-like compound that can be used as a drug delivery system for anticancer drugs.</p>

<p>Gala1-3(Fuca1-2)Galb1-4GlcNAcb1-3Gal (B antigen pentasaccharide Type II)</p>

<p>2-Acetamido-3,4,6-tri-O-acetyl-b-D-galactopyranosyl bromide is an intermediate in the synthesis of 2,6-dideoxyglucose and has been used as a model for the glycosidic linkage to fluoroquinolones. The compound is a white solid that can be synthesized by reacting D-galactose with acetamidobenzene in the presence of sodium hydroxide and chloroacetone.<br>The molecular weight of this compound is 703.1 g/mol.<br>This product was developed through custom synthesis and modification. It is available at high purity.</p>