Biochemicals and Reagents

<p>Applications The Fluorescein Arsenical Hairpin Binder (FlAsH) method is presented for fluorescence labeling of proteins in living cells. Labeling proteins with the membrane-permeant fluorogenic biarsenical dye fluorescein arsenical hairpin binder-ethanedithiol (FlAsH-EDT2). The membrane-permeant fluorogenic biarsenicals FlAsH-EDT2 and ReAsH-EDT2 can be prepared in good yields by a straightforward two-step procedure from the inexpensive precursor dyes fluorescein and resorufin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaietta, G., et al.: Science, 296, 503 (2002), Hoffmann, C., et al.: Nature Methods, 2, 171 (2005), Dyachok, O., et al.: Nature, 439, 349 (2006), Gautier, A., et al.: Chem. Biol., 15, 128 (2008),<br></p>

<p>Applications Carbamoyl-guanidine Amidino Urea Salt, Hydrochloride salt (cas# 926-72-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Fmoc-Ser(TBDMS)-OH (cas# 146346-81-8) is a useful research chemical.<br></p>

<p>Applications Cytidine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.<br>References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications N,N’-Diacetyl-L-lanthionine Disodium Salt is a derivative of N-Acetyl-L-cysteine (A172091), which is a metabolite of Methyl Isocyanate.<br>References Slatter, J. G., et al.: Chem. Res. Toxicol., 4, 157 (1991);<br></p>

<p>Applications Sphingosine base present in crayfish and drosophila, contributing to muscle degeneration<br>References Kita, K., et al.: Eur. J. Biochem., 268, 592 (2001), Fyrst, H., et al.: J. Lipid Res., 49, 597 (2008),<br></p>

<p>Applications Isotope labelled L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);<br></p>

<p>Applications N-Carbobenzoxyglycine is used in the dipeptide synthesis.<br>References Hans, D., et al.: Med. Chem., 2, 627 (2006), Guzman, F., et al.: J. Biotechnol., 10, 279 (2007), Vlieghe, P., et al.: Drug Discov. Today, 15, 40 (2010),<br></p>

<p>Applications It is a potent and selective human CYP2C19 inhibitor.<br>References Suzuki, H., et al.: Drug Metab. Dispos., 30, 235 (2002), Robert, L., et al.: Drug Metab. Dispos., 31, 343 (2003),<br></p>

<p>Stability Light sensitive<br>Applications The insertion of this spin Labelled compound into RNA enables the study of RNA - protein complexes.<br>References Ramos, A. and Varani, G.: J. Am. Chem. Soc., 120, 10992-10993 (1998)<br></p>

<p>Applications 3,3'-Tolidine, is an important aromatic amine used mainly for dye production, but also for the production of certain elastomers. It is also an an intermediate for the production of soluble azo dyes and insoluble pigments used particularly in the textile, leather and paper industries. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, J., et al.: Yejin Fenxi, 26, 21 (2006); Noller C. R., et al.: Textbook of Org. Chem., (1960);<br></p>

<p>Impurity Valaciclovir EP Impurity M<br>Applications N-Formyl Valacyclovir (Valaciclovir EP Impurity M) Valacyclovir (V085000) impurity.<br>References Furman, P., et al.: Antimicrob. Agents Chemother., 20, 518 (1981),<br></p>

<p>Applications Synthetic woody odorant. Used as scent in perfumes, laundry products and cosmetics.<br>References Gras, M., et al.: Perfum. Flavor., 17, 2 (1992), Frosch, P.J., et al.: Contact Dermatitis, 33, 333 (1995),<br></p>

<p>Applications 2,5,5-trimethyl-1,3-dioxane (cas# 766-33-6) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications p-Cresidine is a reagent used in the preparation of enaminones acting as anticonvulsants. Also used in the preparation of crescent oligoamides. Dyes and metabolites, Environmental Testing.<br>References Zhu, J. et al.: J. Am. Chem. Soc., 122, 4219 (2000); Scott, K. et al.: J. Med. Chem., 36, 1947 (1993);<br></p>

<p>Applications 6-N-Biotinylaminohexanol (cas# 106451-92-7) is a compound useful in organic synthesis.<br>References Higson, A.P., et al.: Synthesis, 3, 407 (1999)<br></p>

<p>Stability Hygroscopic<br>Applications Food Red No. 102 is an artificial coloring food additive. Dye. Dyes and metabolites, Environmental Testing<br>References McCann, D. et al.: Lancet. 370, 1560 (2007); Kim, Y. et al.: Text. Res. J., 71, 318 (2001);<br></p>

<p>Stability Air Sensitive<br>Applications (E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylaldehyde (cas# 4206-58-0) is a useful research chemical.<br></p>

<p>Applications L-Arginine-2,3,3,4,4,5,5-d7 HCl (CAS# 204244-77-9) is a useful isotopically labeled research compound. It can be used with Raman scattering for imaging living cells and organisms.<br>References Min, W., et al., PCT Int. Appl. (2014), WO 2014205074 A2<br></p>

<p>Applications A sulfhydryl cross-linking reagent.<br>References Loo, T.W. and Clark, D.M.: J. Biol. Chem., 276, 40, 36877 (2001)<br></p>

<p>Applications Epoxyeicosatrienoic Acid (EET) has antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. N,​N'-​dicyclohexylurea (DCU) increased release of 14,15-EET when the cells were stimulated with a calcium ionophore.Also, it is derived from Arachidonic Acid &gt;97% (A765000), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.<br>References Zhao, X., et al.: J. Am. Soc. Nephrol., 15, 1244 (2004); Fang, X., et al.: J. Biol. Chem., 276, 14867 (2001); Kurosawa, T., et al.: J. Cell. Physiol., 219, 606 (2009); Mazalli, M., et al.: J. Agric. Food Chem., 57, 5028 (2009);<br></p>

<p>Stability Light Sensitive<br>Applications Basic Green 4 (cas# 569-64-2) is a useful research chemical.<br></p>

<p>Applications 1-Palmitoyl-rac-glycerol is a biomarker of metabolic responses to hepatotoxicants and carcinogens.<br>References Broadhurst, D., et al.: Metabolomics, 2, 171 (2006), Shi, J., et al.: Nat. Biotechnol., 25, 930 (2007),<br></p>

<p>Applications 11-Hydroxylauric Acid is used as a substrate to determine the functional expression and characterization of cytochrome P450 52A21.<br>References Kuehnel, K., et al.: Adv. Synthesis. Cata., 349, 1451 (2007); Kim, D.H., et al.: Arch. Biochem. Biophy., 464, 213 (2007);<br></p>

<p>Applications Synthetic retinoic acid receptor-α/β-selective retinoid. Antineoplastic.<br>References Hashimoto, Y., et al.: Jpn. J. Cancer Res., 79, 473 (1988), Mizojiri, K., et al.: Arzneim.-Forsch., 47, 59 (1997), Shinjo, K., et al.: Int. J. Hematol., 72, 470 (2000), Sanda, T., et al.: Leukemia, 19, 901 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications 4-Methylumbelliferyl β-D-Glucuronide is a substrate for glucuronidase. Also used as a test for coliform bacteria in water.Fluorescence: max. Abs. 316nm; max. Em. 375nm; e x 10-3: 12<br>References US Federal Register, 57, 24744 (1992)<br></p>

<p>Applications Furfural is a compound mainly found in agricultural byproducts, and is produced from the hydrolysis and dehydration of xylan contained in lignocellulose using solid acid catalysts. Furfural is also a potential platform for biofuels and inhibits fermentation in yeast.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lange, J., et al.: ChemSusChem, 5, 150 (2012); Mamman, A., et al.: Biofuels, Bioprod. Biorefin., 2, 438 (2008); Navarro, A.: Curr. Microbiol., 29, 87 (1994)<br></p>

<p>Applications An acylglycine present in urniary excretion that can be analyzed and be used as diagnostic tool for metabolic disorders, complementary to organic acids and acylcarnitine profiles.<br>References Bonafe, L. et al.: Mol. Genetics Metab., 69, 302 (2000);<br></p>

<p>Applications N-ACETYLISOLEUCINE (cas# 3077-46-1) is a useful research chemical.<br></p>

<p>Applications A carbohydrate metabolism regulator that has been shown to inhibit gluconeogenesis from lactate plus pyruvate and from substrates that enter the gluconeogenic pathway as triose phosphate.<br>References Joet, T., et al.: Biochem. J., 381, 905 (2004), Girardin, E., et al.: J. Biol. Chem., 280, 38059 (2005), Nghiem, N., et al.: App. Biochem. Biotechnol., 141, 335 (2007),<br></p>

<p>Applications β-Sitosteryl Ferulate is used for purification and identification of components of γ-oryzanol in rice bran oill<br>References Xu, Z., et al.: J. Agric. Food Chem., 47, 2724 (1999);<br></p>

<p>Applications Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neuburger, M., et al.: Eur. J. Biochem., 267, 2882 (2000), Krijt, J., et al.: Clin. Chem., 47, 1821 (2001), Yen, T.-Y., et al.: J. Mass Spectrom., 37, 15 (2002),<br></p>

<p>Applications STANNOUS OCTOATE (cas# 301-10-0) is a useful research chemical.<br></p>

<p>Applications Pregnenolone-d4, is the labeled analogue of the Pregnenolone (P712200), which is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens.<br>References Bjondahl, K., et al.: Med. Biol., 54, 454 (1976), Geick, A., et al.: J. Biol. Chem., 276, 14581 (2001), Johnson, D., et al.: Toxicol. Sci., 66, 16 (2002), Abe, C., et al.: Lipids, 42, 637 (2007),<br></p>

<p>Applications 4-Amino-nicotinonitrile<br></p>

<p>Applications Dyphylline (D826500) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Auterhoff, H.<br></p>

<p>Applications (E)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.<br>References Yang, D. et al.: J. Lipid Res., 53, 529 (2012); El-Mekkawy, S. et al.: Nat. Prod. Res., 27, 146 (2013);<br></p>

<p>Applications 3-Iodothyronamine is a novel metabolite of thyroid hormone (TH). 3-Iodothyronamine (T1AM) is an endogenous and rapid-acting derivative of thyroid hormone. It has alos been found to increase food intake in rodents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, P., et al.: Thyroid, 6, 497 (1996), Falkenstein, E., et al.: Pharmacol. Rev., 52, 513 (2000), Yen, P., et al.: Physiol. Rev., 81, 1097 (2001), Pinna, G., et al.: Endocrinology, 143, 1789 (2002), Dhillo et al.; Diabetes, Obesity &amp; Metabolism (2008), 10(2), 167-70<br></p>

<p>Applications 3,3′-Diaminobenzidine is a peroxidase substrate and a reagent for spectrophotometric determination of selenium.<br></p>

<p>Stability Temperature Sensitive<br>Applications A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis.<br>References Mathias, S., et al.: Proc. Natl. Sci. USA, 88, 10009 (1991), Mathias, S., et al.: Science, 259, 519 (1993), Jarvis, W.D., et al.: Proc. Natl. Acad. Sci. USA, 91, 73 (1994)<br></p>

<p>Applications 2-[[3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]acetic Acid is a therapeutic antisense oligonucleotide agent targeting gene G6PC cDNA for glycogen storage disease type Ia.<br>References Koizumi, M., et al.: PCT Int. Appl. 278pp. (2019)<br></p>

<p>Stability Hygroscopic<br>Applications A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity.<br>References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004); Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006); Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007);<br></p>

<p>Applications AEBSF Hydrochloride is an irreversible serine protease inhibitor.<br>References Diatchuk, V., et. al.: J. Biol. Chem., 272, 13292 (1997)<br></p>

<p>Applications Isotope labelled 17β-Estradiol (E888000), which is the major estrogen (1) secreted by the premenopausal ovary (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.<br></p>

<p>Applications 3-Hydroxy-2-naphthoic acid<br></p>

<p>Stability Light Sensitive<br>Applications The metabolites of o-Aminoazotoluene has been shown to be strongly mutagenic but the mutagenesis is inhibited by 7,8-benzoflavone. Dyes and metabolites, Environmental Testing<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Degawa, M., Kanazawa, C., Hashimoto, Y.: Carcinogenesis, 3, 1113 (1982)<br></p>

<p>Applications Protected (S) enantiomer of the amino acid Phenylalanine.<br>References Zhu, P., et al.: Bioorg. Med. Chem. Lett., 19, 6966 (2009), Cramer, B., et al.: Bioorg. Med. Chem., 18, 343 (2010),<br></p>

<p>Applications Direct Blue 2 is an organic azo dye and ground water pollutant, removed via enzymic decolorization by laccase.<br>References Akkaya, A.; et al.: Anal. Lett., 49, 790 (2016).<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system. The l-form occurs in plants.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications L-Carnosine is a naturally-occurring histidine-containing compound and the biological role of this dipeptide is to act as cytosolic buffering agents. Other roles ascribed to L-Carnosine include actions as neurotransmitters, modulation of enzymic activities and chelation of heavy metals.<br>References Quinn, P.J., et al.: Mol. Aspects. Med., 13, 379 (1992); Aruoma, O.I., et al.: Biochem. J., 264, 863 (1989);<br></p>

<p>Applications A metabolite of Capecitabine.<br>References Arellano, M., ET AL.: Br. J. Cancer, 77, 79 (1998), Budman, D., ET AL.: J. Clin. Oncol., 16, 1795 (1998), Khanna, R., et al.: Cancer Res., 60, 4725 (2000), Charasson, V., et al.: Drug Metab. Dispos., 30, 731 (2002),<br></p>

<p>Applications L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.<br>References Erion, M., et al.: J. Med. Chem., 37, 4430 (1994); Slusarchyk, W., et al.: Bioorg. Med. Chem. Lett., 5, 753 (1995)<br></p>

<p>Applications Glucosinolate analog of Glucoraphanin found in cruciferous vegetables such as broccoli and cauliflower.<br>References Lee, J.G. et al.: Horticult. Env. Biotech., 50, 509 (2009); KIm, J.K. et al.: Food Chem., 119, 423 (2010);<br></p>

<p>Applications H-Glu(Val-OH)-OH (CAS# 2746-34-1) is a useful research chemical compound.<br></p>

<p>Applications A constituent of nucleic acids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miles, et al.: Science, 142, 1458 (1963), Bugg, et al.: Biochem. Biophys. Res. Commun., 3, 436 (1968),<br></p>

<p>Applications 1-Methoxy-2-(methoxymethyl)-4-methyl-2-(propan-2-yl)pentane (cas# 129228-21-3) could be useful as a catalyst for alkene polymerization.<br>References Govindaswamy, P., et al.: Jpn. Kokai Tokkyo Koho (2020), JP 2020139048 A<br></p>

<p>Applications Ticagrelor Epimer is an epimer impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Eupatilin maintains anticoagulant and antiplatelet activity isolated from the Artemisia princeps Pampanini flower.<br>References Ryu, R. et al.: Prev. Nutr. Food Sci., 18, 181 (2013);<br></p>

<p>Applications 4-Methoxyaniline hydrochloride (cas# 20265-97-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications An inhibitor of the enzyme glucose dehydrogenase.<br>References Cozier, G.E. et al.: Biochem. J., 340, 639 (1999);<br></p>

<p>Stability Hygroscopic<br>Applications 5,10-Diformyl-5,6,7,8-tetrahydrofolic acid is a derivative of the coenzyme 5,6,7,8-tetrahydrofolic acid which is essential in primary metabolism for reactions involving the transfer of a one-carbon unit at the formic acid, the formaldehyde or the methanol oxidation levels.<br>References Flaks, J.G., et al.: J. Biol. Chem., 228, 215 (1957),<br></p>

<p>Applications 2-O-a-D-Glucopyranosyl-L-ascorbic Acid is a useful cosmetic gel and skin cleanser.<br>References Aizawa, K., et al.: PCT Int. Appl. (2020), WO 2020226147 A1<br></p>

<p>Applications A metabolite of 17α-Methyltestosterone (M326400).<br>References Dumasia, M., et al.: Xenobiotica, 11, 323 (1981), Tang, P., et al.: Anal. Biochem., 182, 289 (1989),<br></p>

<p>Applications 3,5-Diiodo-DL-tyrosine is used for diagnosis of hypothyroidism caused by DEHAL1 gene defects.<br>References Encinas, S., et al.: Chem. Res. Toxicol., 11, 946 (1998), Daneshvar, A., et al.: Chemosphere, 80, 301 (2010), Eriksson, J., et al.: Photochem. Photobiol., 86, 528 (2010),<br></p>

<p>Applications Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.<br>References Cornford, E.M., et al.: J Clin Invest, 63, 1241-1248 (1979)<br></p>

<p>Applications p-SCN-Bn-NOTA is a bifunctional chelating agent.<br>References Sarkar, S., et al.: J. Med. Chem., 61, 385 (2018)<br></p>

<p>Applications 4-(Dimethylaminobenzylidene)rhodanine is a useful research chemical in analytical techniques such as electrochemistry that investigate adsorption and corrosion inhibition by metals.<br>References Solmaz, R. et al.: Corrosion. Sci., 79, 169 (2014);<br></p>

<p>Applications An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rogler-Brown, T. et al.: Biochem. Pharmacol., 28, 201 (1979); Johnston, J.B. et al.: J. Natl. Canvcer Inst., 80, 765 (1988); Fortune, A.F. et al.: Leuk. and Lymph., 51, 839 (2010); Robak, T. et al.: Drugs, 69, 2415 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications (R)-Butyryl Carnitine is a potential prodrug of Carnitine, used for treating seizure disorders.<br>References Fei, Y., et al.: J. Biol. Chem., 275, 23707 (2000), Duran, J., et al.: J. Membr. Biol., 185, 65 (2002), Brown, A., et al.: J. Biol. Chem., 278, 11312 (2003), Gupta, N., et al.: Life Sci., 78, 2419 (2006),<br></p>

<p>Applications A metabolite of carboxylic acid.<br>References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),<br></p>

<p>Applications 8-Benzyloxy-2’-deoxyguanosine (cas# 96964-90-8) is a compound useful in organic synthesis.<br>References Wang, Y., et al.: Chem. Res. Toxicol., 19, 837 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications Yuanzhen sugar is a polysaccharide polymer, containing a certain amount of fructooligosaccharides.<br>References Watanabe, T., et al.: Biosci. Biotech. Biochem., 72, 3167 (2008), You, Y., et al.: J. Agric. Food Chem., 57, 709 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Acrylonitrile (ACN).<br>References Guengerich, F., et al.: Cancer Res., 41, 4925 (1981), Leonard, A., et al.: Mutation Res., 436, 263 (1999), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004), Dybing, E., et al.: Food Chem. Toxicol., 43, 365 (2005), Rice, J., et al.: Mutation Res., 580, 3 (2005),<br></p>

<p>Applications N-Benzyl-2-amino-3-methoxypropionamide is an impurity of Lacosamide which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013)<br></p>