Heterocycles with Nitrogen (N)

<p>Applications 6-(3-aminophenoxy)pyridine-3-carbonitrile (cas# 1099689-56-1) is a useful research chemical.<br></p>

<p>Applications (4-Acetyl-Piperazin-1-Yl)-Acetic Acid is a useful research chemical. It is used in the preparation of phenylpiperidines as neurokinin NK1 and NK3 antagonists for treatment of neurokinin-mediated diseases<br>References O'Neill, B. T., et al.: From U.S. Pat. Appl. Publ. (2005), US 20050256164 A1 20051117<br></p>

<p>Applications N-Methylpiperidinyl-2-methyl Benzilate (cas# 94909-90-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Methyl-2(1H)-pyridinone-d6 is a reagent used in the preparation of substituted N-aryl pyridinones as fibrotic inhibitors.<br></p>

<p>Applications 4-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride is an intermediate in the synthesis of ent-Rivaroxaban (R538005), the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent.<br>References Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>

<p>Applications 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid<br></p>

<p>Applications 3-Chloro-4-cyanopyridine (cas# 68325-15-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Pyrrolidinyl-3-pyridineacetic Acid is a reagent that is used in the synthesis of phenylalanine cyanomethylamides as cathepsin B inhibitors.<br>References Roy, P., et al.: PCT Int. Appl., 2010:777979 (2010);<br></p>

<p>Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2,3,6-Tetrahydropyridine (cas# 694-05-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic Acid is used to prepare a selective CB2 receptor agonist for the treatment of inflammatory pain.<br>References Giblin, G., et al.: J. Med. Chem., 50, 2597 (2007)<br></p>

<p>Applications 2,4-Dihydroxypyridine (cas# 626-03-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-[4-(Acetyl)piperazin-1-yl]phenol is used in the preparation of fungicidal and bactericidal 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and -1H-1,2,4-triazoles and their salts.<br>References Heeres, J., et al.: Ger. Offen. (1978), DE 2804096 A1 19780803<br></p>

<p>Applications 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride-D5 is an intermediate in the synthesis of Piperacillin-d5 (P479952), which is the labeled analogue of Piperacillin (P479950), an antibacterial agent.<br>References Takai, A., et al.: Chemotherapy, 25, 816 (1977), Bodey, G.P., et al.: Antimicrob. Agents Chemother., 14, 78 (1978), Kuck, N.A., et al.: J. Antibiot., 31, 1175 (1978),<br></p>

<p>Applications Chlorotripyrrolidinophosphonium Hexafluorophosphate acts as a peptide coupling reagent or condensing agent for phosphinate ester formation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prasad, K. et al.: Int. J. Pharm. Sci. Rev. Res., 8, 108 (2011); Winqvist, A. et al.: Eur. J. Org. Chem. 10, 1705 (2008);<br></p>

<p>Applications 5-benzyl-1,3-oxazolidin-2-one (cas# 42746-49-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 4,5-Dihydroxytetrahydro-2h-Imidazol-2-One (cas# 3720-97-6) is a useful research chemical.<br></p>

<p>Applications A 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) Anthracene (A678400).<br></p>

<p>Applications Used as a heterocyclic scaffold<br>References Matysiak, J., et al.: Bioorg. Med. Chem., 11, 2285 (2003), Das, J., et al.: Bioorg. Med. Chem. Lett., 18, 2652 (2008),<br></p>

<p>Applications Urazole derivative.<br></p>

<p>Applications N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide is an intermediate for the synthesis of dTAG-7 (D710015), which is a degradation tag, was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.<br>References Hai-Tsang Huang., eLife, 1-29, (2017)<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Acetylimidazole (cas# 2466-76-4) is a useful research chemical.<br></p>

<p>Applications Shows systemic antifungal activity accompanied by high levels of phytotoxicity.<br>References Carter, G.A., et al.: Ann. Appl. Biol., 84, 333 (1976)<br></p>

<p>Applications N,N-Diethyl-3-pyrrolidinamine Dihydrochloride (cas# 20984-82-1) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-2-iodo-3-methoxypyridine<br></p>

<p>Applications 2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 22288-77-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-α-D-Arabinofuranosyl-2-nitro-1H-imidazole is a synthon for a number of potential markers of tissue hypoxia.<br>References Naimi, E., et al.: Nucleosides. Nucleotides. Nuc. Acid., 24, 173 (2005); Schneider, R.F., et al.: J. Label. Comp. Radiopharma., 39, 541 (1997); Sakaguchi, M., et al.: J. Med. Chem., 26, 20 (1983);<br></p>

<p>Applications 1-[(1-Acetyl-4-piperidinyl)carbonyl]-4-piperidinecarboxylic Acid is a useful synthetic intermediate.<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d17 (CAS# 52168-48-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,4-Dihydro-2(1H)-pyridinone is used as a reactant for the regio- and stereoselective preparation of lactam-fused quinoline derivatives via Povarov-type multicomponent reaction of aldehydes, anilines, and unsaturated lactams followed by oxidation or fragmentation reactions.<br>References Vicente-Garcia, E., et al.: Org. Lett., 12, 860 (2010)<br></p>

<p>Applications 1-(Trimethylsilyl)-1H-benzotriazole (cas# 43183-36-4) is a useful research chemical.<br></p>

<p>Applications 4-Amino-2,2,6,6-tetramethylpiperidine-d17; 1-15N-1-oxyl (CAS# 97461-87-5) is a useful isotopically labeled research compound that is used in various experiments, such as, synthesis of two cysteine-specific spin labels.<br>References Wu,G. J. Label. Compd.Radiopharm., 12,1173-1181,(1995);<br></p>

<p>Applications 2-Fluoropyridine acts as a reagent in the synthesis of aminopyrimidines with antimicrobial and antifungal properties.<br>References Hedidi, M., et al.: Eur. J. Org. Chem., 39, 5903 (2017)<br></p>

<p>Applications 2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 1,​2-​Dihydro-​2-​thioxo-​6-​(trifluoromethyl)​-4-​pyrimidinecarboxylic Acid is a useful synthetic intermediate.<br></p>

<p>Applications 6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.<br>References Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23 (16), 4493 (2013);<br></p>

<p>Applications (7H-Pyrazolo[3,4-b]pyridin-5-yl)methanamine Hydrochloride is a useful research chemical.<br></p>

<p>Applications 3-(Triethoxysilyl)propyl 2-((4-amino-5-hydrazinyl-4H-1,2,4-triazol-3-yl)thio)propanoate is a useful reagent for organic reactions.<br></p>

<p>Applications 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine-d4 is labelled 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine (D448690) which is a derivative of 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine. 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine is used to prepare benzanilide derivatives for use as anticancer agents.<br></p>

<p>Applications 5-(Chloromethyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]pyridine 97% (cas# 906352-80-5) is a useful research chemical.<br></p>

<p>Applications Piperazine-N,N'-bis(2-ethanesulfonic Acid)-d18 (CAS# 352534-95-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Dibromopyridine-d3 (CAS# 1219799-05-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine is an important intermediate in the preparation of the janus kinase inhibitor INCB018424.<br>References Lin, Q. et al.: Org. Lett., 11, 1999 (2009);<br></p>

<p>Applications 1-Benzoyl-4-(2,3-dichlorophenyl)piperazine is an intermediate in the synthesis of Aripiprazole (A771000) related compound.<br>References Satyanarayana, Bollikonda. et al., Heterocyclic. Commun., 11, 485 (2005);<br></p>

<p>Applications 2-Fluoro-5-bromopyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.<br>References Li, J. et al.: J. Med. Chem., 56, 6216 (2013); James, C. et al.: Bioorg. Med. Chem. Lett., 23, 2781 (2013);<br></p>

<p>Applications Piperazine-d10 (CAS# 362049-61-4) is a useful isotopically labeled research compound.<br></p>

<p>Stability Light Sensitive<br>Applications 5-Amino-3-methylpyrazole (cas# 31230-17-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 6,​8-​Dibromo-​3,​4-​dihydro-​3,​3-​bis(1-​pyrrolidinylmethyl)​-2H-1-benzopyran-4-ol is a useful synthetic reagent.<br></p>

<p>Applications (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile-d1 is the deuterated form of (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile (C363780), which is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).<br>References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008);<br></p>

<p>Applications 3-{5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl}propanoic Acid (cas# 832135-73-6) is a useful research chemical.<br></p>

<p>Applications 1,2-Dimethylpiperazine (cas# 25057-77-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miyamoto, T., et al.: J. Med. Chem., 33, 1645 (1990),<br></p>

<p>Applications 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.<br>References Li, X., et al.: PCT Int. Appl., WO 2014183520 A1 20141120 (2014)<br></p>

<p>Applications 4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine-2-thiol (cas# 5498-17-9) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 6-Methylpyridine-3-boronic Acid Hydrochloride Hydrate is the Hydrochloride of M326565, which is used in the preparation of various biologically active compound such as phosphoinositide-3-kinases (PI3K) and c-jun N-terminal kinase (JNK) inhibitors.<br>References Smith, A.L. et al.: J. Med. Chem., 55, 5188 (2012); Perry, B. et al.: Bioorg. Med. Chem. Lett., 18, 4700 (2008); Chambers, J. et al.: ACS Chem. Neurosci., 2, 198 (2011);<br></p>