Building Blocks

<p>Applications Ethyl fluoroacetate is an inhibitor of insect juvenile hormone biosynthesis. It also shows toxic effects against Vibrio fischeri.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Quistad, Gary B., et al.: J. of Agri. and Food Chem., 30(6), 1151-4 (1982);Dawson, D. A., et al.: Archives of Envir. Contam. and Tox., 66(2), 248-258 (2014)<br></p>

<p>Applications 1-Ethyl-3-hydroxypiperidine acts as a reagent for the preparation of new compounds of N,N-dimethyl-[3-(1-alkylpiperidy)]carbamates, as potential cholinesterase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mathison, I. W., et al.: J. Pharm. Sci., 62, 158 (1973)<br></p>

<p>Applications 5,5-Dimethyl-1,3-dioxane is used in preparation of Neopentyl Glycol.<br>References Cao, S., et al.: Faming Zhuanli Shenqing, (2013);<br></p>

<p>Applications 1,3-Diphenylacetone (cas# 102-04-5) is a useful research chemical.<br></p>

<p>Applications Diphenylacetylene is a reagent used in the preparation of polysubstituded pyrroles via oxidative nitrene transfer. Also used in the aerobic coupling of salicyaldehydes with alkynes.<br>References Dewan, A. et al.: ACS Omega, 3, 5327 (2018); Yamane, S. et al.: Chem. A Eur. J., 24, 7852 (2018);<br></p>

<p>Applications N,N-Dimethyltetradecylamine (cas# 112-75-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,3-Diethynylbenzene (cas# 1785-61-1) is a useful research chemical.<br></p>

<p>Applications Phosphorus(V) Oxybromide is a reagent used in the preparation of phosphoryl halide for N-protection of amino acids using group assisted purification (GAP). Phosphorus(V) Oxybromide is a brominating agent.<br>References An, G., et al.: Heterocycles, 90, 344 (2015); Guo, J., et al.: Hebei Gongye Daxue Xuebao, 40, 57 (2011); Golding, D., et al.: J. Org. Chem., 12, 293 (1947)<br></p>

<p>Applications Dicyclohexyl Ketone (cas# 119-60-8) is a compound useful in organic synthesis.<br></p>

<p>Applications N,N-Dicyclohexylmethylamine is used as a reagent in the base preparation of 13C2- and 2H phenethylamines as internal standards for IDMS by Pd-catalyzed double carbonylation of aryl iodides in the presence of amine nucleophiles followed by deoxygenation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, D., J. Org. Chem., 74, 6155 (2012)<br></p>

<p>Applications 4-(1-Methylethyl)benzoic Acid is used in the synthesis of quinuclidine benzamides as agonists for nicotinic acetylcholine receptors. Also used in the synthesis of nifuroxazide analogues showing antimicrobial activity against methicillin-resistant Staphylococcus.<br>References Bodnar, A. et al.: J. Med. Chem., 48, 905 (2005); Masunari, A. et al.: Bioorg. Med. Chem. Lett., 15, 4229 (2007);<br></p>

<p>Applications A potent inhibitor of gluconeogenesis.<br>References Blank, B., et al.: J. Med. Chem., 17, 1065 (1974), Memoli, K.A., Tetrahedron Letters, 37, 21, 3617 (1996)<br></p>

<p>Applications 2,​4-​Diaminoanisole is a component and degredation product of azo dyes in fabrics and textiles. Azo dyes occasionally produce carcinogenic effects and environmental reproductive toxicology. Dyes and metabolites, Environmental TestingEnvironmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nguyen, A. et al.: J. Env. Sci. Health A., 51, 744 (2016);<br></p>

<p>Applications 5,6-Dehydropregabalin is an impurity of the anticonvulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Impurity Cefoperazone EP Impurity C<br>Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),<br></p>

<p>Applications 1,3,5-Tribromobenzene-d3 (CAS# 52921-77-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopentyl chloride (cas# 930-28-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Cystamine dihydrochloride is the dihydrochloride salt of Cystamine, a neuroprotective drug that works by inhibiting transglutaminase activity in the body. Cystamine has also exhibited suppressive effects against HIV replication in infected human cells.<br>References Bergamini, A., et al.: J. Clin. Invest., 93, 2251 (1994); Fox, J., et al.: J. Neuro., 91, 413 (2004); Jeitner, T., et al.: Biochem. Pharm., 69, 961 (2005)<br></p>

<p>Stability Light Sensitive, Decomposes Rapidly in Air, Temperature Sensitive<br>Applications It has been examined as a ligand and as a pseudo-cyanide.<br></p>

<p>Stability Light Sensitive<br>Applications Cinnamyl alcohol is used as a fragrance ingredient and is a known a cause of allergic dermatitis in humans. Cinnamyl alcohol is also part of a group of cinnamic acid derivatives (for example: 4-Methoxycinnamic acid -M262150) that might be useful for the treatment of diabetes and obesity.<br>References Adisakwattana, S., et al.: J. Emzym. Inhib., 28, 1067, (2013); Basketter, D.: Acta-Derm.-Venereol., 72, 264 (1992); Letizia, C. S., et al.: Food Chem. Toxicol., 43, 837 (2005);<br></p>

<p>Applications Cinchophen and its derivatives can show antipyretic, analgesic, anti-oxidative, and anti-inflammatory properties.<br>References Xu, Bo., et al.: Beijing Yike Daxue Xuebao, 29(5), 438-439 (1997); Ibrahim, S. E., et al.: Mansoura J. Pharm. Sci., 6(2), 19-24 (1990); Mishra, Pradeep., et al.: Indian J. Pharm. Sci., 50(5), 269-271 (1988); Kononenko, L. I., et al.: Zhurnal Analiticheskoi Khimii, 30(9), 1716-19 (1975)<br></p>

<p>Applications 1-Methyl-1H-pyrrole-2-carbaldehyde is a substance for the toxicological evaluation of aerosols of a tobacco extract formulation and nicotine formulations in acute and short-term inhalation studies. A substance for ligand-based screening of chemical constituents of Glycyrrhiza glabra in search of inhibitors of xanthine oxidase.<br>References Werley, M. S., et al.: Inhalation Toxicology, 26, 207 (2014); Naeem, S., et al.: Int. J. Biol. Biotechnol., 9, 257 (2012)<br></p>

<p>Applications 3,6-Bis(hydroxymethyl)-2,5-piperazinedione is an intermediate in the synthesis of impurities of Cycloserine (C988800), an antibacterial agent.<br>References Shields, J. E., et al.: Biochem., 5, 1041 (1966); Hidy, P.H., et al.: J. Am. Chem. Soc., 77, 2345 (1955);<br></p>

<p>Applications Cinacalcet-d4 Hydrochloride is a labeled analogue of Cinacalcet Hydrochloride (C441800), the (R) enantiomer of Cinacalcet which is used in clinical trial in secondary hyperparathyroidism.<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003); Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004);<br></p>

<p>Applications Methyl 5-Aminopentanoate Hydrochloride is used as a reactant to synthesize several compounds with therapeutic potential.<br>References Larson, Peter, et al.: ACS Med. Chem. Let, 8(11), 1148-1152 (2017);Li, Yongtao, et al.: J. of Med. Chem., 61(7), 3166-3192 (2018);Lu, Yuzhi, et al.: ACS Med. Chem. Let., 7(12), 1185-1190 (2016)<br></p>

<p>Applications 3-(Methylamino)propanoic acid HCl<br></p>

<p>Applications 4-(Benzyloxy)butanoic acid<br></p>

<p>Applications A novel medical application of isothiocyanate ester in treating various leukemia, with low toxicity, which includes benzyl isothiocyanate, phenylethyl isothiocyanate, allyl isothiocyanate, sulforaphane, and erucin. Benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kubinyi, H., et al.: J. Cancer Res. Clin. Oncol., 116, 529 (1990), Sheridan, R., et al.: J. Med. Chem., 50, 3173 (2007), Sahu, R.P., et al.: Carcinogenesis, 30, 1744 (2009),<br></p>

<p>Applications 2,4,6-Tribromophenyl Acetate (cas# 607-95-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-CHLORO-3-ETHYLBENZENE (cas# 620-16-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,3-Benzenedimethanamine (cas# 1477-55-0) is a useful research chemical.<br></p>

<p>Applications BENZYL CINNAMATE (cas# 103-41-3) is a useful research chemical.<br></p>

<p>Applications 6-(Methylamino)purine, 6-methylade is a reagent for substitution of adenine nucleotide analogs containing bicyclohexane ring system locked in northern conformation enhanced potency as py receptor antagonists. Adenine methylation as an epigenic mark has been observed in single-celled organisms and also rarely in mamalian cells.<br>References Nandanan et al.: J. Med. Chem., 43, 829 (2000); Kim, H. S. et al.: J. Med. chem., 46, 4974 (2003); Chem. and Eng. News p.6 Apr. 4 (2016)<br></p>

<p>Stability Volatile<br>Applications 1-Chloro-2-methylpropene is a reagent in the synthesis of pyrrolyl and indolyl diketo acids and esters as nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Costi, R., et al.: J. Med. Chem., 56, 7431 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications Eye irritant.<br>References Bagley, D. M. et al.; Toxicol. In Vitro 13, 505 (1999); Gilleron, L. et al.; Toxicol. In Vitro 11, 641 (1997)<br></p>

<p>Applications 1-phenyl-1,2,3,4-tetrahydronaphthalene (cas# 3018-20-0) is a useful research chemical.<br></p>

<p>Applications Mono-Ethyl Malonate-1,2,3-13C3 (cas# 1189981-54-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Chloronaphthalene-1-sulfonyl Chloride (cas# 6291-07-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-chloro-1-(4-methylphenyl)propan-1-one is a reagent used in the synthesis of Mannich base-type derivatives which can be used in the treatment of chagas disease.<br>References Martin-Escolano, R. et al.: J. Med. Chem., 61, 5843 (2018);<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloro-N,N-dimethylethylamine is a widely used as an intermediate and starting reagent for organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spulak, M., et al.: Tetrahedron., 69, 1705 (2013); Vaid, R.K., et al.: Synthesis., 44, 2231 (2012);<br></p>

<p>Applications Arecoline has shown regulatory properties of controlling plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts.<br>References Tsai, C.H., et al.: J. Oral. Pathol. Med., 44, 669 (2015);<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Applications (S)-2-((S)-2-Amino-4-methylpentanamido)-4-methylpentanoic acid (cas# 3303-31-9) is a useful research chemical.<br></p>

<p>Impurity Anastrozole Monoacid Impurity<br>Applications Anastrozole Mono Acid is an impurity of Anastrozole (A637435), an aromatase enzyme inhibitor and antineoplastic agent. Anastrozole Monoacid Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications 2-(2-Chloroethoxy)acetyl Chloride (cas# 39229-33-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications An intermediate in the production of many biological inhibitors.<br>References Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009), Lebsack, A., et al.: Bioorg. Med. Chem. Lett., 19, 40 (2009), Griffith, D., et al.: J. Med. Chem., 52, 234 (2009),<br></p>

<p>Applications 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone (cas# 37148-48-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-​Amino-​3-​chloro-​5-​trifluoromethylpyrid​ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.<br>References vManvar, P. et al.: Tetrahedron 72, 1293 (2016);<br></p>

<p>Applications 2-Chloro-N,N-dimethylacetamide is N,M-dialkyl amide used as an organic catalyst in the preparation of phosphorylated thiosemicarbazide.<br>References Yanchuk, N.I. et al.: Zh. Obshch. Khim., 62, 1284 (1992); Yanchuk, N.I. et al.: 35, 568 (1994);<br></p>

<p>Applications Acrolein Diethyl Acetal is used as a reagent in quinoline synthesis by improved Skraup-Doebner-Von Miller reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Used for reduction of off-taste of vinegar.<br>References Chinnici, F., et al.: J. Chromatogr. Sci., 41, 305 (2003), Masino, F., et al.: Food Chem., 92, 673 (2005),<br></p>

<p>Applications: Intermediate in the preparation of Propantheline Bromide.<br></p>

<p>Applications N-[4-(-Carboxycyclohexylmethyl)]maleamidic Acid (cas# 72748-87-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, R., et al.: J. Med. Chem., 52, 4481 (2009); Picard, F., et al.: J. Med. Chem., 45, 3406 (2002)<br></p>

<p>Applications 2,4,5-Trifluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize quinolone antibacterial agnts.<br>References Sanchez, J., et al.: J. Med. Chem., 31, 983 (1988); Tran, T., et al.: Bioorg. Med. Chem. Lett., 14, 4405 (2004)<br></p>

<p>Applications N-Nitrosoatrazine is an Atrazine (A794600) nitrosation product. Exposing human lymphocyte cultures to N-Nitrosoatrazine resulted in elevated levels of chromosome breakage.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Janzowski, C. et al.: ARC Sci. Pub., 31, 329 (1980); Meisner, L.F. et al.: Arch. Environ. Cont. Toxicol., 24, 108 (1993):<br></p>

<p>Applications (R)-Pantoic Acid Sodium Salt, is the derivative of Pantothenic (P190300) and γ-Aminobutyric Acids (A602920), which has shown to have some effect like depressing motor and aggressive behavior, hyperactivity, and body temperature.<br>References Dorofeev, B. F., et al.: Deposited Doc., 14 (1979);<br></p>

<p>Applications α,α'-Dichloro-o-xylene is a useful building block, and has been used in the preparation of nanocomposite copper metal.<br>References Nejadshafiee, V.; et al.: Turkish Journal of Chemistry, 41, 700 (2017).<br></p>

<p>Applications 2,2,2-Trifluoroethyl Tosylate is a trifluoroethylation agent used in the preparation of 2,2,2-trifluoroethyl phenyl sulfone, a potential 2,2,2-trifluoroethyl pronucleophile.<br>References Zhang, W., et. al.: Tetrahedron Lett., 53, 6565 (2012)<br></p>

<p>Stability Light Sensitive<br>Applications 1-Vinylimidazole (cas# 1072-63-5) is a useful research chemical.<br></p>

<p>Applications Mesitaldehyde (cas# 487-68-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Propiolic Acid is a compound used in the synthesis of haloalkyl propiolates, halopropenoates, and transition metal complexes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References J. Organomet. Chem., 456, 271 (1993); Tetrahedron, 49, 4229 (1993); Tetrahedron, 48, 3413 (1992); J. Org. Chem., 57, 709 (1992)<br></p>

<p>Applications 3-Methylindole metabolite.<br>References Skordos, K., et al.: Chem. Res. Toxicol., 11, 741 (1998), Lanza, D., et al.: Drug Metab. Disposition, 29, 950 (2001), Hoenicke, K., et al.: J. Agric. Food Chem., 50, 4303 (2002),<br></p>

<p>Applications 2,2':6',2''-Terpyridine (cas# 1148-79-4) is a useful research chemical.<br></p>

<p>Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);<br></p>