Building Blocks

<p>Impurity Imatinib EP Impurity I<br>Stability Hygroscopic<br>Applications Dimethylamine hydrochloride (Imatinib EP Impurity I) is a precursor to several industrially significant compounds. It is a COVID19-related research product.<br>References Burton, P., et al.: Biochem. J., 432, 575 (2010); Shim, K.S., et al.: DNA Repair., 5, 718 (2006); Robacker, D.C., et al.: J. Chem. Ecol., 23, 1263 (1997);<br></p>

<p>Applications DL-Homocysteine is an allosteric antagonist at the dopamine d2 receptors. Mainly, L-Homocysteine (H591950) exists naturally and is recycled into methionine or converted into cysteine.<br>References Agnati, L. et al.: J. Proteome Res. 5, 3011 (2006); Stipanuk, M. et al.: Ann. Rev. Nutrition., 24, 539 (2004);<br></p>

<p>Applications 4-Fluorobenzoic acid<br></p>

<p>Applications 1,3-Diethynylbenzene (cas# 1785-61-1) is a useful research chemical.<br></p>

<p>Applications Trimethyl Citrate is a reagent used in the preparation of citrate-ciprofloxacin conjugates which has antibacterial activity.<br>References MD-Saleh, S.R., et al.: Bioorg. Med. Chem. Lett., 19, 1496 (2009); Schmitz, F., et al.: Int. J. Antimicrob. Agents 12, 311 (1999)<br></p>

<p>Applications 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is used in preparation and structure of alkaline earth iodide phosphine oxide and urea complexes as reactant or reagents.<br>References Fitts, Lacey S., et al.: New J. of Chem., (2016); Hall, Jessica E., et al.: Angew. Chem. Int. Ed., 55, 11153-11157 (2016)<br></p>

<p>Applications 1-(2,4-Dichlorophenyl)-2-(4H-1,2,4-triazol-4-yl)ethanone is an intermediate in the synthesis of Propiconazole (P770100) related compounds.<br>References Herrero, M., et al.: J. Org. Chem., 73, 36 (2008);<br></p>

<p>Impurity Aripiprazole Diquinoline Butanediol Impurity (USP)<br>Applications An impurity found in the process for the preparation of Aripiprazole (A771000). Aripiprazole Diquinoline Butanediol Impurity (USP).<br>References Burris, K., et al.: J. Pharmacol. Exp. Ther., 302, 381 (2002), Harrison, T., et al.: Drugs, 64, 1715 (2004),<br></p>

<p>Applications Pramoxine impurity. Phenol derivatives induced tumor cell apoptosis.<br>References Li, B., et al.: J. Biochem., 138, 679 (2005), Peltason, L., et al.: J. Med. Chem., 50, 5571 (2007),<br></p>

<p>Impurity Ipratropium EP Impurity D<br>Stability Light Sensitive<br>Applications Atropic acid (Ipratropium EP Impurity D) is an impurity of Ipratropium bromide (I740500) and Atropine Sulfate (A794625).<br>References Lyon, R., et al.: J. Pharm. Sci., 95, 1549 (2006), Loch, M., et al.: Toxicology, 233, 229 (2007), John, H., et al.: Anal. Bioanal. Chem., 396, 751 (2010),<br></p>

<p>Applications Shows some anti-viral activity due to the adamantane structure. In addition it shows anti-microbial activity and cytotoxic application.<br>References Aigami, K. et al.: J. Med. Chem., 18, 713 (1975); Aigami, K. et al.: J. Pharm. Res., 4, 1407 (2011);<br></p>

<p>Applications: Intermediate in the preparation of Propantheline Bromide.<br></p>

<p>Applications 3,3',5,5'-Tetramethylbenzidine is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA). Dyes and metabolites, Environmental Testing.<br>References Josephy, P. David., et al.: J. Biol. Chem., 257, 3669 (1982);<br></p>

<p>Applications An intermediate in the production of many biological inhibitors.<br>References Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009), Lebsack, A., et al.: Bioorg. Med. Chem. Lett., 19, 40 (2009), Griffith, D., et al.: J. Med. Chem., 52, 234 (2009),<br></p>

<p>Applications Used for reduction of off-taste of vinegar.<br>References Chinnici, F., et al.: J. Chromatogr. Sci., 41, 305 (2003), Masino, F., et al.: Food Chem., 92, 673 (2005),<br></p>

<p>Applications 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone (cas# 37148-48-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,3-Dibromoadamantane (cas# 876-53-9) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.<br>References Knox, W.E., et al.: Biochem. J., 49, 686 (1951), LaDu, B.N., et al.: J. Biol. Chem., 217, 777 (1955)<br></p>

<p>Applications 3-(Hydroxymethyl)Benzamide (cas# 126926-34-9) is a useful research chemical.<br></p>

<p>Applications 1-aminoindan (cas# 34698-41-4) is a useful research chemical.<br></p>

<p>Applications 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);<br></p>

<p>Applications DIBOA is an allelopathic biochemical that is produced by grasses. This benzoxazinoid compound displays health-promoting effects in rats.<br>References Adhikari, K. et al.: J. Agri. Food Chem., 60, 11518 (2012);<br></p>

<p>Applications 2,5-Xylidine, is a Vanillin derivative, used as as potential inhibitors of FtsZ. These compounds were also assayed for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, etc.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sun, J., et al.: Med. Chem. Res. (2013);<br></p>

<p>Applications 2,2,6-Trimethyl-4H-1,3-dioxin-4-one is used in the synthesis of dihydropyrimininones as picomolar sodium iodide symporter inhibitors. Also used in the synthesis of resorcinol amide Hsp90 Inhibitor AT13387.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lacotte, P. et al.: Eur. j. Med. Chem., 62, 722 (2013); Patel, B. et al.: J. Org. Chem., 77, 11296 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications 2-Bromopropionic Acid Benzyl Ester (cas# 3017-53-6) is a compound useful in organic synthesis.<br></p>

<p>Applications: 2,4-Dinitrophenylhydrazone (DNPH) derivative. Also, it is used in TLC as internal standards.<br>References Lindsay, R.C., et al.: J. Food Sci., 29, 266 (1964),<br></p>

<p>Stability Temperature sensitive - closes readily. Store at -80°C<br>Applications Used for isolating bases by means of Reinecke's salt.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dudley, H., et al.: Biochem. J., 27, 157 (1933),<br></p>

<p>Applications N1,N4-Di-p-tolylbenzene-1,4-diamine is a useful intermediate for the preparation of some chemically active substances for polymeric materials.<br>References Belorossova, A. G., et al.: Uchenye Zapiski Yaroslavskogo Tekhnologicheskogo Instituta, 11, 200 (1969)<br></p>

<p>Applications Acetylpyrazine (cas# 22047-25-2) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications A non-cyclic silicone oligomer. Used in the methylation of mercury(II) salts. Study shows that it transformed by a specific microflora and in the natural environment degraded by mechanisms similar to other organic compounds.<br>References Radeva, E. et al.: J. Optoelec. Adv. Mat., 11, 1432 (2009); Wasserbauer, R. et al.: Folia Microbiologica, 35, 384 (1990); Watanabe, N. et al.: Ecotoxic. Env. Safety, 11, 174 (1986);<br></p>

<p>Applications Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications Glycidyl Caprate is an epoxy monomer used as a crosslinking agents for alkyd coatings.<br>References Sorokin, M.F. et al.: Lakokras. Mat. Ikh Prim., 5, 9 (1979);<br></p>

<p>Applications δ-Decalactone is a naturally occurring cyclic ester used by food and flavor industries for its coconut fragrance and taste. It is also used as a reagent in the synthesis of (±)-Massoilactone (M197600); a chemical component with antibacterial activity found in volatile oils.<br>References Schneiderman, D.K., et al.: J. Chem. Educ., 91, 131 (2014); Rali, T., et al.: Molecules, 12, 149 (2007); Zhao, J., et al.: Nat. Prod. Commun., 4, 1491 (2009); Jin, Z., et al.: Med. Plant, 3, 45 (2012)<br></p>

<p>Stability Moisture Sensitive<br>Applications A phosphorylating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sartori: Chem. Rev., 48, (1951), Nachmansohn, et al.: Adv. Enzymology, 12, 259 (1951)<br></p>

<p>Applications trans,trans-2,4-Decadienal is an aldehyde with a fat flavor aroma characteristic of chicken but has a citrus odor at lower concentrations. trans,trans-2,4-Decadienal can be found in butter, cooked beef, fish, potato chips, roasted peanut, buckwheat and wheat bread crumb.<br>References Janes, D. et al.: Food Chem., 112, 120 (2008); Vermeulena, N. et al.: J. Cer. Sci., 45, 78 (2007);<br></p>

<p>Applications Intermediate in the preparation of Alfentanil.<br>References Kudzma, L., et al.: J. Med. Chem., 32, 2534 (1989),<br></p>

<p>Applications 1,3-Adamantanediol is used in the synthesis of novel dimethacrylate as possible dental monomers for dental resin mixtures.<br>References Wang, K. et al.: Mat. Sci. Eng. Mat. Biol. Appl., 32, 1141 (2012); Horino, Y. et al.: J. Mol. Catal. A. Chem.,<br></p>

<p>Applications 3'-Aminoacetophenone has potential anti-bacterial properties in addition to being used in the synthesis of selective antagonists at human A2B adenosine receptors. As well, it is used in the synthesis of HIV-1 Integrase Inhibitors.<br>References Kim, Y.C. et al.: J. Med. Chem., 43, 1165 (2000); Pais, G.C.C. et al.: J. Med. Chem., 45, 3184 (2002);<br></p>

<p>Applications Cyclopentyl chloride (cas# 930-28-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Benzylamine Hydrochloride (cas# 3287-99-8) is a useful research chemical.<br></p>

<p>Applications 2,​3-​Cyclopentenopyridine is used as reactant/reagent for ruthenium-mediated dual catalytic reactions of isoquinoline via C-H activation and dearomatization for isoquinolone.<br>References Wang, T., et al.: Adv. Synth. Catal., 358, 2751-2758 (2016)<br></p>

<p>Applications Bicyclo[2.2.1]hept-2-ene is a catalyst used in many reactions such as in the cascade cyclizations of iodoarene, bromobenzylamine, and electron-deficient alkene derivatives and arene C-H amination with aryl halides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Narbonne, V., et. al.: Org. Lett., 16, 628 (2014); Dong, Z., Dong, G.: J. Am. Chem. Soc., 135, 18350 (2013)<br></p>

<p>Applications Arecoline has shown regulatory properties of controlling plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts.<br>References Tsai, C.H., et al.: J. Oral. Pathol. Med., 44, 669 (2015);<br></p>

<p>Stability Hygroscopic<br>Applications A novel labelled metabolite of Butadiene monoepoxide (BMO), a mutagen and carcinogen compound.<br>References Cheng, X., et al.: Drug Metab. Dispos., 21, 121 (1993), Nieusma, J., et al.: Chem. Res. Toxicol., 10, 450 (1997),<br></p>

<p>Applications Cystamine dihydrochloride is the dihydrochloride salt of Cystamine, a neuroprotective drug that works by inhibiting transglutaminase activity in the body. Cystamine has also exhibited suppressive effects against HIV replication in infected human cells.<br>References Bergamini, A., et al.: J. Clin. Invest., 93, 2251 (1994); Fox, J., et al.: J. Neuro., 91, 413 (2004); Jeitner, T., et al.: Biochem. Pharm., 69, 961 (2005)<br></p>

<p>Applications 4-Fluorobenzoic Acid Methyl Ester, is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin (B595850).<br>References Wang, J., et al.: Zhongguo Yiyao Gongye Zazhi, 40, 247 (2009);<br></p>

<p>Applications Alizarin is used widely as a prominent red dye for textile facbrics. Alizarin red is now used in biochemical assay to determine quantitatively by colorimetry, the presence of calcific deposition by cells of the osteogenic lineage. Alzarine derivatives was evaluated as new inhibitors of the HIV-1 reverse transcriptase associated DNA polymerase and RNase H. Alizarin was also shown to inhibit proliferation, tumor growth and suppress tumorigenesis in human osteosarcoma and breast cancer cell representative for bone metastasis. Dyes and metabolites.<br>References Yuan, H.S., et al.: Mycol., 3, 100 (2012); Esposito, F. et al.: FEBS. J., 278, 1444 (2011); Fotia, Caterina, J. Orthop. Rsch. 30, 1486 (2012);<br></p>

<p>Applications 2-Benzoylbenzoic Acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.<br>References Abou-Seri, S. M., et al.: Eur. J. Med. Chem., 107, 165 (2016);<br></p>

<p>Applications Cyanoacetic acid is a dangerous compound that is commonly used as a synthetic intermediate. Cyanoacetic acid has also been found to have teratogenic effects on rat embryos.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simpson, M., et al.: Food Chem. Toxicol., 24, 634 (1986)<br></p>

<p>Applications N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-[5-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]pentyl]-N1-hydroxybutanediamide, is a bifunctional chelator.<br></p>

<p>Applications Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. But it can work as a β-adrenergic partial agonist in isolated organs.<br>References Nakano, J., et al.: Chem. Pharm. Bull., 36, 1399 (1988); Takayanagi, I., et al.: Gen. Pharmacol., 20, 417 (1989); Koike, K., et al.: Gen. Pharmacol., 25, 1477 (1994)<br></p>

<p>Applications 4-Bromobenzoic Acid Methyl Ester is halogenated benzoate used as a reagent in organic synthesis. 4-Bromobenzoic Acid Methyl Ester can be used to stimulate microbial dechlorination of PCBs. 4-Bromobenzoic Acid Methyl Ester is also used in the preparation of stable radioiodinating reagent to label monoclonal antibodies for radiotherapy of cancer.<br>References Wilbur, D.S. et al.: J. Nuclear Med., 30, 216 (1989); DeWeerd, K.A. et al.: Environ. Sci. Technol., 33, 2057 (1999);<br></p>

<p>Applications 9-Bromoanthracene is an intermediate in the synthesis of 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) anthracene (A678400).<br>References Corream A., et al.: J. Am. Chem. Soc., 136, 1062 (2014)<br></p>

<p>Applications Cyanoacetamide has been used in photometric and fluorimetric postcolumn labeling.<br>References Honda S., et. al.: Anal. biochem., 134, 483(1983)<br></p>

<p>Applications 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.<br>References Hojati, S. F., et al.: Can. J. Chem., 88, 135 (2010);<br></p>

<p>Stability Explodes When Heated<br>Applications 2-Cyanoethyl N,N,N’,N’-Tetraisopropylphosphoramidite (cas# 102691-36-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, Y.A., et al.: Bioconjugate Chem., 3, 200 (1992); Liao, T.H., et al.: Anal. Biochem., 148, 365 (1985)<br></p>

<p>Applications 5-Chloro-2-methylphenol can be used in the preparation of dichlorotoluqinones.<br>References James, C., et al.: J. Org. Chem., 16, 328 (1951)<br></p>

<p>Applications 2-(CHLOROMETHYL)NAPHTHALENE (cas# 2506-41-4) is a useful research chemical.<br></p>

<p>Impurity Bupropion Des-t-Butylamino Impurity<br>Applications 3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.<br>References Li, H. et al.: J. Am. Chem. Soc., 127, 8355 (2005); Deepika, G. et al.: J. Pharm. Res., 5, 1105 (2012);<br></p>

<p>Applications bis(2,2,2-trifluoroethyl) carbonate (cas# 1513-87-7) is a useful research chemical.<br></p>

<p>Applications 5-Chloronaphthalene-2-sulfonyl Chloride (cas# 89108-45-2) is a compound useful in organic synthesis.<br></p>

<p>Applications β-Chlorolactic Acid (cas# 1713-85-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4,5-trichlorobenzoic acid (cas# 50-82-8) is a useful research chemical.<br></p>

<p>Applications 2-chloro-3-hydrazinylpyrazine (cas# 63286-28-2) is a useful research chemical.<br></p>

<p>Applications nonanamide (cas# 1120-07-6) is a useful research chemical.<br></p>

<p>Applications 2-Chloroethylamine Hydrochloride is used as a reagent in the synthesis of 6-desfluoroquinolones as potential anti-HIV drugs. Also used as a reagent in the synthesis of ellipticine derivatives as anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sancineto, L., et al.: Bioorg. Med. Chem., 22, 4658 (2014); Mori, R., et al.: Eur. J. Med. Chem., 82, 16 (2014)<br></p>

<p>Applications 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Motoyama, N., et al.: Rev. Pestic. Toxicol., 1, 173 (1991)<br></p>

<p>Applications 3,6-Dichloro-2-hydroxybenzoic Acid Potassium Salt, is a hydroxybenzoic acid derivative and can be synthesized using a Kolbe-Schmitt carboxylation and acidification reaction of 2,5-dichlorophenol.<br>References Zhao, W-H., Song, G-Z.: Huagong Jishu Yu Kaifa, 44, 39-41 (2015)<br></p>

<p>Applications 2-Chloro-4,6-dimethoxy-1,3,5-triazine (cas# 3140-73-6) is a compound useful in organic synthesis.<br></p>

<p>Applications A novel utilization of aminophenone derivative in toxicology, for treating intoxications with cyanogenic toxic substances.<br>References Donoghue, N., et al.: Eur. J. Biochem., 60, 1 (1975), Chen, Y., et al.: J. Bacteriol., 170, 781 (1988),<br></p>

<p>Applications Nucleoside derivatives of 5-substituted uracil have been explored for their potential application as anti-viral agents and in the treatment of tumors.<br>References Ressner, E.C., et al.: J. Med. Chem., 19, 1, 194 (1976)<br></p>

<p>Applications 1-[4-(2-hydroxypropan-2-yl)phenyl]ethan-1-one (cas# 54549-72-3) is a useful research chemical.<br></p>

<p>Applications N-[4-(-Carboxycyclohexylmethyl)]maleamidic Acid (cas# 72748-87-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.<br>References Toyn, J.H., et al.: Yeast, 16, 553, 560 (2000)<br></p>

<p>Applications An Acetanilide and Anisole derivative metabolite by liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pesenti, C., et al.: ChemBioChem., 5, 590 (2004), Sandford, G., et al.: J. Fluorine Chem., 128, 90 (2007),<br></p>