Acids and Synthetic Reagents

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications WAY-100135 is a selective and potent 5-HT1A receptor antagonist.<br></p>

<p>Applications 2-Bromoacetic Acid Phenylmethyl Ester is used in the synthesis of somatostatin analogues with tumor-targeting properties . Also used in the synthesis of inhibitors of phospholipase A2, indolizine and indene derivatives.<br>References Heppeler, A. et al.: Chem. A. Eur. J., 5, 1974 (1999); Hagishita, S. et al.: J. Med. Chem., 39, 3636 (1996);<br></p>

<p>Applications Ammonium Hexafluorophosphate is commonly available form of the hexafluorophosphate anion, inert and hence a suitable counterion. It is a useful synthetic intermediate. It can be used to prepare organometallic diphenols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Powell, C., et al.: J. Am. Chem. Soc., 125, 602 (2003); Macchioni, A., et al.: Organometallics, 18, 3061 (1999)<br></p>

<p>Applications Copper oxychloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,3-Dibromopropene is used in preparation of Quaternary Ammonium Salt derivatives for use as Trimethylamine production inhibitors.Also, used in preparation of Boron containing compounds as Phosphodiesterase PDE4 inhibitors.<br>References Nudel, K., et al.:PCT Int. Appl., (2020); Strohbach, Joseph W., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors<br>References Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)<br></p>

<p>Applications Di-p-toluoyl-d-tartaric Acid Monohydrate is a useful intermediate in the preparation of chiral rivastigmine hydrogen tartrate.<br>References Feng, J., et al.; Nanfang Yike Daxue Xuebao, 27, 177 (2007)<br></p>

<p>Applications methyl 5-(chloromethyl)-2-furoate (cas# 2144-37-8) is a useful research chemical.<br></p>

<p>Applications 4-Bromostyrene<br></p>

<p>Applications Calcium Sulfate is used in the biofilm prevention and management of gram-negative bacterial pathogens involved in periprosthetic infection by using antibiotic-loaded calcium sulfate beads in vitro. Calcium Sulfate is used in the bioactive calcium sulfate-based formulation “Biocas” for bone filler applications. Calcium Sulfate is also used as an antibiotic impregnated calcium sulphate in combination with internal fixation for the treatment of open fractures of extremities that prevents infections and promotes the healing of fractures.<br>References Howlin, R., et al.: Biomed.l Mater., 12, 1 (2017); Sandhya, S., et al.: Biomedical Materials, 12, 015022 (2017); Liao, H., et al.: Guangxi Yixue, 37, 1491 (2015)<br></p>

<p>Applications Inhibits the intestinal absorption of Phenylalanine, making it a prospective treatment for phenylketonuria.<br>References Shimomura, K., et al.: J. Biochem., 78, 269 (1975), Ambler, J., et al.: Bioorg. Med. Chem. Lett., 9, 737 (1999),<br></p>

<p>Applications N-Boc-hydroxylamine is the protected form of Hydroxylamine (HCl: H943705). Hydroxylamine is used as an inhibitor between Z and P680 in photosystem II within plant chloroplasts. Hydroxylamine is also known to induce chromosomal damage in mammalian cells, inducing mutagenesis.<br>References Ghanotakis, D. &amp; Babcock, G.: FEBS Lett., 153, 231 (1983); Somers, C. &amp; Hsu, T.: P. Natl. Acad. Sci. USA, 48, 937 (1962)<br></p>

<p>Applications Reagent commonly used in organic chemistry for the introduction of the BOC protecting group.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diethyl (2-cyanoethyl)phosphonate, is a useful reactant used in various chemical synthesis such as in synthesis of lipophilic oxoamides with activity against phospholipase A2, Triose phosphate isomerase of muscle inhibitors, and also in base-catalyzed stereospecific anti-Markovnikov addition.<br></p>

<p>Applications Protected Glycidol, used as an intermediate in the preparation of neurochemicals.<br>References Qian, L., et al.: ChemMedChem., 1, 376 (2006), Shimizu, K., et al.: Bioorg. Med. Chem., 14, 1838 (2006), Pedersen, P., et al.: J. Med. Chem., 52, 3408 (2009),<br></p>

<p>Applications N-Methyl-1,3-propanediamine is used as a reagent in the lipase-catalyzed synthesis of novel linear polyamidoamine oligomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Monsalve, L.N., et al.: Polymer, 51, 2998 (2010)<br></p>

<p>Applications (S)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is often used in biosynthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spelberg, J.H., Tetrahedron, Asy., 10, 2863 (1999);<br></p>

<p>Applications 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression<br>References Qian, F., et al.: Cancer Immunology Immunothrapy, 61, 2013 (2012)<br></p>

<p>Applications A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral). PDE inhibitor (non-selective).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983), Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986), Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988),<br></p>

<p>Applications R-(+)-1,1'-Bi-2-Naphthol is used in biosynthetic preparation for enantioselective oxidation of naphthols to binaphthyldiols with horseradish peroxidase catalyst.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sridhar, M., et al.: Tetrahedron Lett., 38, 5695 (1997)<br></p>

<p>Applications L-AP3 is a selective antagonist of the PI-linked metabotropic glutamate response.<br></p>

<p>Applications 4-Bromophenylhydrazine Hydrochloride is a reactant in the synthesis of fluoro substituted novel pyrazolylpyrazolines scaffold with antibacterial activity, antituberculosis activity against Mycobacterium tuberculosis H37Rv and antimalarial activity against Plasmodium falciparum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Karad, S.C., et. al.: Eur. J. Med. Chem., 84, 51 (2014)<br></p>

<p>Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.<br>References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);<br></p>

<p>Applications 4-Chloro-7-methoxy-2-methylquinoline (cas# 75896-68-3) is a useful reagent for preparing multi-substituted 4-anilinoquin(az)olines that have antiviral activity.<br>References Saul, S., et al.: Bioorg. Med. Chem. Lett., 30, 127284 (2020)<br></p>

<p>Applications 7-Methoxy-2-naphthol is used as a reactant in the preparation of 9-hydroxy benzopyrene (H829410). It is also used in the preparation of (pyridyl)naphthalenes as highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.<br>References Pinto-Bazurco Mendieta, M.A.E., et al.: J. Med. Chem. 56, 6101 (2013)<br></p>

<p>Applications An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.<br>References Senderowicz, A.M., et al.: J. Clin. Oncol., 16, 2986 (1998), Thomas, J.P., et al.: Cancer Chemother. Pharmacol., 50, 465 (2002), Raju, U., et al.: Cancer Res., 63, 3263 (2003), Pumfery, A., et al.: Curr. Pharm. Des., 12, 1949 (2006),<br></p>

<p>Applications 1-Bromooctadecane is a reagent in the preparation of branched glycosyl phosphatidyl inositol (GPI) anchors of rat brain Thy-1.<br>References Pekari, K., et al.: J. Org. Chem., 68, 1295 (2003);<br></p>

<p>Applications Aluminum isopropoxide is a compound used as an initiator for the polymerization of various compounds, such as lactides. Aluminum isopropoxide is also used as a reducing agent for the reduction of Cinnamaldehyde (C442020).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dubois, P., et al.: Macromolecules. 24, 2266 (1991); Hájek, J., et al.: Appl. Catal. A: Gen., 251, 385 (2003); Lou, X., et al.: Macromol. Rapid Comm., 23, 126 (2002)<br></p>

<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>

<p>Stability Volatile<br>Applications 2-Furfurylamine is used in the synthesis of 2-Amino-N-(2-furylmethyl)propanamide, as a novel alanylglycine equivalent synthesized by bacilysin synthetase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mah, R., et al.: Appl. Microbiol., 15, 866 (1967), Faber, K., et al.: Pure Appl. Chem., 69, 1613 (1997), Marahiel, M., et al.: Chem. Biol. 4, 561 (1997),<br></p>

<p>Applications 3-Chloro-2-fluorobenzyl Bromide (cas# 85070-47-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Light Sensitive<br>Applications Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.<br>References Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);<br></p>

<p>Applications 4-Nitrobenzoyl Chloride is used inorganic syntheses such as Michael additions. Also used in the synthesis of polysubstituted furanonaphthoquinoines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, J. et al.: Catal. Comm., 32, 18 (2013); Wu, Z. et al.: Org. Biomol. Chem., 11, 828 (2013);<br></p>

<p>Applications (R)-(+)-3-Methylcyclopentanone (cas# 6672-30-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-(tert-Butoxycarbonyl)-D-prolinol is used to prepare (azetidinyl)methoxy]pyridines and 2-(aryloxymethyl) azacyclic analogs with therapeutic potetials for the treatment of central nervous system (CNS) disorders.<br>References Abreo, M., et al.: J. Med. Chem., 39, 817 (1996); Elliott, R., et al.: Bioorg. Med. Lett., 6, 2283 (1996)<br></p>

<p>Stability Very Hygroscopic<br>Applications Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).<br>References (1) Klamer, D., et al.: Eur. J. Pharmacol. (2004) 503: 103-107(2) Marletta, M.A.: J. Med. Chem., 37(13), 1899 (1994)(3) Zhang, H.Q., et al.: J. Med. Chem., 40, 3869 (1997)<br></p>

<p>Applications: Trimethoxy(2-phenylethyl)silane is used in the loading and releasing of two anti-cancer drugs, 9-Aminoacridine (9AA) and Camptothecin (CPT) from magnetic mesoporous silica nanoparticle materials.<br>References Knezevic, N. Z., et al.: ChemPlusChem, 77, 48-55 (2012)<br></p>

<p>Applications 1,4-Dichloro-2-butyne used in the synthesis of 1,4-disubstituted 1,2,3-triazoles. Also, it is used in the approach of the 20S-camptothecin family of antitumor agents.<br>References Feldman, A. et al.: Org. Lett., 6, 3897 (2004); Josien, H. et al.: Chem. Eur. J., 4, 67 (1998);<br></p>

<p>Applications N-Carbobenzoxy-1,4-diaminobutane HCl is used in the synthetic preparation of pyrazolyl glucopyranoside and galactopyranoside derivative inhibitors of human sodium-glucose cotransporter 1 (SGLT1) for preventives or therapeutics for diseases related to hyperglycemia or galactosemia.<br>References Teranishi, H.; et al.: PCT Int. Appl. 215 pp. Patent 2004 CODEN:PIXXD2<br></p>

<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>

<p>Applications Main metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Harvilchuck, J., et al.: Toxicol. Lett., 183, 28 (2008), Harvilchuck, J., et al.: Toxicol., 264, 171 (2009), Woo, J., et al.: App. Microbiol., Biotechnol., 82, 873 (2009),<br></p>

<p>Applications Bismuth Subnitrate is a compound used in the synthesis of anti-inflammatory and anti-microbial pharmaceuticals for use in mammals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parker, K.. et al.: J. Dairy, Sci., 91, 169 (2008); Lougheed, K. et al.: Tuberculo., 89, 364 (2009);<br></p>

<p>Applications Rhodium Carbonyl Chloride is a reagent for rhodium-catalyzed [4+2+1] cycloaddition of in situ generated ene/yne-ene-allenes and carbon monoxide to produce [4+2+1] cycloadducts<br>References Tian, Z.Y., et al.: Angewandte Chemie Int. Ed.’ 57, 15544 (2018)<br></p>

<p>Applications 2-Fluoroiodobenzene is used as a reagent in various organic reactions. It is used in the synthesis of spirocyclic [1,2,3]-triazolooxazine nucleosides which have antiviral properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dell'Isola, A., et al.: Chem-Eur. J., 20, 11685 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications Ytterbium(III) Trifluoromethanesulfonate functions as a catalyst in the organic synthesis of heterocycles. Also functions as a Lewis acid in variety of organic reactions.<br>References Sakhuja, R., et al.: Synthesis, 48, 4305 92016); Molander, G. A., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2004)<br></p>

<p>Applications (S)-2-AMINO-1,1-DIPHENYL-1-PROPANOL (cas# 78603-91-5) is a useful research chemical.<br></p>

<p>Applications (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Bromobenzenesulfonyl Chloride is an intermediate used to prepare sulfonamide-substituted cyclooctylpyranones as nonpeptidic HIV protease inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skulnick, H., et al.; J. Med. Chem., 40, 1149 (1997)<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.<br></p>

<p>Applications Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.<br>References Shao, J., et al.: Shiyong Yixue Zazhi, 31, 4143 (2015); Gerstner, E. R., et al.: Transl. Cancer Res., 5, 211 (2016)<br></p>

<p>Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.<br>References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);<br></p>

<p>Applications (R)-tert-Butyl 2-hydroxypropanoate is an intermediate used in the stereo controlled synthesis of hydroxy carboxylic acids from L-amino acids.<br>References Kunz, H., et al.: Tetrahedron Lett., 28, 1873 (1987)<br></p>

<p>Applications Cyclopropylmethanol used to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A, inhibitors against phosphodiesterase 3 (PDE3). Also used in the synthesis of benzodiazapin-2-ones<br>References Hu, E. et al.: Bioorg. Med. Chem. Lett., 22, 6938 (2012);<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-​(Chloromethyl)​allyl-​trimethylsilane is one of the reagents to synthesize Leucasandrolide A Macrolide (I) via Mukaiyama aldol coupling.2-​(Chloromethyl)​allyl-​trimethylsilane was used in catalytic Sakurai reaction of α,​β-​enones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kopecky, D., et al.: J. Am. Chem. Soc., 123, 8420 (2001).Lee, P., et al.: J. Org. Chem., 66, 8646 (2001).<br></p>

<p>Applications Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.<br>References Ren, J. et al.: Eur. J. Med. Chem., 44, 4259 (2009)<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.<br></p>

<p>Stability Air Sensitive (Oxidize)<br>Applications 3,3-Dimethylbutyraldehyde is an intermediate used to prepare spiro-oxindoles as potent, specific small-molecule Inhibitors of the MDM2-p53 Interaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ding, K., et al.: J. Med. Chem., 49, 3432 (2006); Yu, S., et al.: J. Med. Chem., 52, 7970 (2009)<br></p>

<p>Applications A useful wittig reagent.<br></p>