Carboxylic Acids

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications tert-Butyl carbamate is used to prepare N-Boc-protected anilines. It is also used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.<br>References Bhagwanth, S., et al.: J. Org. Chem., 74, 4634 (2009); Cadierno, V., et al.: J. Heterocycl. Chem., 47, 233 (2010)<br></p>

<p>Stability Moisture Sensitive<br>Applications Tripropyl phosphate is an organophosphorus flame retardant and plasticizer.<br>References Bacaloni, A., et al.: Environ. Sci. Technol., 42, 1898 (2008)<br></p>

<p>Applications (S)-tert-butyl 4-aminoazepane-1-carboxylate (cas# 878630-84-3) is a useful research chemical.<br></p>

<p>Applications 2-Cyclohexylideneacetic acid (cas# 1552-91-6) is a useful research chemical.<br></p>

<p>Applications B-[3-[[2-Hydroxy-3-[3-(triethoxysilyl)propoxy]propyl]amino]phenyl]boronic acid was prepared for the use as porous polymeric monolith for the specific capture of cis-​diol-​containing flavone under neutral condition.<br>References Pan, J., et al.: Chem. Eng. J., 317, 317-330 (2017);<br></p>

<p>Applications 3,4-Epoxycyclohexanecarboxylate Methyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications 2-Aminobenzeneboronic acid pinacol ester is a reagent used to synthesize regiospecific quinolines. It can also be used to synthesize (±)-Epimeloscine and (±)-Meloscine.<br>References Zhang, H., et al.: J. Am. Chem. Soc. 133, 10376 (2011); Horn, J., et al.: Org. Lett 10, 4117 (2008)<br></p>

<p>Applications Trithiocyanuric acid (cas# 638-16-4) is a useful research chemical.<br></p>

<p>Applications tert-Butyl (2-((4-Aminophenyl)amino)-2-oxoethyl)carbamate is an intermediate in the synthesis of (E)-2-Formamido-N-(4-((4-(4-hydroxybutyl)phenyl)diazenyl)phenyl)acetamide (F792100), a compound useful in organic synthesis.<br></p>

<p>Applications methyl 2,4-dichlorothiazole-5-carboxylate (cas# 861708-66-9) is a useful research chemical.<br></p>

<p>Applications 3-Phosphonobenzoic Acid (cas# 14899-31-1) is a useful research chemical.<br></p>

<p>Applications Dibenzo[b,d]furan-2-sulfonic acid (cas# 83863-63-2) is a useful research chemical.<br></p>

<p>Applications tert-Butyl 3-Cyanomorpholine-4-carboxylate is used as a reactant for the synthesis of HIV integrase inhibitors.<br>References Gardelli, C., et. al.: J. Med. Chem., 50, 4953 (2007); Pace, P., et. al.: J. Med. Chem., 50, 2225 (2007); Summa, V., et. al.: J. Med. Chem., 49, 6646 (2006)<br></p>

<p>Applications (1S,3R,4S)-Ethyl 4-Amino-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate Oxalate has been used as a reactant for the preparation of oxadiazole compounds containing cyclohexanediamine moiety.<br></p>

<p>Applications Used for preparation of Terfenadine (T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications Methyl 2-Chloro-1-cyclopentenecarboxylate is a versatile reactant that can be synthesized from Methyl 2-Cyclopentanonecarboxylate (M294705), which is used in the preparation of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Steinman, D.H. et al.: Bioorg. Med. Chem. Lett., 8, 2087 (1998); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003): Neri, P. et al.: J. Org. Chem., 59, 3880 (1994);<br></p>

<p>Applications Benzothiophene-5-boronic acid<br></p>

<p>Applications 2-​Hydroxy-​3-​phenyl-​acrylic Acid is a chemical reagent in the synthesis of an atropos biphenyl biphosphine ligand as well as in the synthesis of novel cinnamanilides as potential immunosuppressive agents.<br>References Shi, L. et al.: Eur. J. Med. Chem., 47, 585 (2012);<br></p>

<p>Applications Ethynylboronic Acid MIDA Ester is a useful reagent in preparatino of borono-substited 1(2H)-isoquinolinones by rhodium-catalyzed cycloaddition.<br>References Wang, H., et al.: J. Am. Chem. Soc., 134, 19592 (2012);<br></p>

<p>Applications Trimethyl Bromoorthoacetate is an intermediate in the synthesis of 3,6-Bis(2-hydroxyethyl)-2-pyrazinepropanoic Acid (B444100), an impurity of Clavulanic Acid (C563750).<br>References Zupke, C., et al.: Biotechnol. Prog., 10, 489 (1994), Finlay, J., et al.: J .Antimicrob. Chemother., 52, 18 (2003),<br></p>

<p>Applications L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977); Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005); Kametani, T., et al.: Heterocycles, 25, 241 (1987)<br></p>

<p>Applications 4-Oxooctanoic Acid is one of mid-chain oxocarboxylic acids detected in Antarctic aerosols and possible precursors to the production of low molecular weight diacids such as succinic acid.Also, it is derived from 4-Octanolide (O239723), which is one of the fine organic aerosol emitted from meat cooking operations that was examined by high-resolution gas chromatography.<br>References Nishikiori, M., et al.: Chikyu Kagaku, 30, 27-34 (1996); Rogge, W., et al.: Environ. Sci. Technol., 25, 1112 (1992)<br></p>

<p>Applications 3-{4-[(furan-2-ylmethyl)sulfamoyl]phenyl}prop-2-enoic acid (cas# 391229-93-9) is a useful research chemical.<br></p>

<p>Applications 2-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid (cas# 13193-24-3) is a useful research chemical.<br></p>

<p>Applications (2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of renin inhibitors.<br>References Yuan, J. et al.: Bioorg. Med. Chem. Lett., 21, 4836 (2011); Fish, P. et al.: Tetra. Lett., 50, 389 (2009);<br></p>

<p>Applications 2,5-Dihydroxybenzoic Acid Butylamine Salt [Matrix for MALDI-TOF/MS] (cas# 666174-80-7) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxybut-2-ynoic Acid (cas# 7218-52-2) is a useful reagent for the green preparation of polyseleno-substituted enamines.<br>References Wang, Y. C., et al.: Green Chem., 20, 604 (2018)<br></p>

<p>Applications 2-Aminomethylphenylacetic Acid is an intermediate of Ceforanide (C242930), a cephalosporin based antibiotic used in the sterilization in various medical procedures.<br>References Zhao, Y., et. al.: Res. Chem. Int. 40, 1637 (2014); Sifakis, S. et al.: Arch. Gyne. Obst., 272, 201 (2005); DiPiro, J. et al.: Antimicrob. Agents Chemother., 27, 287 (1985)<br></p>

<p>Applications 4-(Acetamidomethyl)benzoic acid<br></p>

<p>Applications o-Bromophenoxyacetic acid<br></p>

<p>Applications 2-Ethylheptanoic Acid is used in the preparation of prostaglandin which is for for promoting bone growth<br>References Barrett, S., et al.: PCT Int. Appl., 331 (2015)<br></p>

<p>Applications 4-Isopropylphenylacetic acid (cas# 4476-28-2) is a useful research chemical.<br></p>

<p>Applications 4-(4-hydroxyphenyl)butanoic acid (cas# 7021-11-6) is a useful research chemical.<br></p>

<p>Applications Used in the preparation of herbicides.<br></p>

<p>Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.<br>References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);<br></p>

<p>Applications Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-​[[[3-​(Aminomethyl)​-​5-​methyl-​1-​oxohexyl]​amino]​methyl]​-​5-​methyl-hexanoic Acid is an intermediate in synthesizing 4,9-Diisobutyl-1,6-diazecane-2,7-dione (D456300), an impurity of rac-Pregabalin (P704800) which is a GABA analogue used as an anticonvulsant.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>

<p>Applications 3-​Hydroxypivalic Acid is a general reagent used in the synthesis of AZD8835, a potent and selective inhibitor of PI3K and PI3Kδ in the treatment of cancers.<br>References Barlaam, B. et al.: Bioorg. Med. Chem. Lett., 25, 5155 (2015);<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Applications Triethyl Orthoacetate is used in the preparation of potent and selective human A3 adenosine receptor antagonists. Also used in the preparation of 1,3,4-oxadiazoles for potential antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squarcialupi, L. et al.: J. Med. Chem., 56, 2256 (2013); Vodela, S. et al.: Chin. Chem. Lett., 24, 625 (2013);<br></p>

<p>Applications Ethyl 4-Oxo-5-hexanoic Acid Ester is used in the synthesis of analogs of 5-aminolevulinic acid (ALA), which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis;Also, it is an intermediate of 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid (O858780), which is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2<br>References Appleton, D., et al.: J. Chem. Soc., Perkin Trans., 89-101 (1998); Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)<br></p>

<p>Applications Ethyl 3,4-dihydro-2H-pyran-2-carboxylate (cas# 83568-11-0) is a useful research chemical.<br></p>

<p>Applications Isopropenylboronic Acid Pinacol Ester, can be used as an intermediate in the synthesis of variety of cyclic and acyclic organic compounds. It is also shown that the α-Substituted Allyl/Croty of this compound can be used for highly Diastereo- and Enantioselective allylboration of aldehydes.<br>References Salaun, J. et al.: Topics in Curr. Chem. 1, 144 (1988); Chen, J. et al.: J. Amer. Chem. Soci., 135, 5316 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications 4,5-dimethylthiophene-3-carboxylic acid (cas# 19156-52-6) is a useful research chemical.<br></p>

<p>Applications 4-(2,3-Dihydro-1H-indol-1-yl)-4-oxobutanoic Acid (cas# 105105-00-8) could be useful in biological studies. It has been used to screen and target LsrK kinase inhibitors.<br>References Medarametla, P., et al.: ChemMedChem, 13, 2400 (2018)<br></p>

<p>Applications Phosphoric acid diethyl octyl ester is part of a group of phosphate derivatives that enhance drug penetration through the skin. Phosphoric acid diethyl octyl ester is also used as a reagent to prepare trialkyl phosphate and phosphorothiolate anticholinesterases.<br>References Aoyagi, T., et al.: Drug Des. Discovery, 8, 47 (1991); Bracha, P. &amp; O’Brien, R.: Biochemistry, 7, 1555 (1968)<br></p>

<p>Applications 3,4-Diaminobenzenesulfonic Acid is a useful organic synthetic reagent and a sulfonate-aminium zwitterion.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, J., et al.: Acta Crystallogr. B., 66, 3281 (2010)<br></p>

<p>Applications 2-Acetylthioisobutyric Acid (cas# 135937-96-1) is a compound useful in organic synthesis.<br>References Souers, A., et al.: Bioorg. Med. Chem. Lett., 8, 2297 (1998), Deaton, D., et al.: Bioorg. Med. Chem. Lett., 18, 732 (2008),<br></p>

<p>Applications Furan-2-boronic acid<br></p>

<p>Applications Phosphorodichloridic Acid is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.<br>References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)<br></p>

<p>Applications 5-Formylfuran-2-boronic Acid Pinacol Ester could be useful for the diastereoselective synthesis of cyclic peptide macrocycles via Petasis borono-Mannich reaction<br>References Yamaguchi, A., et al.: Chem. Commun. (Cambridge, U. K.), 55, 10567 (2019)<br></p>

<p>Applications 5-(Diphenylphosphinyl)pentanoic Acid, can be used for the preparation of praseodymium coordination polymers with diphenylphosphorylvalerate ligand. It is also a by product in the preparation of prostaglandin analogs.<br>References Spichal, Z., et al.: Polyhedron, 48, 99 (2012); Zhao Y. et al.: PCT Int. Appl. 43pp.Patent, 2016<br></p>

<p>Applications Methyl 2-(benzhydrylthio)acetate is a useful reagent for organic synthesis.<br></p>

<p>Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.<br>References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)<br></p>

<p>Applications Intermediate in the synthesis of angiotensin and fosinopril. Impurity in the preparation of Fosinopril Sodium.<br>References Anderson, N. et al.; Org. Proc Res. and Develop 1, 315 (1997)<br></p>

<p>Applications 6-Bromohexanoic Acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosen, D. B., et al.: PCT Int. Appl. (2020), WO 2020254617 A1<br></p>

<p>Applications Reagent used in the addition of cyclopropane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006),<br></p>

<p>Applications 5-(3,4-Dichlorophenyl)-2-furoic acid is a reactant in the preparation of dantrolene (D185000) which has a potential to treat vascular dysfunction.<br>References Ellis, K.O., et al.: J. Pharm. Sci., 69, 327 (1980); Harrison, G.G., et al.: Brit. J. Anaesth., 60, 279 (1988); Murasawa, S., et al.: Bioorg. Med. Chem., 20, 6384 (2012);<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>

<p>Applications Azidoacetic acid NHS ester (cas# 824426-32-6) is a useful research chemical.<br></p>

<p>Applications 3,4-Dihydro-2H-1,4-benzoxazine-7-boronic acid pinacol ester is a useful intermediate for the synthesis of naphthamides which functions as VEGFR-2 kinase inhibitors for cancer treatment.<br>References Lv, Y., et al.: ACS Med. Chem. Lett., 5, 592 (2014)<br></p>

<p>Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.<br>References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),<br></p>

<p>Applications 2,5-Dimethylterephthalic acid<br></p>

<p>Applications DL-3-(Benzylthio)lactic Acid is used in the preparation of somatostatin analogs, affecting growth hormones.<br></p>