Antimicrobials

<p>Clindamycin-d3 hydrochloride is an isotopically labeled pharmaceutical compound, specifically designed for use in the field of analytical chemistry and pharmacokinetics. It is derived from clindamycin, a known antibiotic sourced from modifications of the naturally occurring compound lincomycin, produced by the actinobacterium Streptomyces lincolnensis. The incorporation of deuterium atoms, replacing hydrogen, allows for its use in sophisticated analytical methods such as mass spectrometry, where it serves to trace the metabolic pathways and to quantify the bioavailability and distribution of clindamycin in biological systems with high precision.</p>

<p>Fosfomycin calcium monohydrate is an antibacterial agent, derived from Streptomyces species. This compound functions as a structural analog of phosphoenolpyruvate, interfering with cell wall synthesis. Specifically, it targets and irreversibly inhibits the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), which is critical in the early stages of bacterial cell wall biosynthesis. This inhibition prevents the formation of peptidoglycan, leading to bacterial cell lysis.</p>

<p>Naftifine N-Oxide is an antifungal agent, which is derived from synthetic chemical processes. Its structure is based on the modification of the known antifungal, naftifine, by introducing an N-oxide functional group, which may enhance certain pharmacokinetic properties. As a synthetic derivative, Naftifine N-Oxide is specifically designed to interfere with the biosynthesis of ergosterol, an essential component of fungal cell membranes. By inhibiting squalene epoxidase, an enzyme crucial to the ergosterol pathway, Naftifine N-Oxide effectively disrupts the development and maintenance of the fungal cell membrane, compromising cell integrity and leading to antifungal activity.</p>

<p>Ceftibuten Hydrate is a third-generation cephalosporin antibiotic, which is a synthetic derivative of naturally occurring cephalosporin C, derived from the fungus Acremonium. It functions by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. This bactericidal action is accomplished through the binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, disrupting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls.</p>

<p>Propicillin is a broad-spectrum antimicrobial agent that has been shown to be effective against both gram-positive and gram-negative bacteria. Propicillin belongs to the group of nonsteroidal anti-inflammatory drugs. It is a particle that is soluble in water and lipid. Propicillin does not inhibit the growth of Streptococcus species, but does cause cell lysis by attaching to fatty acids on the surface of cells. Propicillin also inhibits microbial infection by inhibiting enzymes involved in fatty acid synthesis. The human serum pharmacokinetics of propicillin have been studied and found to be similar to those of ampicillin, which allows for use as an intravenous drug in humans. The pharmacokinetics, biochemical properties, and cellular mechanisms are complex, but it is known that propicillin binds to bacterial ribosomes and inhibits protein synthesis by binding to the peptidyl transferase centre on the ribosome.</p>

<p>Coronarin D ethyl ether is a diterpenoid compound, which is derived from the plant Hedychium coronarium, also known as white ginger lily. This compound belongs to a class of naturally occurring chemicals with complex polycyclic structures. The source of Coronarin D ethyl ether is the rhizome of Hedychium coronarium, which is part of the Zingiberaceae family. These plants are often studied for their bioactive properties and potential therapeutic applications.</p>

<p>Pyrimorph is a fungicide, which is a synthetic compound with specific activity against oomycete pathogens. It belongs to the chemical class of morpholines. Its mode of action involves the disruption of the biosynthetic pathways essential for the survival and proliferation of oomycetes, leading to their effective inhibition. Pyrimorph specifically targets the biosynthesis of cellulose in the cell walls of these pathogens, inhibiting their capacity to multiply and cause disease.</p>

<p>Clindamycin 4-phosphate is a semi-synthetic antibiotic, which is a derivative of the natural antibiotic lincomycin. It is specifically synthesized from Streptomyces lincolnensis cultures. The mode of action of Clindamycin 4-phosphate involves inhibiting bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, thus preventing peptide chain elongation and subsequent bacterial growth.</p>

<p>A2ti-1 is a specialized therapeutic agent, which is derived from recombinant DNA technology with the specific mode of action of targeting and modulating cytokine signaling pathways within the immune system. It is designed to interact with specific cytokine receptors, thereby inhibiting or modulating the downstream signaling cascades that are pivotal in the inflammatory response and immune regulation.</p>

<p>Acetoxypolygodial is a sesquiterpenoid compound, which is a naturally derived product from the roots of the plant Polygonum hydropiper. This compound exhibits its mode of action through its ability to disrupt microbial cell membranes, leading to increased permeability and eventual cell death. Its primary mechanism involves direct interaction with lipid bilayers, causing destabilization.</p>

<p>Artelinic acid is a synthetic antimalarial agent, which is derived from artemisinin, a natural compound sourced from the sweet wormwood plant (Artemisia annua). The mode of action of Artelinic acid involves the generation of free radicals within the Plasmodium parasite, leading to oxidative stress and damage to the parasite’s cellular components, ultimately resulting in parasite death. This mechanism is particularly effective against Plasmodium species, including those strains resistant to other antimalarial drugs.</p>

<p>6,11-Di-O-methyl erythromycin is a semi-synthetic derivative of erythromycin, which is a macrolide antibiotic originally sourced from the bacterium *Saccharopolyspora erythraea*. This compound is produced through chemical modification of the natural antibiotic to improve its pharmacokinetic properties, such as stability and absorption.</p>

<p>Puromycin-D3 is a deuterium-labeled antibiotic, which is synthetically derived from the bacterium *Streptomyces alboniger*, with three hydrogen atoms replaced by deuterium. Its mode of action involves the inhibition of protein synthesis by mimicking the aminoacyl end of tRNA, causing premature chain termination during translation on ribosomes. This mechanism specifically targets growing peptides in cells, making it a valuable tool for studying protein synthesis.</p>

<p>(E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin is a semisynthetic macrolide antibiotic, which is derived from erythromycin, a natural product obtained from the bacterium *Saccharopolyspora erythraea*. This compound functions as an inhibitor of protein synthesis by binding to the 50S ribosomal subunit of bacteria, thus preventing the growth and proliferation of susceptible bacterial strains. The alteration in its chemical structure, notably the methylation at the 6-O position, enhances its stability and improves its pharmacokinetic profile compared to the parent compound, erythromycin.</p>

<p>Telavancin is a lipoglycopeptide antibiotic, which is a semi-synthetic derivative of vancomycin. Its source is derived through modifications of the glycopeptide antibiotic, specifically aimed to enhance antibacterial activity. Telavancin functions by inhibiting cell wall synthesis in Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It does this by binding to the D-alanyl-D-alanine terminus of cell wall precursors, disrupting peptidoglycan polymerization and, consequently, cell wall integrity. Additionally, Telavancin increases membrane permeability and disrupts membrane potential, further enhancing its bactericidal activity.</p>

<p>Sisunatovir hydrochloride is an antiviral agent, which is a synthetic compound with a mechanism of action specifically targeting the respiratory syncytial virus (RSV). As a potent inhibitor, Sisunatovir hydrochloride interferes with the viral replication process by binding to a specific protein essential for the virus's ability to replicate within host cells.</p>

<p>Pivmecillinam hydrochloride is an antibacterial prodrug, which is derived from the source compound mecillinam, a beta-lactam antibiotic. It functions by inhibiting bacterial cell wall synthesis, specifically targeting the penicillin-binding protein 2 (PBP2). This affinity leads to a weakening of the bacterial cell wall, causing cell lysis and death, particularly in gram-negative bacteria.</p>

<p>Censavudine is an antiviral compound, which is a synthetic nucleoside analog designed to interfere with viral replication processes. The source of this compound lies in its chemical synthesis, which involves precise structural modifications to resemble natural nucleosides. Its mode of action involves incorporation into viral RNA by the viral polymerase, leading to chain termination. This mechanism effectively hinders the replication of viral genomes, thus preventing the proliferation of the virus within the host organism.</p>

<p>Spiramycin hexanedioate is a macrolide antibiotic, which is derived from the bacterium *Streptomyces ambofaciens*. Its mode of action involves binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis. This interaction results in the interruption of bacterial growth and reproduction, particularly effective against Gram-positive organisms.</p>

<p>Piperacillin-d5 is a stable isotopically labeled antibiotic, which is synthesized chemically to incorporate deuterium atoms. It is derived from the β-lactam group of antibiotics, sharing properties with its non-labeled counterpart, piperacillin. The incorporation of five deuterium atoms allows researchers to use it as a tracer in various pharmacokinetic and metabolic studies without altering its biological activity.</p>

<p>Please enquire for more information about Sibofimloc including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pantoprazole magnesium is a pharmaceutical compound that belongs to the class of proton pump inhibitors (PPIs). It is derived from the benzimidazole chemical family and synthesized through a chemical process that involves the formation of a magnesium salt of pantoprazole. This compound's mode of action involves the irreversible inhibition of the H+/K+ ATPase enzyme system located on the gastric parietal cell surface. By blocking this enzyme system, pantoprazole magnesium effectively reduces the secretion of gastric acid.</p>

<p>Sordarin sodium salt is an antifungal agent, characterized as a semisynthetic derivative produced from the fermentation products of filamentous fungi, specifically belonging to the phylum Ascomycota. This compound exerts its effects by selectively inhibiting fungal protein synthesis. It achieves this by obstructing the function of elongation factor 2 (EF-2), an essential component of fungal ribosomal activity, thereby disrupting the translational elongation step of protein synthesis.</p>

<p>Sulbenicillin is a semi-synthetic penicillin antibiotic, which is derived from 6-aminopenicillanic acid, a natural precursor in the biosynthesis of penicillins. With its beta-lactam structure, Sulbenicillin disrupts bacterial cell wall synthesis by inhibiting penicillin-binding proteins, which are essential enzymes in the cross-linking of peptidoglycan layers. This disruption compromises the structural integrity of the bacterial cell wall, resulting in cell lysis and death, particularly in Gram-negative bacteria.</p>

<p>Thienamycin p-nitrobenzyl ester, N-methylpyrrolidinone hydrochloride is a synthetic compound commonly utilized in biochemical research, particularly in the study of beta-lactam antibiotics. It is derived through synthetic pathways involving the modification of thienamycin, a naturally occurring beta-lactam antibiotic, to enhance its stability and facilitate its study in various experimental settings. This modification allows for investigation into the structure-activity relationships and potential enhancements of antibiotic function.</p>

<p>Methicillin sodium hydrate is a semi-synthetic β-lactam antibiotic, which is a derivative of the naturally occurring antibiotic penicillin. It is sourced from the modification of the penicillin nucleus, specifically designed to resist degradation by the bacterial enzyme penicillinase. This enzyme, produced by certain bacterial strains, can render penicillin ineffective. Methicillin operates by inhibiting the synthesis of bacterial cell walls, specifically binding to penicillin-binding proteins (PBPs). This action disrupts the cross-linking of peptidoglycan chains, a critical component for bacterial cell wall integrity, ultimately leading to cell lysis and death.</p>

<p>Macrosphelide A is a bioactive macrocyclic lactone, which is a secondary metabolite derived from the culture of certain fungal species. It functions primarily through the disruption of cell adhesion processes, which is facilitated by its ability to interfere with the function of specific cell surface receptors. This mode of action underlies its potential as an immunosuppressive agent, where it can inhibit the activities of immune cells by altering cellular communication and adhesion.</p>

<p>Inhibitor of protein synthesis; lincosamide class</p>

<p>Cyprazine-desisopropyl is a metabolite, which is a derivative form resulting from the biotransformation of cyromazine, an insect growth regulator. Cyromazine is originally sourced as a triazine-class pesticide, commonly used to control insect populations by disrupting their growth processes. Cyprazine-desisopropyl, similarly, impacts the development stages of target insect species.</p>

<p>Biotinamidocaproate tobramycin amide is a chemical conjugate, serving as an innovative antimicrobial agent derived from the integration of biotin with tobramycin, an aminoglycoside antibiotic. This product embodies the amalgamation of tobramycin’s robust antibacterial properties with biotin’s ability to guide compounds specifically to targets through biotin-avidin interactions.</p>

<p>Nifedipine is a pharmaceutical compound belonging to the class of dihydropyridine calcium channel blockers, which is synthetically derived. Its mode of action involves the inhibition of calcium ions entering vascular smooth muscle and cardiac muscle cells, leading to vasodilation. By blocking these channels, it reduces peripheral vascular resistance, thereby decreasing blood pressure and easing cardiac workload.</p>

<p>Vebufloxacin is an antibacterial agent, which is synthesized as a member of the fluoroquinolone class of antibiotics. This compound is derived from chemical synthesis, specifically designed to target and inhibit bacterial DNA gyrase and topoisomerase IV. These enzymes play crucial roles in DNA replication and transcription, making them ideal targets for disrupting bacterial cell function.</p>

<p>Showdomycin is an antibiotic, which is derived from the bacterium *Streptomyces showdoensis*. The mode of action of Showdomycin involves its role as a nucleoside analog that disrupts nucleic acid synthesis by incorporating itself into the nucleic acid chains during replication and transcription, thereby impairing cellular functions.</p>

<p>Oxacillin sodium is a beta-lactam antibiotic with action on bacterial cell wall synthesis and is used for treating infections caused by penicillin-resistant Staphylococcus aureus.</p>

<p>Voxilaprevir is an antiviral compound, which is a product of chemical synthesis with a unique mode of action targeting the Hepatitis C virus (HCV). It acts as a potent inhibitor of the HCV NS3/4A protease, a crucial enzyme required for the viral replication process. By inhibiting this protease, Voxilaprevir disrupts the viral life cycle, preventing replication and aiding in the clearance of the virus from the host.</p>

<p>Aqabamycin F is a type of antibiotic compound, which is derived from marine natural sources, specifically from bacteria found in oceanic environments. This product is characterized by its unique molecular structure that offers potent antimicrobial properties. The mode of action of Aqabamycin F involves inhibiting essential bacterial enzymes, thus disrupting the cellular processes necessary for bacteria to survive and proliferate. This mechanism makes it effective against a wide range of bacterial pathogens, contributing to its potential in treating infections that are resistant to conventional antibiotics. Research into Aqabamycin F continues to explore its full spectrum of activity, offering insights into new therapeutic pathways for antibiotic-resistant bacterial infections. Its unique origin and molecular activity position Aqabamycin F as a promising candidate for addressing the growing challenge of antibiotic resistance.</p>

<p>BRITE-338733 is an advanced biotechnological product, which is derived from microbial fermentation with high specificity enzymatic action. This product is engineered to efficiently catalyze specific biochemical reactions, thereby facilitating various lab-scale processes.</p>

<p>Flutimide is a nonsteroidal antiandrogen, which is synthesized chemically. It functions by competitively inhibiting the binding of androgens, such as testosterone, to androgen receptors. This interferes with the action of androgens at the cellular level, leading to a reduction in the growth effects mediated by these hormones.</p>

<p>Grazoprevir hydrate is a direct-acting antiviral agent used in the treatment of hepatitis C virus (HCV) infections. It is a synthetic compound derived through targeted pharmaceutical synthesis aimed at inhibiting viral replication. This compound operates by selectively inhibiting the NS3/4A protease, an enzyme critically involved in the post-translational processing and replication of the HCV polyprotein. By blocking this protease, grazoprevir effectively disrupts the virus's life cycle, thereby reducing viral load in patients.</p>

<p>Hexazinone Metabolite C is a chemical compound that serves as a marker for the metabolic degradation of hexazinone, a systemic herbicide. This metabolite is derived from the biological and chemical transformation processes that hexazinone undergoes when applied to plants and soil environments.</p>

<p>Bromuconazole is a systemic fungicide, which is a synthetic chemical compound primarily used to protect crops from fungal diseases. It is derived from the triazole class of fungicides, which are known for their ability to inhibit important biochemical processes within fungal cells. The mode of action of Bromuconazole involves the inhibition of the enzyme C14-demethylase, a key component in the biosynthesis of ergosterol. Ergosterol is an essential component of fungal cell membranes, and its disruption leads to impaired cellular function and ultimately the death of the fungal organism.</p>

<p>3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole is a synthetic chemical compound, classified as an organochlorine derivative. This compound originates from the modification of pyrrole structures, which are heterocyclic aromatic compounds. The synthesis involves chlorination and nitration processes to enhance its potential activity and specificity.</p>

<p>14-Chloro daunorubicin is a chemotherapeutic agent, which is a synthetic derivative of the naturally occurring anthracycline antibiotic, daunorubicin. This compound is specifically modified to include a chlorine atom at the 14th position, which enhances its pharmacological effectiveness compared to its parent compound. The drug acts primarily by intercalating into DNA, disrupting the function of topoisomerase II, and generating free radicals. These mechanisms collectively inhibit DNA replication and transcription, leading to cell apoptosis, particularly in rapidly dividing cancer cells.</p>

<p>Nafcillin sodium is a beta-lactam antibiotic, which is a semisynthetic derivative of the organic compound penicillin. It is specifically engineered to be resistant to the inactivation by penicillinase enzymes produced by certain bacteria. This feature allows it to remain effective against a range of penicillinase-producing staphylococcal infections.</p>

<p>Beclabuvir is an investigational antiviral agent, which is synthetically derived with the purpose of targeting the hepatitis C virus (HCV). It functions as a non-nucleoside inhibitor, specifically inhibiting the HCV NS5B RNA-dependent RNA polymerase, a crucial enzyme necessary for viral replication. By obstructing the polymerase activity, Beclabuvir effectively impedes the replication cycle of the virus, thereby reducing viral load in infected individuals.</p>

<p>Hexazinone metabolite B is a chemical byproduct of the breakdown of Hexazinone, which is an herbicide. This metabolite emerges from an extensive metabolic pathway in plants, fungi, and soil microorganisms as they degrade the parent compound. Its mode of action involves interacting with plant processes, potentially affecting growth and development, as it may influence photosynthetic pathways or other vital physiological functions.</p>

<p>Hexazinone metabolite E is a degradation product of the herbicide Hexazinone, which is derived from synthetic chemical processes. This metabolite emerges as a result of the biochemical breakdown of Hexazinone in soil and water environments. The mode of action involves the contamination and persistence in various environmental matrices, making it a key compound of interest for understanding the environmental impact of herbicide application. Hexazinone initially acts by inhibiting photosynthesis in plants, and its metabolites, including metabolite E, provide insights into the degradation pathways and long-term behavior of the herbicide in ecosystems.</p>

<p>Demethylbleomycin A2 sulfate is an antineoplastic agent, which is derived from the bacterium Streptomyces verticillus. This compound functions by binding to DNA, inducing strand breaks and inhibiting DNA synthesis, ultimately leading to apoptosis or programmed cell death. Its mechanism of action involves the generation of free radicals, which cause oxidative damage to the DNA strands, impairing cellular replication and tumor growth.</p>

<p>Mesosulfuron is a selective herbicide, which is a synthetic chemical compound with a specific mode of action designed to inhibit acetolactate synthase (ALS). This enzyme inhibition disrupts the biosynthesis of essential amino acids such as valine, leucine, and isoleucine, leading to the cessation of cell division and consequent plant growth arrest. The herbicide is primarily utilized in agricultural settings, particularly for post-emergence control of various grass weeds within cereal crops, including wheat and barley. Its application is crucial for managing weed competition that can significantly impact crop yield and quality. Mesosulfuron is absorbed through the foliage and roots of targeted species, providing systemic action that ensures effective control. Its usage is governed by stringent regulations to minimize environmental impact and to manage herbicide resistance through integrated weed management strategies.</p>

<p>Oxaquin is a synthetic antibiotic, which is a derivative of the fluoroquinolone class, developed through chemical synthesis. It disrupts bacterial DNA replication by inhibiting the DNA gyrase and topoisomerase IV enzymes, which are crucial for DNA synthesis and repair. This mode of action prevents bacterial cells from dividing and leading to cell death.</p>