Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65694 products of "Quinazoline and Quinoline Derivatives"
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Chloropretadalafil
CAS:<p>Applications An intermediate in the synthesis of Tadalafil (T004500), which is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003),<br></p>Formula:C22H19ClN2O5Color and Shape:White To Light Orange ColourMolecular weight:426.858-Chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one
CAS:Controlled Product<p>Impurity CLOZAPINE EP IMPURITY A<br>Stability Store in Freezer<br>Applications A useful intermediate for the preparation of pharmaceutical actives and fine chemicals. Antipsychotic drug.<br>References Venkat Rao, S., Arab. J. Chem., 13, 6040 (2020)<br></p>Formula:C13H9ClN2OColor and Shape:NeatMolecular weight:244.686-Hydroxy Chlorzoxazone-d2
CAS:Controlled Product<p>Applications 6-Hydroxy Chlorzoxazone-d2 is a labeled analogue of 6-Hydroxy Chlorzoxazone (H825120), A major metabolite of chlorzoxazone and formed by the actions of cytochrome P450IIE1.<br>References Twele, et al.: Arzneim.-Forsch., 32, 759 (1982); Peter, et al.: che. Res. Toxicol., 3, 566 (1990)<br></p>Formula:C7H2D2ClNO3Color and Shape:White To BrownMolecular weight:187.58Niclosamide Ethanolamine Salt
CAS:<p>Applications Niclosamide Ethanolamine Salt is an ethanolamine salt of Niclosamide (N395500), which is used as an anthelmintic drug (Cestodes)<br>References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),<br></p>Formula:C13H8Cl2N2O4·C2H7NOColor and Shape:Dark YellowMolecular weight:388.20Dehydronitrosonisoldipine
CAS:Controlled Product<p>Impurity Nisoldipine<br>Applications Dehydronitrosonisoldipine is an impurity of Nisoldipine (N489125). Nisoldipine is a dihydropyridine calcium channel blocker and it is antihypertensive and antianginal.<br>References Kazda, S., et al.: Arzneimittel-Forsch., 30, 2144 (1980); Pasanisi, F., et al.: Eur. J. Clin. Pharmacol., 29, 21 (1985); Lam, J., et al.: J. Am. Col. Cardiol., 6, 447 (1985)<br></p>Formula:C20H22N2O5Color and Shape:NeatMolecular weight:370.4Imiquimod
CAS:Controlled Product<p>Applications An immune response modifier. It stimulates the production of interferon-a.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998)<br></p>Formula:C14H16N4Color and Shape:White To Off-WhiteMolecular weight:240.30A77 1726-d4
CAS:Controlled Product<p>Applications The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formula:C122H4H5F3N2O2Color and Shape:Off-WhiteMolecular weight:274.232-[5-amino-3-(2-thienyl)-1H-pyrazol-1-yl]-6-methylpyrimidin-4(3H)-one
CAS:Purity:95.0%Molecular weight:273.30999755859375(E)-3-(3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid
CAS:Purity:98%Molecular weight:350.37399291992192-Chloro-1-(5-(furan-2-yl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one
CAS:Purity:98%Molecular weight:294.75Hydroxymethoxy-N-desmethyl Toremifene
Formula:C26H28ClNO3Purity:>80%Color and Shape:NeatMolecular weight:437.96Nepafenac
CAS:<p>Applications A non-steroidal anti-inflammatory with analgesic activity; selective COX-2 inhibitor. Prodrug of Amfenac.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walsh, D.A., et al.: J. Med. Chem., 33, 2296 (1990), Gamache, D.A., et al.: Inflammation, 24, 357 (2000), Lindstrom, R., et al.: Curr. Med. Res. Opin., 22, 397 (2006),<br></p>Formula:C15H14N2O2Color and Shape:NeatMolecular weight:254.28Dolutegravir-d4
CAS:Controlled Product<p>Applications Isotope labelled Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);<br></p>Formula:C20H15D4F2N3O5Purity:>80%Color and Shape:NeatMolecular weight:423.404-Chloro-2-phenylquinazoline
CAS:Purity:95.0%Color and Shape:Solid, White solidMolecular weight:240.69000244140625Clofedanol Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.<br>References Yuizono, T., et al.: Yakugaku Zasshi, 87, 915 (1967), Nomura, A., et al.: Oyo Yakuri, 8, 119 (1974),<br></p>Formula:C17H20ClNO·ClHColor and Shape:White To Off-WhiteMolecular weight:326.265’-Hydroxymethyl 5’-Desmethyl Meloxicam
CAS:Formula:C14H13N3O5S2Color and Shape:NeatMolecular weight:367.40Axitinib Sulfoxide
CAS:Controlled ProductFormula:C22H18N4O2SColor and Shape:NeatMolecular weight:402.476-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:313.36099243164063,4-Dimethoxybenzoic Acid (Veratric Acid)
CAS:Controlled Product<p>Applications Veratric Acid is a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.<br>References Alissandrakis, E., et al.: Eur. Food Res. Technol., 229, 365 (2009), Spaccini, R., et al.: Soil Biol. Biochem., 41, 1164 (2009), Narasimhan, B., et al.: Eur. J. Med. Chem., 44, 689 (2009), Pereira, L., et al.: J. Biotechnol., 139, 68 (2009),<br></p>Formula:C9H10O4Color and Shape:NeatMolecular weight:182.17[[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]methyl]oxirane
CAS:Controlled ProductFormula:C15H20O3Color and Shape:NeatMolecular weight:248.322-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide
CAS:Controlled ProductFormula:C11H10ClN3OSColor and Shape:NeatMolecular weight:267.732-Cyclopropyl-quinoline-4-carboxylic acid
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:213.235992431640622,2,2-Trifluoroethyl 2,5-Bis(2,2,2-trifluoroethoxy)benzoate
CAS:Controlled Product<p>Applications Intermediate in the production of antiarrhythmic N-(Piperidylalkyl)trifluoroethoxybenzamides. Possible Flecainide impurity.<br>References Banitt, E., et al.: J. Med. Chem., 20, 821 (1977),<br></p>Formula:C13H9F9O4Color and Shape:NeatMolecular weight:400.193-[2-[4-(4-Fluoro-2-hydroxybenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Hydrochloride
CAS:Controlled Product<p>Applications Risperidone (R525000) metabolite.<br>References Meuldermans, W. et al.; Drug Metab. Dispos. 22, 129 (1994); Mannens, G. et al.; Drug Metab. Dispos. 21, 1134 (1993)<br></p>Formula:C23H28FN3O3·HClColor and Shape:NeatMolecular weight:449.946Xanthurenic Acid
CAS:<p>Applications Excreted by pyridoxine-deficient animals after the ingestion of tryptophan.<br>References Aquilina, J., et al.: Biochemistry, 39, 16176 (2000), Roberts, J., et al.: Photochem. Photobiol., 74, 740 (2001),<br></p>Formula:C10H7NO4Color and Shape:NeatMolecular weight:205.173,4-Dehydro Cilostazol
CAS:Controlled Product<p>Impurity Cilostazol USP Related Compound B<br>Applications A metabolite of Cilostazol.<br></p>Formula:C20H25N5O2Color and Shape:Off WhiteMolecular weight:367.44Tert-Butyl 4-chloro-2-morpholino-5H-pyrrolo[2,3-d]pyrimidine-7(6H)-carboxylate
CAS:Purity:95.0%Molecular weight:340.80999755859375(4S)-Brivaracetam
CAS:Controlled ProductFormula:C11H20N2O2Color and Shape:NeatMolecular weight:212.2893-(4-CHLOROPHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
CAS:Purity:95.0%Molecular weight:282.7300109863281Darunavir
CAS:<p>Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>Formula:C27H37N3O7SColor and Shape:BeigeMolecular weight:547.66Pseudo Vardenafil
CAS:<p>Applications Vardenafil analog.<br>References Blok-Tip, L., et al.: Food Addit. Contam., 21, 737 (2004), Reffelmann, T., et al.: Curr. Pharm. Des., 12, 3485 (2006), Reepmeyer, J., et al.: J. Pharm. Biomed. Anal., 43, 1615 (2007),<br></p>Formula:C22H29N5O4SColor and Shape:NeatMolecular weight:459.56Haloperidol
CAS:Controlled Product<p>Applications Antidyskinetic; antipsychotic. Neuroprotective product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980), Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>Formula:C21H23ClFNO2Color and Shape:Off-WhiteMolecular weight:375.867-chloro-4-methoxy-N-(pyridin-2-ylmethyl)benzo[d]thiazol-2-amine
CAS:Purity:95.0%Molecular weight:305.77999877929696-fluoro-N-(pyridin-3-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Purity:95.0%Molecular weight:259.29998779296875(R)-(+)-Thalidomide
CAS:Controlled Product<p>Applications Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.<br>References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>Formula:C13H10N2O4Color and Shape:NeatMolecular weight:258.23Thiazolylmethyl-4-nitrophenylcarbonate
CAS:Controlled Product<p>Applications Retinovir intermediate.<br>References Randad, R., et al.: Bioorg. Med. Chem. Lett., 4, 1247 (1994), Scholz, et al.: J. Med. Chem., 37, 3079 (1994), Vacca, J., et al.: Bioorg. Med. Chem. Lett., 4, 499 (1994),<br></p>Formula:C11H8N2O5SColor and Shape:Light YellowMolecular weight:280.26Desethylene Aripiprazole
CAS:<p>Impurity Aripiprazole Desethylene Impurity<br>Applications Desethylene Aripiprazole is an Aripiprazole derivative. Aripiprazole Desethylene Impurity<br></p>Formula:C21H25Cl2N3O2Color and Shape:NeatMolecular weight:422.351-Chloro-2-nitrobenzene
CAS:Controlled Product<p>Applications 1-Chloro-2-nitrobenzene is a useful synthetic intermediate. It was used in the synthesis of 1-hydroxybenzotriazole derivatives. Reaction of 1-chloro-2-nitrobenzene with dinitrogen pentoxide in dichloromethane is strongly catalysed by H-Faujasite-720.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fathalla, M., et al.: J. Chem. Soc. Pak., 33, 324 (2011); Claridge, R., et al.: J. Chem. Soc. Perkin Trans. II, 9, 1815, (1999)<br></p>Formula:C6H4ClNO2Color and Shape:NeatMolecular weight:157.55Desmethyl Ofloxacin
CAS:Controlled Product<p>Impurity Ofloxacin EP Impurity E<br>Applications Desmethyl Ofloxacin (Ofloxacin EP Impurity E) is a metabolite of Ofoxacin (O245750), a fluorinated quinolone antibacterial.<br>References Leysen, D., et al.: Antimicrob. Agents Chemother., 33, 1 (1989); Polk, R., et al.: J. Antimicrob. Chemother., 27, 17 (1991); Todo, Y., et al.: Chem. Pharm. Bull., 42, 2049 (1994); Furuhata, K., et al.: Biol. Pharm. Bull., 21, 456 (1998); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>Formula:C17H18FN3O4Color and Shape:White To Light BeigeMolecular weight:347.34N-Formyl Lenalidomide
CAS:Controlled ProductFormula:C14H13N3O4Color and Shape:NeatMolecular weight:287.27Domperidone N-Oxide
CAS:Controlled Product<p>Impurity Domperidone EP Impurity C<br>Stability Hygroscopic<br>Applications Domperidone N-Oxide (Domperidone EP Impurity C) is an oxygenated metabolite of the gastrokinetic and antinauseant drug Domperidone (D531100).<br>References Van Vaeck, L. et al.: Biomed. Env. Mass Spec., 16, 121 (1988);<br></p>Formula:C22H24ClN5O3Color and Shape:White To Off-WhiteMolecular weight:441.91rac-Talinolol
CAS:Controlled Product<p>Applications Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.<br>References Assmann, I., et al.: Curr. Med. Res. Opin., 13, 325 (1995), Trausch, B., et al.: Biopharm. Drug Dispos., 16, 403 (1995),<br></p>Formula:C20H33N3O3Color and Shape:White To Light PinkMolecular weight:363.49Tazarotene-d8
CAS:Controlled Product<p>Applications Labelled Tazarotene (T010050). An acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Antiacne; antipsoriatic. Used in treatment of photodamaged skin.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>Formula:C21H13D8NO2SColor and Shape:YellowMolecular weight:359.51Gabapentin Related Compound D
CAS:<p>Impurity Gabapentin EP Impurity D; Gabapentin USP Related Compound D<br>Applications Gabapentin Related Compound D (Gabapentin EP Impurity D; Gabapentin USP Related Compound D) is a Gabapentin analogue.<br></p>Formula:C18H29NO3Color and Shape:White To Off-WhiteMolecular weight:307.434-Chloro-4'-fluorobutyrophenone
CAS:Controlled Product<p>Applications 4-Chloro-4'-fluorobutyrophenone (cas# 3874-54-2) is a compound useful in organic synthesis.<br></p>Formula:C10H10ClFOColor and Shape:NeatMolecular weight:200.64Ref: 10-F794544
1gTo inquire5gTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire250mgTo inquire2-[3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic Acid Methyl Ester
CAS:Controlled Product<p>Applications An intermediate in the synthesis of Montelukast.<br>References Labelle, M., et al.: Bioorg. Med. Chem. Lett., 4, 463 (1994), Roberge, C., et al.: J. Ferment. Bioeng., 81, 530 (1996), Shafiee, A., et al.: App. Microbiol. Biotechnol., 49, 709 (1998),<br></p>Formula:C28H22ClNO3Color and Shape:NeatMolecular weight:455.93N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine
CAS:Purity:95.0%Color and Shape:Solid, Yellow powderMolecular weight:431.89999389648443-Hydroxybenzaldehyde
CAS:<p>Impurity Roxatidine Impurity 3<br>Applications 3-Hydroxybenzaldehyde (cas# 100-83-4) is a compound useful in organic synthesis.<br></p>Formula:C7H6O2Color and Shape:Off-WhiteMolecular weight:122.122-Hydroxymethyl Loratadine
CAS:Controlled Product<p>Impurity Loratadine 2-Hydroxymethyl Impurity (USP)<br>Applications A usual impurity in Loratadine syrup formulations, a nonsedating-type histamine H1-receptor. Loratadine 2-Hydroxymethyl Impurity (USP).<br>References Okamoto, T., et al.: Chem. Pharm. Bull ., 7, 130 (1959), Eyjolfsson, R., et al.: Pharmazie, 58, 154 (2003),<br></p>Formula:C23H25ClN2O3Color and Shape:NeatMolecular weight:412.913-Hydroxy-4-morpholino-1,2,5-thiazole
CAS:<p>Impurity Timolol EP Impurity D; Timolol BP Impurity D; Timolol USP Related Compound D<br>Applications 3-Hydroxy-4-morpholino-1,2,5-thiazole (Timolol EP Impurity D; Timolol BP Impurity D; Timolol USP Related Compound D) is an intermediate for the preparation of Timolol.<br>References Bodor, N., et al.: J. Med. Chem., 31, 100 (1988),<br></p>Formula:C6H9N3O2SColor and Shape:White To Off-WhiteMolecular weight:187.22Tulobuterol-d9 Hydrochloride
CAS:Controlled Product<p>Applications Labelled Tulobuterol (T897250). A sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. A β-adrenergic receptor agonist, related structurally to Terbutaline (T109750).<br>References Kubo, S., et al.: Arzneim.-Forsch., 25, 1028 (1975), Uematsu, T., et al.: Eur. J. Clin. Pharmacol., 44, 361 (1993), Qureshi, S., et al.: J. Exp. Med., 189, 615 (1999),<br></p>Formula:C122H9H9ClNO·ClHColor and Shape:White To Off WhiteMolecular weight:273.25Hemiacetorphan
CAS:Controlled Product<p>Applications Hemiacetorphan is an impurity of Racecadotril (R070600), which is antidiarrheal, enkephalinase inhibitor, and also capable of reducing the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009),<br></p>Formula:C14H17NO4SColor and Shape:NeatMolecular weight:295.35(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
CAS:Controlled ProductFormula:C19H18IN3OColor and Shape:White To Light YellowMolecular weight:431.27Telmisartan
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Formula:C33H30N4O2Color and Shape:NeatMolecular weight:514.62Pericyazine
CAS:Controlled Product<p>Applications Psychotherapeutic phenothiazine. Antipsychotic.<br>References Schafer, et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972), Kaye, J., et al.: Br. J. Clin. Pharmacol., 56, 569 (2003), Tschoner, A., et al.: Pharmacopsychiatry, 42, 29 (2009),<br></p>Formula:C21H23N3OSColor and Shape:Light Yellow To YellowMolecular weight:365.496-Pyrrolidin-1-ylpyridin-3-amine
CAS:Formula:C9H13N3Purity:95%Color and Shape:SolidMolecular weight:163.224Tert-Butyl 2-(pyridin-4-yl)acetate
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:193.24600219726562Clozapine
CAS:Controlled Product<p>Applications An antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)<br></p>Formula:C18H19ClN4Color and Shape:Off-WhiteMolecular weight:326.82Lenalidomide-d5
CAS:Controlled Product<p>Applications Lenalidomide-d5, is the labeled analogue of Lenalidomide (L328000), an immunomodulatory drug; analog of Thalidomide.<br>References Bartlett, J.B., et al.: Nature Rev., 4, 314 (2004), Mitsiades, C.S., et al.: Curr. Opin. Invest. Drugs, 5, 635 (2004), List, A., et al.: N. Engl. J. Med., 352, 549 (2005),<br></p>Formula:C13H8D5N3O3Color and Shape:Off-WhiteMolecular weight:264.293-Aminopiperidine-2,6-dione Hydrochloride
CAS:Controlled Product<p>Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.<br>References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)<br></p>Formula:C5H8N2O2·ClHColor and Shape:Off-WhiteMolecular weight:164.5904-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride
CAS:Controlled Product<p>Impurity Paroxetine EP Impurity G<br>Applications 4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride (Paroxetine EP Impurity G) is the active metabolite of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (M325910), N-Methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gerlach, M., et al.: Eur. J. Pharmacol., 208, 273 (1991), Tipton, K., et al.: J. Neurochem., 61, 1191 (1993), Wimalasena, D., et al.: J. Biol. Chem., 279, 15298 (2004),<br></p>Formula:C12H14FN·ClHColor and Shape:Light YellowMolecular weight:227.712,3,4-Trimethoxybenzaldehyde
CAS:Controlled Product<p>Applications 2,3,4-Trimethoxybenzaldehyde is a trimethoxylated aromatic aldehyde. 2,3,4-Trimethoxybenzaldehyde is an impurity of the anti-anginal drug Trimetazidine (T795610).<br>References Medenica, M.B. et al.: J. Chrom. Sci., 46, 430 (2008);<br></p>Formula:C10H12O4Color and Shape:Off-WhiteMolecular weight:196.201-Hydroxycyclopentyl 2-chlorophenyl Ketone
CAS:Controlled ProductFormula:C12H13ClO2Color and Shape:Colourless To Light YellowMolecular weight:224.68Propoxyphenyl Thiosildenafil
CAS:Controlled Product<p>Applications Propoxyphenyl-thiosildenafil is an analogue of Thiosildenafil (T371500). Propoxyphenyl-thiosildenafil has been used in the preparation of novel pyrazolopyrimidinethiones as PDE5 inhibitors for treating erectile dysfunction.<br></p>Formula:C23H32N6O3S2Color and Shape:NeatMolecular weight:504.672-Hydroxy-6-(trifluoromethyl)nicotinamide
CAS:Formula:C7H5F3N2O2Purity:≥97%Color and Shape:SolidMolecular weight:206.1244-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzaldehyde
CAS:<p>Impurity Bisoprolol EP Impurity L (Metoprolol EP Impurity C)<br>Stability Hygrscopic<br>Applications 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzaldehyde (Bisoprolol EP Impurity L (Metoprolol EP Impurity C)) is a Metoprolol impurity .<br>References Baldwin, J.J. , et al.: J. Med. Chem., 29, 1065 (1986), Ravelet, C., et al.: J. Sep. Sci., 29, 1322 (2006),<br></p>Formula:C13H19NO3Color and Shape:NeatMolecular weight:237.295-(1-Methyl-4-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol
CAS:Controlled Product<p>Applications 5-(1-Methyl-4-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol is a derivative of Cyproheptadine (C989200) which is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Cyproheptadine is a 5-HT2/5-HT1C serotonin receptor antagonist; H1 histamine receptor antagonist; antipruritic.<br>References Marchei, E., et al.: J. Pharm. Biomed. Anal., 41, 1633 (2006); de-Benedictis, F., et al.: Allergy, 63, 1395 (2008); Feas, X., et al.: J. Pharm. Biomed. Anal., 50, 1044 (2009); Yu, C., et al.: Talanta, 2011, 83, 1376 (2011);<br></p>Formula:C21H23NOColor and Shape:NeatMolecular weight:305.41Benzophenone-2,3,4,5,6-d5
CAS:Controlled Product<p>Applications Benzophenone-2,3,4,5,6-d5 is derived from Benzene-d6 (B185282), which is an isotope labelled benzene, an organic compound that is a natural constituent of crude oil and one of the most basic petrochemicals.<br>References Feng, Z.X.. et al.: J. Phys. Chem. Lett. 4, 285 (2013); Pilling. M., et al.: Chem. Eng. Prog., 108, 32 (2012);<br></p>Formula:C13D5H5OColor and Shape:NeatMolecular weight:187.25Riluzole 4-Trifluoromethoxy Isomer
CAS:Controlled Product<p>Applications Riluzole 4-Trifluoromethoxy Isomer is an impurity of Riluzole (R510000), a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.<br>References Satyanarayana, B., et. al.: ARKIVOC, 14, 109 (2008); Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formula:C8H5F3N2OSColor and Shape:NeatMolecular weight:234.20Ethyl 4[[6-(4-Carbamimidoylphenoxy)hexyl]oxy]benzoate Hydrochloride
<p>Applications Ethyl 4[[6-(4-Carbamimidoylphenoxy)hexyl]oxy]benzoate is an impurity of Hexamidine Diisetionate (H294205), which is an amidine compound used in the treatment of amyloid-related diseases; it is also used as preservative in cosmetics as an antispetic.<br>References Siddall, T., et al.: J. Org. Chem., 31, 3719 (1966)<br></p>Formula:C22H28N2O4·HClColor and Shape:NeatMolecular weight:384.47 +(36.46)N-Desmethyl Tadalafil
CAS:Controlled Product<p>Applications A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.<br>References Beghyn, T. et al.: Bioorg. Med. Chem. Lett., 17, 789 (2007); Daugan, A. et al.: J. Med. Chem., 46, 4533 (2003);<br></p>Formula:C21H17N3O4Color and Shape:White SolidMolecular weight:375.386-BROMO-5-CYANO-NICOTINIC ACID ETHYL ESTER
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:255.07099914550783,6-Bis(5-bromothiophen-2-yl)-2,5-bis(2-octyldodecyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione
CAS:Purity:95%Molecular weight:1019.2199707031252-[5-chloro-2-(pyridin-4-yl)-1H-indol-3-yl]ethan-1-amine hydrochloride
CAS:Purity:95.0%Molecular weight:308.20999145507814-(3-Phenothiazin-10-ylpropyl)-1-piperazineethanol
CAS:Controlled Product<p>Impurity Perphenazine EP Impurity B; Perphenazine USP Related Compound B<br>Applications 4-(3-Phenothiazin-10-ylpropyl)-1-piperazineethanol (Perphenazine EP Impurity B; Perphenazine USP Related Compound B) is the dechlorinated analogue of Perphenazine (P291100), an D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist.<br>References Tozer, T.N., et al.: J. Pharma. Sci., 54, 1169 (1965); Takada, A., et al.: Chem, Pharma. Bull., 10, 1 (1962);<br></p>Formula:C21H27N3OSColor and Shape:NeatMolecular weight:369.524-(Phenylamino)-1-benzyl-4-piperidinecarbonitrile
CAS:Controlled Product<p>Applications Used as modulators of muscarinic receptors for treatment of CNS disorders.<br>References Coghlan, M., et al.: J. Med. Chem., 44, 1627 (2001), Ashcroft, F., et al.: J. Clin. Invest., 115, 2047 (2005), Bryan, J., et al.: Curr. Pharm. Des., 11, 2699 (2005),<br></p>Formula:C19H21N3Color and Shape:NeatMolecular weight:291.39N-Methyl Omeprazole (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Controlled Product<p>Applications Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Formula:C18H21N3O3SColor and Shape:Off White SolidMolecular weight:359.444-Methylbenzenesulfonic Acid Monohydrate
CAS:Controlled Product<p>Impurity Lisinopril EP Impurity B/ Anastrozole EP Impurity F<br>Applications 4-Methylbenzenesulfonic Acid Monohydrate (Lisinopril EP Impurity B) is used in the synthesis of resveratrol. Also used in the synthesis of oxane derivatives as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, M. et al.: Org. Prep. Proc. Int., 45, 304 (2013); Wang, X. et al.: J. Med. Chem., 56, 2547 (2013);<br></p>Formula:C7H8O3S·H2OColor and Shape:WhiteMolecular weight:190.22
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