Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65578 products of "Quinazoline and Quinoline Derivatives"
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3,3-Diphenyl-oxiranecarboxylic Acid Methyl Ester
CAS:<p>Applications Ambrisentan intermediate.<br>References Amberg, W., et al.: J. Med. Chem., 42, 3026 (1999),<br></p>Formula:C16H14O3Color and Shape:NeatMolecular weight:254.28Ambroxol Cycloimine Impurity
CAS:Controlled Product<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C14H16Br2N2OColor and Shape:NeatMolecular weight:388.0976Brivaracetam-d7 (Mixture of Diastereomers)
Controlled Product<p>Applications Brivaracetam-d7 (Mixture of Diastereomers), is a mixture of 2 diastereomers of Brivaracetam-d7 (B677647), and a labeled analogue of Brivaracetam (B677645), 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formula:C11H13D7N2O2Color and Shape:NeatMolecular weight:219.33Ethyl 2-Methoxy-5-sulfamoylbenzoate
CAS:Controlled Product<p>Impurity Sulpiride EPimpurity C<br>Applications ethyl 2-methoxy-5-sulfamoylbenzoate (cas# 33045-53-3) is a useful research chemical.<br></p>Formula:C10H13NO5SColor and Shape:NeatMolecular weight:259.282-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS:Controlled Product<p>Applications 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C12H14N2OColor and Shape:NeatMolecular weight:202.25N-(1-Carboxy-3-phenylpropyl)-S-lisinopril (Mixture of diastereomers)
CAS:Controlled Product<p>Applications N-(1-Carboxy-3-phenylpropyl)-S-lisinopril (Mixture of diastereomers) is an impurity of lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor.<br>References Shinde, V., et. al.: J. Pharm. Biomed. Anal., 43, 381 (2007); Goa, K.L., et al.: Drugs, 52, 564 (1996), Chaturvedi, N., et al.: Lancet, 351, 28 (1998)<br></p>Formula:C31H41N3O7Color and Shape:NeatMolecular weight:567.67Anastrozole Diacid
CAS:Controlled Product<p>Impurity Anastrozole Diacid Impurity<br>Applications Anastroloze Diacid is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic. Anastrozole Diacid Imp<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Formula:C17H21N3O4Color and Shape:WhiteMolecular weight:331.37N-[3-Methyl-1-(1-phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride
CAS:Controlled Product<p>Applications N-[3-Methyl-1-(phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>Formula:C17H27N·ClHColor and Shape:NeatMolecular weight:281.86N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>Formula:C31H35NO8Color and Shape:NeatMolecular weight:549.61(S)-Carisbamate
CAS:<p>Applications Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.<br>References Novak GP, et al. 2007. Neurotherapeutics. Jan;4(1):106-9Nau C, 2004. J Membr Biol. Sep 1;201(1):1-8Codd EE, 2008. Pain. Feb;134(3):254-62. Epub 2007 May 25<br></p>Formula:C9H10ClNO3Color and Shape:NeatMolecular weight:215.631,4,8,11-Tetraazacyclotetradecane
CAS:Controlled Product<p>Applications 1,4,8,11-Tetraazacyclotetradecane is macrocyclic ligand that is used as an antioxidant in rubber and has been shown to suppress oxidation catalyzed by some metal ions.<br>References Goh, S.H.: Poly, Degrad, Stab., 8, 123 (1984);<br></p>Formula:C10H24N4Color and Shape:NeatMolecular weight:200.323-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CAS:Controlled Product<p>Stability Air Sensitive<br>Applications 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine is used in the preparation of c-Src and Abl inhibitors based on the scaffold present in Imatinib (G407000), used in the treatment of myelogenic leukemia. It is a COVID19-related research product.<br>References Seeliger, M. et al.: Canc. Res., 69, 2384 (2009); Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)<br></p>Formula:C11H10N3F3Color and Shape:NeatMolecular weight:241.213-Hydroxy Anagrelide-13C3 (~80%)
CAS:Controlled Product<p>Applications 3-Hydroxy Anagrelide-13C3 is a major labelled metabolite of Anagrelide, an antithrombotic.<br>References Fleming, J., et al.: Thromb. Res., 15, 373 (1979), Gillespie, E., et al.: Biochem. Pharmacol., 37, 2866 (1988), Mazur, E., et al.: Blood, 79, 1931 (1992), Wang, G., et al.: Br. J. Pharmacol., 146, 324 (2005), Wagstaff, A., et al.: Drugs, 66, 111 (2006),<br></p>Formula:C713C3H7Cl2N3O2Purity:~80%Color and Shape:NeatMolecular weight:275.074-Hydroxy-2-methyl- 1,1-dioxide-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide
CAS:Controlled ProductFormula:C8H8N2O4S2Color and Shape:NeatMolecular weight:260.295-Hydroxy Propranolol Hydrochloride
CAS:Controlled Product<p>Applications A metabolite of Propranolol.<br>References Otton, S., et al.: Br. J. Clin. Pharmacol., 30, 751 (1990), Fujita, S., et al.: J. Pharmacol. Exp. Ther., 264, 226 (1993), Bichara, N., et al.: Drug Metab. Dispos., 24, 112 (1996), Tasaki, T., et al.: J. Biochem., 123, 162 (1998),<br></p>Formula:C16H21NO3·HClColor and Shape:NeatMolecular weight:311.804Desacetyl Diltiazem-d4
CAS:Controlled Product<p>Applications A labelled metabolite of Diltiazem (D460620).<br></p>Formula:C20H20D4N2O3SColor and Shape:NeatMolecular weight:376.513-Bromo-2-methylpropionic Acid
CAS:<p>Impurity Captopril EP Impurity D<br>Stability Hygroscopic<br>Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.<br>References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);<br></p>Formula:C4H7BrO2Color and Shape:Colourless LiquidMolecular weight:167.00Loratadine-d5 (ethyl-d5)
CAS:Controlled Product<p>Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.<br></p>Formula:C22D5H18ClN2O2Color and Shape:NeatMolecular weight:387.92Benzo[b]thien-2-yl Ketone (Zileuton Impurity)
CAS:Controlled Product<p>Applications Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. & Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>Formula:C17H10OS2Color and Shape:NeatMolecular weight:294.394-Hydroxy Ramelteon
CAS:<p>Applications A metabolite of Ramelteon (R110051)<br></p>Formula:C16H21NO3Color and Shape:Off White SolidMolecular weight:275.34N-Isopropyl Carvedilol
CAS:Controlled Product<p>Applications Carvedilol (C184625) derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C27H32N2O4Color and Shape:White To Off-WhiteMolecular weight:448.55Loratadine-d5
CAS:Controlled Product<p>Applications Loratadine-d5 is the labeled analogue of Loratadine (L469575), a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989); Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H18D5ClN2O2Color and Shape:NeatMolecular weight:387.913-Methoxy Favipiravir
CAS:Controlled ProductFormula:C6H6FN3O2Color and Shape:NeatMolecular weight:171.13DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate
CAS:Controlled Product<p>Applications DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate is an isotope labeled compound of DL-threo-Droxidopa (D689950), a synthetic amino acid precursor of Norepinephrine. An Antiparkinson.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994)<br></p>Formula:C9H8D3NO5•HCl•x(H2O)Color and Shape:NeatMolecular weight:216.2136461802(Z)-4-(2,4-Difluorobenzoyl)piperidine Oxime
CAS:Controlled Product<p>Applications Intermediate in the preparation of Risperidone (R525000) and it’s derivatives.<br></p>Formula:C12H14F2N2OColor and Shape:NeatMolecular weight:240.24927-Hydroxyquinoline-(1H)-2-one
CAS:Controlled ProductFormula:C9H7NO2Color and Shape:NeatMolecular weight:161.163-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one
CAS:Controlled Product<p>Applications 3-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one (cas# 147687-17-0) is a compound useful in organic synthesis.<br></p>Formula:C18H17ClN2O2Color and Shape:NeatMolecular weight:328.79N10-Monodesmethyl Rizatriptan
CAS:Controlled Product<p>Impurity Rizatriptan EP Impurity I<br>Applications N10-Monodesmethyl Rizatriptan (Rizatriptan EP Impurity I) is a metabolite of Rizatriptan.<br>References Dechant, K., et al.: Drugs, 43, 776 (1992), Castro, J., et al.: Bioorg. Med. Chem. Lett., 3, 993 (1993), Lee, Y., et al.: Biopharm. Drug Dispos., 19, 577 (1998), Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004),<br></p>Formula:C14H17N5Color and Shape:NeatMolecular weight:255.32N-Formyl Carvedilol
Controlled Product<p>Applications N-Formyl Cardevilol is an impurity of Carvedilol (C184625).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C25H26N2O5Color and Shape:NeatMolecular weight:434.484,5-Dichlorothiophene-2-carboxylic Acid
CAS:Controlled Product<p>Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.<br>References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)<br></p>Formula:C5H2Cl2O2SColor and Shape:NeatMolecular weight:197.04N-Ethyl-N-nitroso-2-propanamine (100 μg/mL in Methanol)
CAS:Controlled ProductFormula:C5H12N2OColor and Shape:ColourlessMolecular weight:116.1616Ebastine N-Oxide
CAS:<p>Stability -20°C Freezer<br>Applications Ebastine N-Oxide is an impurity of Ebastine (E320000). Ebastine impurity F and G (mixture of cis/trans).<br>References Yardley, J., et al.: J. Med. Chem., 33, 2899 (1990), Johnson, R., et al.: J. Antibiot., 49, 788 (1996), Takekawa, K., et al.: Xenobiotica, 31, 11 (2001), Chen, Z., et al.: Bioorg. Med. Chem. Lett., 14, 5275 (2004),<br></p>Formula:C32H39NO3Color and Shape:NeatMolecular weight:485.66Chlorpromazine-d6 Hydrochloride
CAS:Controlled Product<p>Applications Labelled Chlorpromazine (C424750). Used as an antiemetic; antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990),<br></p>Formula:C172H6H13ClN2S·ClHColor and Shape:White To Light YellowMolecular weight:361.36Repirinast (>80%)
CAS:Controlled ProductFormula:C20H21NO5Purity:>80%Color and Shape:NeatMolecular weight:355.38Montelukast Cyclized Ether impurity
CAS:Controlled Product<p>Applications A cyclic ether impurity of antiasthmatic Montelukast (M568000).<br>References Egekeze, J.O. et al.: Anal. Chem., 67, 2292 (1995);<br></p>Formula:C29H26ClNOColor and Shape:NeatMolecular weight:439.98N-Nitroso-(1S,2R)-ephedrine
CAS:Controlled ProductFormula:C10H14N2O2Color and Shape:NeatMolecular weight:194.23N-Nitrosomorpholine-13C4
CAS:Controlled ProductFormula:C4H8N2O2Color and Shape:NeatMolecular weight:120.0910-Acetyloxy Oxcarbazepine
CAS:Controlled Product<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Formula:C17H14N2O4Color and Shape:NeatMolecular weight:310.30Indomethacin Ethyl Ester
CAS:Controlled ProductFormula:C21H20ClNO4Color and Shape:Off-WhiteMolecular weight:385.84α-(2,4-Difluorophenyl)-1H-1,2,4-triazole-1-ethanol
CAS:Controlled ProductFormula:C10H9F2N3OColor and Shape:NeatMolecular weight:225.19Desalkyl Ebastine-d5
CAS:Controlled Product<p>Applications A labelled metabolite of Ebastine.<br>References Wiseman, L., et al.: Drugs, 51, 260 (1996), Takanori, H., et al.: Drug Metab. Dispos., 26, 566 (1998), Moss, A., et al.: Clin. Exp. Allergy 1999, 29, 200 (1999), Simons, F., et al.: Clin. Pharmacokinet., 36, 329 (1999), Hashizume, T., et al.: J. Pharmacol. Exp. Theor., 300, 298 (2002),<br></p>Formula:C18H16D5NOColor and Shape:NeatMolecular weight:272.4Dacomitinib
CAS:Controlled Product<p>Applications Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.<br>References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);<br></p>Formula:C24H25ClFN5O2Color and Shape:NeatMolecular weight:469.944-(Methylamino)-3-nitrobenzoic Acid
CAS:Controlled Product<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>Formula:C8H8N2O4Color and Shape:NeatMolecular weight:196.16N-[4-(Aminocarbonyl)-3-fluorophenyl]-2-methylalanine Methyl Ester
CAS:Controlled ProductFormula:C12H15FN2O3Color and Shape:NeatMolecular weight:254.26Nifekalant Hydrochloride
CAS:<p>Applications Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.<br>References Takenaka, K. Jap. Circ. J., 65, 60 (2001); Igawa, M. et al.: J. Cardio. Pharmacol., 40, 735 (2002); Washizuka, T. et al.: Circ. J., 69, 1508 (2005);<br></p>Formula:C19H27N5O5·ClHColor and Shape:Light Yellow SolidMolecular weight:441.9091Haloperidol Decanoate N-Oxide
Controlled ProductFormula:C31H41ClFNO4Color and Shape:NeatMolecular weight:546.11Elvitegravir-d6 (Major)
CAS:Controlled Product<p>Applications A novel labelled inhibitor of human immunodeficiency virus type 1 integrase.<br>References Chou, T., et al.: Eur. J. Biochem., 115, 207 (1981), Baba, M., et al.: Antimicrob. Agents Chemother., 31, 1613 (1987), Craigie, R., et al.: J. Biol. Chem., 276, 23213 (2001), Chen, X., et al.: J. Mol. Biol., 380, 504 (2008),<br></p>Formula:C23H17D6ClFNO5Color and Shape:NeatMolecular weight:453.913-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin
CAS:Controlled Product<p>Applications 3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin is an impurity of Sitagliptin (S490990). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Formula:C26H23F9N6O2Color and Shape:NeatMolecular weight:622.48543-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] Balsalazide Sodium Salt (>90%)
CAS:Controlled Product<p>Applications An impurity of the anti-inflammatory drug Balsalazide (B116300).<br></p>Formula:C27H24N6O9xNaPurity:>90%Color and Shape:NeatMolecular weight:576.51(free acid)L-Valinol
CAS:Controlled Product<p>Applications L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.<br>References Chen, N., et al.: Phosphorus Sulfur, 190, 112 (2015); Zhao, Y., et al.: J. Med. Chem., 58, 1038 (2015)<br></p>Formula:C5H13NOColor and Shape:WhiteMolecular weight:103.1631H-1-Ethyl Candesartan
CAS:Controlled Product<p>Applications Candesartan (C175575) impurity.<br></p>Formula:C26H24N6O3Color and Shape:WhiteMolecular weight:468.51Ibudilast
CAS:Controlled Product<p>Applications A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral). PDE inhibitor (non-selective).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983), Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986), Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988),<br></p>Formula:C14H18N2OColor and Shape:NeatMolecular weight:230.314-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthalenol Hydrochloride (Duloxetine Impurity)
CAS:Controlled Product<p>Impurity D721000<br>Applications Duloxetine impurity; also a related compound of Duloxetine metabolite.<br></p>Formula:C18H19NOS·ClHColor and Shape:NeatMolecular weight:333.88Desmethyl Cariprazine
CAS:<p>Applications Desmethyl Cariprazine, is a derivative of Cariprazine (C183490) which is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.<br>References Gruender, G.: Curr. Opin. Invest. Drugs, 11, 823 (2010); Seneca, N. et al.: Psychopharmacology, 218, 579 (2011); Kiss, B. et al.: J. Pharmacol. Exp. Therap., 333, 328 (2010)<br></p>Formula:C20H30Cl2N4OColor and Shape:NeatMolecular weight:413.381-(2,4-Bis(benzyloxy)phenyl)ethanone
CAS:Controlled Product<p>Applications 1-(2,4-Bis(benzyloxy)phenyl)ethanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Chen, D., et al.: Eur. J. Med. Chem., 87, 765 (2014); Malik, N., et al.: Tetrahedron Lett., 54, 4121 (2013)<br></p>Formula:C22H20O3Color and Shape:NeatMolecular weight:332.394-(Diphenylmethyl)-1-nitrosopiperidine
CAS:Controlled ProductFormula:C18H20N2OColor and Shape:NeatMolecular weight:280.37Anagrelide-13C3
CAS:Controlled ProductFormula:C713C3H7Cl2N3OColor and Shape:NeatMolecular weight:259.072-Methylthieno[2,3-d]isothiazol-3(2H)-one 1,1-Dioxide
CAS:Controlled ProductFormula:C6H5NO3S2Color and Shape:NeatMolecular weight:203.24Nitroso Norquetiapine-d8
Controlled ProductFormula:C17D8H8N4OSColor and Shape:NeatMolecular weight:348.4495-Amino-4-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid
CAS:Controlled ProductFormula:C13H13N3O6Color and Shape:Off-WhiteMolecular weight:307.259N-Desmethyl-4'-hydroxy Tamoxifen-d3 (E/Z Mixture)
CAS:Controlled Product<p>Applications A labelled metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Heiman, D., et al.: J. Med. Chem., 23, 994 (1980), Kier, L., et al.: Pharm. Res., 7, 801 (1990),<br></p>Formula:C25H24D3NO2Color and Shape:NeatMolecular weight:376.515-(4-methylphenyl)imidazolidine-2,4-dione
CAS:Controlled Product<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>Formula:C10H10N2O2Color and Shape:NeatMolecular weight:190.203-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS:Controlled Product<p>Applications 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.<br>References Romanelli, M. et al.: Bioorg. med. CHem., 13, 1211 (2005);<br></p>Formula:C15H18ClNO3Color and Shape:NeatMolecular weight:295.76(4-Methyl-1H-imidazol-5-yl)methanol Hydrochloride
CAS:Controlled Product<p>Applications (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride (cas# 38585-62-5) is a useful research chemical.<br></p>Formula:C5H8N2O·ClHColor and Shape:NeatMolecular weight:148.59α,α'-Diethyl-4,4'-stilbenediol-d4
CAS:Controlled Product<p>Applications α,α'-Diethyl-4,4'-stilbenediol-d4 is an intermediate in the synthesis of d in the synthesis of isotope labelled metabolites of Diethylstibestrol (D445026).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schuller, P.L., et al.: J. Chromatograph., 31, 237 (1967);<br></p>Formula:C18H16D4O2Color and Shape:NeatMolecular weight:272.37Ticagrelor Acetate
CAS:Controlled Product<p>Applications Ticagrelor Acetoxide is an acetoxy impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Formula:C25H30F2N6O5SColor and Shape:White To Off-WhiteMolecular weight:564.6(S)-(-)-O-Desmethyl Carvedilol
CAS:Controlled Product<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity. [α]D= -18.7 (c= 0.1 methanol)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Formula:C23H24N2O4Color and Shape:NeatMolecular weight:392.451,3-Dichloroacetone
CAS:Controlled Product<p>Applications 1,3-Dichloroacetone (cas# 534-07-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C3H4Cl2OColor and Shape:NeatMolecular weight:126.97(D,L)-erythro-α-Phenyl-2-piperidineacetamide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Intermediate in the preparation of D-threo-Methylphenidate (Ritalin)<br></p>Formula:C13H18N2OColor and Shape:NeatMolecular weight:218.29Efavirenz 1-Desamine-1-oxy
Controlled Product<p>Applications Efavirenz 1-Desamine-1-oxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C14H8ClF3O3Color and Shape:NeatMolecular weight:316.66(R)-(+)-Tolvaptan
CAS:Controlled Product<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formula:C26H25ClN2O3Color and Shape:Off White SolidMolecular weight:448.94Tilidine-d6 Hydrochloride (100μg/ml in Methanol)
CAS:Controlled ProductFormula:C172H6H17NO2·ClHColor and Shape:ColourlessMolecular weight:315.87Hydrolyzed Pomalidomide M10
CAS:Controlled Product<p>Applications Hydrolyzed Pomalidomide M10 is an impurity of pomalidomide (P688200), which is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.<br>References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)<br></p>Formula:C13H13N3O5Color and Shape:NeatMolecular weight:291.26Ofloxacin Isopropyl Ester
CAS:Controlled ProductFormula:C21H26FN3O4Color and Shape:NeatMolecular weight:403.45Ezetimibe-13C6
CAS:Controlled Product<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C1813C6H21F2NO3Color and Shape:NeatMolecular weight:415.382-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid
CAS:Controlled Product<p>Impurity Ambrisentan Impurity E<br>Applications 2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid is an acrylic acid derivative that can be used as an endothelin receptor antagonist useful for treating hypertension or pulmonary artery hypertension. Ambrisentan Impurity E<br>References Zhang, D., et al.: Faming Zhuanli Shenqing. CN 102093286 A 20110615. Jun 15, 2011<br></p>Formula:C21H18N2O3Color and Shape:White To Off-WhiteMolecular weight:346.382-Bromomethyl-6-nitrobenzoic Acid Methyl Ester
CAS:Controlled ProductFormula:C9H8BrNO4Color and Shape:Light YellowMolecular weight:274.07rac Toltrazuril Sulfoxide
CAS:<p>Applications Toltrazuril metabolite.<br>References Benoit, E., et al.: Biochem. Pharmacol., 46, 2337 (1993), Martinez-Villalba, A., et al.: Anal. Bioanal. Chem., 397, 2893 (2010),<br></p>Formula:C18H14F3N3O5SColor and Shape:Off-WhiteMolecular weight:441.384-Butyrylamino-3-methyl-5-nitrobenzoic Acid Methyl Ester
CAS:Controlled Product<p>Applications 4-Butyrylamino-3-methyl-5-nitrobenzoic Acid Methyl Ester is a useful synthetic intermediate in the production of Telmisartan, an antihypertensive drug. 4-Butyrylamino-3-methyl-5-nitrobenzoic Acid Methyl Ester is part of a more efficient process of synthesizing Telmisartan in terms of impurity, yield, cost, and large-scale production.<br>References Reddy, K., et al.: Org. Process Res. Dev., 11, 81 (2007)<br></p>Formula:C13H16N2O5Color and Shape:NeatMolecular weight:280.281-Dehydroxy Terfenadine
CAS:Controlled ProductFormula:C32H41NOColor and Shape:NeatMolecular weight:455.674-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-formylpiperidine
CAS:Controlled Product<p>Impurity Buspirone EP Impurity B<br>Applications An impurity of the gastrokinetic and antinauseant drug Domperidone (D531100).<br></p>Formula:C13H14ClN3O2Color and Shape:BeigeMolecular weight:279.72N-Nitrososotalol-d6
CAS:Controlled ProductFormula:C12D6H13N3O4SColor and Shape:Off-WhiteMolecular weight:307.399Bicalutamide Sulfoxide
CAS:Controlled Product<p>Impurity Bicalutamide USP Related Compound A<br>Applications Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Formula:C18H14F4N2O3SColor and Shape:NeatMolecular weight:414.376-Oxo-(S,S)-Palonosetron (~90%)
CAS:Controlled Product<p>Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>Formula:C19H22N2O2Purity:~90%Color and Shape:NeatMolecular weight:310.394'-Desmethoxy Omeprazole
CAS:Controlled Product<p>Applications 4'-Desmethoxy Omeprazole is one of two impurities in the synthesis of Esomeprazole, an anti-ulcerative drug for treatment of acid-related diseases.<br>References Liu, X., et al.: Lat. Am. J. Pharm., 34, 1265-1268 (2015);<br></p>Formula:C16H17N3O2SColor and Shape:NeatMolecular weight:315.39[3-(9H-Carbazol-4-yloxy)-2-hydroxy]propyl Carvedilol
CAS:Controlled ProductFormula:C39H39N3O6Color and Shape:NeatMolecular weight:645.74Leflunomide EP Impurity F
CAS:Controlled ProductFormula:C12H9F3N2O2Color and Shape:WhiteMolecular weight:270.21Telmisartan tert-Butyl Ester
CAS:Controlled Product<p>Impurity Telmisartan EP Impurity C<br>Applications Telmisartan tert-Butyl Ester (Telmisartan EP Impurity C) is an impurity of Telmisartan (T017000). Telmisartan impurity C.<br>References Ruth, R., et al.: J. Med. Chem., 39, 625 (1996), Merlos, M., et al.: J. Drugs Future, 22, 1112 (1997), Battershill, A., et al.: J. Drugs, 66, 51 (2006),<br></p>Formula:C37H38N4O2Color and Shape:White To Off-WhiteMolecular weight:570.72XL518
CAS:Controlled Product<p>Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.<br>References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);<br></p>Formula:C21H21F3IN3O2Color and Shape:White To Off-WhiteMolecular weight:531.31Dipyridamole Tripiperidine
CAS:Controlled Product<p>Impurity Dipyridamole EP Impurity A<br>Applications Dipyridamole Tripiperidine (Dipyridamole EP Impurity A) is a Dipyridamole (D492625) impurity.<br>References Bakken, G.A., et al.: J. Med. Chem., 43, 4534 (2000),<br></p>Formula:C25H40N8O2Color and Shape:NeatMolecular weight:484.646-Amino-1-methyl-5-nitrosouracil
CAS:Controlled Product<p>Stability Light and temperature sensitive<br>Applications 6-Amino-1-methyl-5-nitrosouracil is known to exhibit anitmicrobial activity and form complexation with platinum (II).<br>References Gaballa, A.S., et al.: Molec. Biomolec. Spectro. 75A, 146 (2010);<br></p>Formula:C5H6N4O3Color and Shape:NeatMolecular weight:170.13Dehydroxydehydro Terfenadine
CAS:Controlled ProductFormula:C32H39NOColor and Shape:NeatMolecular weight:453.66(S)-4-Phenyl-2-oxazolidinone
CAS:Controlled Product<p>Applications S)-4-Phenyl-2-oxazolidinone is an intermediate for the synthesis and development for cholesterol absorption inhibitor AZD4121.<br>References Soloshonok, V.A., et al.: Tetrahedron. Lett., 46, 1107 (2005); Luo, Y., et al.: Chinese. Chem. Lett., 17, 1551 (2006); Karlsson, S., et al.: Org. Process.Res. Develop., 16, 586 (2012);<br></p>Formula:C9H9NO2Color and Shape:NeatMolecular weight:163.1733Iguratimod
CAS:Controlled Product<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>Formula:C17H14N2O6SColor and Shape:NeatMolecular weight:374.37rac Timolol Maleate
CAS:Controlled Product<p>Applications Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.<br>References Wasson, et al.: J. Med. Chem., 15, 651 (1972), Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972), Heel, R.C., et al.: Drugs, 17, 38 (1979), Rofman, B.A., et al.: Hypertension, 2, 643 (1980), Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987),<br></p>Formula:C13H24N4O3S·C4H4O4Color and Shape:NeatMolecular weight:432.49Dehydroxy Terfenadine
CAS:Controlled ProductFormula:C32H41NOColor and Shape:NeatMolecular weight:455.67D-threo-Ritalinic Acid-d9 (Major)
CAS:Controlled Product<p>Applications A metabolite of Methylphenidate.<br>References Teo, S., et al.: J. Clin. Pharmacol., 44, 173 (2004), Balcioglu, A., et al.: Neuropharmacol., 57, 687 (2009),<br></p>Formula:C13H8D9NO2Color and Shape:White To Off-WhiteMolecular weight:229.342-Acetylbutyrolactone
CAS:Controlled Product<p>Applications An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.<br>References Toche, R.B. et al.: H. Heterocyclic Chem., 45, 1711 (2008); Sabry, S.M., J. Pharm. Biomed. Anal., 40, 1057 (2006);<br></p>Formula:C6H8O3Color and Shape:NeatMolecular weight:128.131,3-Bis(bromomethyl)-5-methylbenzene
CAS:Controlled Product<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,3-Bis(bromomethyl)-5-methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>Formula:C9H10Br2Color and Shape:NeatMolecular weight:277.98rac 4-(3-Aminobutyl)phenol
CAS:Controlled Product<p>Applications A metabolite of the antihypertensive agent, Labetalol (L096500).<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>Formula:C10H15NOColor and Shape:NeatMolecular weight:165.23Benperidol
CAS:<p>Applications Benperidol is an antipsychotic which can be used for the treatment of schizophrenia, but is primarily used to control antisocial hypersexual behaviour.<br>References Bobon, J., et al.: Acta Neurol Belg, 63, 839-43 (1963);<br></p>Formula:C22H24FN3O2Color and Shape:White To Off-WhiteMolecular weight:381.44rac-Bromo-Descyanobicalutamide
Controlled Product<p>Applications Descyano-Bromo-Bicalutamide is related to Bicalutamide(B382000). A non-steroidal androgen receptor antagonist that binds the androgen receptor and prevents its activation<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990)<br></p>Formula:C17H14BrF4NO4SColor and Shape:NeatMolecular weight:484.26Quetiapine Carboxylate Impurity
CAS:Controlled Product<p>Applications Quetiapine Carboxylate is an impurity of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Wetzel, H., et al.: Psychopharmacol., 119, 231 (1995); Bharathi, C., et al.: Pharmazie., 63, 14 (2008);<br></p>Formula:C22H25N3O4SColor and Shape:Light Orange ColourMolecular weight:427.52Isopropyl 4-Hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity I)
CAS:Controlled Product<p>Impurity Piroxicam EP Impurity I<br>Applications Piroxicam impurity I.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Formula:C12H13NO5SColor and Shape:NeatMolecular weight:283.3rac N-Methyl Epinephrine-d6 Hydrochloride (>90%)
CAS:Controlled Product<p>Applications Labelled N-Methylepinephrine, the N-methylated analogue of the sympathomimetic hormone Epinephrine (E588585). Recent studies suggest that N-Methylepinephrine may be synthesized from Epinephrine by phenylethanolamine N-methyltransferase present in the brain.<br>References Kajita, M. et al.: Nip. Iyo Masu Sup. Gak. Kon., 19, 107 (1994); Plummer, C.J. et al.: Eur. J. Med. Chem., 148, 481 (1988);<br></p>Formula:C10H9D6NO3•HClPurity:>90%Color and Shape:Off-White To Light GreenMolecular weight:203.273646N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide
CAS:Controlled Product<p>Applications N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide is derived from Diethyl 2-Acetamidomalonate (D443130), which is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin (N888500) analogues as potential heat shock protein 90 inhibitors.<br>References Gunaherath, G. M., et al.: Bioorg. Med. Chem., 21, 5118 (2013);<br></p>Formula:C25H39NO5Color and Shape:NeatMolecular weight:433.58(R)-Propranolol-d7 Hydrochloride
CAS:Controlled Product<p>Applications The labelled R-enantiomer of Propranolol (P831800). β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>Formula:C16H15D7ClNO2Color and Shape:NeatMolecular weight:302.85N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
CAS:Controlled Product<p>Applications N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine is an impurity of Cimetidine (C441650)<br>References Ellis, D. R., et al.: J. Chromatogr. A, 808, 269-275 (1998)<br></p>Formula:C16H24N8S2Color and Shape:NeatMolecular weight:392.54Leflunomide 3-Isomer
CAS:Controlled Product<p>Impurity Leflunomide EP Impurity C/ Leflunomide BP Impurity C<br>Applications Leflunomide 3-Isomer (Leflunomide EP Impurity C) is a Leflunomide analogue, with potential antiinflammatory and anti-viral activity. Leflunomide (L322750) Impurity E.<br>References Bertolini, G., et al.: J. Med. Chem., 40, 2011 (1997), Huang, W., et al.: Chem. Pharm. Bull., 51, 313 (2003),<br></p>Formula:C12H9F3N2O2Color and Shape:White To Off-WhiteMolecular weight:270.21Ticagrelor TCG Sulfonate
<p>Applications Ticagrelor TCG Sulfonate is an impurity of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O7S2Color and Shape:NeatMolecular weight:602.63Ticagrelor Sulfone
CAS:Controlled Product<p>Applications Ticagrelor Sulfone is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O6SColor and Shape:NeatMolecular weight:554.57N1-Methyl-N2-2-pyridinylethanediamide
CAS:Controlled ProductFormula:C8H9N3O2Color and Shape:NeatMolecular weight:179.18Varenicline Carbamoyl β-D-Glucuronide
CAS:Controlled Product<p>Applications A metabolite of Varenicline.<br>References Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005), Obach, R., et al.: Drug Metab. Dispos., 33, 262 (2005),<br></p>Formula:C20H21N3O8Color and Shape:NeatMolecular weight:431.45-(2-Fluorophenyl)-5-oxovaleric Acid
CAS:Controlled Product<p>Applications 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.<br>References Yamamoto, I., et al.: Preparation of indole derivatives as cell protective agents, WO Patent 9745410, Dec 4, 1997; Yanagisawa, A., et al.: Org. Lett., 14, 2434 (2012);<br></p>Formula:C11H11FO3Color and Shape:NeatMolecular weight:210.24-Desisopropyl-4-ethyl Nateglinide
CAS:Controlled Product<p>Applications D-phenylanaline derivative and an analog Nateglinide (N379375) with similar hypoglycemic activity.<br>References Shinkai, H. et al.: J. Med. Chem., 32, 1436 (1989);<br></p>Formula:C18H25NO3Color and Shape:NeatMolecular weight:303.403-[2-[4-(4-Fluoro-2-hydroxybenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:Controlled Product<p>Applications 3-[2-[4-(4-Fluoro-2-hydroxybenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one is an intermediate used in the synthesis of Bicyclo Risperidone (B382800), which is an impurity of Risperidone (R525000); a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Formula:C23H28FN3O3Color and Shape:NeatMolecular weight:413.49(R)-5-Chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol
CAS:Controlled ProductFormula:C13H11ClF3NOColor and Shape:NeatMolecular weight:289.68N’-Benzylidene-2-ethoxybenzimidohydrazide Hydroiodide
Controlled ProductFormula:C16H17N3O·HIColor and Shape:Off-WhiteMolecular weight:395.238N-[1-(4-Chlorophenyl)cyclobutylmethyl]-N,N-dimethylamine Hydrochloride
CAS:Controlled Product<p>Applications N-[1-(4-Chlorophenyl)cyclobutylmethyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>Formula:C13H19Cl2NColor and Shape:NeatMolecular weight:260.2Levofloxacin Hydroxy Acid
CAS:Controlled Product<p>Applications Levofloxacin Hydroxy Acid is found in the synthesis of Levofloxacin (L360000), S-(-)-form of Ofloxacin. An antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formula:C18H21F2N3O4Color and Shape:Light YellowMolecular weight:381.3738Hydroxy Vildagliptin
<p>Applications Hydroxy Vildagliptin is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>Formula:C17H25N3O3Color and Shape:NeatMolecular weight:319.40Losartan Carboxylic Acid Acyl-β-D-Glucuronide, 90%
CAS:Controlled Product<p>Applications A metabolite of Losartan (L470500).<br></p>Formula:C28H29ClN6O8Purity:90%Color and Shape:NeatMolecular weight:613.02Dasatinib-d8 N-Oxide
CAS:Controlled Product<p>Applications The labelled oxidative metabolite of Dasatinib (M5 metabolite). It is a COVID19-related research product.<br>References Cashman, J.R., et al.: Chem. Res. Toxicol., 8, 165 (1995), Aasmoe, L., et al.: Toxicol. Appl. Pharmacol., 150, 86 (1998), Galetin, A., et al.: J. Pharmacol. Exp. Ther., 314, 180 (2005), Christopher, L.J., et al.: Drug Metab. Dispos., 36, 1357 (2008),<br></p>Formula:C22H18D8ClN7O3SColor and Shape:NeatMolecular weight:512.05Zosuquidar Trihydrochloride
CAS:Controlled Product<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>Formula:C32H31F2N3O2·3ClHColor and Shape:NeatMolecular weight:636.992,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate
CAS:Controlled Product<p>Applications 2,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate is an antibiotic.<br>References Marrero-Ponce, Yovani, et al.: Bioorg. & Med. Chem., 13(8), 2881-2899 (2005)<br></p>Formula:C14H14N2O6Color and Shape:NeatMolecular weight:306.27Indomethacin Acyl-β-D-glucuronide (>90%)
CAS:Controlled Product<p>Applications Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Formula:C25H24ClNO10Color and Shape:NeatMolecular weight:533.91ZK 159222
CAS:Controlled Product<p>Stability Light Sensitive, Temperature Sensitive<br>Applications ZK 159222 is a vitamin D receptor antagonist. It is a derivative of Vitamin D3 (V676045).<br>References Mizwicki, M., et al.: J. Bio. Chem., 284, 36292 (2009); Ochiai, E., et al.: Mol. Endocrinol., 19, 1147 (2005)<br></p>Formula:C32H48O5Color and Shape:NeatMolecular weight:512.72rac-trans-7-Hydroxy Pramipexole
CAS:Controlled Product<p>Impurity Pramipexole Related Compound F<br>Applications Pramipexole derivative used for the preparation of (S)-Pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives.<br>References Validation of a column liquid chromatographic method for the analysis of pramipexole and its 5 impurities. Journal of AOAC International (2010), 93(4), 1102-1112. Gegoe, Csaba Lehel; Fejes, Imre; Garaczi, Sandor; Kovacs, Imre; Lukacs, Ferenc; Majercsik, Orsolya; Schneider, Geza. Process for preparation of (S)-pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives. Eur. Pat. Appl. (2008), 26pp. CODEN: EPXXDW EP 1878731<br></p>Formula:C10H17N3OSColor and Shape:NeatMolecular weight:227.331-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
CAS:<p>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)<br></p>Formula:C14H10N3NaO3Color and Shape:NeatMolecular weight:291.24De(methypiperazinyl) Sildenafil Dimer Impurity
CAS:Controlled Product<p>Applications A related dimeric impurity of Sildenafil (S435000).<br></p>Formula:C34H38N8O6SColor and Shape:NeatMolecular weight:686.783-[(Methylamino)sulfonyl]-2-thiophenecarboxylic Acid
CAS:Controlled ProductFormula:C6H7NO4S2Color and Shape:Off-WhiteMolecular weight:221.25Zileuton-d4 (major)
CAS:Controlled Product<p>Applications An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.<br>References Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991), Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1992), McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)<br></p>Formula:C112H4H8N2O2SColor and Shape:NeatMolecular weight:240.31N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylnitrous amide
CAS:Controlled ProductFormula:C12H14N4O2Color and Shape:NeatMolecular weight:246.27Benzoin
CAS:Controlled Product<p>Applications Benzoin has been used as a catalyst in photoinitiation.<br>References Voll, D., et. al.: Macromolecules, 44, 2542 (2011)<br></p>Formula:C14H12O2Color and Shape:Off-WhiteMolecular weight:212.24(S)-5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-a-(trifluoromethyl)benzenemethanol
CAS:Controlled Product<p>Applications (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is the S enantiomer of rac-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol (C365145). (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is also an impurity of Efavirenz (E425000), an HIV-1 reverse transcriptase inhibitor.<br>References Pierce, M., et al.: J. Org. Chem., 63, 8536 (1998)<br></p>Formula:C21H19ClF3NO2Color and Shape:NeatMolecular weight:409.83(2,5-Difluorophenyl)(piperidin-4-yl)methanone Hydrochloride
CAS:Controlled ProductFormula:C12H13F2NO·HClColor and Shape:NeatMolecular weight:261.702-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
CAS:Controlled Product<p>Impurity Omeprazole EP Impurity XI<br>Applications 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride (Omeprazole EP Impurity XI) is an intermediate in the production of the antiulcer agent Omeprazole.<br>References Roma, G., et al.: J. Med. Chem., 50, 2886 (2007), Hoffmann, S., et al.: Toxicol. Lett., 180, 9 (2008),<br></p>Formula:C9H12ClNO·ClHColor and Shape:WhiteMolecular weight:222.11Granisetron
CAS:Controlled Product<p>Applications Granisetron is a selective 5HT-3 antagonist.<br></p>Formula:C18H24N4OColor and Shape:NeatMolecular weight:312.41Iproniazid
CAS:Controlled Product<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>Formula:C9H13N3OColor and Shape:White SolidMolecular weight:179.22Dipyridamole Mono-O-b-D-glucuronide
CAS:Controlled Product<p>Applications A metabolite of Dipyridamole.<br>References Zak, S.B., et al.: J. Pharmacol. Exp. Ther., 141, 392 (1963),<br></p>Formula:C30H48N8O10Color and Shape:NeatMolecular weight:680.75Vortioxetine Hydrobromide (1 mg/mL in Methanol)
CAS:Formula:C18H22N2S·BrHColor and Shape:Single SolutionMolecular weight:379.358Plerixafor-d4
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Formula:C28H50D4N8Color and Shape:Off White SolidMolecular weight:506.811-Hydroxy-3,4-dihydroquinolin-2(1H)-one
CAS:Controlled ProductFormula:C9H9NO2Color and Shape:NeatMolecular weight:163.17Homopiperazine
CAS:Controlled Product<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>Formula:C5H12N2Color and Shape:NeatMolecular weight:100.163-Bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
CAS:Formula:C16H11BrN2OColor and Shape:Light Brown To Dark BrownMolecular weight:327.18(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
CAS:Controlled Product<p>Applications Intermediate in the production of Ramelteon.<br>References Uchikawa, O., et al.: J. Med. Chem., 45, 4222 (2002),<br></p>Formula:C16H23NO3Color and Shape:NeatMolecular weight:277.363-O-Benzyl-4,5-O-(1-methylethyldiene)-β-D-fructopyranose
CAS:Controlled Product<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Formula:C16H22O6Color and Shape:NeatMolecular weight:310.34Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride
CAS:Controlled Product<p>Applications Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride is an impurity of Cobicistat (C633150), a HIV protease inhibitor that has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012)<br></p>Formula:C23H27N3O2S·HClColor and Shape:NeatMolecular weight:446.0Ethyl 3,4-Dihydroxybenzoate
CAS:Controlled ProductFormula:C9H10O4Color and Shape:NeatMolecular weight:182.17Dasatinib Carboxylic Acid
CAS:Controlled Product<p>Applications An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C22H24ClN7O3SColor and Shape:Light YellowMolecular weight:501.993-Amino-5-chloro Salicylic Acid Methyl Ester
CAS:<p>Applications Intermediate in the preparation of Azasetron.<br>References Kawakita, T., et al.: Chem. Pharm. Bull., 40, 624 (1992),<br></p>Formula:C8H8ClNO3Color and Shape:NeatMolecular weight:201.61Cilostazol-d4
CAS:Controlled Product<p>Applications Cilostazol-d4 is the labeled analogue of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998); Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999); Tsuchikane, E., et al.: Circulation, 100, 21 (1999)<br></p>Formula:C20H23D4N5O2Color and Shape:NeatMolecular weight:373.49Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)
CAS:Formula:C18H16ClFN4O2Color and Shape:NeatMolecular weight:374.8N-Nitroso-desethyl-Hydroxychloroquine
Controlled ProductFormula:C16H21ClN4O3Color and Shape:NeatMolecular weight:336.817N,N’-Desethylene Levofloxacin Hydrochloride
CAS:<p>Impurity Levofloxacin USP Related Compound E<br>Applications Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution. Levofloxacin USP Related Compound E.<br>References Yoshida, Y., et al.: Arzneim.-Forsch., 43, 601 (1993),<br></p>Formula:C16H18FN3O4·ClHColor and Shape:Off White SolidMolecular weight:371.795-(4'-Methyl-2-biphenyl)tetrazole-d4
CAS:Controlled Product<p>Applications Labelled Valsartan (V095750) impurity.<br>References Thai, H., et al.: J. Cardiovasc. Pharmacol., 50, 703 (2007), Lukas, J., et al.: Science, 313, 662 (2006),<br></p>Formula:C14H8D4N4Color and Shape:Off-WhiteMolecular weight:240.3013-Hydroxy-4-methoxybenzaldehyde
CAS:Controlled ProductFormula:C8H8O3Color and Shape:NeatMolecular weight:152.153,3'-Disulfanediylbis[(2S)-2-methylpropanoic] Acid
CAS:Controlled ProductFormula:C8H14O4S2Color and Shape:NeatMolecular weight:238.322S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane
CAS:Controlled ProductFormula:C23H27N3O3SColor and Shape:NeatMolecular weight:425.54Manidipine
CAS:Controlled Product<p>Applications A dihydropyridine calcium channel blocker. Antihypertensive.<br>References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992)<br></p>Formula:C35H38N4O6Color and Shape:Off White PowderMolecular weight:610.704-Desfluoro-2-Fluoro Droperidol
CAS:<p>Applications 4-Desfluoro-2-Fluoro Droperidol is an impurity of Droperidol (D679500), a D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.<br>References Yelnosky, J., et al.: Toxicol. Appl. Pharmacol., 6, 37 (1964), Janicki, C.A., et al.: Anal. Profiles Drug Subs., 7, 171 (1978), Hamik, et al.: Cancer Chemother. Pharmacol., 24, 307 (1989), Heyer, E.J., et al.: Brain Res., 863, 20 (2000),<br></p>Formula:C22H22FN3O2Color and Shape:NeatMolecular weight:379.4274Lisinopril (8R,S)-Diketopiperazine (Mixture of Diastereomers)Mps1-IN-1 dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Lisinopril (L468985) impurity.<br>References Drummer, O., et al.: Arzneim.-Forsch. Drug Res., 38, 647 (1988), Simpson, K., et al.: Drugs, 59, 1149 (2000),<br></p>Formula:C21H29N3O4Color and Shape:NeatMolecular weight:387.47N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide
CAS:Controlled Product<p>Applications N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide was used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.<br>References Edupuganti, R., et al.: Bioorg. Med. Chem., 25, 2609 (2017); Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formula:C29H31N5O2Color and Shape:NeatMolecular weight:481.593-Chloro-1,2-propanediol-d5 (10 ug/mL in methanol)
CAS:Controlled ProductFormula:C32H5H2ClO2Color and Shape:ColourlessMolecular weight:115.574-Isobutylamino-3-aminoquinoline
CAS:Controlled Product<p>Applications 4-Isobutylamino-3-aminoquinoline is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formula:C13H17N3Color and Shape:NeatMolecular weight:215.29N-[(2Z)-Piperazin-2-ylidene]-2,2,2-trifluoroacetohydrazide
CAS:Controlled Product<p>Applications Sitagliptin intermediate.<br>References Sarges, R, et al.: J. Med. Chem., 33, 2240 (1990),<br></p>Formula:C6H9F3N4OColor and Shape:NeatMolecular weight:210.16Thiorphan Disulfide
CAS:Controlled Product<p>Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski<br></p>Formula:C24H28N2O6S2Color and Shape:NeatMolecular weight:504.62N-Triphenylmethyl-5-[4'-methylbiphenyl-2-yl]tetrazole
CAS:Controlled Product<p>Applications An intermediate in the preparation of Candesartan. Also used in the synthesis of novel biphenyltetrazole derivatives.<br>References Chao, S. et al.: J. Chin. Chem. Soc., 52, 539 (235);<br></p>Formula:C33H26N4Color and Shape:NeatMolecular weight:478.593-Chlorobenzyl Cyanide
CAS:Controlled Product<p>Applications 3-Chlorobenzyl Cyanide is a useful synthetic intermediate. It was used to design EGFR Tyrosine Kinase Inhibitors. It can also be used to synthesize imidoyl thioureas as non-nucleoside reverse transcriptase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999); Ludovici, D., et al.: Bioorg. Med. Chem. Lett., 11, 2225 (2001)<br></p>Formula:C8H6ClNColor and Shape:NeatMolecular weight:151.59Leflunomide EP Impurity G
CAS:Controlled ProductFormula:C12H12N2O2Color and Shape:NeatMolecular weight:216.245-Sulfosalicylic Acid Dihydrate
CAS:Controlled Product<p>Applications 5-Sulfosalicylic Acid Dihydrate is for reducing and fixation of proteins in agarose and polyacrylamide gels.<br></p>Formula:C7H6O6S·2H2OColor and Shape:WhiteMolecular weight:254.212-Amino-5-methyl-3-thiophenecarbonitrile
CAS:Controlled Product<p>Applications An impurity generated in the preparation of Olanzapine (O253750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rao, R. et al.: J. Sep. Sci., 31, 107 (2008); Cui, D. et al.: Analyst, 136, 3149 (2011);<br></p>Formula:C6H6N2SColor and Shape:NeatMolecular weight:138.19Efavirenz 3-Desoxy
CAS:<p>Applications Efavirenz 3-Desoxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C15H11ClF3NOColor and Shape:Off White SolidMolecular weight:313.70Ambrisentan-d10
CAS:Controlled Product<p>Applications Ambrisentan-d10, is the labeled analogue of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Formula:C22H12D10N2O4Color and Shape:NeatMolecular weight:388.48R-Mirtazapine
CAS:Controlled Product<p>Applications R-Mirtazapine is an enantiomer of Mirtazapine (M365000); an antidepressant. R-Mirtazapine showed antinociceptive effects in acute thermal nociception, whereas S-Mirtazapine showed pronociceptive effects.<br>References Muth-Selbach, Uta., et al.: Brain Res. Bull., 79(1), 63-68 (2009); Smith, Donald F., et al.: Psychopharmacology, 200(2), 273-279 (2008); Freynhagen, Rainer., et al.: Brain Res. Bull., 69(2), 168-173 (2006)<br></p>Formula:C17H19N3Color and Shape:NeatMolecular weight:265.353-Isoniazid
CAS:Controlled Product<p>Applications An impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.<br>References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Andrade, C., et al.: Lett. Drug. Des. Discov., 5, 377 (2008)<br></p>Formula:C6H7N3OColor and Shape:Off White PowderMolecular weight:137.14N-Ethyl-3-buteno-o-toluidide
CAS:Controlled ProductFormula:C13H17NOColor and Shape:NeatMolecular weight:203.284-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid
CAS:Controlled ProductFormula:C13H15N3O4Color and Shape:Off WhiteMolecular weight:277.28Indigo Carmine 5,7'-Isomer (~90%)
CAS:<p>Applications Indigo Carmine 5,7’-Isomer is an analog of 5,5’-Indigodisulfonic Acid Disodium Salt (I521300) and synthesized from Indigo (I512250). Indigo is a chemical compound used as a dye in industrial clothing and textile processes. Also used in the synthesis of organic semiconductors.<br>References He, B. et al.: J. Am. Chem. Soc., 136, 15093 (2014); Pitayatanakul, O. et al.: J. mat. Chem. C., Mat. Op. Elec. Dev., 9311 (2014);<br></p>Formula:C16H8N2Na2O8S2Purity:~90%Color and Shape:Dark Blue SolidMolecular weight:466.35N-De[2-(methylsulfonyl)ethyl] Lapatinib
CAS:Controlled Product<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>Formula:C26H20ClFN4O2Color and Shape:NeatMolecular weight:474.91Olanzapine Dimer Impurity
Controlled Product<p>Applications An impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Formula:C29H28N6S2Color and Shape:NeatMolecular weight:524.703Nintedanib Acetyl Impurity
CAS:Controlled Product<p>Applications An impurity of Nintedanib, which is an antifibrotic drug.<br>References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)<br></p>Formula:C26H23N3O4Color and Shape:NeatMolecular weight:441.49(2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride
CAS:<p>Impurity Amorolfine EP Impurity C<br>Stability Hygroscopic<br>Applications (2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride (1:1), is used in the preparation of Amorolfine (A634170), a morpholine antifungal drug.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Formula:C16H26ClNOColor and Shape:NeatMolecular weight:283.84Diphenhydramine-d6 N-Oxide
CAS:Controlled Product<p>Applications A labelled metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Formula:C17H15D6NO2Color and Shape:NeatMolecular weight:277.39Loratadine Impurity F
CAS:Controlled Product<p>Impurity Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity<br>Applications Loratadine Impurity F (Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity) is a fluorinated analog of Loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H24ClFN2O2Color and Shape:White To Off-WhiteMolecular weight:402.894-O-Des(difluoromethyl) Roflumilast
CAS:Controlled ProductFormula:C16H14Cl2N2O3Color and Shape:NeatMolecular weight:353.20Decarboxyl Norfloxacin
CAS:Controlled ProductFormula:C15H18FN3OColor and Shape:NeatMolecular weight:275.32Defluoro-MDV 3100 (Defluoro-enzalutamide)
CAS:Controlled Product<p>Applications Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);<br></p>Formula:C21H17F3N4O2SColor and Shape:Light YellowMolecular weight:446.45Zuclopenthixol (1 mg/mL In Methanol)
CAS:Formula:C22H25ClN2OSColor and Shape:Single SolutionMolecular weight:400.96
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