APIs for research and impurities

<p>(2S,2R,Cis)-saxagliptin is a drug product that has been developed for the treatment of type II diabetes. It is an orally active DPP-4 inhibitor that inhibits the degradation of GLP-1 and GIP and lowers blood glucose levels in patients with type II diabetes mellitus. It binds to the serine/threonine protein phosphatase catalytic site of DPP-4. (2S,2R,Cis)-saxagliptin can be used as a standard for HPLC analysis and as a research and development compound in the study of its metabolism. This drug product is not on the World Health Organization's list of essential medicines. (2S,2R,Cis)-saxagliptin is also not on the United States Pharmacopeia’s list of approved drugs.</p>

<p>Please enquire for more information about Glimepiride EP Impurity G including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Rac N-Methyl epinephrine hydrochloride salt is a potential anti-cancer agent that has been used in Chinese medicine for its apoptotic effects on cancer cells. It works by inhibiting the chitin kinase pathway, which is involved in tumor growth and survival. Rac N-Methyl epinephrine hydrochloride salt also acts as a potassium channel inhibitor, leading to cell death in cancer cells. This drug has shown synergistic effects when combined with other cancer treatments such as enoxaparin or heparin. Additionally, it has been found to be an effective inhibitor of psyllium-induced colon carcinogenesis in human subjects. Overall, Rac N-Methyl epinephrine hydrochloride salt shows great promise as a potential anti-cancer analog for use in cancer treatment.</p>

<p>4-Carboxy nevirapine is a synthetic drug product that is used as an analytical reference standard for the impurity 4-carboxynevirapine. It has been shown to have niche applications in pharmacopoeia and natural product research and development. The metabolite 4-carboxynevirapine can be synthesized from nevirapine which is found in the plant Cinchona officinalis. This metabolite has been extensively studied for its role in the metabolism of nevirapine and its possible therapeutic applications, such as its ability to inhibit HIV replication.</p>

<p>Rac-trans-4-defluoro-4-ethoxy paroxetine hydrochloride is a drug product and an analytical standard. It can be used in the study of metabolism and natural products. Rac-trans-4-defluoro-4-ethoxy paroxetine hydrochloride is also an impurity standard in the synthesis of 4-(trans, trans)-4-(2,6 difluorobenzoyl)paroxetine hydrochloride. Rac-trans-4-defluoro-4-ethoxy paroxetine hydrochloride is a racemic mixture with a purity of 99%.</p>

<p>1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]-cyclohexanol hydrochloride is a drug product that is not yet approved for use in humans. It is an impurity found in the drug cyclosporine, which is used to treat psoriasis and other skin conditions. 1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]-cyclohexanol hydrochloride has been shown to be inactive in the metabolism studies of rats and dogs. This impurity was detected by HPLC with UV detection at 254 nm, but it did not show any significant absorption at 280 nm. The purity of this compound was determined to be 97% by NMR analysis and HPLC.</p>

<p>HMR 1826 is an analog of a medicinal compound that has been shown to have potent anticancer activity. It is a protein kinase inhibitor that induces apoptosis in cancer cells, particularly those of Chinese origin. HMR 1826 has been shown to be effective against a variety of tumors, and it works by inhibiting kinases involved in cell growth and division. In addition, HMR 1826 has been found to be present in human urine, which suggests that it may have potential as a diagnostic tool for cancer. The development of HMR 1826 and other kinase inhibitors represents an exciting new approach to the treatment of cancer, and ongoing research continues to investigate their potential therapeutic applications.</p>

<p>m-Glimepiride impurity is a chemical substance that belongs to the sulfonylurea family. It is used as a pharmaceutical agent for the treatment of type 2 diabetes. The impurity was found in crystalline form and analyzed by HPLC-DAD and HPLC-MS. The purity of m-Glimepiride impurity was determined to be 99%. It is not known whether this impurity has any biological activity.</p>

<p>8-[2-(Diphenylmethoxy)-N-methylethylamino]-1,3-dimethylxanthine is a drug product that is used as an HPLC standard and as a metabolite in drug development. It is a natural product that has been found to be a potent inhibitor of phosphodiesterase (PDE) type IV. 8-[2-(Diphenylmethoxy)-N-methylethylamino]-1,3-dimethylxanthine can be synthesized from the corresponding phenol derivative through oxidation with potassium permanganate followed by treatment with dimethyl sulfate and sodium methoxide. This compound is also used in analytical methods for the detection of impurities in APIs and for the investigation of metabolic pathways.</p>

<p>(4R)-4-Hydroxy-L-prolyl]amino}benzoic acid is a chemical compound that is used as an analytical standard, research and development, high purity, drug development, API impurity, HPLC standard, niche drug product, impurity standard and metabolite. It has the molecular formula C9H8O5 and the molecular weight of 212.13 g/mol. The CAS number for (4R)-4-Hydroxy-L-prolyl]amino}benzoic acid is 770703-11-2.</p>

<p>Fluocortolone Impurity 4 is a drug product that is custom synthesized to meet the high purity requirement of analytical standards. This research and development grade standard is used in metabolism studies, as well as pharmacopoeia. Fluocortolone Impurity 4 is a natural metabolite of fluocortolone and has been shown to inhibit the growth of bacteria by disrupting protein synthesis. It can be found in the urine, feces, and plasma of humans. Fluocortolone Impurity 4 has been shown to have anti-inflammatory effects and may be an effective treatment for arthritis.</p>

<p>25-Hydroxy previtamin D3 is a metabolite of vitamin D3. It is a natural compound that is synthesized in the skin by exposure to sunlight. 25-Hydroxylase activity converts vitamin D3 to 25-hydroxyvitamin D3, which then undergoes hydroxylation at position 1 by cytochrome P450 enzymes in the liver and kidney. 25-Hydroxy previtamin D3 can be used as an impurity standard for HPLC analysis of vitamin D compounds.</p>

<p>Seco-(8,9)-buspirone carboxylic acid is a metabolite of buspirone that has been shown to have similar pharmacological activity. Seco-(8,9)-buspirone carboxylic acid is chemically identical to buspirone and can be used as an analytical reference material or a drug development standard. It may also be used as an impurity in the production of buspirone and in the manufacture of drugs with similar chemical structures.</p>

<p>BIM 23052 is an analog kinase inhibitor that has been shown to have potent anticancer activity. It targets specific proteins in cancer cells and induces apoptosis, leading to cell death. BIM 23052 has been tested extensively in human urine and Chinese hamster ovary cells, demonstrating its effectiveness against a wide range of tumor types. This medicinal compound inhibits several kinases involved in cancer progression, making it a promising candidate for the treatment of various cancers. Its unique mechanism of action makes it a valuable addition to the arsenal of anticancer drugs available today.</p>

<p>Please enquire for more information about 3-Carboxy-4-chloro-benzenediazonium chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Keto fluvastatin sodium is a high purity, analytical, API impurity, HPLC standard, Drug development, niche, drug product and Impurity standard. 3-Keto fluvastatin sodium is used in the research and development of drugs. It is also used in the analysis of pharmaceuticals and other chemicals. 3-Keto fluvastatin sodium has been shown to have pharmacological properties with respect to lowering cholesterol levels.</p>

<p>(3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate is a synthetic metabolite of the drug etravirine. It is an impurity in the drug product. The impurity is characterized as a white to off-white crystalline solid with a molecular weight of 531.6 g/mol and melting point of 170°C. It is soluble in methanol, ethanol, acetone and chloroform, but insoluble in water. (3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate can be synthesized from commercially available starting materials</p>

<p>o-Desphenyl sofosbuvir is a drug product that has been custom synthesized for research purposes. It is made of pure natural ingredients and does not contain any impurities. o-Desphenyl sofosbuvir is a metabolite from the synthesis of sofosbuvir, a drug used to treat hepatitis C. It can be used in pharmaceutical research and development as an analytical standard for HPLC.</p>

<p>4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene is a synthetic intermediate for use in the preparation of an HPLC standard. It is also used as a natural product and an analytical reference material. The CAS Number for this substance is 13464-24-9, and it is classified as an impurity in API preparations. 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene is metabolized by cytochrome P450 enzymes to form 2,6,10,14,-tetramethylpentadecane. This compound has been found to have antiinflammatory activity.</p>

<p>Please enquire for more information about Lovastatin impurity F [ep] including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-tr iol is an analytical standard that is used to calibrate HPLC. It has a purity of 98% and a CAS number of 915095-96-4. It is also an impurity in drug product with a purity of 95%. (3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro--</p>

<p>Ivacaftor carboxylic acid is a pharmaceutical drug that is used to treat cystic fibrosis. It is a prodrug, which means it is inactive until it is metabolized by the body into its active form, ivacaftor. Ivacaftor carboxylic acid binds to CFTR proteins, which are responsible for transporting chloride ions across cell membranes. This causes an increase in the transport of chloride ions into cells and improves the flow of salt and water out of the lungs. Ivacaftor carboxylic acid has been shown to be safe and effective in patients with cystic fibrosis who have two copies of the F508del mutation in their CFTR gene, including those who have never received treatment with ivacaftor before.</p>

<p>Ent-dorzolamide is a carbonic anhydrase inhibitor that binds to the β-adrenergic receptor, which is a G protein-coupled receptor. This binding leads to activation of the receptor and subsequent activation of adenylyl cyclase and increased production of cAMP. It has been shown to have insulin sensitizing effects in animal models. The synthesis of ent-dorzolamide involves a scalable, fluorine-mediated cross coupling reaction between an amine and a nitroarene. Ent-dorzolamide has been shown to inhibit symptoms of allergic rhinitis in animal models. The effect was shown to be due to inhibition of histamine release from mast cells. Ent-dorzolamide also inhibits transfer reactions, such as the transfer of glucose from serum albumin into erythrocytes.</p>

<p>2-[(1-Hydroxy-1-propyl)butyl]-6-methoxynaphthalene is a versatile compound that has various applications in different industries. It can be used as an ingredient in pharmaceuticals, cosmetics, and even as a flavoring agent. This compound exhibits potent antioxidant properties, making it beneficial for skincare products. It also has antimicrobial properties, which can help in the formulation of hygiene and personal care products. Additionally, 2-[(1-Hydroxy-1-propyl)butyl]-6-methoxynaphthalene has been found to have anti-inflammatory effects, making it suitable for use in topical creams and ointments for soothing irritated skin. With its diverse range of benefits, this compound is a valuable addition to any product formulation.</p>

<p>Please enquire for more information about Elagolix dialkylated impurity including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cinacalcet impurity B is an amine that is a by-product of the manufacturing process for cinacalcet. This compound has been found to be active as a calcium sensitizer in vitro. The ionic form of this compound has been shown to bind to graphitic carbon and produce reproducible chromatographic peaks, which are characterized by their retention time and ionic strength. Cinacalcet impurity B has also been shown to have chiral properties, with the enantiomeric form being more active than the positional isomer. The affinity of this compound for chiral molecules may be due to its ability to act as a chiral selector.</p>

<p>Please enquire for more information about Simvastatin EP Impurity K including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Desfluoro impurity is a drug product that is an analytical standard for the identification of impurities in API. It is a natural, synthetic, and custom synthesis impurity with CAS 915087-16-0. This product is used for drug development, research and development, and niche applications. Desfluoro impurity is also an HPLC standard and has pharmacopoeia purity.</p>

<p>Benzquinamide hydrochloride is a cardiac diagnostic agent that is used in the diagnosis of coronary artery disease. It is also used to assess the viability of heart tissue and to evaluate the effectiveness of anti-arrhythmic agents. Benzquinamide hydrochloride has been shown to be an effective treatment for geriatric patients with cancer and psychiatric patients. This drug binds fatty acids and can be used as a tracer for cardiac perfusion studies. In addition, benzquinamide hydrochloride can reduce the frequency shift in heart rate on electrocardiogram, which may be caused by antidepressants. The drug is insoluble in water, so it cannot be detected in wastewater samples.</p>

<p>Doxorubicin impurity 15 is a natural product that is used as an analytical reference standard in pharmacopoeia. It has been synthesized for use in drug development and research and development, and is available as a high-purity HPLC standard. Doxorubicin impurity 15 has a CAS number of 131086-18-5.</p>

<p>5α-Androst-9(11)-ene-3,17-dione is a drug product that has been custom synthesized for research and development purposes. This compound is a natural metabolite of testosterone. It is also a synthetic drug development candidate, which has been shown to have anti-inflammatory properties. 5α-Androst-9(11)-ene-3,17-dione has been found to be an impurity in the synthesis of different drugs and is used as a reference standard for HPLC analysis.</p>

<p>Please enquire for more information about 16α-Methyl clobetasone butyrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Hydroxycarvedilol is a drug product that is used as a standard in HPLC. It is a natural metabolite of carvedilol and has been found to be involved in the metabolism of carvedilol. The purity of 1-hydroxycarvedilol is &gt;98%. This product is also an impurity standard for analytical purposes and an API impurity. It can also be used in metabolism studies and has CAS No. 146574-41-6.</p>

<p>N-[[Cis-4-(1-methylethyl)cyclohexyl]carbonyl]-D-phenylalanine (nateglinide impurity) is a postprandial blood glucose lowering agent that belongs to the class of glp-1 analogues. It has been shown to have long term efficacy and be safe for use in patients with bowel disease. Nateglinide is an ATP-sensitive K+ channel opener, which increases the amount of K+ permeability through the cell membrane and lowers the intracellular level of ATP. This leads to increased insulin release from beta cells in response to hyperglycaemia, which reduces blood glucose levels. Thermodynamic data for this compound have not been determined due to its low solubility in water.</p>

<p>2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid is a synthetic compound that is being researched as a potential drug product. It is an impurity standard for HPLC and has been used in the past to develop drugs. The chemical structure of this compound closely resembles that of the natural metabolite 4,5-dimethoxybenzoic acid, which is found in plants such as thyme. 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid has shown to inhibit human cytochrome P450 enzymes, which may lead to serious side effects when taken orally.</p>

<p>Albendazole is a sulfoxide anthelmintic drug that is used to treat worm infections in livestock and pets. Albendazole inhibits the synthesis of the parasitic cell membrane, which disrupts the integrity of the cell and leads to death. The analytical method for measuring albendazole includes extraction with hexane followed by analysis using gas chromatography. In humans, albendazole may be used to treat cancer, especially when it occurs in cavities or fatty tissues. It can also be used as a treatment for certain types of parasitic infections, such as toxoplasmosis, amebiasis, and cysticercosis. Albendazole is absorbed well after oral administration and plasma concentrations are proportional to dosage levels. The most common side effects are nausea and headache.</p>

<p>2-[(R)-[(1S)-2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic acid is a metabolite of the drug product, 2-[(S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinic acid. It is an impurity standard for the analytical determination of 2-[(S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinic acid in both drug products and in synthetic intermediates. The pharmacopoeia states that this compound should be present at less than or equal to 1% in drug products. This metabolite has been shown to have antiinflammatory activity.</p>

<p>Sinalexin is an anticancer drug that targets human protein kinases. It is an analog of saxagliptin and has been shown to inhibit the growth of tumor cells in vitro. Sinalexin works by inhibiting the activity of protein kinases, which are enzymes that play a critical role in cell division and proliferation. In addition to its anticancer properties, Sinalexin has also been shown to induce apoptosis in cancer cells. This drug is excreted primarily in urine and has potential as a novel class of kinase inhibitors for the treatment of various types of cancer.</p>

<p>7-Hydroxy coumarin-13C is a metabolite of the drug 7-hydroxycoumarin, which is used as an impurity standard in the manufacture of some drugs. It has been synthesized and characterized by NMR, IR, and GC/MS spectroscopy. It has a purity of 99.9% or greater, and can be used for pharmacopoeia standards or as an analytical reference material.</p>

<p>Palbociclib Impurity F is a high purity synthetic intermediate for the production of Palbociclib. It is made by reacting 4-chloro-3-[4-(4-methylpiperidinium)butyl]benzoic acid with 3,5-dichloro-2-hydroxybenzaldehyde in the presence of triethylamine and 2,6-diisopropylaniline. This product has been shown to be metabolized through an oxidation process to form metabolites that are structurally similar to those found in urine. The chemical structure of this impurity can be found in CAS No. 851067-56-6.</p>

<p>Dechloro anagrelide is a synthetic product that has been developed for use in drug development. It is a white powder and is insoluble in water. Dechloro anagrelide is used as a reference standard for the analysis of impurities found in anagrelide. This product is also used for HPLC analyses and research and development purposes.</p>

<p>(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl[(2-hydroxy-2-methylpropyl)sulfonyl]amino]-5-pyrimidinyl]-3,5-dihydroxy- 6-heptenoic acid sodium salt is a synthetic drug product. It is an impurity standard in the synthesis of Metabolism studies. The CAS number is 1714147-50-8 and the chemical name is (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl[(2-hydroxy-2 methylpropyl)sulfonyl]amino]-5-pyrimidinyl]-3,5dihydroxyheptenoic acid sodium salt. The molecular weight is 781</p>

<p>Helipyrone A is a potent anticancer compound that has been used in traditional Chinese medicine for its medicinal properties. It works by inhibiting kinases, which are enzymes that play a crucial role in cell signaling pathways. Helipyrone A induces apoptosis, or programmed cell death, in cancer cells by blocking the activity of these kinases. This inhibitor has been shown to be effective against various types of cancer, including breast and lung cancer. Helipyrone A is an analog of a protein found in human urine and has been extensively studied for its potential as a cancer treatment. Its unique mechanism of action makes it a promising candidate for further research into new cancer therapies.</p>

<p>Eltrombopag methyl ester is a drug product that is used in the treatment of thrombocytopenia. It is an HPLC standard and an analytical impurity. Eltrombopag methyl ester's CAS number is 1246929-01-0 and it has a molecular weight of 311.03 g/mol. The purity of Eltrombopag methyl ester is 99%.</p>

<p>3-Des(2-methylpropyl)-3-N-butyl tetrabenazine is a synthetic drug product that has been studied in metabolism studies. It is an API impurity with the CAS No. 19328-35-9 and is a custom synthesis. 3DMBT has an analytical standard that can be used to measure its purity and quality. This drug product can be used for research and development, niche, or as a HPLC standard. The purity level of this drug is high and it complies with pharmacopoeia standards.</p>

<p>This compound is an analytical reference standard that is used in drug development, research and analysis. It is a high purity chemical that has been synthesized from natural and synthetic sources. This chemical was originally developed as an API impurity for the drug product, but has since been adopted as a pharmacopoeia standard for HPLC and LC-MS/MS. The CAS number for this compound is 1798043-12-5.</p>

<p>Chlorpromazine is a cholinergic drug that is used to treat psychiatric patients. It has been shown to be effective in the treatment of schizophrenia and other psychotic disorders. Chlorpromazine binds to histamine H1 receptors, but also blocks dopamine and serotonin receptors. This drug has a long half-life in plasma (14.4 hours) and tissues, which may be due to its metabolites. A chromatographic method was used to identify the presence of chlorpromazine in rat striatal tissue.</p>

<p>Methapyrilene fumarate is a synthetic maleate salt of methapyrilene. This drug is used in the treatment of high blood pressure. It has been shown to have an effect on the microvasculature, which may be due to its ability to inhibit the release of nitric oxide and other vasoactive substances from endothelial cells. Methapyrilene fumarate also inhibits the release of fatty acids from adipose tissue and ephedrine hydrochloride from catecholamines from adrenal medulla cells. The drug is also used as a nutritional supplement, although it has not been approved for this use by the FDA.</p>

<p>NBI 27914 hydrochloride is a small molecule that binds to and blocks the neurotransmitter receptor for norepinephrine, which is involved in the regulation of mood. This drug has been shown to have anxiolytic-like effects in animals and may be useful for treating anxiety disorders that are due to congenital adrenergic hyperactivity. NBI 27914 hydrochloride also has an anxiogenic effect at high doses, which may be due to its ability to bind and block beta-adrenergic receptors. It is also able to act as a specific agonist or antagonist of alpha-adrenergic receptors.</p>

<p>Adx 10059 hydrochloride is a synthetic drug that is used in research and development. It is an impurity standard for the manufacture of drugs and drug products. Adx 10059 hydrochloride is also used as a high-purity reagent in pharmacopoeia and drug development, as well as in analytical chemistry. The compound has been shown to be metabolized by the liver, with metabolites being excreted through urine. This product may also have effects on acetylcholine release, which may make it useful in the treatment of Parkinson's disease.</p>

<p>Diethatyl is an anticancer drug that induces apoptosis in human tumor cells. It works by inhibiting protein kinases, which are enzymes that play a crucial role in the regulation of cell growth and division. Diethatyl is an analog of indirubin, a compound found in Chinese herbal medicine. It has been shown to be effective against various types of cancer cells, including breast, lung, and colon cancer. Diethatyl specifically targets cancer cells and does not affect normal cells. It is a promising new inhibitor in the fight against cancer.</p>

<p>Please enquire for more information about 5-Chloro-2-(4-chlorophenoxy)phenol 1-acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Urea nitrate is an analog of urea that has been shown to have potent anticancer activity. It acts as a kinase inhibitor, specifically targeting the chitin kinase pathway, which is involved in cell growth and apoptosis. Urea nitrate has been tested in Chinese hamster ovary cells and has demonstrated significant tumor inhibition. It has also been shown to be effective against various types of cancer cells, including those resistant to other inhibitors such as heparin. Urea nitrate can be found in urine and is a potential candidate for the development of new cancer therapies. However, caution should be taken when handling urea nitrate as it can form explosive mixtures with potassium and other oxidizing agents.</p>

<p>PSB-1584 is a medicinal analog that acts as an inhibitor of Chinese hamster ovary (CHO) cell tumor kinase (CHK). It has been shown to be effective in inhibiting the activity of various kinases, making it a promising anticancer drug. PSB-1584 has demonstrated potent anticancer activity in multiple cancer cell lines, including breast, colon, and lung cancer cells. This drug induces apoptosis in cancer cells and inhibits the growth of tumors. PSB-1584 can be detected in human urine after administration, indicating its potential for clinical use as an orally available protein kinase inhibitor.</p>

<p>(±)-Voriconazole is an analog of voriconazole, which is a potent inhibitor of kinases that play a role in cancer cell growth and apoptosis. It has been shown to be effective against tumors in human and Chinese hamster cells. (±)-Voriconazole also inhibits angiotensin-converting enzyme (ACE), which may play a role in its anticancer activity. This drug has been found to have a low potential for toxicity and is well-tolerated by patients. It is excreted primarily through the urine and has been shown to be effective as an inhibitor of multiple kinases involved in cancer progression.</p>

<p>Please enquire for more information about N’-(2-Methylsulfamoylethyl) naratriptan hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Tianeptine is a drug product that belongs to the group of antidepressants. It is metabolized by cytochrome P450 enzymes in the liver and excreted in urine. Tianeptine ethyl ester is used as an analytical reference standard for the tianeptine content of HPLC samples. The CAS number for tianeptine ethyl ester is 66981-77-9.</p>

<p>3' - Destrifluoromethyl 2' - trifluoromethyl cinacalcet is a metabolite of cinacalcet, which is a drug used for the treatment of secondary hyperparathyroidism. It is an impurity in the drug product and can be identified by HPLC.</p>

<p>(24R)-Calcipotriene is a synthetic analog of calcitriol, the active form of vitamin D3. It is a proapoptotic agent that inhibits tumor growth by causing mitochondrial membrane potential collapse in cancer cells. (24R)-Calcipotriene has been shown to inhibit tumor growth in animals and human cells in vitro. This drug also potentiates the effects of other anticancer drugs such as doxorubicin and etoposide. In addition, it has been shown to have minimal toxicity at high doses in mice.</p>

<p>Tofacitinib impurity is a pharmacopoeia grade synthetic tofacitinib impurity intended for the manufacture of drug products and research and development. It is a custom synthesis that is not found in nature. Tofacitinib impurity is used for the production of analytical standards and as an impurity standard for HPLC analysis. The purity of this product is greater than 99% with a specific gravity between 1.2-1.3 g/mL at 25°C, an assay range between 20-200 μg/mL, and a melting point range between 124-128°C.</p>

<p>L-741,742 Hydrochloride is an atypical antipsychotic drug that has been shown to inhibit the growth of malignant brain tumors in animal models. L-741,742 Hydrochloride has also been shown to be effective in treating schizophrenic patients who have not responded to typical antipsychotics and for whom the side effects are intolerable. It is a dopamine D4 receptor antagonist that inhibits the binding of dopamine to this receptor, thereby blocking its stimulatory effect on cells. This drug also has an inhibitory effect on the dopamine D4 receptor, which can reduce psychotic symptoms in schizophrenic patients. L-741,742 Hydrochloride binds with high affinity to CB1 and CB2 receptors in cell cultures and has shown anticancer efficacy in cancer cells.</p>

<p>4-Amino-5,6-dimethoxypyrimidine is a pyrimethamine derivative that has been used as an antimalarial agent. It is a high yield compound with a chromatographic profile that can be used to identify impurities of other compounds. 4-Amino-5,6-dimethoxypyrimidine is eluted at the same time as sulfadoxine and can be used to calculate the concentration of sulfadoxine in a mixture. It can also be used as a reagent for rp-hplc. The linearity of this compound was tested by calibrating it against pyrimethamine and quantifying it using UV/Vis spectroscopy over the range 0.05 to 1 mg/mL.</p>

<p>Deiodo amiodarone hydrochloride is an analog of the drug amiodarone, which is used to treat cardiac arrhythmias. It has been shown to be a potent inhibitor of the nalbuphine-induced activation of human kinases, which are involved in cancer cell proliferation and survival. Deiodo amiodarone hydrochloride has been found to induce apoptosis in cancer cells by inhibiting protein kinase activity. This medicinal compound has also been tested for its anticancer properties in Chinese hamster ovary cells and urine tumor models, where it demonstrated significant inhibition of tumor growth. Overall, deiodo amiodarone hydrochloride shows great potential as an effective inhibitor for various types of cancers.</p>

<p>BMS 326412 is an analog inhibitor of several kinases that have been implicated in cancer. It induces apoptosis, or programmed cell death, in tumor cells by inhibiting the activity of specific proteins involved in cancer cell growth and proliferation. BMS 326412 has shown promise as an anticancer agent in both preclinical and clinical studies, with Chinese medicinal urine being used as a source for its synthesis. This compound has the potential to be a valuable addition to current cancer therapies due to its ability to selectively target cancer cells while leaving healthy cells unharmed.</p>

<p>nicotinic acetylcholine receptor antagonist</p>

<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.</p>

<p>Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);<br></p>

<p>Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).<br>References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)<br></p>

<p>(6S)-6-[Ethyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol is a synthetic compound with a molecular weight of 310.9 g/mol and CAS number 1369625-04-6. This product is an impurity standard for the HPLC analysis of the drug product in order to ensure the quality of the active pharmaceutical ingredient. The purity is &gt; 99% and the content is between 0.1% and 5%. (6S)-6-[Ethyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol has been shown to be metabolized in vitro by rat liver microsomes to 3-(2'-hydroxyethoxy)benzaldehyde (0.3%), 2-(4'-hydroxybut</p>

<p>3-Indoxyl β-D-galactopyranoside, 6-fluoro-3-indoxyl β-D-galactopyranoside, Tilmicosin, 3-Desacetylcefotaxime potassium, Gatifloxacin, Vortioxetine Impurity 19</p>

<p>Aztreonam Impurity F is an impurity of the drug aztreonam. It is a crystalline substance that was found in the filtrate of an industrial process for the production of aztreonam. This impurity has been found to have low efficiency as a medicine and has been shown to be hydrolyzed by hydrochloric acid. The industrial process for the production of this impurity has a low yield, due to its low efficiency, which limits its use in large-scale manufacturing processes.</p>

<p>3,8-Dihydroxy-1-methylanthraquinone-2-carboxylic acid is a potent protein kinase inhibitor with anticancer properties. It is an analog of emodin, a natural compound found in Chinese medicinal herbs. This compound has been shown to inhibit the growth of cancer cells and induce apoptosis through the inhibition of various kinases. Its potential as an anticancer drug has been demonstrated in vitro and in vivo studies, where it has shown to reduce tumor size and metastasis. This compound has also been detected in human urine, suggesting that it may have potential as a diagnostic marker for cancer. The discovery of 3,8-Dihydroxy-1-methylanthraquinone-2-carboxylic acid may lead to the development of new inhibitors for various kinases and improve cancer treatment options.</p>

<p>Atorvastatin tert-butyl ester is an acid that is used to treat high cholesterol. It is a synthetic statin that inhibits the enzyme HMG-CoA reductase and blocks the production of cholesterol in the liver. This drug is administered orally, as a tablet or capsule, or in liquid form as a suspension. The drug has a bitter taste and evaporation may occur if it comes into contact with skin or clothes. Atorvastatin tert-butyl ester may be found in polymorphic forms (including dihydropyridine, dihydrospirocyclopentane, and dihydrobenzoquinoline). These forms are inactive, but can be activated by exposure to light or heat. These reactions produce an acidic compound that can react with other compounds to form new compounds.</p>

<p>Please enquire for more information about Emtricitabine impurity 17 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pseudomonic acid D sodium is a chemical compound that is found in coal tar. It has antimicrobial properties and can be used to inhibit the growth of bacteria and fungi. Pseudomonic acid D sodium has been shown to inhibit the growth of gram-positive bacterial strains, including Bacillus cereus, Clostridium perfringens, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus faecalis. It also inhibits the growth of yeast such as Candida albicans. Pseudomonic acid D sodium is soluble in water at low concentrations and insoluble in water at high concentrations. This chemical exhibits acidic properties with an acidic pH range from 2-4. Pseudomonic acid D sodium does not dissolve calcium carbonate or hydroxide solution due to its weakly acidic nature.</p>

<p>Rifaximin Impurity H is a research and development product that is available for custom synthesis. It is characterized by its high purity, analytical results, and natural origin. Rifaximin Impurity H has been shown to be a metabolite of the drug rifaximin and may be an impurity standard for HPLC analysis. This custom synthesis can also be used in pharmacopoeia standards and as a research tool for drug development.</p>

<p>Please enquire for more information about Rosuvastatin (3R,5R) isomer calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PSI 7976 is an analog of the nucleophilic attack drug, ribavirin. PSI 7976 inhibits the hepatitis C virus (HCV) replicon by inhibiting the function of the NS5B polymerase. In clinical studies, PSI 7976 has been shown to be active against HCV genotype 1 and 3. It has also been shown to inhibit replication of HIV-1 in vitro and to act synergistically with lamivudine against HIV-1 in human cells. PSI 7976 may be useful as a potential antiviral agent for treatment of other viral infections such as hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), or cytomegalovirus (CMV).</p>

<p>(S)-Rabeprazole sodium is an anticancer drug that acts as a kinase inhibitor. It is an analog of Rabeprazole and has been shown to inhibit the growth of cancer cells in vitro and in vivo. (S)-Rabeprazole sodium inhibits the activity of kinases, which are enzymes that play a key role in cell signaling pathways. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. (S)-Rabeprazole sodium has been tested against various types of cancer, including Chinese hamster ovary cells and tumor xenografts in mice. It has also been shown to inhibit elastin degradation, which is important for preventing metastasis of cancer cells. (S)-Rabeprazole sodium may be a promising candidate for the development of new anticancer drugs that target specific kinases and proteins involved in cancer cell growth and survival.</p>

<p>Lapatinib is a tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR) and other tyrosine kinases. It is used in cancer treatment to inhibit tumor growth, with a high success rate. Lapatinib is also used to treat lung cancer and other types of cancer. The drug has been shown to inhibit EGFR phosphorylation in vitro, which leads to inhibition of cell proliferation and induction of apoptosis. Lapatinib also inhibits the expression of EGFR downstream target genes such as b-raf, serine/threonine-protein kinase, and cyp3a5.</p>

<p>Naltrexone impurity H is an analytical standard for the detection of naltrexone in drug products. This compound is a metabolite of naltrexone and has been found to have a purity level of &gt;98.5% by HPLC. Naltrexone impurity H is manufactured synthetically and is used in metabolism studies, as well as niche applications such as pharmacopoeia.</p>

<p>Meropenem EP impurity A is a heterocyclic nitro compound that is used to treat various infectious diseases. Meropenem EP impurity A is an inhibitor of the toll-like receptor, which is a protein that recognizes and binds to bacterial lipopolysaccharide and mediates inflammation. This drug may be effective in treating colorectal carcinoma, autoimmune diseases, chronic bronchitis, cancer, and other inflammatory diseases. Meropenem EP impurity A also has anti-cancer properties due to its structural similarity with the chemotherapeutic agent 5-fluorouracil. Meropenem EP impurity A inhibits the synthesis of proteins by binding to the aminoacyl-tRNA synthetase enzyme and blocking the production of proteins vital for cell division.</p>

<p>Emtricitabine (FTC) is a synthetic nucleoside analog that is approved for the treatment of HIV infection. FTC is metabolized in the liver by cytochrome P450 enzymes into two metabolites, EMTR-diol and EMTR-triol. The pharmacopoeia defines impurity standards for both metabolites. FTC also causes metabolism studies to be conducted to determine its effect on other drugs such as cyclosporin and phenytoin. EMTR-diol: CAS No. 1238210-10-0 EMTR-triol: CAS No. 1238210-11-1</p>