APIs for research and impurities

<p>Cefazolin impurity A is a by-product in the synthesis of Cefazolin, which is a drug product. It has CAS No. 30246-33-4 and is used as an impurity standard for analytical purposes. The Impurity Standard is also known as Metabolite A. Research and Development (R&amp;D) studies are needed to identify the appropriate analytical impurities for this API, which will be reported on Pharmacopoeia's List of Impurities for reference. The high purity and custom synthesis of this API makes it ideal for use in R&amp;D studies, HPLC standards, or niche markets.<br>CAS No.: 30246-33-4<br>Synonyms: Metabolite A<br>Formula: C11H14N2O5S <br>Molecular weight: 289.24 g/mol <br>Appearance: white solid powder</p>

<p>Hordatine A is an analog of neopterin, a protein found in human urine. It is a potent inhibitor of tumor kinases and has shown promising results as an anticancer agent. Hordatine A induces apoptosis (cell death) in cancer cells by inhibiting kinase activity. This compound has been tested on Chinese hamster ovary cells and human cancer cell lines with positive results. Hordatine A may have potential as a therapeutic agent for the treatment of various types of cancer. Its ability to inhibit kinases makes it a valuable tool for studying the role of these enzymes in cancer development and progression.</p>

<p>O-Methyl atorvastatin calcium is a drug product that is an HPLC standard. It is a natural metabolite of atorvastatin, which is synthesized by cytochrome P450 3A4 in the liver. O-Methyl atorvastatin calcium has been shown to be an impurity in some batches of atorvastatin calcium. It has been observed to have pharmacological effects similar to those of atorvastatin. O-Methyl atorvastatin calcium has been used as a research and development (R&amp;D) tool for studies on the metabolism of drugs, including its own synthesis and the study of the effect on other drugs such as amiodarone.</p>

<p>2-[[[(4-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole is a protonated sulfonamide that is used as an analytical method to detect the presence of other drugs in human liver tissue. It has been shown to inhibit the activity of cytochrome P450 3A4 (CYP3A4), one of the enzymes responsible for metabolizing many drugs. Bromoenol lactone and powder diffraction spectrum are two additional analytical methods that can be used to detect 2-[([(4-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole.</p>

<p>2-Hydroxybenzimidazole is a benzimidazole compound that is used in the treatment of nervous system diseases. It has been shown to have anti-inflammatory properties and can be used in the treatment of syncytial virus infection. 2-Hydroxybenzimidazole inhibits the production of reactive oxygen species and nitric oxide, which are involved in neurodegenerative disorders. The mechanism of action for 2-Hydroxybenzimidazole involves the formation of hydrogen bonds with hydroxyl groups on proteins. It also has been shown to reduce locomotor activity and increase sleep time in mice, which may be due to inhibition of acetylcholine release from cholinergic neurons.</p>

<p>3,3'-(3,6-Dihydropyrazine-2,5-diyl)dipropanoic acid (DPPA) is a potent metal chelator that can be used in the treatment of cancer. DPPA binds to metal ions and prevents their access to vital cellular components such as DNA and proteins. This agent has been shown to inhibit the growth of carcinoma cells in culture. It also has an effect on the synthesis of demyelination, which may account for its ability to prevent reactive oxygen species from damaging DNA. DPPA is a strong inhibitor of mitochondrial function and at high concentrations it damages mitochondria by releasing hydrogen peroxide into the cell cytoplasm. The release of hydrogen peroxide causes catalase to become active, leading to cell death.</p>

<p>1-Phenyl-1-(2-pyridinyl)methanol is an organic compound that has a reactive, functional group. It is used as a solvent in the laboratory and industry. This chemical reacts with chloride to produce 1-chloro-1-phenylmethanol. It can also be reacted with basic groups such as sodium hydroxide to produce 1-phenyl-1-(2-hydroxy pyridinium) methanol. The reaction of 1-phenyl-1-(2-pyridinyl) methanol with carbon tetrachloride produces trichlorobenzene and carbon dioxide. Impurities in this compound include inorganic acids such as hydrochloric acid and sulfuric acid, which are found at levels below 0.5%. Alcohols found in this compound include ethanolamine, which is an impurity at levels exceeding 2%.</p>

<p>N-(5-Aminopentyl) methotrexate amide is a fluorescent probe that is used to study the transport of drugs across cell membranes. It binds to the plasma membrane of cells and can be visualized with a fluorescence microscope. N-(5-Aminopentyl) methotrexate amide has been shown to bind to leukemia cells in murine leukemia models. It has a high affinity for drug-resistant cells, which makes it useful for studying drug resistance mechanisms. This probe can be used at nanomolar concentrations for imaging studies, as well as for measuring the uptake of drugs into cancer cells by flow cytometry.</p>

<p>Sildenafil is a selective PDE-5 inhibitor that is used in the treatment of erectile dysfunction. It has been shown to have anticancer activity in vitro and in vivo. Sildenafil inhibits the activity of cyclic guanosine monophosphate (cGMP) phosphodiesterase type 5 (PDE-5), which is found in the corpus cavernosum of the penis and inhibits cGMP degradation, leading to vasodilation and increased blood flow. Sildenafil has been shown to inhibit cancer cell proliferation by blocking the synthesis of both DNA and protein, as well as inhibiting the expression of genes encoding for anti-apoptotic proteins. Sildenafil binds to PDE-5 with high affinity, but does not bind to other PDEs or ion channels at therapeutic concentrations.</p>

<p>Daunorubicin metabolite</p>

<p>2-Mercaptobenzimidazole is a chemical compound that can be used for the treatment of infectious diseases. It has been shown to have antioxidative properties and inhibit the growth of bacteria. 2-Mercaptobenzimidazole also has an effect on human serum, which may be due to its ability to bind with proteins in serum and form hydrogen bonds. 2-Mercaptobenzimidazole is stable at high temperatures and has been shown as an effective antimicrobial agent against gram positive and gram negative bacteria.</p>

<p>2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt is a white to off-white crystalline powder. It is soluble in water and sparingly soluble in alcohol. This product is used as an analytical standard and has been found to be a metabolite of the drug clozapine. 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt has also been found to be an impurity in the drug product lamotrigine.</p>

<p>The compound is a natural product and its structure is similar to that of the neurotransmitter dopamine. The compound has been used in pharmacological studies as a tool for understanding the neurotoxicity of dopamine and other drugs. This drug has also been used to investigate the level of dopamine receptor occupancy by various dopaminergic drugs.</p>

<p>Doxorubicin is an organic compound that belongs to the class of polycyclic aromatic hydrocarbons. It is used as a cancer therapy, primarily in the treatment of breast cancer. The chemical sensing of impurities in doxorubicin can be done using phase transfer methods. The quantification of these impurities can be done using high-performance liquid chromatography (HPLC) or gas chromatography (GC).</p>

<p>Valsartan is a drug that belongs to the class of angiotensin II receptor blockers. It has a molecular weight of 376.5 and an empirical formula of C21H28N2O4S. Valsartan Impurity 23 is a synthetic impurity with CAS No. 2459446-44-5, which has a molecular weight of 464.3 and an empirical formula of C25H30N2O6S. It is used as a metabolite standard in pharmacopoeia and drug development, as well as for analytical purposes in natural products and metabolism studies.</p>

<p>2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid ethyl ester is a drug product that has been custom synthesized for use in research and development. This chemical has analytical properties, which can be used to study the metabolism of this compound. It is also used as a pharmacopoeia impurity standard and an API impurity. 2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid ethyl ester is metabolized in vivo to form metabolites with different spectra of activity. These metabolites are used as analytical standards for HPLC analysis.</p>

<p>N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine tartrate (DMNPA) is a synthetic compound with the molecular formula C14H17NO. DMNPA is used as an analytical reference standard for the quantification of N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2thienyl) propanamine HCl by HPLC. DMNPA has been shown to be a metabolite of the drug product, where it is formed from oxidation of the parent drug.</p>

<p>O3-Desethyl apremilast is an experimental drug product that belongs to the class of drug products. This drug product has been shown to be a natural, synthetic and analytical impurity in API. It is also an impurity standard for HPLC analysis. O3-Desethyl apremilast can be used in research and development, as well as niche applications in the pharmaceutical industry.</p>

<p>2-Acetamido-7-[[2-(acetyloxy)ethoxy]methyl]-6,7-dihydro-1H-purin-6-one is a drug development impurity that is manufactured by the pharmaceutical company. This impurity has been shown to be a metabolite of the drug.</p>

<p>Soluble in Chloroform &amp; in Methanol Confirmed<br>Insoluble in Water</p>

<p>Please enquire for more information about Empagliflozin R/S-furanose including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ene sacubitril is an impurity in the drug product sacubitril. It is a synthetic compound that belongs to the class of drugs called angiotensin II receptor antagonists. This impurity can be used as a research and development standard, custom synthesis, or drug product impurity standard. Ene sacubitril is also a metabolite of sacubitril and can be used for metabolism studies or HPLC standard.</p>

<p>Sertraline metabolite</p>

<p>Remdesivir impurity</p>

<p>Tirzepatide impurity.</p>

<p>Lisdexamfetamine dimesylate impurity C is a drug product that is an analytical standard. It is a synthetic impurity found in the drug Lisdexamfetamine Dimesylate, which is used for the treatment of ADHD and narcolepsy. Lisdexamfetamine Dimesylate Impurity C has been shown to be metabolized through oxidation by cytochrome P450 enzymes and conjugation with glucuronic acid. The impurity has been shown to have no effect on the pharmacological activity of the parent compound.</p>

<p>Remdesivir impurity 12 is a drug product that is used in research and development. It is a synthetic impurity standard for HPLC analytical methods. Remdesivir impurity 12 is an impurity of the drug, remdesivir, which has antiviral activity against HIV-1. Metabolism studies have been conducted to investigate how this impurity affects the pharmacokinetics of remdesivir. The use of synthetic material ensures high purity and quality for this product.</p>

Duloxetine succinamide is a chromatographic, solid, acidic compound. It has been synthesized by reacting (S)-duloxetine hydrochloride with succinic anhydride in the presence of triethylamine and acetonitrile. The reaction mixture was purified by high-performance liquid chromatography to produce the desired product. The purity of the compound was confirmed by postulating that it should have a reversed-phase HPLC profile similar to that of duloxetine succinate. Duloxetine succinamide is not soluble in water and is insoluble in organic solvents such as acetone, chloroform, ether, or benzene. The compound is stable at room temperature but decomposes when heated at higher temperatures. !--

<p>Pravastatin lactone is a prodrug of pravastatin that is hydrolyzed in vivo to its active form. It is used for the treatment of bowel disease and has been shown to have concentration-time curves that are linear and dose-dependent. Pravastatin lactone has an acidic pH, which may be due to the presence of carboxyl groups on the molecule. This drug also inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is an enzyme that catalyzes the conversion of HMG CoA to mevalonate in order to produce cholesterol. Pravastatin lactone also suppresses the production of fatty acids by inhibiting their synthesis at the level of acetyl-coenzyme A (acetyl-CoA). The drug has not shown any evidence of toxicity when administered to rats at doses up to 10 mg/kg body weight per day</p>

<p>5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphonyl]-1H-benzimidazole N-oxide is a cyclic sulfoxide that has shown to be a potent inhibitor of gastric acid secretion. It is an important intermediate in the synthesis of esomeprazole magnesium, a proton pump inhibitor used to treat gastroesophageal reflux disease and other gastrointestinal disorders. 5-Methoxy-2-[(4-methoxy 3,5 dimethyl 2 pyridinyl) methyl] sulphonyl]-1H benzimidazole N oxide is also known as (RS)-N-[4-(4′ methoxyphenyl)-3,5 dimethylpyrazol -2 - ylmethyl] methanesulfonamide. This compound has been shown to have a polymorphic form with two different</p>

<p>3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanamide is a synthetic drug product. It is not found in natural products and it has no pharmacopoeia name. 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanamide is an impurity standard for the manufacture of pharmaceuticals. It is also used as a research and development reagent and analytical standard. 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanamide has not been evaluated by the FDA as a food additive, but it has been evaluated by the European Union as a flavoring agent.</p>

<p>Tirzepatide Impurity</p>

<p>Biotin impurity C is a metabolite that is found in drugs that contain biotin. It is an impurity standard for HPLC analysis, which can be used to identify and quantify the amount of biotin in a drug product. Biotin impurity C is also used as an analytical standard. This compound has been shown to have pharmacological properties, such as anti-inflammatory effects and immunomodulatory effects.</p>

<p>D-Thr(7)-Semaglutide is a semaglutide impurity. The amino acid at position 7 has been replaced by the D-form of the amino acid D-threonine (D-Thr). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

Degradation product of olanzapine

<p>Apixaban impurity 2 is a drug product that is used as an impurity standard in the research and development of drugs. It is also used as a synthetic intermediate in the synthesis of other drugs. Apixaban impurity 2 has been shown to be pharmacologically active, with the ability to inhibit bacterial growth by binding to DNA-dependent RNA polymerase. This compound is not toxic to mammalian cells at high concentrations, but has been shown to have some effects on the central nervous system, including depression of spontaneous motor activity and decrease in locomotor activity. Apixaban Impurity 2 is soluble in acetone and chloroform, but insoluble in water. The molecular weight of this compound is not known, but it can be determined using HPLC. Apixaban Impurity 2 has CAS number 2187409-01-2 and its molecular formula is C21H22N2O4S.</p>

<p>2-Isopropyl-6-propylphenol is a reactive alkylating agent that reacts with proteins and enzymes. It binds to the hydroxyl group of a protein target, which modifies the activity of the target molecule by introducing a new functional group. 2-Isopropyl-6-propylphenol has been shown to bind to the active site of several enzymes, including human serum albumin and cytochrome P450 reductase. The binding constants for these targets have been determined computationally using an algorithm based on quantum chemical calculations. These values are in good agreement with experimental data obtained from titration calorimetry experiments at different temperatures.</p>

<p>Tirzepatide impurity</p>

<p>Please enquire for more information about 2-[[1-(Methylamino)-2-nitroethenyl]amino]-ethanethiol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Desmethoxy omeprazole sulfide is a metabolite of omeprazole, a drug that is used to treat ulcers and gastroesophageal reflux disease. 4-Desmethoxy omeprazole sulfide is not an impurity in the production of omeprazole, but is present as a natural component of omeprazole. This compound has been shown to be an impurity standard for HPLC analysis. The pharmacopoeia defines 4-desmethoxy omeprazole sulfide as an API impurity in drug products. It is also being studied for its potential use in drug development and research and development.</p>

<p>D-Arg(30)-Semaglutide is a semaglutide impurity. The amino acid at position 30 has been replaced by the D-form of the amino acid D-arginine (D-Arg). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Remdesivir Related Compound 4 is a synthetic compound that is structurally related to remdesivir. It has been shown to have anti-HIV activity in vitro. Remdesivir Related Compound 4 may be used as an impurity standard for HPLC, and as an intermediate in the synthesis of other drugs.</p>

<p>Please enquire for more information about Clobetasol propionate EP Impurity F including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Chlorthalidone impurity H is an impurity standard for chlorthalidone. It is a synthetic chemical and its CAS number is 2200280-98-2. It has the molecular formula C14H14ClN4O4S, molecular weight of 336.36 g/mol, and melting point of 174°C. Chlorthalidone impurity H is soluble in water and ethanol, but insoluble in ether or chloroform. It can be used as an analytical standard for HPLC and as an API impurity in the pharmacopoeia. This drug can also be used in drug development, natural product synthesis, metabolism studies, and drug product manufacturing.</p>

<p>Sildenafil N-Oxide is a solvate, hydrate, and prodrug of sildenafil citrate. It is used for the treatment of erectile dysfunction or pulmonary hypertension. Sildenafil N-Oxide is an oral drug that is converted to its active form, sildenafil, in the liver by CYP3A4. Sildenafil N-Oxide's effects on human erection are thought to be due to its ability to block phosphodiesterase type 5 (PDE5), which increases the levels of cGMP in smooth muscle cells and causes relaxation of the corpus cavernosum. This leads to increased blood flow into the penis and an erection.</p>

<p>N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester is a drug product. It is a synthetic substance that is used in the development of new drugs and for research and development. This impurity standard is used as an analytical reference in the testing of other compounds. N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester has been shown to be a metabolite of CAS No. 915979-44-1, which is also known as N-[(2S)-2-[[5-[3-(Trifluoromethoxy)phenoxy]-2-pyridinyl]methyl]-2,5-dioxopyrrolidin-1-yl]-3,</p>

<p>Ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate is a custom synthesis. It is a metabolite of the drug product, ethyl 2-(5-isopropenyl-4-methylphenoxy)propanoate. Its CAS number is 157356-73-5.</p>

<p>Olmesartan lactone impurity is a high-purity, low-cost, and stable pharmaceutical intermediate. It is an ester of olmesartan and medoxomil. The synthesis of this compound can be achieved through the esterification of olmesartan with medoxomil using a solvent such as dioxane. This compound is used to produce olmesartan medoxomil, which is a non-selective angiotensin II receptor antagonist. Olmesartan lactone impurity has been shown to have no effects on the human body when tested in animals.</p>

<p>Olsalazine sodium impurity C is a metabolite of olsalazine sodium. It is a natural product that can be custom synthesized for research and development purposes. Olsalazine sodium impurity C has been shown to have pharmacopoeia-grade purity and can be used as an analytical standard or an API impurity in drug products. The CAS number for this substance is 259151-72-9.</p>

<p>Dapagliflozin Impurity 30 is a natural impurity found in the drug Dapagliflozin. It is an analytical standard used for HPLC quantification of dapagliflozin, and it can be used as a pharmacopoeia reference material or research and development material. Dapagliflozin Impurity 30 is synthesized by using a custom synthesis protocol. The CAS number for this compound is 1373321-04-0.</p>

<p>2-(N-Methyl-propanamine)-3-(2-naphthyl) thiophene is a synthetic compound that has been used as an impurity standard for the drug product and API. It has also been used for the pharmacopoeia, research and development, and analytical purposes. This compound is a metabolite of erythromycin.</p>

<p>5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole is an inhibitor of cytochrome P450 2C19. It has been shown to inhibit the activity of this enzyme in a concentration dependent manner and to enhance the activity of omeprazole by inhibiting its metabolism. 5-Methoxy-2-[(4-methoxy, 3,5 dimethylpyridiniumyl)methyl]sulfonyl]-1H benzimidazole is used as a model system for studying drug interactions due to its ability to inhibit cytochrome P450 2C19 and CYP2C19 protein expression. 5 METHOXY - 2 - [[ ( 4 - METHOXY - 3 , 5 - DIMETHYL - 2 - PYRIDINYL ) M</p>

<p>5-((tert-Butylamino)methyl)-3-(3-fluoro-(2-morpholinyl)phenyl)oxazolidin-2-one (5FAMPO) is a metabolite of the drug product, CAS No. 109467-92-6, and has been synthesized for use as an analytical reference standard and impurity standard in drug development studies. 5FAMPO is a synthetic molecule that has not been found in nature, but is structurally similar to natural molecules. 5FAMPO is metabolized by CYP450 enzymes to produce 2-(tert-butylamino)-4'-hydroxyphenylacetic acid (HPA), which can be quantified by HPLC analysis. 5FAMPO is also used as a research and development compound and pharmacopoeia impurity standard.</p>

<p>10,11-Dihydroxy-d10 Carbamazepine is a drug product that is used as an analytical reference standard. It is natural and synthetic impurity in the API (active pharmaceutical ingredient) Carbamazepine. The CAS number for 10,11-Dihydroxy-d10 Carbamazepine is 513-81-5. This compound has been synthesized by custom synthesis and is an impurity standard for HPLC analysis of carbamazepine. 10,11-Dihydroxy-d10 Carbamazepine is also a research and development chemical for the drug development industry. It has been classified as a niche chemical due to its high purity and pharmacopoeia grade.</p>

<p>Cetirizine metabolite</p>

<p>4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid, ethyl ester 1,1-dioxide (4HMBC) is an organic compound that is used as a precursor in the synthesis of other chemicals. 4HMBC is used to produce xylene, sulfoxide and diethyl ether by reacting with magnesium and ethylene. It is also used in the production of dimethylformamide, a solvent that is useful for the manufacture of many products including pharmaceuticals. 4HMBC reacts with methyl iodide to form 4-(dimethylamino)pyridine which can be used for the synthesis of piroxicam. The chemical has been shown to be effective as an insecticide against ants and cockroaches. It can also be used to synthesize dyes or pigments. The chemical can be obtained by methylating 4HBC with methanol in the presence</p>

<p>2-N-Butyl 3-(4-methoxy benzoyl)-benzofuran is a x-ray crystal structure of an antibacterial agent that belongs to the class of β-unsaturated ketones. It has been shown to have cardiovascular activity, and is used in the treatment of depression. The compound binds to the active methylene group on the bacterial cell wall, which prevents cross linking of peptidoglycan chains. This leads to a reduction in cell wall synthesis and increased permeability of cells, which may result in death. The 2-N-butyl 3-(4-methoxy benzoyl)-benzofuran molecule also contains two phenyl groups that are able to form hydrogen bonds with each other, as well as dihedral angles that can form hydrogen bonds with water molecules. These properties contribute to its antidepressant activity.</p>

<p>Paclitaxel breakdown product</p>

<p>Dapagliflozin Impurity 4 is a research and development impurity standard for the drug Dapagliflozin. Dapagliflozin Impurity 4 is a white crystalline solid with a molecular weight of 646.5 and an empirical formula of C20H22N2O2. It is soluble in water, methanol, ethanol, and acetonitrile. The compound has a melting point of 181°C with decomposition and a boiling point of 254°C at 760 mm Hg. It is not oxidizable under aerobic conditions and does not react with acid or alkali to form any ionizable species.</p>

<p>Thiotepa impurity B sodium is an analytical standard for HPLC and is used as a reference in pharmaceutical research and development. It also has niche applications as an impurity standard for drug product, Metabolite, pharmacopoeia, CAS No. 14056-57-6(free base), and Custom synthesis</p>

<p>Tirzepatide impurity.</p>

<p>6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxaldehyde is a colorimetric reagent that can be used to detect Cl. It has been shown to react with Cl in the presence of an acidic solution and produce a red color. The reagent is stable in organic solvents, such as chloroform, but decomposes in water. 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxaldehyde is also used to detect chloride by titrimetric or polarographic methods.</p>

<p>D-Glu(21)-Semaglutide is a semaglutide impurity. The amino acid at position 21 has been replaced by the D-form of the amino acid D-glutamic acid (D-Glu). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>N-Hydroxy riluzole N-b-D-glucuronide (NHRG) is a drug product that has been used as an analytical reference standard in metabolism studies. It is a natural impurity found in the API Rilutek (riluzole), which is used to treat ALS and related diseases. NHRG exhibits a retention time of 9.5 minutes on HPLC, and its purity should be at least 98%. NHRG can also be custom synthesized to order, and it can be used as an impurity standard in drug development research and development, or for pharmacopoeia testing.</p>

<p>Tirzepatide Impurity</p>

<p>Metoclopramide is a dopamine receptor ligand used as an antiemetic in the treatment of nausea and vomiting. It also has been shown to be effective in the treatment of neuropathic pain, including post-herpetic neuralgia, diabetic neuropathy, and post-mastectomy pain syndrome. Metoclopramide has been shown to relieve allodynia by binding to opioid receptors in the central nervous system. It also has been found to have metabolic effects that may help reduce the risk of developing metabolic syndrome and other related conditions such as diabetes mellitus type 2, which are associated with chronic pain conditions. Metoclopramide is used as a medicament for chemotherapy patients experiencing severe nausea or vomiting.</p>

<p>Calcipotriol EP Impurity G is an impurity in calcipotriol, which is a drug product. Calcipotriol EP Impurity G has a CAS number of 126825-26-3 and is a natural metabolite of calcipotriol. It is also known as calcipotriol EP Impurity G or calcipotriol EPIG. It has been shown to be an analytical impurity in calcipotriol, and it has been detected by HPLC analysis. Calcipotriol EP Impurity G can be used for research and development, as well as for the production of pharmacopoeia standards.</p>

<p>3-o-Methyl colterol is a synthetic drug product. It is an impurity found in the natural product colterol, which is used as a drug for the treatment of high blood pressure. 3-o-Methyl colterol can be prepared by reacting its dihydropyridine with methyl iodide and hydrochloric acid. The compound has been found to be an impurity in colterol, which prevents its use as a therapeutic agent. 3-o-Methyl colterol has been studied in Metabolism studies and has shown no toxic effects on animals or humans.</p>

<p>N-((-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl) acetamide is a custom synthesis, drug product, niche, Metabolite, Drug Development, CAS No. 224323-50-6. It is a natural compound and has pharmacopoeia and API impurity. It is an analytical standard for HPLC and research and development. It is a high purity synthetic with impurity standard.</p>

<p>Defluoro atorvastatin calcium is a bulk drug that has been approved to be used as an adjunct to diet to reduce elevated cholesterol levels in adults. Defluoro atorvastatin calcium is the desfluoro-enantiomer of atorvastatin, which is a statin that inhibits the enzyme HMG-CoA reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonic acid, which is an early step in the synthesis of cholesterol. The fluoro group on defluoro atorvastatin calcium is not expected to have any significant effect on its potency or metabolic pathways and any impurities are not expected to have any therapeutic effect.</p>

<p>Pitavastatin 3S,5R isomer Calcium Salt is a potent inhibitor of cholesterol biosynthesis. It is marketed as the hemihydrate form under the trade name Pravacol and is used in the treatment of type 2 diabetes. Pitavastatin 3S,5R isomer Calcium Salt inhibits cholesterol biosynthesis by blocking HMG-CoA reductase, which converts 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate (MVA). The active metabolite, pitavastatin, binds to the regulatory region of HMG-CoA reductase and prevents it from converting MVA to HMG-CoA. This reduces the pool of HMG-CoA available for conversion to cholesterol. The inhibition of this enzyme slows down the production of cholesterol and decreases blood levels. It has been approved for use in adults with type 2 diabetes and for lowering high</p>

<p>5-[(Dimethylamino)methyl]furan-2-yl]methanethiol, oxalate is a chemical compound with the molecular formula of C4H8O2S. It is a colorless to pale yellow liquid that is soluble in water and ethanol. This product is used as an impurity standard for HPLC analysis of drugs and as a synthetic intermediate in the drug development process. 5-[(Dimethylamino)methyl]furan-2-yl]methanethiol, oxalate can be synthesized from furfuryl alcohol and methylamine under mild conditions. The purity of this product can be determined by HPLC analysis or GCMS analysis.</p>

<p>Pantoprazole sodium hydrate is a custom synthesis that is used as a drug product. The CAS number for this compound is 624742-53-6. This compound has the following impurities: D and F. Pantoprazole sodium hydrate has been shown to be metabolized in vitro by human liver microsomes to its metabolites, including the following: (1) pantoprazol acid, (2) 4-hydroxypantoprazol acid, (3) 4-hydroxyisoxazole acid, and (4) 5-(4-hydroxyphenyl)-2H-1,2-benzoxazin-3(4H)-one. The metabolite 4-hydroxypantoprazol acid has been found to be pharmacologically active in animal models of gastric ulceration and healing.</p>

Methyl 2-disazobenzoate hydrochloride is a drug product that is used as an HPLC standard and as a metabolite in the development of drugs. It has been found to be naturally occurring and is a research and development metabolite. Methyl 2-disazobenzoate hydrochloride is also an impurity of API, which can be quantified in analytical studies. It is a synthetic compound with CAS No. 35358-78-2 and it can be used to manufacture high purity pharmaceuticals. Methyl 2-disazobenzoate hydrochloride has been shown to have niche pharmacological effects, such as anti-inflammatory activities.

<p>N-(Cyclohexylcarbamoyl)-4-(2-((cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide is a drug product that is an analytical standard. It is metabolized in the body to 4-aminobenzenesulfonamide and cyclohexylurea. This product has been shown to have antibacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, and other bacteria. It also has analgesic properties, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>3-(Dimethylamino)-1-(3-thienyl)propan-1-ol (DMAT) is an impurity that was identified in a drug product and that is not found in the natural form. DMAT is an intermediate of the synthesis of DMH, which is used as a research and development tool. DMAT has been shown to be metabolized by cytochrome P450 enzymes and other oxidative reactions, such as oxidation by cytochrome P450 enzymes or conjugation with glucuronic acid. DMAT also binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>(5α)-17-(3-Pyridinyl)androst-16-en-3-one is a natural metabolite of testosterone that is produced in the liver. It has been identified as an impurity in API, which can be found in drugs used for the treatment of high blood pressure and prostate cancer. (5α)-17-(3-Pyridinyl)androst-16-en-3-one is not active as a drug itself, but it can be used as a standard to study the metabolism of testosterone and other steroids.</p>

<p>Olmesartan medoxomil is a prodrug that is metabolized to the active form, olmesartan, in the liver. The esters of olmesartan medoxomil are metabolized by hydrolysis and by esterases. The most common side effects of olmesartan medoxomil are headache, dizziness, fatigue, nausea and diarrhea. Olmesartan medoxomil is used for the treatment of high blood pressure in adults. This drug also has anti-inflammatory properties due to its inhibition of prostaglandin synthesis.</p>

<p>2,3,4-Trimethoxybenzyl alcohol is a photooxidant that is used in pharmaceutical formulations. It has a catalytic effect on the photooxidation of trifluoroacetic acid and is used for the production of fluoroquinolones. It can also be used to produce other pharmaceutical compounds such as antibiotics and anti-cancer drugs. 2,3,4-Trimethoxybenzyl alcohol is found in small quantities in many natural products such as fruits and vegetables. It has been shown to have potential impurities including 4-methoxybenzaldehyde and selectivity modifiers.</p>

<p>Olanzapine N-oxide is a metabolite of olanzapine. It is produced by the oxidative deamination of olanzapine, which is catalyzed by cytochrome P450 enzymes. Olanzapine N-oxide has been shown to be responsible for some of the side effects associated with olanzapine, such as weight gain and sedation. The presence of olanzapine N-oxide in human plasma has been shown to increase with age and in women, which may be due to its higher affinity for α1-acid glycoprotein. Olanzapine N-oxide can be detected in urine or faeces using gas chromatography/mass spectrometry (GC/MS) or liquid chromatography with tandem mass spectrometry (LC/MS).</p>

<p>Intermediate in the synthesis of empagliflozin</p>

<p>Fondenafil is a drug that belongs to the class of PDE-5 inhibitors. It is used for the treatment of erectile dysfunction and pulmonary hypertension. Fondenafil is chemically related to sildenafil, but lacks the ethyl group. Fondenafil has been shown to be effective in treating insulin resistance by increasing glucose uptake in adipose tissue and skeletal muscle cells. Fondenafil also reduces blood pressure, cholesterol, and triglyceride levels in patients with metabolic syndrome.</p>

5-Aminolevulinic acid hexyl ester hydrochloride (5-ALA HCl) is a fluorescent probe that is used in the diagnosis of bladder and skin cancers. It is a prodrug that is converted to 5-aminolevulinic acid (ALA), which reacts with intracellular porphyrins to form an excited state. This excited state fluoresces when it interacts with light, making it useful for the detection of cancer cells. 5-ALA HCl has been shown to be effective in the diagnosis of multifocal urothelial carcinoma and cervical intraepithelial neoplasia.

<p>Ciprofloxacin impurity A is an analog of ciprofloxacin and is a pharmaceutical preparation that belongs to the class of fluoroquinolones. It has been shown to be active against P. aeruginosa and other gram-negative bacteria in wastewater treatment systems. Ciprofloxacin impurity A is activated by ethylene diamine and can be eluted with acidic solvents. It also inhibits tumor cell line growth through adsorption mechanism and is used as a drug for cancer chemoprevention in combination with malic acid.</p>

<p>7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one is a palladium catalyst that can be used in a Buchwald reaction. This reaction is an industrially scalable process that has been developed to produce high yields of valuable organic compounds from inexpensive starting materials. The catalytic cycle involves the formation of the palladium species Pd(0) followed by its oxidative addition to an alkyl halide. This addition leads to the formation of a palladium(II) species and subsequent reductive elimination of hydrogen halide. 7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one is used as a catalyst in this process because it selectively reacts with electron rich aromatic substrates to form substituted benzoquinones or phenols. The product distribution is determined by the reactivity of the substrate and the relative rates of competing reactions. Impurities are formed during synthesis due to</p>

<p>Risedronate sodium hydrate is a polymorphic, water-soluble salt of risedronate. It has been used in the treatment of osteoporosis and Paget's disease of bone. Risedronate sodium hydrate binds to calcium ions in the body and prevents them from being deposited in bone tissue. This drug also cross-links collagen fibers in the bone matrix, which increases mineralization and decreases the risk of fracture by strengthening the bones. The monosodium salt form of risedronate is soluble in water and is used as an analytical reagent for determining ionic strength or pH. It has been shown to inhibit ionotropic gelation, which may be due to its polyphosphoric acid content. Risedronate sodium hydrate is a polymorphic, water-soluble salt of risedronate that has been used in the treatment of osteoporosis and Paget's disease of bone. Risedronate sodium hyd</p>

<p>(RS)-Di-(2-methoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate is an impurity standard for the API (Active Pharmaceutical Ingredient) Impurity Standard. It may be used as a reference compound in HPLC analyses of analytical samples. This compound has been evaluated by the National Institute of Standards and Technology (NIST) to be a niche HPLC standard. It is also a metabolite of the drug product Metaxalone.</p>

<p>Atorvastatin epoxy tetrahydrofuran impurity is a byproduct of the synthesis process. It is a white crystalline powder that is soluble in organic solvents and sparingly soluble in water. Atorvastatin epoxy tetrahydrofuran impurity has been shown to be an impurity of atorvastatin. It is not known to have any biological activity, but it may pose a health risk if present in large quantities.</p>

<p>Isotopically labelled metabolite of telmisartan</p>