Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(546 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(268 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(126 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3904 productos de "Ciclo celular / Checkpoint"
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CCT-271850
CAS:CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.Fórmula:C24H29N7OPureza:98%Forma y color:SolidPeso molecular:431.53BIO-7662
CAS:BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.Fórmula:C38H48N6O8SPureza:98%Forma y color:SolidPeso molecular:748.89Pelitrexol
CAS:Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .Fórmula:C20H25N5O6SPureza:98.03%Forma y color:SolidPeso molecular:463.51H3B-968
CAS:H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFórmula:C22H18F6N4O4SPureza:98%Forma y color:SolidPeso molecular:548.46Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Fórmula:C24H20N4O5Forma y color:SolidPeso molecular:444.44ROCK-IN-10
CAS:ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].Fórmula:C25H25N5O3Forma y color:SolidPeso molecular:443.507OXA-06 hydrochloride
CAS:OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].Fórmula:C21H20Cl2FN3Forma y color:SolidPeso molecular:404.31DYRKs-IN-2
CAS:DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.Fórmula:C32H38ClN9O3Pureza:98%Forma y color:SolidPeso molecular:632.165-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFórmula:C16H10IN3O2Forma y color:SolidPeso molecular:403.17KSP-IA
CAS:KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.Fórmula:C21H22F2N2OPureza:98%Forma y color:SolidPeso molecular:356.41CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Fórmula:C22H25F3N6Pureza:98%Forma y color:SolidPeso molecular:430.47Leucettinib-92
CAS:Leucettinib-92 is a multi-kinase inhibitor of DYRK and CLK families with differential nanomolar activity, supporting studies of kinase signaling regulation.Fórmula:C21H22N4OSPureza:98%Forma y color:SolidPeso molecular:378.49CDK9-IN-8
CAS:CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).Fórmula:C31H32FN7O3Pureza:99.54%Forma y color:SolidPeso molecular:569.63Galidesivir hydrochloride
CAS:Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.Fórmula:C11H16ClN5O3Pureza:98%Forma y color:SolidPeso molecular:301.73CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H27FN4O4Pureza:98%Forma y color:SolidPeso molecular:442.48G4/HDAC-IN-1
G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.Fórmula:C36H49ClFN7O4Forma y color:SolidPeso molecular:698.27NITD008
CAS:NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.Fórmula:C13H14N4O4Pureza:98.04%Forma y color:SolidPeso molecular:290.27m-Se3
CAS:m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Fórmula:C29H23IN2SePureza:98%Forma y color:SolidPeso molecular:605.37DNA gyrase B-IN-3
CAS:DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFórmula:C14H9Cl2N3O4SPureza:98%Forma y color:SolidPeso molecular:386.21PLK4-IN-4
CAS:PLK4-IN-4 (compound 22), a potent inhibitor of PLK4, exhibits an IC50 value of 7.9 nM, suggesting its potential use in cancer research [1].Fórmula:C21H23F2N9Forma y color:SolidPeso molecular:439.46PLK1/p38γ-IN-1
CAS:PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellularFórmula:C21H26ClN3O2Pureza:98%Forma y color:SolidPeso molecular:387.9GSK2646264
CAS:GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.Fórmula:C24H26N2O2Forma y color:SolidPeso molecular:374.48Carotegrast
CAS:Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Fórmula:C27H24Cl2N4O5Forma y color:SolidPeso molecular:555.41USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Fórmula:C29H27F3N8OForma y color:SolidPeso molecular:560.57CDK8-IN-3
CAS:CDK8-IN-3 is an inhibitor of CDK8.Fórmula:C22H23N5O2Pureza:98%Forma y color:SolidPeso molecular:389.45DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Fórmula:C19H14BrN5OPureza:98%Forma y color:SolidPeso molecular:408.25Cdk4 Inhibitor
CAS:PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.Fórmula:C20H10BrN3O2Forma y color:SolidPeso molecular:404.2CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Fórmula:C21H23ClN6OPureza:99.07%Forma y color:SolidPeso molecular:410.9Ref: TM-T14901
1mg90,00€5mg210,00€10mg308,00€25mg520,00€50mg745,00€100mg1.018,00€1mL*10mM (DMSO)192,00€hDHODH-IN-1
CAS:hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Fórmula:C17H14N2O2Pureza:99.97%Forma y color:SolidPeso molecular:278.31Ref: TM-T11546
1mg34,00€5mg71,00€10mg103,00€25mg200,00€50mg290,00€100mg404,00€200mg545,00€1mL*10mM (DMSO)78,00€BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Fórmula:C32H26Cl2FN7O3Pureza:98%Forma y color:SolidPeso molecular:646.5DAM-IN-1
CAS:DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Fórmula:C16H17NO4Pureza:98%Forma y color:SolidPeso molecular:287.31MC-Val-Cit-PAB-Ispinesib
CAS:MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].Fórmula:C59H71ClN10O10Forma y color:SolidPeso molecular:1115.71Lamifiban
CAS:Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Fórmula:C24H28N4O6Pureza:98%Forma y color:SolidPeso molecular:468.5Alatrofloxacin
CAS:Alatrofloxacin is a prodrug of trovafloxacin.Fórmula:C26H25F3N6O5Forma y color:SolidPeso molecular:558.51SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Fórmula:C22H24F3N3O4Pureza:98%Forma y color:SolidPeso molecular:451.44MOMA-341
CAS:MOMA-341, ATP-competitive WRN allosteric inhibitor (Cys727 site), induces DNA damage and tumor regression in dMMR/MSI-H models, for solid tumors.Fórmula:C28H26F4N6O3Forma y color:SolidPeso molecular:570.54ML 315 hydrochloride
CAS:ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].
Fórmula:C18H14Cl3N3O2Forma y color:SolidPeso molecular:410.682DHX9-IN-6
CAS:DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.Fórmula:C23H18ClFN4O4S2Pureza:99.71%Forma y color:SolidPeso molecular:533Spirofylline
CAS:Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.Fórmula:C24H28N6O5Pureza:98%Forma y color:SolidPeso molecular:480.52DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Fórmula:C17H19N5OForma y color:SolidPeso molecular:309.37Kif15-IN-2
CAS:Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Fórmula:C20H20N6O4SPureza:98.17%Forma y color:SolidPeso molecular:440.48LDC3140
CAS:LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Fórmula:C23H33N7OPureza:98%Forma y color:SolidPeso molecular:423.55Senexin C
CAS:Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Fórmula:C28H27N5OPureza:98.06%Forma y color:SolidPeso molecular:449.55FAICAR
CAS:FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.Fórmula:C10H15N4O9PForma y color:SolidPeso molecular:366.22ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Fórmula:C17H17N3O2SPureza:98%Forma y color:SolidPeso molecular:327.4Myt1-IN-2
CAS:Myt1-IN-2, a highly potent Myt1 inhibitor, exhibits remarkable anticancer properties with an IC50 value below 10 nM (WO2021195782A1; compound 28) [1].Fórmula:C18H16N6O2SForma y color:SolidPeso molecular:380.425'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].Fórmula:C42H51N4O9PForma y color:SolidPeso molecular:786.85DNA polymerase-IN-1
CAS:DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.Fórmula:C10H7ClO4Pureza:99.16%Forma y color:SolidPeso molecular:226.61CDK9-IN-19
CAS:CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.Fórmula:C26H22F2N4O5Forma y color:SolidPeso molecular:508.47DHX9-IN-4
CAS:DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Fórmula:C21H22ClN5O4S2Pureza:98.12%Forma y color:SolidPeso molecular:508.0112R-LOX-IN-1
CAS:12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.Fórmula:C15H11NO2Forma y color:SolidPeso molecular:237.25Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Fórmula:C24H28N4O4Pureza:99.67% - 99.84%Forma y color:SolidPeso molecular:436.5Ref: TM-T14960
1mg73,00€5mg160,00€10mg250,00€25mg430,00€50mg645,00€100mg888,00€1mL*10mM (DMSO)173,00€ATN-161
CAS:ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Fórmula:C23H35N9O8SPureza:98%Forma y color:SolidPeso molecular:597.64MS-444
CAS:MS-444 (BE-34776) is an MLCK and HuR inhibitor with antitumor activity that can be used to study triple-negative breast cancer and colorectal cancer.Fórmula:C13H10O4Pureza:99.45% - 99.45%Forma y color:SolidPeso molecular:230.22Xylocydine
CAS:Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.Fórmula:C12H14BrN5O5Forma y color:SolidPeso molecular:388.17Cytarabine 5′-monophosphate
CAS:Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.Fórmula:C9H14N3O8PForma y color:SolidPeso molecular:323.198Gly-Arg-Gly-Asp-Ser TFA
CAS:Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Fórmula:C19H31F3N8O11Forma y color:SolidPeso molecular:604.495′-Guanylyl methylenediphosphonate sodium
CAS:5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].Fórmula:C11H15N5Na3O13P3Forma y color:SolidPeso molecular:587.15Cdc7-IN-12
CAS:Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).Fórmula:C16H14N2O2SForma y color:SolidPeso molecular:298.36RAD51-IN-4
CAS:RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Fórmula:C31H34FN5O5S2Forma y color:SolidPeso molecular:639.76Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Forma y color:SolidPeso molecular:512.46CDK7-IN-14
CAS:CDK7-IN-14 (compound 3) is a pyrimidine-derived CDK7 inhibitor applicable for studying cancers associated with transcriptional dysregulation.Fórmula:C22H24F3N6OPPureza:99.24% - 99.48%Forma y color:SolidPeso molecular:476.43Lotrafiban
CAS:Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.Fórmula:C23H32N4O4Forma y color:SolidPeso molecular:428.52TAS-114
CAS:TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.Fórmula:C21H29N3O6SPureza:99.76%Forma y color:SolidPeso molecular:451.54VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Fórmula:C31H34N6O3Pureza:98%Forma y color:SolidPeso molecular:538.64Cdc7-IN-7
CAS:Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.
Fórmula:C21H22N4O5Pureza:98.78%Forma y color:SolidPeso molecular:410.42IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Fórmula:C23H21Cl2NO5Pureza:98%Forma y color:SolidPeso molecular:462.32Brodimoprim
CAS:Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).Fórmula:C13H15BrN4O2Pureza:98% - 99.71%Forma y color:SolidPeso molecular:339.19MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Fórmula:C15H15BrF3N7Forma y color:SolidPeso molecular:430.23SB-743921 free base
CAS:SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Fórmula:C31H33ClN2O3Pureza:98%Forma y color:SolidPeso molecular:517.06Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Pureza:95%Forma y color:LiquidPeso molecular:143.64 kDa5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS:5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.Fórmula:C49H56N5O9PForma y color:SolidPeso molecular:889.97LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Fórmula:C23H29N7O3HClForma y color:SolidPeso molecular:488PD-L1-IN-2
CAS:PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.Fórmula:C33H38N4O6Pureza:98%Forma y color:SolidPeso molecular:586.68WRN inhibitor 1
CAS:WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.Fórmula:C16H13FN2O4SPureza:98%Forma y color:SolidPeso molecular:348.35DCB-3503
CAS:DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.Fórmula:C24H27NO5Forma y color:SolidPeso molecular:409.47ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Fórmula:C20H20FN5O2Pureza:98%Forma y color:SolidPeso molecular:381.4Zaurategrast
CAS:Zaurategrast (CDP323) is an oral α4-integrin antagonist that blocks VCAM-1 interactions and is used to study immune cell trafficking.Fórmula:C26H25BrN4O3Pureza:98%Forma y color:SolidPeso molecular:521.41TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Fórmula:C19H29ClN6OPureza:98%Forma y color:SolidPeso molecular:392.93COH1
CAS:COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].Fórmula:C11H10N2O3SPureza:98%Forma y color:SolidPeso molecular:250.27L 738167
CAS:L 738167 is a potent antagonist of the long-acting fibrinogen receptor.Fórmula:C25H34N6O6SForma y color:SolidPeso molecular:546.64GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Fórmula:C19H16N6OPeso molecular:344.37ROCK2-IN-7
CAS:ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.Fórmula:C26H28FN5OPureza:98%Forma y color:SolidPeso molecular:445.53CI 972 anhydrous
CAS:CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.Fórmula:C11H12ClN5OSPureza:98%Forma y color:SolidPeso molecular:297.76RNA polymerase II-IN-1
CAS:RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Fórmula:C38H53N11O12SPureza:98%Forma y color:SolidPeso molecular:887.96Pencitabine
CAS:Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.Fórmula:C15H20F3N3O6Forma y color:SolidPeso molecular:395.33BMT-090605 hydrochloride
CAS:BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.Fórmula:C21H25ClN4O2Forma y color:SolidPeso molecular:400.91BMT-090605
CAS:BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.Fórmula:C21H24N4O2Pureza:98%Forma y color:SolidPeso molecular:364.44PTC258
CAS:PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivoFórmula:C16H18ClN3S2Forma y color:SolidPeso molecular:351.92L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Fórmula:C22H26N4O5S3Forma y color:SolidPeso molecular:522.66G-5758
CAS:G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.Fórmula:C27H24F4N6O3SForma y color:SolidPeso molecular:588.58T521
CAS:T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Fórmula:C17H14FNO5S2Pureza:99.71%Forma y color:SolidPeso molecular:395.43CDK7-IN-25
CAS:CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].Fórmula:C33H32N6O3Pureza:98%Forma y color:SolidPeso molecular:560.65TNP-351
CAS:Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.Fórmula:C21H24N6O5Forma y color:SolidPeso molecular:440.45(2S,3R)-Voruciclib
CAS:(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.Fórmula:C22H19ClF3NO5Pureza:98%Forma y color:SolidPeso molecular:469.84Voruciclib hydrochloride
CAS:Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Fórmula:C22H20Cl2F3NO5Pureza:98%Forma y color:SolidPeso molecular:506.3Mps1-IN-10
CAS:Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFórmula:C24H27N7O2Forma y color:SolidPeso molecular:445.52ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Fórmula:C14H13NO2SPureza:99.73%Forma y color:SolidPeso molecular:259.32Ref: TM-T22991
1mg46,00€2mg60,00€5mg90,00€10mg144,00€25mg289,00€50mg462,00€100mg672,00€1mL*10mM (DMSO)88,00€Lerociclib
CAS:Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Fórmula:C26H34N8OPureza:99%Forma y color:SolidPeso molecular:474.6Mefenidil
CAS:Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Fórmula:C12H11N3Pureza:98.27%Forma y color:SolidPeso molecular:197.24
