Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(546 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(226 productos)
- HSP(179 productos)
- Integrin(253 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(124 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
Mostrar 10 subcategorías más
Se han encontrado 3872 productos de "Ciclo celular / Checkpoint"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Ceftriaxone
CAS:Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Fórmula:C18H18N8O7S3Pureza:96.08%Forma y color:SolidPeso molecular:554.586-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS:6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical andFórmula:C11H15N5O4Forma y color:SolidPeso molecular:281.27CDK-IN-12
CAS:CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].Fórmula:C26H29FN6OSForma y color:SolidPeso molecular:492.61Endo-1,4-β-xylanase
CAS:Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Forma y color:SolidMethylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Forma y color:Odour SolidhuATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Forma y color:Odour LiquidCCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Fórmula:C23H29Cl2FN4O4Forma y color:SolidPeso molecular:515.41m7GpppUmpG
CAS:m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Fórmula:C31H42N12O26P4Forma y color:SolidPeso molecular:1122.636-Methoxypurine-9-β-D-(3-methoxy riboside)
6-Methoxypurine riboside is a purine analog with anti-lymphoma activity via DNA synthesis inhibition and apoptosis induction.Fórmula:C12H16N4O5Forma y color:SolidPeso molecular:296.28Ribonuclease T1
CAS:Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.
Forma y color:SolidFarletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Pureza:> 95%Forma y color:LiquidPeso molecular:145.36 kDaSR15006
CAS:SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).Fórmula:C16H20ClN3O4SPureza:99.87%Forma y color:SoildPeso molecular:385.87Garenoxacin
CAS:Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Fórmula:C23H20F2N2O4Pureza:98%Forma y color:SolidPeso molecular:426.41HLB-0532259
CAS:HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Fórmula:C40H44N8O7Forma y color:SolidPeso molecular:748.8275'-O-DMT-ibu-dC
CAS:5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Fórmula:C34H37N3O7Forma y color:SolidPeso molecular:599.67LL-K8-22
LL-K8-22: potent CDK8/cyclin C degrader; DC50 ~2.5μM; hinders STAT1 phosphorylation; curbs E2F/MYC cancer pathways; for TNBC study.Fórmula:C37H43N5OForma y color:SolidPeso molecular:573.77JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Fórmula:C21H26N2O2Pureza:98.57%Forma y color:SolidPeso molecular:338.44Ficellomycin
CAS:Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.Fórmula:C13H24N6O3Forma y color:SolidPeso molecular:312.37dUTP trisodium
CAS:dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
Fórmula:C9H12N2Na3O14P3Pureza:100.00%Forma y color:SolidPeso molecular:534.09(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.
Fórmula:C31H30Cl3N7O2Pureza:99.51%Forma y color:SolidPeso molecular:638.98KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Fórmula:C33H31ClF3N9O4Forma y color:SolidPeso molecular:710.105RNase L ligand 1
RNase L ligand 1 (Compound F1-COOH) serves as a ligand for RNase L and is utilized in the synthesis of F1-RIBOTAC.Fórmula:C21H21Cl2NO3Forma y color:SolidPeso molecular:406.302PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Fórmula:C44H52Cl2N10O7Pureza:98%Forma y color:SolidPeso molecular:903.855-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS:5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.Fórmula:C22H31N3O5SiForma y color:SolidPeso molecular:445.58CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFórmula:C20H22F3N7O3S2Pureza:99.97%Forma y color:SolidPeso molecular:529.56MORF-627
CAS:MORF-627 is an orally active selective inhibitor of integrin αvβ6 (integrinαvβ6), with an IC50 of 9.2 nM as measured in a human serum ligand binding assay. It effectively inhibits αvβ6-mediated activation of TGF-β1 with an IC50 of 2.63 nM and suppresses SMAD2/3 phosphorylation, showing an IC50 of 8.3 nM. Additionally, MORF-627 ameliorates bleomycin-induced pulmonary fibrosis in mice.Fórmula:C31H40FN3O4Forma y color:SolidPeso molecular:537.672'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolentFórmula:C22H43FN7O7PForma y color:SolidPeso molecular:567.59FRα-targeting peptide C7
CAS:FRα-targeting peptide C7 is a selective peptide ligand for folate receptor α (FRα), exhibiting specific binding capabilities to cells expressing FRα and potential for in vivo tumor targeting. This peptide is utilized in research for tumor diagnosis and therapy.Fórmula:C62H90N18O16SPeso molecular:1375.55PARP-1-IN-32
CAS:PARP-1-IN-32 (compound 15) is an inhibitor of poly (ADPribose) polymerase-1 (PARP-1), specifically designed for use in cancer research.Fórmula:C21H16N2O5Forma y color:SolidPeso molecular:376.36dTAG Targeting Ligand 1
CAS:dTAG Targeting Ligand 1 (SUBSTITUTE SHEET 245) serves as a ligand for target proteins in PROTAC (Proteolysis Targeting Chimera) applications. It is used in the synthesis of PROTACs.Fórmula:C22H27N5O4Forma y color:SolidPeso molecular:425.482'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Fórmula:C9H11FN2O5Forma y color:SolidPeso molecular:246.19Cy5-dATP
Cy5-dATP is a Cy5 -labeled dATP . Cy5-dATP can be incorporated into a DNA primer [1] [2] .
Fórmula:C47H58N7O19P3S2Forma y color:SolidPeso molecular:1182.05Cdk2/Cyclin Inhibitory Peptide II
CAS:Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, demonstrates dose-dependent cytotoxic effects on U2OS osteosarcoma cells [1].Fórmula:C110H200N48O25Forma y color:SolidPeso molecular:2595.07Levomefolate magnesium
CAS:Levomefolate magnesium is the main active folate in food and plasma, essential for DNA synthesis and amino acid regulation, safe for use as a supplement.Fórmula:C20H23MgN7O6Forma y color:SolidPeso molecular:481.74Anticancer agent 190
Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ, demonstrating efficacy against breast cancer.Fórmula:C21H13ClF2N2OSPeso molecular:414.04052Arg-Gly-Glu-Ser TFA
Arg-Gly-Glu-Ser TFA, an RGD-related peptide, serves as a control for evaluating the inhibitory activity of RGDS on fibrinogen binding to activated platelets.Fórmula:C18H30F3N7O10Forma y color:SolidPeso molecular:561.47YRGDS Fibronectin Fragment
CAS:This is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets. It is RGD consisting of sequence.Fórmula:C24H36N8O10Pureza:98%Forma y color:SolidPeso molecular:596.592'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium, an ATP analog, exhibits robust mixed-type inhibition of poly(AU) synthesis.Fórmula:C10H11FLi4N5O12P3Forma y color:SolidPeso molecular:532.95'-O-TBDMS-N2-ibu-dG
CAS:5'-O-TBDMS-N2-ibu-dG: a nucleoside derivative with strong anti-BVDV activity, useful in lead compound synthesis.Fórmula:C20H33N5O5SiForma y color:SolidPeso molecular:451.592'-O-(2-Methoxyethyl)guanosine 5'-triphosphate ammonium
2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate (ammonium), a purine nucleoside analog, exhibits extensive antitumor properties, particularly against indolentFórmula:C13H34N9O15P3Forma y color:SolidPeso molecular:649.38Zelavespib HCl
CAS:PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.Fórmula:C18H22ClIN6O2SPureza:99.45%Forma y color:SoildPeso molecular:548.83c-Myc ligand 1
CAS:c-Mycligand 1 is a c-Myc inhibitor and functions as a ligand for target proteins in PROTAC (Proteolysis Targeting Chimeras). It is utilized in the synthesis of PROTAC c-Myc inhibitor 7.Fórmula:C13H10N2O2Peso molecular:226.23TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Fórmula:C30H33N7O2Pureza:97.39%Forma y color:SolidPeso molecular:523.63EC-1456
CAS:EC-1456 is a folate-microtubule targeting agent that exhibits significant antiproliferative activity against folate receptor (FR) positive tumors, including models resistant to anticancer drugs. EC-1456 is utilized in cancer research.Fórmula:C110H165N23O45S3Forma y color:SolidPeso molecular:2625.81SP27
CAS:SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Fórmula:C40H40F2N12O5Pureza:98%Forma y color:SolidPeso molecular:806.82αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Fórmula:C25H32F2N4O3Forma y color:SolidPeso molecular:474.54Emofolin sodium
CAS:Emofolin sodium, a synthetic folate analogue, inhibits DNA/RNA/protein synthesis by blocking dihydrofolate reductase.Fórmula:C21H25N7Na2O6Pureza:98%Forma y color:SolidPeso molecular:517.45Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester
Uridine analogue with antitumor effects; inhibits DNA synthesis, induces apoptosis in lymphoid cancers.Fórmula:C24H24N2O9Forma y color:SolidPeso molecular:484.46T20-M
T20-M is a precursor peptide with strong binding affinity for UBE2C.Fórmula:C87H140N22O26SForma y color:SolidPeso molecular:1942.24DNA Gyrase-IN-10
DNA Gyrase-IN-10 is a potent inhibitor of DNA gyrase, exhibiting strong antibacterial activity. It effectively inhibits both Gram-positive and Gram-negative bacteria.Fórmula:C26H24BrFN6O3Peso molecular:566.10773CDK12-IN-2
CAS:CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.
Fórmula:C32H32N6O2Pureza:99.31%Forma y color:SolidPeso molecular:532.642'-Deoxy-2'-fluoro-N3-(n-dodecyl)uridine
2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C21H35FN2O5Forma y color:SolidPeso molecular:414.51Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Fórmula:C15H18FN3O2SPureza:98%Forma y color:SolidPeso molecular:323.39Ref: TM-T7492
1mg75,00€5mg150,00€10mg238,00€25mg530,00€50mg873,00€100mg1.459,00€1mL*10mM (DMSO)166,00€c-Myc inhibitor 5
DA3: Fluorescent c-Myc inhibitor, targets c-MYC G-quadruplex (K D 16 μM), selective, suppresses c-MYC expression.Fórmula:C30H46N12Forma y color:SolidPeso molecular:574.771-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine
1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog.Fórmula:C18H21N5O5Forma y color:SolidPeso molecular:387.395'-ODMT cEt G Phosphoramidite (Amidite)
CAS:5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Fórmula:C46H56N7O9PForma y color:SolidPeso molecular:881.95Ac-dA Phosphoramidite
CAS:Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Fórmula:C42H50N7O7PForma y color:SolidPeso molecular:795.878SD49-7
CAS:SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.Fórmula:C18H14N2O3Pureza:99.91%Forma y color:SoildPeso molecular:306.32Ref: TM-T67781
1mg57,00€5mg124,00€10mg178,00€25mg359,00€50mg520,00€100mg745,00€500mg1.485,00€1mL*10mM (DMSO)141,00€DG1
DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressingFórmula:C19H17N5O5SForma y color:SolidPeso molecular:427.43HB-3-20
HB-3-20 induces the degradation of integrin αVβ5 on the cell surface. Transglutaminase 2 (TG2) specifically interacts with HB-3-20, exhibiting a catalytic efficiency (kcat/KM) of 0.16 μM^-1min^-1.Fórmula:C69H102N20O20Forma y color:SolidPeso molecular:1531.67Tirandamycin A
Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.Fórmula:C22H27NO7Forma y color:SolidPeso molecular:417.458c(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Fórmula:C29H42F3N9O9Forma y color:SolidPeso molecular:717.69N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C14H21N5O6Forma y color:SolidPeso molecular:355.356-Thioguanosine
CAS:6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.Fórmula:C10H13N5O4SPureza:97.05%Forma y color:Yellow-Green PowderPeso molecular:299.31CDK6/9-IN-1
CAS:CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).Fórmula:C22H25ClN8OForma y color:SolidPeso molecular:452.95Nocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.Fórmula:C29H42N6O9Forma y color:Odour SolidPeso molecular:618.68IBU-DC Phosphoramidite
CAS:IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Fórmula:C43H54N5O8PForma y color:SolidPeso molecular:799.906GS-443902 trisodium
CAS:GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.Fórmula:C12H16N5O13P3·xNaForma y color:SolidDeoxythymidine-5'-triphosphate
CAS:Deoxythymidine-5'-triphosphate (dTTP) is a nucleoside triphosphate involved in DNA synthesis.Fórmula:C10H17N2O14P3Forma y color:SolidPeso molecular:482.167Cytidine 5'-diphosphate trisodium salt
CAS:CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.Fórmula:C9H15N3Na3O11P2Pureza:99.55%Forma y color:White Crystalline PowderPeso molecular:472.15Biotin-PEG7-C2-NH-Vidarabine-S-CH3
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG linker with Vidarabine, an anti-herpes/zoster antiviral.Fórmula:C37H62N8O12S2Forma y color:SolidPeso molecular:875.06Chk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Fórmula:C16H18F3N7Forma y color:SolidPeso molecular:365.3646-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity byFórmula:C15H17N5O6Forma y color:SolidPeso molecular:363.33IRE1α kinase-IN-6
CAS:IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.Fórmula:C25H23Cl2FN6O3S2Forma y color:SolidPeso molecular:609.52LDV FITC
CAS:fluorescent ligand that binds to the α4β1 integrin (VLA-4)Fórmula:C69H81N11O17SPureza:98%Forma y color:SolidPeso molecular:1368.532'-Chloro-N6-(3-trifluoromethyl)benzyl adenosine
2’-Chloro-N6-(3-trifluoromethyl)benzyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoidFórmula:C18H17ClF3N5O4Forma y color:SolidPeso molecular:459.81α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFórmula:C14H22N4O9Pureza:98%Forma y color:SolidPeso molecular:390.35LL-K12-18
LL-K12-18 is a dual-site molecular gel that enhances PPI between CDK12-DDB1 complexes thereby promoting the degradation of Cyclin K and anti-proliferation.Fórmula:C25H32Cl2N10OPureza:98.08% - 99.77%Forma y color:SoildPeso molecular:559.495'-O-DMT-N4-Bz-2'-F-dC
CAS:5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.Fórmula:C37H34FN3O7Forma y color:SolidPeso molecular:651.68CDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Fórmula:C21H20ClN3O2Pureza:98.55% - 99.22%Forma y color:SoildPeso molecular:381.86Ref: TM-T72048
1mg52,00€5mg101,00€10mg150,00€25mg250,00€50mg363,00€100mg509,00€200mg695,00€1mL*10mM (DMSO)116,00€Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Fórmula:C12H16N6O5Forma y color:SolidPeso molecular:324.29GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Fórmula:C21H22N6O2Forma y color:SolidPeso molecular:390.44UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Fórmula:C39H35NO10C6H15NForma y color:SolidPeso molecular:778.34655Psammaplin A
CAS:Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.Fórmula:C22H24Br2N4O6S2Forma y color:SolidPeso molecular:664.38Viquidacin
CAS:NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.Fórmula:C25H29FN2O4S2Forma y color:SolidPeso molecular:504.64JB-11 isethionate
CAS:JB-11 isethionate is a bioactive chemical.Fórmula:C21H29N5O7SForma y color:SolidPeso molecular:495.55Carboxy-pyridostatin
CAS:Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
Fórmula:C35H34N10O7Forma y color:SolidPeso molecular:706.71XT17
XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.Forma y color:Odour SolidDSPE-PEG1000-iRGD
DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.Forma y color:Odour SolidBSJ-03-204 triTFA
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for theFórmula:C49H51F9N10O14Pureza:98%Forma y color:SolidPeso molecular:1174.97BLINK15
BLINK15 is a blood-brain barrier-permeable Cdk5 inhibitor. It reduces CDK5 activity in CDK5/p35 (IC50= 29.34 nM) and CDK5/p25 (IC50= 12.08 nM) complexes. Additionally, BLINK15 exhibits antidiabetic and neuroprotective effects. It lowers blood glucose levels in type 2 diabetes (T2D) mice, enhances cognitive abilities, and diminishes neurodegenerative lesions.Forma y color:Odour SolidOdulimomab
CAS:Odulimomab: anti-LFA-1 antibody, inhibits T cell growth, protects against ischemic injury, used in transplant rejection research.Forma y color:LiquidLDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Forma y color:SolidPeso molecular:979.138β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS:8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].Fórmula:C15H18O4Forma y color:SolidPeso molecular:262.3CDK12-IN-4
CAS:CDK12-IN-4 is a pyrazolotriazine that inhibits CDK12 (IC50: 0.641 μM) with high ATP (2 mM) and spares CDK2/Cyclin E and CDK9/Cyclin T1 (IC50: >20 μM).Fórmula:C20H20F2N8OForma y color:SolidPeso molecular:426.432T-2513
CAS:T-2513 inhibits topoisomerase I by covalently bonding to its DNA complex, blocking DNA replication and causing cell death.Fórmula:C25H27N3O5Forma y color:SolidPeso molecular:449.507KGDS
CAS:KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].Fórmula:C15H27N5O8Forma y color:SolidPeso molecular:405.4IV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Fórmula:C23H32FN5O2SiForma y color:SolidPeso molecular:457.62516,16-dimethyl Prostaglandin A1
CAS:16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Fórmula:C22H36O4Forma y color:SolidPeso molecular:364.526Sp-dUTPαS tetrasodium
Sp-dUTPαS tetrasodium is an isomer of the sulfur-containing nucleotide dUTPαS.Forma y color:Odour Solid
![6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT75185.webp&w=3840&q=75)
