Metabolismo

<p>Mefentrifluconazole: potent, selective oral fungicide; strong CYP51 blocker, weaker on human aromatase; novel azole for broad-spectrum use.</p>

<p>SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.</p>

<p>Hi 76-0079: HSL inhibitor, IC50=184 nM; potential for obesity and diabetes research.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>

<p>NE 10790, similar to risedronate, is a mild bone resorption inhibitor but poorly blocks FPP synthase.</p>

<p>Praziquantel (Droncit) is an anthelmintic that paralyzes worms by increasing calcium in muscle cells, causing tegument damage and immune response.</p>

<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>

<p>3-Pyridinemethanol (Roniacol) is an alcohol analog of nicotinic acid which is a peripheral vasodilator that causes flushing and may decrease blood pressure.</p>

<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>

<p>FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).</p>

<p>Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).</p>

<p>Abiraterone Acetate (CB7630) is an androstene derivative that inhibits steroid 17-alpha-hydroxylase and is used as an antineoplastic agent.</p>

<p>Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.</p>

<p>Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.</p>

<p>PKR-IN-2 is a activator of pyruvate kinase (PKR).</p>

<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>

<p>CRAC intermediate 1 (5-(S)-Fluorowillardiine) is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors.</p>

<p>PF-06424439 methanesulfonate: oral, potent, selective DGAT2 inhibitor (IC50=14 nM), noncompetitive, slowly reversible.</p>

<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>

<p>5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. It can be used in the preparation of disease-modifying antirheumatic drugs (DMARDs).</p>

<p>Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.</p>

<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>

<p>Eliglustat hemitartrate (Genz-112638) , with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.</p>

<p>Olutasidenib (FT-2102), an IDH1 inhibitor (IC50: 21.2/114 nM), is studied for treating AML/MDS and can cross the blood-brain barrier.</p>

<p>PEP 3 CHA: a carbohydrate metabolite with cytoprotection and antioxidant properties; cell membrane permeable.</p>

<p>Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.</p>

<p>SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties.</p>

<p>AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM).</p>

<p>JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor with anticancer and antitumor activity for the study of breast, lung, and esophageal cancers.</p>

<p>Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.</p>

<p>N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.</p>

<p>LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.</p>

<p>APOL1-IN-2 (Compound 467) acts as an inhibitor of apolipoprotein L1 (APOL1). It effectively reduces HEK293 cell death induced by APOL1 G2/G1, with EC50 values of 4.74 nM and 14.3 nM, respectively. Additionally, APOL1-IN-2 decreases the mortality of trypanosomes triggered by APOL1 G2/G1/G0, with EC50 values of 2.24, 6.03, and 3.72 nM, respectively.</p>

<p>5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is a metabolic byproduct of gut microbiota processing of (-)-Epicatechin. [5-(3',4'-Dihydroxyphenyl)-γ-valerolactone] exhibits antioxidant properties.</p>

<p>L-Hisidine is an essential amino acid for infants and acts as an inhibitor of mitochondrial glutamine transport.</p>

<p>1,2-Dihexadecyl-sn-glycero-3-PC can be used in related research in the field of life sciences. Its product number is T37043 and CAS number is 36314-47-3.</p>

<p>Norpropranolol hydrochloride is the active metabolite of Propranolol.</p>

<p>5-Aminoisotonitazene is a metabolite of the synthetic opioid analgesic agent, Isotonitazene, found in urine.</p>

<p>BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).</p>

<p>PKM2-IN-3 inhibits PKM2 kinase with 4.1 μM IC50, curbing glycolysis and NLRP3, reducing neuroinflammation.</p>

<p>Boc-L-aspartic acid 4-benzyl ester (Boc-Asp(OBzl)-OH) is an aspartic acid derivative.</p>

<p>Photo-DL-lysine is a photo-reactive amino acid based on DL-lysine used to capture proteins that are post-translationally modified by lysine binding.</p>

<p>TPH1-IN-1 (compound 40) is a xanthine derivative that serves as an inhibitor of tryptophan hydroxylase TPH1, with an IC50 of 110.1 nM.</p>

<p>Antiproliferative agent-13 is a compound with antiproliferative activity.</p>

<p>Endogenous metabolite: 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine, a phosphatidylcholine example.</p>

<p>E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.</p>

<p>Propionylcarnitine (Propionyl carnitine) is a widely used dietary supplement that has been associated with glaucoma and does it ruptu</p>

<p>MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3, with a Ki value of 0.55 μM for ALDH1A3 and 78.2 μM for ALDH1A1. It inhibits retinoic acid biosynthesis and can reduce the viability of glioblastoma cells GSC-83 and GSC-326.</p>

<p>Muvalaplin tetrahydrochloride (LY3473329) is an orally active lipoprotein (a)Lp(a) agent currently under investigation. Research on the oral formulation of Muvalaplin tetrahydrochloride is ongoing.</p>