Neurociencia

<p>Amisulpride (Solian/Deniban), a dopamine antagonist antipsychotic, treats psychosis and schizophrenia in Europe/Australia, not in the US.</p>

<p>Venlafaxine HCl, a cyclohexanol phenethylamine, acts as an SNRI antidepressant.</p>

<p>Domperidone EP Impurity A is used as pharmaceutical intermediates.</p>

<p>Tenoxicam (Tilcotil), an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.</p>

<p>Prucalopride (R-93877), a selective 5-HT4A/4B agonist (Ki: 2.5/8 nM), is &gt;290x more specific for these receptors.</p>

<p>Frovatriptan treats all migraine types, nausea, vomiting, light/sound sensitivity, and prevents menstrual migraines; it targets 5-HT1B/D and 5-HT7 receptors.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Cattle GH protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Cattle GH. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Cattle GH in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Gantenerumab (R-1450) is a humanized antibody targeting amyloid-β (Aβ), used in studies of Alzheimer's disease.</p>

<p>Bemegride (3-Ethyl-3-methylglutarimide), a central nervous system stimulant, serves as an antidote for barbiturate poisoning.</p>

<p>Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.</p>

<p>Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).</p>

<p>Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is an effective competitive inhibitor of BChE (Ki value: 3 uM).</p>

<p>Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.</p>

<p>Iloperidone (HP 873) is an atypical antipsychotic agent that is used for treatment of schizophrenia.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pig PGD2S. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Pig PGD2S. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Pig PGD2S, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Pig PGD2S in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.</p>

<p>Carvedilol EP IMpurity E (Carvedilol USP E) is used as a pharmaceutical intermediate.</p>

<p>Benactyzine hydrochloride (Neuroleptone) is a centrally acting muscarinic antagonist.</p>

<p>Molindone hydrochloride (EN-1733A) is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.</p>

<p>Duloxetine hydrochloride is an SNRI used for depression, anxiety, and pain in diabetes and fibromyalgia.</p>

<p>Org-26576 is a positive allosteric modulator of the AMPA receptor.</p>

<p>Nefiracetam (DM9384), in Phase 2 trials, enhances GABA, choline, monoamine systems, and treats Ro 5-4864 convulsions.</p>