Métabolisme

<p>Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). High-Quality, Low-Cost!</p>

<p>1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is a human endogenous metabolite.</p>

<p>Pyrithioxin (Encefabol), a nootropic, enhances cerebral metabolism and, with HV, aids hemiplegic stroke recovery.</p>

<p>ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).</p>

<p>N-Desethyl Chloroquine Hydrochloride ((±)-Desethylchloroquine 2HCl) is a desethylchloroquine derivative.</p>

<p>AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes</p>

<p>LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM).</p>

<p>Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.</p>

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).

<p>Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) relaxes arterioles and lowers blood pressure in mice.</p>

<p>MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.</p>

<p>Cecropin B acetate activates NF-κB, inhibits CYP3A29, disrupts PXR/RXR-α-DNA binding, and has potent antimicrobial properties.</p>

<p>Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.</p>

<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>

<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>

<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>

<p>Amlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker.</p>

<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>

<p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>

<p>Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.</p>

<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.</p>

<p>JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor with anticancer and antitumor activity for the study of breast, lung, and esophageal cancers.</p>

<p>Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.</p>

<p>2-Pyridinecarbohydrazide (2-Picolinyl hydrazide) is an effective inhibitor of Catalase-peroxidase-NAPDH.</p>

<p>Cefdinir (FK-482), a semi-synthetic third-gen cephalosporin antibiotic, treats ear, sinus, throat, and skin infections.</p>

TNO155 inhibits SHP2 enzyme with an IC50 of 0.011 μM, potentially aiding cancer treatment.

<p>Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.</p>

<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).</p>

<p>(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19.Cost-effective and quality-assured.</p>

<p>Naringinase, with α-L-rhamnosidase and β-D-glucosidase activities, transforms steroids, antibiotics, and glycosides.</p>

<p>Hyaluronic acid sodium (MW 40 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>

<p>Hyaluronic acid sodium (MW 20 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.</p>

<p>Hyaluronic acid sodium (MW 100 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>Hyaluronic acid sodium (MW 300 kDa) is a medium molecule sodium hyaluronate that penetrates into the dermis and stimulates skin metabolism.</p>

<p>Hyaluronic acid sodium (MW 200 kDa) is a medium molecule sodium hyaluronate that penetrates into the dermis and stimulates skin metabolism.</p>

<p>It is an organic compounds with molecular fomula C5H9NO3.</p>

<p>Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.</p>

<p>CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).</p>

<p>IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).</p>

<p>Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity.</p>

<p>Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .</p>

<p>Dehydro Nifedipine (BAY-b 4759), main human plasma nifedipine metabolite, blocks glucose in PC-12 cells, IC50 at 130 μM, forms via CYP3A4/3A5.</p>

<p>GV-58 agonizes N/P-Q-type Ca2+ channels (EC50: 7.21/8.81 μM) with 20x less inhibition on CDK kinases.</p>

<p>Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.</p>

<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>

<p>Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues.</p>

<p>Rivaroxaban (BAY 59-7939) is an oral, direct factor Xa inhibitor with anticoagulant properties, interfering with thrombin formation.</p>

<p>Liarozole dihydrochloride inhibits CYP450, estrogen, androgen synthesis; an oral drug for prostate cancer/skin disorders.</p>

<p>Emicizumab (ACE 910), a humanized antibody, mimics factor VIII, treating and preventing hemophilia A.</p>

<p>MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human,</p>

<p>Turosteride is a small molecule steroidal 5α-reductase (5α-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and</p>

<p>Diminazene is a trypanocidal agent.</p>

<p>PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.</p>

<p>NE 10790, similar to risedronate, is a mild bone resorption inhibitor but poorly blocks FPP synthase.</p>

<p>Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.</p>

Bis(4-cyanophenyl)methanol (4, 4'-Dicyanobenzhydrol) is a metabolite of Letrozole.

<p>IDH-305: Oral, mutation-specific IDH1 inhibitor, 200x selective for R132 mutants; IC50: 27/28/6.14 nM for R132H/C/WT.</p>

<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>

<p>K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM.</p>

<p>Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.</p>

<p>Clorgyline hydrochloride (Clorgiline hydrochloride), a white powder, is served as monoamine oxidase inhibitor.</p>

<p>Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.</p>

<p>Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.</p>

<p>L-Carnitine aids fatty acid oxidation in mitochondria for energy, excluding the brain.</p>

<p>Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling</p>

<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>

<p>2-(Hydroxymethyl)pyridine (Piconol) is an intermediate for the synthesis of the stimulant laxative bisacodyl, and as a pyridinol with hypoglycemic activity.</p>

<p>BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease.</p>

<p>Oteseconazole (VT-1161) is an orally active anti-fungal agent.</p>

<p>Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.</p>

<p>Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.</p>

<p>10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) is used as pharmaceutical intermediates.</p>

<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>

<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>

<p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>

<p>OGT inhibitor 4a is an O-linked n-acetylglucosaminyltransferase (OGT) inhibitor with anticancer activity for the study of autoimmune and neurological disorders.</p>

<p>Caldaret HCl is an intracellular Ca2+ modulator that regulates calcium homeostasis at the sarcoplasmic reticulum and cell membrane, and can be used to study acute myocardial infarction and heart failure.</p>

<p>(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll.</p>

<p>Potent, reversible, non-toxic MPO inhibitor; reduces stroke damage &amp; study aid for bronchial dysplasia.</p>

<p>PF-06424439 methanesulfonate: oral, potent, selective DGAT2 inhibitor (IC50=14 nM), noncompetitive, slowly reversible.</p>

<p>Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: &lt; 72 nM).</p>

<p>1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.</p>

<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>

<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>

<p>Dafadine-A, a dafadine analog, inhibits DAF-9 P450 in C. elegans and mammalian CYP27A1.</p>

<p>Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.</p>

<p>Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.</p>

<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>

<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>

<p>DATPT is a 12WLVSKF17 peptide mimetic molecule with anti-inflammatory and antimicrobial activities.DATPT inhibits the production of reactive oxygen species.</p>

<p>Lunularic acid, a dihydrostilbene analog, efficiently inhibits hyaluronidase activity and can be used as an endogenous growth inhibitor in moss plants.</p>

<p>SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 µM),and used in the research of Alzheimer’s disease.</p>

<p>L-Tyrosine ((S)-Tyrosine) is a naturally occurring tyrosine and is synthesized in vivo from L-phenylalanine, considered a non-essential amino acid.</p>