Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(647 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.028 produtos)
- BACE(37 produtos)
- Beta Amilóide(231 produtos)
- CaMK(73 produtos)
- COX(602 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(373 produtos)
- Gama-secretase(62 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(42 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5638 produtos de "Neurociência"
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UCM 608
CAS:UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.Fórmula:C19H20N2O2Pureza:98.88%Cor e Forma:SolidPeso molecular:308.37L-368,899 hydrochloride
CAS:L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.Fórmula:C26H43ClN4O5S2Pureza:99.59%Cor e Forma:SolidPeso molecular:591.23Ref: TM-T11794
2mg105,00€5mg147,00€1mL*10mM (DMSO)200,00€10mg230,00€25mg439,00€50mg685,00€100mg964,00€3,4-Dihydroxyphenylacetic Acid-13C,18O2
CAS:Applications A labelled metabolite of Dopamine.
References Johnson, S., et al.: J. Physiol., 450, 455 (1992), Kolesnikov, Y., et al.: Eur. J. Pharmacol., 296, 17 (1996), Leshner, A., et al.: Science, 278, 45 (1997), Li, J., et al.: Acta Pharmacol. Sin., 20, 375 (1999), Gibson, D., et al.: Brain Res., 952, 71 (2002), Volpicelli, L., et al.: Pharmacol. Biochem. Behav., 64, 487 (1999),Wei, X., et al.: Eur. J. Pharmacol., 515, 99 (2005)Fórmula:C713CH8O218O2Cor e Forma:NeatPeso molecular:173.14Ketanserin tartrate
CAS:Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist for the study of systemic sclerosis.Fórmula:C26H28FN3O9Pureza:99.68%Cor e Forma:SolidPeso molecular:545.51(R)-Mirtazapine
CAS:(R)-Mirtazapine ((R)-Org3770) is a 5-HT3 receptor antagonist, a potential analgesic with anti-injury perception properties.Fórmula:C17H19N3Pureza:99.75%Cor e Forma:SolidPeso molecular:265.35EasyStep Human PSA(ProstateSpecific Antigen) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PSA, and the Human PSA standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human PSA. After TMB substrate solution is added, only those wells that contain Human PSA and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PSA in the samples is then determined by comparing the OD of the samples to the standard curve.Cor e Forma:Colourless TransparentliquidJatrorrhizine chloride
CAS:Jatrorrhizine chloride (Neprotine chloride) is an alkaloid isolated from Rhizoma coptidis with neuroprotective, antimicrobial, and antiplasmodial activities.Fórmula:C20H20ClNO4Pureza:99.79%Cor e Forma:SolidPeso molecular:373.8ACT-462206
CAS:ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.Fórmula:C20H24N2O4SPureza:99.45%Cor e Forma:SolidPeso molecular:388.48Ref: TM-T26559
1mg42,00€1mL*10mM (DMSO)87,00€5mg88,00€10mg130,00€25mg264,00€50mg423,00€100mg670,00€500mg1.341,00€WAY-100635 maleate
CAS:WAY-100635 Maleate is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).Fórmula:C25H34N4O2·xC4H4O4Pureza:99.96%Cor e Forma:White SolidPeso molecular:538.645Ref: TM-T3453
2mg43,00€5mg63,00€1mL*10mM (DMSO)74,00€10mg89,00€25mg150,00€50mg215,00€100mg316,00€500mg765,00€Rotigotine
CAS:Rotigotine (1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-) is an antiparkinson agent and dopamine receptor agonist.Fórmula:C19H25NOSPureza:99.04% - 99.88%Cor e Forma:SolidPeso molecular:315.47Citalopram
CAS:Citalopram (Lu 10-171), a serotonin and 5-HT reuptake inhibitor.Citalopram has antidepressant activity and may be used to study dementia.Fórmula:C20H21FN2OPureza:99.78% - 99.89%Cor e Forma:SolidPeso molecular:324.39Velufenacin
CAS:Velufenacin is an antagonist of muscarinic receptor[1].Fórmula:C19H20ClFN2O2Pureza:99.65%Cor e Forma:SolidPeso molecular:362.83Ref: TM-T9771
1mg47,00€5mg96,00€1mL*10mM (DMSO)105,00€10mg156,00€25mg270,00€50mg370,00€100mg522,00€200mg687,00€Riluzole
CAS:Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.Fórmula:C8H5F3N2OSPureza:99.71% - 99.88%Cor e Forma:PowderPeso molecular:234.2Syk Inhibitor II
CAS:Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).Fórmula:C14H15F3N6OPureza:97.63%Cor e Forma:SolidPeso molecular:340.3Donepezil-d5
CAS:Donepezil-d5 is a deuterated compound of Donepezil. Donepezil has a CAS number of 120014-06-4. Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alzheimer's type.Fórmula:C24H24D5NO3Cor e Forma:SolidPeso molecular:384.52Acephate-d3 (acetyl-d3)
CAS:Acephate-d3 (acetyl-d3) is a deuterated compound of Acephate. Acephate has a CAS number of 30560-19-1. Acephate is an anticholinesterase insecticide with a weak inhibitory effect on AChE in rats, but it can effectively inhibit AChE in cockroaches.Fórmula:C4H7D3NO3PSCor e Forma:SolidPeso molecular:186.18Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Fórmula:C20H14D3FO2SCor e Forma:SolidPeso molecular:343.43Pyridostigmine-d6 bromide
CAS:Pyridostigmine D6 bromide is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible inhibitor of cholinesterase.Fórmula:C9H13BrN2O2Pureza:98%Cor e Forma:SolidPeso molecular:267.15Chlorpyrifos (diethyl-d10)
CAS:Chlorpyrifos (diethyl-d10) is a deuterated compound of Chlorpyrifos. Chlorpyrifos has a CAS number of 2921-88-2. Chlorpyrifos is an organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.Fórmula:C9H1D10Cl3NO3PSCor e Forma:SolidPeso molecular:360.65Fenitrothion-d6 (O,O-dimethyl-d6)
CAS:Fenitrothion-d6 (O,O-dimethyl-d6) is a deuterated compound of Fenitrothion. Fenitrothion has a CAS number of 122-14-5. Fenitrothion is an organothiophosphate cholinesterase inhibitor. Fenitrothion is used as an insecticide.
Fórmula:C9H6D6NO5PSCor e Forma:SolidPeso molecular:283.27Varenicline
CAS:Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.Fórmula:C13H13N3Pureza:99.76%Cor e Forma:SolidPeso molecular:211.26Ref: TM-T4246L
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg137,00€50mg200,00€100mg313,00€200mg464,00€R 59-022
CAS:R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.Fórmula:C27H26FN3OSPureza:98.55%Cor e Forma:SolidPeso molecular:459.58Ref: TM-T16709
1mg35,00€5mg74,00€1mL*10mM (DMSO)75,00€10mg119,00€25mg269,00€50mg447,00€100mg733,00€200mg973,00€Cyproheptadine hydrochloride
CAS:Cyproheptadine hydrochloride (Periactin hydrochloride) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.Fórmula:C21H21N·HClPureza:99.88% - 99.97%Cor e Forma:SolidPeso molecular:323.86Dilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Pureza:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Cor e Forma:LiquidAnatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Fórmula:C22H28N2O14Pureza:98%Cor e Forma:SolidPeso molecular:544.46Unasnemab
CAS:Unasnemab (MT-3921) binds RGMa, promoting neuroregeneration and locomotor function, showing potential for spinal cord injury and regenerative research.Pureza:95% - 97.4% (SDS-PAGE); 98.3% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.90 kDa(+)-Tomoxetine hydrochloride
CAS:(+)-Tomoxetine hydrochloride is a bioactive chemical.Fórmula:C17H22ClNOPureza:98%Cor e Forma:SolidPeso molecular:291.82Dezamizumab
CAS:Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.Pureza:95% - 98.2% (SDS-PAGE); 98.7% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.82 kDaAtropine hydrobromide
CAS:Atropine hydrobromide is a biochemical.Fórmula:C17H24BrNO3Cor e Forma:SolidPeso molecular:370.28AChE-IN-65
CAS:AChE-IN-65 (Compound DABA_1) serves as a mixed inhibitor of acetylcholinesterase (AChE), exhibiting a Ki of 556.4 μM against Electrophorus electricus AChE.Fórmula:C15H8N2O6Cor e Forma:SolidPeso molecular:312.23Risperidone Mesylate
CAS:Risperidone Mesylate is a selective serotonin 5-HT2 receptor and dopamine D2 receptor blocker.Fórmula:C24H31FN4O5SPureza:98%Cor e Forma:SolidPeso molecular:506.59Keto Ziprasidone
CAS:Ziprasidone, an antipsychotic agent, functions as a dual antagonist of 5-HT (serotonin) and dopamine receptors.Fórmula:C21H19ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:426.92Escitalopram
CAS:Escitalopram (Seroplex), a serotonin inhibitor for depression, curbs alcohol intake and is favored over tricyclics for tardive dyskinesia.Fórmula:C20H21FN2OPureza:99.82%Cor e Forma:White Or White Crystalline PowderPeso molecular:324.39Benmoxin
CAS:Benmoxin is a monoamine oxidase inhibitor (MAOI) that is irreversible and nonselective.Fórmula:C15H16N2OPureza:98%Cor e Forma:SolidPeso molecular:240.30BChE-IN-25
CAS:BChE-IN-25 (compound 4I) acts as a selective inhibitor of BChE, demonstrating an IC 50 of 3.77μM and exhibiting 22-fold greater selectivity towards BChE over AChE [1].Fórmula:C17H23NO2Cor e Forma:SolidPeso molecular:273.37eeAChE/eqBuChE-IN-1
CAS:eeAChE/eqBuChE-IN-1 (compound 3F) serves as a reversible dual inhibitor of eeAChE/eqBuChE, exhibiting IC50 values of 1.3 μM and 0.81 μM, respectively. In addition, this compound demonstrates anti-inflammatory properties and provides neuroprotective effects against Aβ25-35-induced injury in PC12 cells [1].Fórmula:C14H16N2O2Cor e Forma:SolidPeso molecular:244.29Remternetug
CAS:Remternetug (LY3372993) is a humanised monoclonal antibody targeting N3pG-Aβ, recognising pyroglutamated Aβ within amyloid plaques, Alzheimer's disease.Pureza:95% - 97.6% (SDS-PAGE); 98.7% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.87 kDaTarextumab
CAS:Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.Pureza:95%Cor e Forma:LiquidPeso molecular:~150 kDaBapineuzumab
CAS:Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).Pureza:95%Cor e Forma:LiquidPeso molecular:145.86 kDaN-Methyl amisulpride
CAS:N-Methyl amisulpride (Amisulpride impurity H) is a 5-HT7 receptor, D2 receptor, and D3 receptor antagonist used in the study of acute schizophrenia.Fórmula:C18H29N3O4SCor e Forma:SolidPeso molecular:383.51Arazasetron HCl
CAS:Arazasetron is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27.Fórmula:C17H20ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:349.81Monoamine Oxidase B inhibitor 4
CAS:Monoamine Oxidase B Inhibitor 4 (compound 1l), with a potent IC50 value of 8.3 nM, is a selective human monoamine oxidase-B (hMAO-B) inhibitor. This compound demonstrates anti-neuroinflammatory properties and exhibits low neurotoxicity. It effectively inhibits the release of NO, TNF-α, and IL-1β induced by LPS and Aβ1-42, and additionally mitigates the cytotoxic effects triggered by Aβ(1-42) .Fórmula:C15H11Cl2NO3Cor e Forma:SolidPeso molecular:324.16Rocatinlimab
CAS:Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated IgG1 anti-OX40 monoclonal antibody indicated for atopic dermatitis (AD) research [1].Cor e Forma:Liquid(-)-Deguelin
CAS:Fórmula:C23H22O6Pureza:>95.0%(HPLC)Cor e Forma:White to Yellow to Green powder to crystalPeso molecular:394.42Serotonin Creatinine Sulfate Monohydrate
CAS:Fórmula:C14H19N5O2·H2SO4·H2OPureza:>98.0%(T)Cor e Forma:White to Light yellow powder to crystalPeso molecular:405.43Gestrinone
CAS:Fórmula:C21H24O2Pureza:>98.0%(T)Cor e Forma:Light yellow to Yellow powder to crystalPeso molecular:308.424,5,6,7-Tetrabromobenzotriazole
CAS:Fórmula:C6HBr4N3Pureza:>97.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:434.71Ruthenium(II) Nitrosyl Chloride
CAS:Fórmula:RuCl3NOPureza:>97.0%(T)Cor e Forma:Yellow to Amber to Dark red powder to crystalPeso molecular:255.45Tomatine from Tomato
CAS:Fórmula:C50H83NO21Pureza:>80.0%(HPLC)Cor e Forma:White to Yellow to Orange powder to crystalPeso molecular:1,034.20Medroxyprogesterone
CAS:Fórmula:C22H32O3Pureza:>98.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:344.50Tetrasodium 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
CAS:Fórmula:C22H20N2Na4O10Pureza:>98.0%(T)Cor e Forma:White to Almost white powder to crystalPeso molecular:564.37Hyodeoxycholic Acid
CAS:Fórmula:C24H40O4Pureza:>98.0%(T)Cor e Forma:White to Orange to Green powder to crystalPeso molecular:392.58Pipamperone
CAS:Fórmula:C21H30FN3O2Pureza:>98.0%(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:375.49Lubiprostone
CAS:Fórmula:C20H32F2O5Pureza:>97.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:390.471,2-Dimyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt
CAS:Fórmula:C34H66NaO10PPureza:>98.0%(T)Cor e Forma:White to Almost white powder to crystalPeso molecular:688.86Prostaglandin F2α
CAS:Fórmula:C20H34O5Pureza:>95.0%(T)Cor e Forma:White or Colorless to Almost white or Almost colorless powder to lump to clear liquidPeso molecular:354.49Tyrphostin AG 494
CAS:Fórmula:C16H12N2O3Pureza:>98.0%(HPLC)(N)Cor e Forma:Light yellow to Amber to Dark green powder to crystalPeso molecular:280.28KB-R 7943
CAS:Fórmula:C16H17N3O3S·CH4O3SPureza:>98.0%(HPLC)Cor e Forma:White to Yellow to Green powder to crystalPeso molecular:427.49Milnacipran-d10 Hydrochloride
CAS:Milnacipran-d10 Hydrochloride is a deuterated compound of Milnacipran Hydrochloride. Milnacipran Hydrochloride has a CAS number of 101152-94-7. Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Levomilnacipran is an enantiomer of milnacipran, which is used to treat fibromyalgia. Levomilnacipran and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice.Fórmula:C15H13D10ClN2OCor e Forma:SolidPeso molecular:292.87Homotaurine-d6
CAS:Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.Fórmula:C3D6H3NO3SCor e Forma:SolidPeso molecular:145.21Mirtazapine D3
CAS:Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .Fórmula:C17H19N3Pureza:98%Cor e Forma:SolidPeso molecular:268.37Brexpiprazole-d8
CAS:Brexpiprazole D8 is a deuterium-modified partial agonist of 5-HT1A and dopamine receptors, with Ki values of 0.12 nM and 0.3 nM respectively.Fórmula:C25H27N3O2SPureza:98%Cor e Forma:SolidPeso molecular:441.62Amitriptyline-d6 Hydrochloride
CAS:Amitriptyline-d6 Hydrochloride is a deuterated compound of Amitriptyline Hydrochloride. Amitriptyline Hydrochloride has a CAS number of 549-18-8. Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.Fórmula:C20H18D6ClNCor e Forma:SolidPeso molecular:319.90Pardoprunox
CAS:Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.Fórmula:C12H15N3O2Pureza:98%Cor e Forma:SolidPeso molecular:233.27Hydroxy ziprasidone
CAS:Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.Fórmula:C21H21ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:428.94Catestatin
CAS:Non-competitive inhibitor of nicotinic receptors; blocks cationic signalling and catecholamine release; stimulates histamine release. IC50 ~200-250nM.Fórmula:C107H173N37O26SPureza:98%Cor e Forma:SolidPeso molecular:2425.84Aprofene
CAS:Aprofene blocks acetylcholine receptors, used for peptic ulcers, endarteritis, cholecystitis, and colitis.Fórmula:C21H27NO2Cor e Forma:SolidPeso molecular:325.44Ketanserinol
CAS:Ketanserinol is a metabolite of the antihypertensive drug ketanserin, which blocks 5-HT2 receptors to treat protamine-induced pulmonary hypertension.Fórmula:C22H24FN3O3Cor e Forma:SolidPeso molecular:397.44Biperiden lactate
CAS:Biperiden lactate is a biochemical.Fórmula:C24H35NO4Cor e Forma:SolidPeso molecular:401.54Diclofensine
CAS:Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine.Fórmula:C17H17Cl2NOPureza:97.01% - 98.13%Cor e Forma:SolidPeso molecular:322.23VU0029767
CAS:VU0029767 is an allosteric enhancer of the M1 muscarinic receptor, capable of modulating the receptor's activity. This compound enhances M1 receptor activity by increasing agonist affinity. However, VU0029767 demonstrates distinct characteristics from other compounds, particularly under varying experimental conditions such as its interaction with mutated M1 receptors and its effects on downstream signaling pathways.
Fórmula:C21H21N3O3Cor e Forma:SolidPeso molecular:363.41Aβ1-42 aggregation inhibitor 1
CAS:Aβ1-42 aggregation inhibitor 1 effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), demonstrating IC50 values of 2.64 μM and 1.29Fórmula:C29H32N4SCor e Forma:SolidPeso molecular:468.667-Acetoxy-1-methylquinolinium iodide
CAS:7-Acetoxy-1-methylquinolinium iodide (AMQI) is a cholinesterase substrate for inhibitor detection with 320 nm Ex and 410 nm Em.Fórmula:C12H12INO2Cor e Forma:SolidPeso molecular:329.13Dianicline dihydrochloride
CAS:Dianicline dihydrochloride is a partial agonist of α4β2 nicotinic acetylcholine receptor. It increases cessation rates in a dose-dependent manner.Fórmula:C13H16N2OPureza:98%Cor e Forma:SolidPeso molecular:216.28AN317
CAS:AN317 is a selective agonist for the nicotinic acetylcholine receptor (nAChR) containing α6β2, with dissociation constants (Ki) of 6.2 nM and 4.1 nM for the α6/α3β2β3 and α4β2 receptor subtypes, respectively. It induces dopamine release in rat striatal synaptosomes, enhances the activity of dopaminergic neurons in the substantia nigra, and exhibits protective effects against the dopaminergic neurotoxin MPP+ in rat neurons. AN317 also demonstrates favorable pharmacokinetic properties in rats and permeability across the blood-brain barrier (BB).Fórmula:C13H19N3Cor e Forma:SolidPeso molecular:217.31Eprodisate
CAS:Eprodisate disrupts protein-glycosaminoglycan binding, halting amyloid fibril formation, potentially delaying AA amyloidosis progression.Fórmula:C3H8O6S2Cor e Forma:SolidPeso molecular:204.227-Desmethyl-3-hydroxyagomelatine
CAS:7-Desmethyl-3-hydroxyagomelatine, less active than parent drug Agomelatine, is a melatonergic agonist and 5-HT2C antagonist.Fórmula:C14H15NO3Pureza:98%Cor e Forma:SolidPeso molecular:245.27Penbutolol sulfate
CAS:Penbutolol sulfate ((-)-Terbuclomine) is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.Fórmula:C18H29NO2H2O4SPureza:99.95%Cor e Forma:SolidPeso molecular:340.474-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).Fórmula:C14H11BrN2SPureza:98%Cor e Forma:SolidPeso molecular:319.22VU0477886
CAS:VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.Fórmula:C20H13ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:392.80SB 271046 hydrochloride
CAS:SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist and is > 200-fold selective over 55 other receptors, enzymes and ion channels.Fórmula:C20H22ClN3O3S2·HClPureza:99.77%Cor e Forma:SolidPeso molecular:488.45Phenglutarimide hydrochloride
CAS:Phenglutarimide hydrochloride is an anticholinergic. It is used as an antiparkinsonian agent.Fórmula:C17H25ClN2O2Cor e Forma:SolidPeso molecular:324.85Aftin-5
CAS:Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.Fórmula:C19H26N6OCor e Forma:SolidPeso molecular:354.45Nicardipine pyridine metabolite II
CAS:Nicardipine pyridine metabolite II is a biaoctive chemical.Fórmula:C26H27N3O6Cor e Forma:SolidPeso molecular:477.51MCI-225 dehydratase
CAS:MCI-225 dehydratase is an oral, selective inhibitor of noradrenaline reuptake, and functions as a 5-HT3 antagonist, exhibiting antidepressant effects in vivo .Fórmula:C17H18ClFN4SCor e Forma:SolidPeso molecular:364.87N-Biotinyl p-aminophenyl arsenic acid
CAS:N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that binds to streptavidin and disulfide compounds. It diminishes the binding sites of rbungarotoxin on reduced nicotinic receptors with an IC50 ranging from 10-300 nM, thus shielding the receptors from irreversible alkylation by bromoacetylcholine.Fórmula:C16H22AsN3O4SCor e Forma:SolidPeso molecular:427.356-hydroxy Buspirone
CAS:6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.Fórmula:C21H31N5O3Cor e Forma:SolidPeso molecular:401.505-Methyltryptamine hydrochloride
CAS:5-Methyltryptamine hydrochloride is a high-affinity 5-HT1C receptor ligand and a partial agonist of 5-HT. 5-Methyltryptamine hydrochloride protects mice subjected to burn, tourniquet and endotoxin shock.Fórmula:C11H15ClN2Pureza:99.45%Cor e Forma:SolidPeso molecular:210.7032-(3-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride
CAS:Produto ControladoFórmula:C13H17Cl2NOCor e Forma:NeatPeso molecular:274.192-(4-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride
CAS:Produto ControladoFórmula:C13H17Cl2NOCor e Forma:NeatPeso molecular:274.192Z-Nalfurafine
CAS:Produto ControladoApplications 2Z-Nalfurafine is a geometric isomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.
References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)Fórmula:C28H32N2O5Cor e Forma:NeatPeso molecular:476.56(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid
CAS:Produto ControladoApplications (4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid (CAS# 53587-33-0) is a useful isotopically labeled research compound.
Fórmula:C9H8D2O4Cor e Forma:NeatPeso molecular:184.196S-Nalfurafine
CAS:Produto ControladoApplications 6S-Nalfurafine is a stereoisomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.
References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)Fórmula:C28H32N2O5Cor e Forma:NeatPeso molecular:476.56Dolasetron Mesylate
CAS:Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea followingFórmula:C20H24N2O6SPureza:99.05%Cor e Forma:White PowderPeso molecular:420.48Paroxetine hydrochloride hemihydrate
CAS:Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).Fórmula:C38H44Cl2F2N2O7Pureza:99.949%Cor e Forma:SolidPeso molecular:749.67LY 344864
CAS:LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.Fórmula:C21H22FN3OPureza:98%Cor e Forma:SolidPeso molecular:351.42LY 334370 hydrochloride
CAS:5-HT1F receptor agonistFórmula:C21H23ClFN3OPureza:98%Cor e Forma:SolidPeso molecular:387.88mGAT3/4-IN-1
CAS:mGAT3/4-IN-1 inhibits mGAT3/4 with pIC50: 5.31/5.24, reduces neuropathic pain in diabetic mice.Fórmula:C26H31ClN2O2S2Cor e Forma:SolidPeso molecular:503.12TC 2559 difumarate
CAS:partial agonist of α4β2 nicotinic acetylcholine receptorFórmula:C12H18N2OC4H404Pureza:98%Cor e Forma:SolidPeso molecular:380.39VU0361747
CAS:VU0361747 is a positive allosteric modulators (PAM) of metabotropic glutamate receptor subtype 5 (mGlu5).Fórmula:C19H17FN2O2Cor e Forma:SolidPeso molecular:324.35
