Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(648 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.028 produtos)
- BACE(37 produtos)
- Beta Amilóide(231 produtos)
- CaMK(73 produtos)
- COX(602 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(372 produtos)
- Gama-secretase(63 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(42 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(42 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5637 produtos de "Neurociência"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.Fórmula:C30H42N4OCor e Forma:SolidPeso molecular:474.68BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Fórmula:C29H29FN6O4SCor e Forma:SolidPeso molecular:576.64Illudinine
CAS:Illudinine is a sesquiterpene alkaloid that acts as an inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 18.3 μM. It is applicable in research focused on neurological disorders.Fórmula:C16H17NO3Cor e Forma:SolidPeso molecular:271.31DSP-1053 benzenesulfonate
CAS:DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Fórmula:C32H38BrNO7SCor e Forma:SolidPeso molecular:660.62MAO-A/SERT-IN-1
CAS:MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.Fórmula:C19H14N2O5Cor e Forma:SolidPeso molecular:350.32Rocavorexant
CAS:Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392OX2R agonist 1
CAS:OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Fórmula:C21H28F2N2O5SCor e Forma:SolidPeso molecular:458.52β-CCM
CAS:β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and convulsant effects. It enhances emotional reactivity and reduces interference sensitivity in spatial working memory tasks. β-CCM is applicable in research related to anxiety disorders.Fórmula:C13H10N2O2Cor e Forma:SolidPeso molecular:226.231S-8510 phosphate
CAS:S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).Fórmula:C12H13N4O6PPureza:98%Cor e Forma:SolidPeso molecular:340.23CGS-9895
CAS:CGS-9895 is a GABA antagonist that operates by interacting with the benzodiazepine binding site on GABA receptors containing the γ subunit (ag).Fórmula:C17H13N3O2Cor e Forma:SolidPeso molecular:291.3045-HT2A/5-HT2C inverse agonist 1
CAS:5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.Fórmula:C24H35N5O2Cor e Forma:SolidPeso molecular:425.57MADAM
CAS:MADAM demonstrates high affinity and selectivity for 5-HTT, with a Ki value of 1.6 nM. It is utilized as a PET radiotracer for visualizing serotonin transporters.Fórmula:C16H20N2SCor e Forma:SolidPeso molecular:272.408PDE4B/7A-IN-1
CAS:5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.Fórmula:C25H35N3O3Cor e Forma:SolidPeso molecular:425.56VU6005806
CAS:VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.Fórmula:C17H16F3N7O2SPureza:98%Cor e Forma:SolidPeso molecular:439.415-HT7R antagonist 3
CAS:Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.Fórmula:C30H33FN4O3Cor e Forma:SolidPeso molecular:516.61BChE-IN-38
CAS:BChE-IN-38 (compound 13) is a potent BChE inhibitor, with Ki values of 62.05, 28.78, 14.09, and 1.15 nM for hCAI, hCAII, AChE, and BChE, respectively. BChE-IN-38 also demonstrates cytotoxic activity.Fórmula:C27H20N4Cor e Forma:SolidPeso molecular:400.474LRRK2-IN-4
CAS:LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Fórmula:C25H29ClF2N6O2Cor e Forma:SolidPeso molecular:518.99Gabaculine HCl
CAS:Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.Fórmula:C7H10ClNO2Cor e Forma:SolidPeso molecular:175.61SEP-363856 mesylate
CAS:SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.Fórmula:C10H17NO4S2Cor e Forma:SolidPeso molecular:279.38MAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.Fórmula:C23H26N2O4Cor e Forma:SolidPeso molecular:394.46LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFórmula:C9H13NO4Pureza:98%Cor e Forma:SolidPeso molecular:199.2RTIOXA-43
CAS:RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Fórmula:C37H37N5O5SPureza:99.17%Cor e Forma:SolidPeso molecular:663.79Ref: TM-T87345
1mg210,00€5mg516,00€1mL*10mM (DMSO)754,00€10mg833,00€25mg1.607,00€50mg2.582,00€100mg3.492,00€MAO-B-IN-5
CAS:MAO-B-IN-5: potent, selective oral MAO-B inhibitor, IC50=0.204μM, potential for Parkinson's research.
Fórmula:C19H21FN2O2Pureza:97.68%Cor e Forma:SolidPeso molecular:328.38Nafimidone hydrochloride
CAS:Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.Fórmula:C15H13ClN2OCor e Forma:SolidPeso molecular:272.73β-Secretase Inhibitor III
β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.Fórmula:C20H20F2N4O3SCor e Forma:SolidPeso molecular:434.46Tiprenolol hydrochloride
CAS:Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.Fórmula:C13H22ClNO2SCor e Forma:SolidPeso molecular:291.84AChE-IN-79
AChE-IN-79 (compound 3i) is an acetylcholinesterase inhibitor with an IC50 of 2.7 µM, suitable for studies related to Alzheimer's disease.Fórmula:C29H27NO6SCor e Forma:SolidPeso molecular:517.59Tuclazepam
CAS:Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.Fórmula:C17H16Cl2N2OCor e Forma:SolidPeso molecular:335.23Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.Fórmula:C37H51NOCor e Forma:SolidPeso molecular:525.81AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Fórmula:C22H21F2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:473.55-IAI hydrochloride
CAS:5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.Fórmula:C9H11ClINCor e Forma:SolidPeso molecular:295.548BF-168
CAS:BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Fórmula:C18H17FN2O2Cor e Forma:SolidPeso molecular:312.34(R,R)-LRRK2-IN-7
CAS:(R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.Fórmula:C24H26N6OPeso molecular:414.50LY367385 hydrochloride
CAS:LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.Fórmula:C10H12ClNO4Cor e Forma:SolidPeso molecular:245.66FCOB02
CAS:FCOB02 is a monoamine oxidase B (MAO-B) ligand. It can be labeled as [18F]FCOB02, serving as a 4-methylcoumarin-like targeting probe. [18F]FCOB02 demonstrates high affinity for MAO-B, with an IC50 of 10.68 nM. It is utilized for specific imaging and quantitative analysis of MAO-B in vivo.Fórmula:C16H12FNO3Cor e Forma:SolidPeso molecular:285.27PXS-5153A monohydrochloride
CAS:PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.Fórmula:C20H25Cl2FN4O2SPureza:98%Cor e Forma:Odour SolidPeso molecular:475.41CVN636
CAS:CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for humanFórmula:C19H20FNO4SCor e Forma:SolidPeso molecular:377.43THRX-194556
CAS:THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.Fórmula:C28H41N5O5SCor e Forma:SolidPeso molecular:559.721SB 224289
CAS:SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.Fórmula:C32H32N4O3Pureza:98%Cor e Forma:SolidPeso molecular:520.62GABAA receptor agonist 1
Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45PF-06648671
CAS:PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.Fórmula:C25H23ClF4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:538.92AChE-IN-24
AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.Fórmula:C22H30N2O4S2Cor e Forma:SolidPeso molecular:450.61BACE1-IN-4
CAS:BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Fórmula:C21H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:511.57cSPM
cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.Fórmula:C27H57N7Cor e Forma:SolidPeso molecular:479.79Befiradol hydrochloride
CAS:Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.Fórmula:C20H23Cl2F2N3OPureza:99.64%Cor e Forma:SolidPeso molecular:430.32MAO-B-IN-40
CAS:MAO-B-IN-40 (3a) is an inhibitor of MAOB, exhibiting an IC50 value of 0.493 μM against hMAOB, and demonstrates significant neuroprotective and antioxidant effects. MAO-B-IN-40 (3a) is applicable in Parkinson's disease research.Fórmula:C17H15N3O3Cor e Forma:SolidPeso molecular:309.319MMB-4
CAS:MMB-4 is an oxime that can reactivate cholinesterases (cholinesterases) which have been inactivated due to exposure to organophosphates such as Sarin or Soman.Fórmula:C13H14Br2N4O2Cor e Forma:SolidPeso molecular:418.0845-HT1A modulator 4
CAS:5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.Fórmula:C9H14N4Cor e Forma:SolidPeso molecular:178.234AChE-IN-83
CAS:AChE-IN-83 (compound f1) is an AChE inhibitor that suppresses nematode growth and acetylcholinesterase activity in rice seeds while being safe for the seeds. It specifically targets Aphelenchoides besseyi, with an LC50 of 19.0 μg/mL over 48 hours. AChE-IN-83 impedes nematode populations and behaviors in rice seeds, damages the nematode cuticle, and induces reactive oxygen species, lipofuscin, and lipid generation within the nematodes.Fórmula:C10H7ClN2O2SCor e Forma:SolidPeso molecular:254.693AChE/BChE-IN-1
AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.Fórmula:C32H35ClN6O3Cor e Forma:SolidPeso molecular:587.11
