Neurociência

Gantenerumab (R-1450) is a humanized antibody targeting amyloid-β (Aβ), used in studies of Alzheimer's disease.

Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Procaine HCl is a benzoic acid derivative used as a local anesthetic, blocking nerve impulses and sensation.

Molindone hydrochloride (EN-1733A) is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.

Lintopride HCl is a 5HT-4 antagonist.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CNR2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CNR2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CNR2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CNR2 in the samples is then determined by comparing the OD of the samples to the standard curve.