Tirosina Quinase/Adaptador

EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, …

Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib …

N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and …

EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by …

BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) …

RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer …

Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in …

Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor …

EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. …

CEP-28122 is a highly potent and selective orally active ALK inhibitor.

EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that …

Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective …

RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and …

Panomifene HCl is a selective anti-estrogenic compound with antitumor activity for the treatment of breast …

OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits …

NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki …

TG 100801 is a dual inhibitor of VEGFr2 and Src family (Src and YES) kinases …

Jaceidin (Quercetagetin 3,3',6-trimethyl ether) is a membrane-permeable inhibitor of VEGFR with anti-tumor activities.

HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase. HNMPA inhibits tyrosine and …

AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG …

Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.

Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration …

EGFR-IN-76 is a potent EGFR inhibitor.

RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 …

AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM …

RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities …

S6K2-IN-1 (Compound 2) is an inhibitor of S6K2 with an IC50 of 22 nM and …

Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth …

VEGFR2-IN-1 is a selective and potent VEGFR2 inhibitor with antitumor activity that inhibits cell proliferation …

KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 …

Cyt-PTPε Inhibitor-1 (A Inhibitor-1) is an inhibitor of cytosolic protein tyrosine phosphatase ε. Cyt-PTPε Inhibitor-1 …

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can …

ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.ALK-IN-26 induces …

Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, …

5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may …

VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values …

Coprelotamab (GB-221) is an IgG-κ monoclonal antibody that targets EGFR2, frequently produced in CHO DG44 …

KLTWQELYQLKYKGI (QK) is a VEGF-mimicking peptide that competes with VEGF by binding to its receptors. …

Evobrutinib(M2951) , also known as M-2951 and MSC-2364447C, is a highly selective inhibitor of the …

AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth …

Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase …

ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 …

EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects …

(Z)-FeCP-oxindole is a selective inhibitor of VEGFR2 with an IC50 of 200 nM for human. …

Syk-IN-8 (compound 19q) functions as a Syk inhibitor with demonstrated antiproliferative effects on a variety …

EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) …

EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values …

DBt-10 is a potent Bruton's tyrosine kinase (BTK) degrader [1].

BEBT-109 is a potent selective inhibitor of pan-mutant EGFR with enhanced pharmacokinetic properties, suitable for …

C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier …

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for …

hCA/VEGFR-2-IN-4 (compound 15b), an indolinylbenzenesulfonamide, serves as a potential dual inhibitor targeting cancer-related human carbonic …

FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing …

Fenlean (FLZ) is a tyrosine kinase Src inhibitor, a synthetic cyclic derivative of squamous amide …

Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity …

FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to …

Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it …

YK-2-69 is a highly selective DYRK2 inhibitor with anti-prostate cancer effects.

FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3 with IC50s of 460, …