Tirosina Quinase/Adaptador
Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.
Subcategorias de "Tirosina Quinase/Adaptador"
- ALK(123 produtos)
- CSF-1R(42 produtos)
- EGFR(595 produtos)
- Receptor de Efrina(23 produtos)
- FLT(88 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(176 produtos)
- HER(4 produtos)
- Hck(3 produtos)
- IGF-1R(102 produtos)
- PDGFR(126 produtos)
- PYK2(7 produtos)
- Src(81 produtos)
- Receptor TAM(33 produtos)
- Tie-2(20 produtos)
- Receptor TrK(59 produtos)
- Tirosina Quinases(25 produtos)
- VEGFR(252 produtos)
- c-Fms(111 produtos)
- c-Kit(113 produtos)
- c-Met/HGFR(134 produtos)
- c-RET(58 produtos)
Exibir 13 mais subcategorias
Foram encontrados 1236 produtos de "Tirosina Quinase/Adaptador"
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2-D08
CAS:2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.Fórmula:C15H10O5Pureza:98.58% - 98.95%Cor e Forma:SolidPeso molecular:270.24Dacomitinib hydrate
CAS:Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family ofFórmula:C24H27ClFN5O3Pureza:99.52%Cor e Forma:SolidPeso molecular:487.96AZD2932
CAS:<p>AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.</p>Fórmula:C24H25N5O4Pureza:97.71% - 98.37%Cor e Forma:SolidPeso molecular:447.49BMS-911543
CAS:<p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>Fórmula:C23H28N8OPureza:97.69% - 99.98%Cor e Forma:SolidPeso molecular:432.52Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Fórmula:C28H31F3N8O2Pureza:99.87%Cor e Forma:SolidPeso molecular:568.59GNF-5837
CAS:<p>GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).</p>Fórmula:C28H21F4N5O2Pureza:97.26% - 98.08%Cor e Forma:SolidPeso molecular:535.49Tolimidone
CAS:<p>Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.</p>Fórmula:C11H10N2O2Pureza:99.85% - 99.85%Cor e Forma:SolidPeso molecular:202.21Tie2 kinase inhibitor 1
CAS:<p>Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 μM, which is 200-fold more effective</p>Fórmula:C26H21N3O2SPureza:99.51%Cor e Forma:SolidPeso molecular:439.53CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Fórmula:C28H30N4O2Pureza:98.96%Cor e Forma:SolidPeso molecular:454.56Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Fórmula:C18H16N2O3Pureza:97.18%Cor e Forma:SolidPeso molecular:308.33Tyrphostin 23
CAS:<p>Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.</p>Fórmula:C10H6N2O2Pureza:99.7% - 99.86%Cor e Forma:Yellow-Tan SolidPeso molecular:186.17AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Fórmula:C22H19F4N7OPureza:99.49% - 99.75%Cor e Forma:SolidPeso molecular:473.43ALK-IN-1
CAS:<p>ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.</p>Fórmula:C26H34ClN6O2PPureza:99.74% - 99.80%Cor e Forma:SolidPeso molecular:529.01Zorifertinib
CAS:Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.Fórmula:C22H23ClFN5O3Pureza:98.20% - 99.36%Cor e Forma:White To Off-White SolidPeso molecular:459.9ML167
CAS:<p>ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.</p>Fórmula:C19H17N3O3Pureza:99.82% - >99.99%Cor e Forma:SolidPeso molecular:335.36WRG-28
CAS:WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)Fórmula:C21H18N2O5SPureza:97.21%Cor e Forma:SolidPeso molecular:410.44LM22A-4
CAS:<p>LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).</p>Fórmula:C15H21N3O6Pureza:99.56%Cor e Forma:SolidPeso molecular:339.34MTX-211
CAS:MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Fórmula:C20H14Cl2FN5O2SPureza:97.6% - >99.99%Cor e Forma:SolidPeso molecular:478.33GSK3179106
CAS:GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nMFórmula:C22H21F4N3O4Pureza:99.8% - 99.90%Cor e Forma:SolidPeso molecular:467.41Desmethyl Erlotinib hydrochloride
CAS:<p>Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.</p>Fórmula:C21H21N3O4·HClPureza:99.49%Cor e Forma:SolidPeso molecular:415.87NVP-BVU972
CAS:<p>NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.</p>Fórmula:C20H16N6Pureza:97.24% - >99.99%Cor e Forma:SolidPeso molecular:340.38Bafetinib
CAS:<p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>Fórmula:C30H31F3N8OPureza:94.16% - 99.68%Cor e Forma:SolidPeso molecular:576.62XL 999
CAS:<p>Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）</p>Fórmula:C26H28FN5OPureza:98.24% - 99.55%Cor e Forma:SolidPeso molecular:445.53EAI045
CAS:EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.Fórmula:C19H14FN3O3SPureza:98.00% - 99.12%Cor e Forma:SolidPeso molecular:383.4BPR1J-097 hydrochloride (1327167-19-0(free base))
<p>BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo.</p>Fórmula:C27H29ClN6O3SPureza:98% - 98.54%Cor e Forma:SolidPeso molecular:553.07Pyridostatin
CAS:<p>Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or</p>Fórmula:C31H32N8O5Pureza:98%Cor e Forma:SolidPeso molecular:596.64TAS0728
CAS:TAS0728 is a HER2 inhibitor, with antitumor activityFórmula:C26H32N8O3Pureza:97.78%Cor e Forma:SolidPeso molecular:504.58ANA-12
CAS:<p>ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.</p>Fórmula:C22H21N3O3SPureza:99.28% - 99.87%Cor e Forma:SolidPeso molecular:407.49TX1-85-1
CAS:TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Fórmula:C32H36N8O3Pureza:97.16% - 98.12%Cor e Forma:SolidPeso molecular:580.68TPX-0046
CAS:<p>TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.</p>Fórmula:C21H21FN6O3Pureza:99.95%Cor e Forma:SolidPeso molecular:424.43Repotrectinib
CAS:<p>Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.</p>Fórmula:C18H18FN5O2Pureza:99.92% - >99.99%Cor e Forma:SolidPeso molecular:355.37Fisogatinib
CAS:<p>Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C24H24Cl2N4O4Pureza:99.27% - ≥95%Cor e Forma:SolidPeso molecular:503.38XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Fórmula:C22H31N9OPureza:99.07%Cor e Forma:SolidPeso molecular:437.54Tetramethylcurcumin
CAS:Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it alsoFórmula:C25H28O6Pureza:97.69% - 99.94%Cor e Forma:SolidPeso molecular:424.49AG 555
CAS:<p>AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.</p>Fórmula:C19H18N2O3Pureza:98.02% - 99.94%Cor e Forma:SolidPeso molecular:322.36H3B-6527
CAS:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.Fórmula:C29H34Cl2N8O4Pureza:97.45%Cor e Forma:SolidPeso molecular:629.54PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Fórmula:C82H134N28O26Pureza:99.30%Cor e Forma:SolidPeso molecular:1928.11E-4031 dihydrochloride
CAS:E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Fórmula:C21H29Cl2N3O3SPureza:99.31% - 99.87%Cor e Forma:SolidPeso molecular:474.44SU5214
CAS:SU5214 is a modulator of tyrosine kinase signal transduction.Fórmula:C16H13NO2Pureza:99.45% - 99.55%Cor e Forma:SolidPeso molecular:251.28ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Fórmula:C22H16N4OPureza:99.30% - ≥95%Cor e Forma:SolidPeso molecular:352.39123C4
CAS:123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4 (Ki=0.65 μM)[1].Fórmula:C43H47ClN8O6Pureza:98.94%Cor e Forma:SolidPeso molecular:807.34XL092
CAS:<p>XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.</p>Fórmula:C29H25FN4O5Pureza:98.60%Cor e Forma:SolidPeso molecular:528.53Tirbanibulin
CAS:Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of a variety of cancers.Fórmula:C26H29N3O3Pureza:99.43% - 99.67%Cor e Forma:SolidPeso molecular:431.53NRC-2694 hydrochloride
CAS:NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.Fórmula:C24H27ClN4O3Cor e Forma:SolidPeso molecular:454.95AG1557
CAS:<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Fórmula:C16H14IN3O2Pureza:98.61% - 99.23%Cor e Forma:SolidPeso molecular:407.21PKI (5-24) Acetate(99534-03-9 free base)
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).Fórmula:C96H152N32O33Pureza:99.47%Cor e Forma:SolidPeso molecular:2282.43GW788388
CAS:<p>GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.</p>Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Cor e Forma:SolidPeso molecular:425.48ONO-7475
CAS:<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Fórmula:C32H26N4O6Pureza:98.74%Cor e Forma:SolidPeso molecular:562.57CZC-8004
CAS:<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Fórmula:C17H16FN5Pureza:99.29%Cor e Forma:SolidPeso molecular:309.34WZ-3146
CAS:WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).Fórmula:C24H25ClN6O2Pureza:97.15%Cor e Forma:SolidPeso molecular:464.95
