EGFR
EGFR (epidermal growth factor receptor) inhibitors are compounds that block the signaling of EGFR, a receptor that is often overexpressed in various cancers and plays a critical role in angiogenesis. EGFR inhibitors are used to prevent tumor growth and metastasis by disrupting the pathways that promote blood vessel formation in tumors. These inhibitors are widely used in cancer research and therapy. At CymitQuimica, we offer a diverse selection of high-quality EGFR inhibitors to support your research in oncology and angiogenesis.
Found 572 products of "EGFR"
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SU5214
CAS:SU5214 is a modulator of tyrosine kinase signal transduction.Formula:C16H13NO2Purity:99.45% - 99.55%Color and Shape:SolidMolecular weight:251.28Chrysophanol
CAS:Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.Formula:C15H10O4Purity:99.44% - 99.91%Color and Shape:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMolecular weight:254.24AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.85%Color and Shape:Yellow SolidMolecular weight:294.3SYR127063
CAS:SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.Formula:C23H20ClF3N4O3Purity:98.57%Color and Shape:SolidMolecular weight:492.88AZD8931 diFuMaric acid
CAS:AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).Formula:C31H33ClFN5O11Purity:99.92%Color and Shape:SolidMolecular weight:706.1Ref: TM-T8751
1mg62.00€5mg125.00€10mg180.00€25mg298.00€50mg419.00€100mg567.00€200mg752.00€1mL*10mM (DMSO)178.00€CP-724714
CAS:CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2
Formula:C27H27N5O3Purity:97.1% - 98.82%Color and Shape:SolidMolecular weight:469.54PF-6274484
CAS:PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formula:C18H14ClFN4O2Purity:97.71%Color and Shape:SolidMolecular weight:372.78Ref: TM-T22396
2mg38.00€5mg57.00€10mg96.00€25mg177.00€50mg333.00€100mg495.00€500mg1,071.00€1mL*10mM (DMSO)63.00€WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purity:97.93% - 99.94%Color and Shape:SolidMolecular weight:569.58CL-387785
CAS:CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Formula:C18H13BrN4OPurity:99.56% - 99.62%Color and Shape:SolidMolecular weight:381.23Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Formula:C18H16N2O3Purity:97.18%Color and Shape:SolidMolecular weight:308.33Ref: TM-T22450
1mg39.00€5mg82.00€10mg115.00€25mg192.00€50mg264.00€100mg380.00€200mg515.00€1mL*10mM (DMSO)90.00€lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formula:C14H13NO5Purity:98.06%Color and Shape:Yellow To Tan PowderMolecular weight:275.26Ref: TM-T4185
1mg42.00€2mg55.00€5mg93.00€10mg152.00€25mg330.00€50mg492.00€100mg707.00€1mL*10mM (DMSO)90.00€Canertinib
CAS:Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.Formula:C24H25ClFN5O3Purity:98% - >99.99%Color and Shape:White Or Similar To White Crystalline PowderMolecular weight:485.94AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formula:C16H15ClIN3O2Purity:98.64%Color and Shape:SolidMolecular weight:443.66Tyrphostin AG 879
CAS:Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formula:C18H24N2OSPurity:99.05%Color and Shape:SolidMolecular weight:316.46Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14NS309
CAS:NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.Formula:C8H4Cl2N2O2Purity:97.55%Color and Shape:SolidMolecular weight:231.04Ref: TM-T4612
5mg57.00€10mg69.00€25mg119.00€50mg216.00€100mg323.00€200mg470.00€500mg752.00€1mL*10mM (DMSO)63.00€Cetuximab
CAS:Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).Formula:C107H179N35O36S7Purity:95 - 98.60%Color and Shape:LiquidMolecular weight:145.54 kDaEndoxifen (Z-isomer)
CAS:Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Formula:C25H27NO2Purity:99.19% - 99.81%Color and Shape:SolidMolecular weight:373.49Ref: TM-T2280
1mg34.00€5mg66.00€10mg88.00€25mg167.00€50mg259.00€100mg389.00€200mg563.00€1mL*10mM (DMSO)75.00€Mubritinib
CAS:Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Formula:C25H23F3N4O2Purity:98.61% - 99.85%Color and Shape:SolidMolecular weight:468.47Epitinib
CAS:Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).
Formula:C24H26N6O2Color and Shape:SolidMolecular weight:430.5AG1557
CAS:AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
Formula:C16H14IN3O2Purity:98.61% - 99.23%Color and Shape:SolidMolecular weight:407.21E-4031 dihydrochloride
CAS:E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formula:C21H29Cl2N3O3SPurity:99.31% - 99.87%Color and Shape:SolidMolecular weight:474.44Derazantinib dihydrochloride
CAS:Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.Formula:C29H31Cl2FN4OColor and Shape:SolidMolecular weight:541.49Tyrphostin AG 528
CAS:Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).Formula:C18H14N2O3Purity:99.64%Color and Shape:SolidMolecular weight:306.32AG 1406
CAS:AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.Formula:C16H18N2OPurity:98.12%Color and Shape:SolidMolecular weight:254.33TAS0728
CAS:TAS0728 is a HER2 inhibitor, with antitumor activityFormula:C26H32N8O3Purity:97.78%Color and Shape:SolidMolecular weight:504.58Ref: TM-T7819
1mg48.00€5mg105.00€10mg166.00€25mg304.00€50mg485.00€100mg658.00€200mg888.00€1mL*10mM (DMSO)111.00€NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formula:C24H26N4O3Purity:99.90%Color and Shape:SolidMolecular weight:418.49Ref: TM-T16343
1mg56.00€5mg105.00€10mg170.00€25mg281.00€50mg371.00€100mg537.00€200mg712.00€1mL*10mM (DMSO)116.00€Theliatinib
CAS:Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formula:C25H26N6O2Purity:99.67%Color and Shape:SolidMolecular weight:442.51(E)-AG 99
CAS:(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).Formula:C10H8N2O3Purity:99.23%Color and Shape:SolidMolecular weight:204.18JCN037
CAS:JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formula:C16H11BrFN3O2Purity:99.5%Color and Shape:SolidMolecular weight:376.18PKI-166 hydrochloride
CAS:EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.Formula:C20H19ClN4OColor and Shape:SolidMolecular weight:366.85SU 4313
CAS:SU 4313 is a bioactive chemical.Formula:C18H17NOPurity:99.51% - 99.89%Color and Shape:SolidMolecular weight:263.33Ref: TM-T3568
1mg35.00€5mg70.00€10mg97.00€25mg170.00€50mg250.00€100mg373.00€200mg547.00€1mL*10mM (DMSO)78.00€EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS:EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)Formula:C23H21N3O3Purity:99.55%Color and Shape:SolidMolecular weight:387.43Ref: TM-T21954
1mg50.00€5mg94.00€10mg140.00€25mg245.00€50mg369.00€100mg537.00€200mg712.00€1mL*10mM (DMSO)103.00€Oritinib mesylate
CAS:Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.Formula:C32H41N7O5SColor and Shape:SolidMolecular weight:635.78PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formula:C17H13BrN4OPurity:99.13% - 99.83%Color and Shape:SolidMolecular weight:369.22Ref: TM-T6932
1mg37.00€2mg50.00€5mg63.00€10mg94.00€25mg146.00€50mg210.00€100mg294.00€1mL*10mM (DMSO)52.00€AEE788
CAS:AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formula:C27H32N6Purity:98% - >99.99%Color and Shape:SolidMolecular weight:440.58Ref: TM-T2116
2mg47.00€5mg70.00€10mg103.00€25mg188.00€50mg325.00€100mg490.00€500mg1,103.00€1mL*10mM (DMSO)77.00€WHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formula:C16H15N3O3Purity:99.21%Color and Shape:SolidMolecular weight:297.31NRC-2694 hydrochloride
CAS:NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.Formula:C24H27ClN4O3Color and Shape:SolidMolecular weight:454.95Trastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Purity:97.1% (SDS-PAGE); 99.2% (SEC-HPLC) - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Color and Shape:LiquidMolecular weight:Approximately 145.53 kDaSulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formula:C6H9NOS2Purity:97.55% - 99.67%Color and Shape:Slightly Yellowish LiquidMolecular weight:175.27Ref: TM-TL0016
1mg34.00€2mg46.00€5mg66.00€10mg92.00€25mg167.00€50mg241.00€100mg359.00€200mg525.00€1mL*10mM (DMSO)65.00€SU5204
CAS:SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFormula:C17H15NO2Purity:99.46%Color and Shape:SolidMolecular weight:265.31PP2
CAS:PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.Formula:C15H16ClN5Purity:98% - 98.21%Color and Shape:White SolidMolecular weight:301.77Ref: TM-T6266
2mg44.00€5mg65.00€10mg110.00€25mg178.00€50mg304.00€100mg482.00€200mg687.00€1mL*10mM (DMSO)71.00€Tyrphostin AG30
CAS:Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.Formula:C10H7NO4Purity:99.02%Color and Shape:SolidMolecular weight:205.17PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formula:C26H35Cl2N7OPurity:99.92%Color and Shape:SolidMolecular weight:532.51Ref: TM-T23127
1mg34.00€5mg96.00€10mg141.00€25mg289.00€50mg465.00€100mg662.00€200mg888.00€1mL*10mM (DMSO)118.00€Lazertinib
CAS:Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Formula:C30H34N8O3Purity:98.7% - 99.90%Color and Shape:SolidMolecular weight:554.64Ref: TM-T4485
1mg46.00€2mg59.00€5mg96.00€10mg130.00€25mg215.00€50mg309.00€100mg444.00€200mg655.00€1mL*10mM (DMSO)104.00€Tyrphostin A1
CAS:Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .Formula:C11H8N2OPurity:98.32%Color and Shape:SolidMolecular weight:184.19WZ4002
CAS:WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.Formula:C25H27ClN6O3Purity:97.51%Color and Shape:SolidMolecular weight:494.97Ref: TM-T6238
2mg34.00€5mg49.00€10mg70.00€25mg111.00€50mg177.00€100mg313.00€200mg464.00€1mL*10mM (DMSO)50.00€MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurity:98.53%Color and Shape:SolidMolecular weight:314.38Gefitinib-based PROTAC 3
CAS:Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).Formula:C47H57ClFN7O8SPurity:97.29% - 98.25%Color and Shape:SolidMolecular weight:934.51Dacomitinib hydrate
CAS:Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family ofFormula:C24H27ClFN5O3Purity:99.52%Color and Shape:SolidMolecular weight:487.96Ref: TM-T19965
5mg48.00€10mg75.00€25mg100.00€50mg133.00€100mg200.00€200mg295.00€1mL*10mM (DMSO)57.00€
