Thrombin
Thrombin inhibitors are compounds that block thrombin, an enzyme involved in the blood coagulation process that also has a role in promoting angiogenesis. Thrombin can stimulate the formation of new blood vessels in tumors, aiding in their growth and metastasis. By inhibiting thrombin, these compounds can reduce angiogenesis and tumor progression. Thrombin inhibitors are important in both cancer research and the study of vascular diseases. At CymitQuimica, we provide a selection of high-quality thrombin inhibitors to support your research in hemostasis, oncology, and angiogenesis.
Found 47 products of "Thrombin"
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Dabigatran ethyl ester hydrochloride
CAS:<p>Dabigatran prevents blood clots, inhibiting NQO2 and thrombin with IC50 0.8 μM.</p>Formula:C27H30ClN7O3Purity:99.65%Color and Shape:SolidMolecular weight:536.03Dabigatran etexilate
CAS:<p>Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.</p>Formula:C34H41N7O5Purity:98.19% - 99.98%Color and Shape:White PowderMolecular weight:627.73Ichorcumab
CAS:<p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Color and Shape:LiquidThrombin inhibitor 13
<p>Thrombin inhibitor 13 (Compound 13a) acts as a covalent reversible inhibitor of thrombin (thrombin, FIIa) with an IC50 of 0.7 nM. This compound prolongs activated partial thromboplastin time (aPTT) and prothrombin time (PT), demonstrating both antithrombotic and anticoagulant properties.</p>Formula:C16H17ClN6OSColor and Shape:SolidMolecular weight:376.864Thrombin (MW 37kDa)
CAS:<p>Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.</p>Purity:98%Color and Shape:SolidMolecular weight:37kDaH-Gly-Arg-pNA dihydrochloride
CAS:<p>H-Gly-Arg-pNA 2HCl, a peptide, binds 1,2 thrombin; colorimetric quantification at 405 nm indicates thrombin activity.</p>Formula:C14H23Cl2N7O4Purity:99.14%Color and Shape:SolidMolecular weight:424.28Fibrinopeptide B, human
CAS:<p>Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer.</p>Formula:C66H93N19O25Purity:98%Color and Shape:SolidMolecular weight:1552.56Platelet aggregation-IN-1
<p>Platelet aggregation-IN-1 (Compound 10e) acts as an inhibitor of platelet aggregation and can achieve complete (100%) inhibition of thrombin-induced platelet aggregation at a concentration of 50 μM.</p>Formula:C18H13N3O4Molecular weight:335.09061Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Color and Shape:Odour SolidSulodexide
CAS:<p>Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.</p>Color and Shape:SolidBefovacimab
CAS:<p>Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.</p>Color and Shape:LiquidPM 102
CAS:<p>Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro).</p>Formula:C235H425N111O64Purity:98%Color and Shape:SolidMolecular weight:5830Metolazone
CAS:<p>Metolazone (SR-720-22) is a quinazoline-sulfonamide derived diuretic that inhibits sodium chloride symporters.</p>Formula:C16H16ClN3O3SPurity:98.14% - 98.5%Color and Shape:Crystals From Ethanol SolidMolecular weight:365.83Coagulation Factor II Protein, Rat, Recombinant (His)
<p>Coagulation Factor II Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Color and Shape:Lyophilized PowderMolecular weight:69.5 kDa (predicted)Anti-Coagulation Factor II Antibody (2P591)
<p>Anti-Coagulation Factor II Antibody (2P591) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (2P591) can be used in WB.</p>Color and Shape:Odour LiquidAnti-Coagulation Factor II Antibody (8M286)
<p>Anti-Coagulation Factor II Antibody (8M286) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (8M286) can be used in ELISA.</p>Color and Shape:Odour LiquidDabigatran ethyl ester
CAS:<p>Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.</p>Formula:C27H29N7O3Purity:99.98%Color and Shape:SolidMolecular weight:499.56Coagulation Factor II Protein, Mouse, Recombinant (His)
<p>Coagulation Factor II Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Color and Shape:Lyophilized PowderMolecular weight:69.3 kDa (predicted); 85 kDa (reducing conditions)TRAP-6
CAS:<p>TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).</p>Formula:C34H56N10O9Purity:>99.99%Color and Shape:SolidMolecular weight:748.87Lusutrombopag
CAS:<p>Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with</p>Formula:C29H32Cl2N2O5SPurity:99.96%Color and Shape:SolidMolecular weight:591.55Avatrombopag
CAS:<p>Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation</p>Formula:C29H34Cl2N6O3S2Purity:99.01% - 99.63%Color and Shape:SolidMolecular weight:649.65Dabigatran
CAS:<p>Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.</p>Formula:C25H25N7O3Purity:97.44% - 98.7%Color and Shape:Tan SolidMolecular weight:471.51Enoxaparin sodium
CAS:<p>Enoxaparin, a low-weight heparin approved by FDA for STEMI, enhances antithrombin and prevents clotting by inhibiting factors XIa, IXa, Xa, IIa.</p>Formula:C42H59N3Na4O35S2Purity:98%Color and Shape:SolidMolecular weight:1322AEBSF hydrochloride
CAS:<p>AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.</p>Formula:C8H11ClFNO2SPurity:98% - 99.81%Color and Shape:White PowderMolecular weight:239.69H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS:<p>H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238) is a sensitive and accurate thrombin detection substrate for measuring antithrombin-heparin cofactor (AT-III).</p>Formula:C27H38Cl2N8O5Purity:99.47%Color and Shape:SolidMolecular weight:625.55Bivalirudin
CAS:<p>Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting</p>Formula:C98H138N24O33Purity:98.8% - >99.99%Color and Shape:White To Off-White PowderMolecular weight:2180.29Dabigatran Etexilate Mesylate
CAS:<p>Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor.</p>Formula:C34H41N7O5·CH4O3SPurity:99.91%Color and Shape:SolidMolecular weight:723.84Argatroban Monohydrate
CAS:<p>Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Formula:C23H38N6O6SPurity:99.51%Color and Shape:SolidMolecular weight:526.65Edoxaban Tosylate Monohydrate
CAS:<p>Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.</p>Formula:C31H40ClN7O8S2Purity:99.86% - 99.91%Color and Shape:SolidMolecular weight:738.27Cycloolivil
CAS:<p>Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees.</p>Formula:C20H24O7Purity:98%Color and Shape:SolidMolecular weight:376.4NQ301
CAS:<p>NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).</p>Formula:C18H12ClNO3Purity:99.74% - 99.76%Color and Shape:SolidMolecular weight:325.75Ximelagatran
CAS:<p>Ximelagatran, oral direct thrombin inhibitor, transforms to active melagatran in body.</p>Formula:C24H35N5O5Purity:95.48% - 99.60%Color and Shape:SolidMolecular weight:473.57MNS
CAS:<p>MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.</p>Formula:C9H7NO4Purity:98.53%Color and Shape:Yellow PowderMolecular weight:193.16Argatroban
CAS:<p>Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Formula:C23H36N6O5SPurity:99.77% - >99.99%Color and Shape:White To Off-White Crystalline SolidMolecular weight:508.63Efegatran sulfate
CAS:<p>Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.</p>Formula:C21H34N6O7SPurity:≥98% - ≥98%Color and Shape:SolidMolecular weight:514.6OM-189
CAS:<p>OM-189 is a selective inhibitor of synthetic thrombin.</p>Formula:C24H36N6O3SPurity:98%Color and Shape:SolidMolecular weight:488.65Atopaxar Hydrobromide
CAS:<p>Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Formula:C29H39BrFN3O5Purity:98%Color and Shape:SolidMolecular weight:608.54Flovagatran
CAS:<p>Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.</p>Formula:C27H36BN3O7Purity:99.56%Color and Shape:SolidMolecular weight:525.4Atopaxar
CAS:<p>Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Formula:C29H38FN3O5Purity:97.07% - 98.07%Color and Shape:SolidMolecular weight:527.63Melagatran
CAS:<p>Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.</p>Formula:C22H31N5O4Purity:98.29% - >99.99%Color and Shape:SolidMolecular weight:429.51NP-313
CAS:<p>NP-313 (NSC-4264) is a potent antithrombotic that blocks platelet aggregation via thromboxane A2 synthesis inhibition and targets SOCC-mediated Ca2+ efflux.</p>Formula:C12H8ClNO3Purity:98.97%Color and Shape:SolidMolecular weight:249.65SCH79797 dihydrochloride
CAS:<p>SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.</p>Formula:C23H27Cl2N5Purity:99.5%Color and Shape:SolidMolecular weight:444.4Thrombin inhibitor 1
CAS:<p>Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).</p>Formula:C22H20Cl2F2N4O3Purity:98%Color and Shape:SolidMolecular weight:497.32Odiparcil
CAS:<p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>Formula:C15H16O6SPurity:98%Color and Shape:SolidMolecular weight:324.35LK-732
CAS:<p>LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.</p>Formula:C25H29N5O3SColor and Shape:SolidMolecular weight:479.59SAR107375
CAS:<p>SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].</p>Formula:C24H30ClN5O5S2Color and Shape:SolidMolecular weight:568.11Antiplatelet agent 3
CAS:<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Formula:C38H32N2O5Color and Shape:SolidMolecular weight:596.671
