Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(91 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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NLRP3-IN-62
CAS:NLRP3-IN-62 (Compound 1) is an inhibitor of NLRP3. It effectively inhibits pyroptosis in THP-1 cells with an IC50 of 0.7 nM and suppresses IL-β release with an IC50 of 108.5 nM.Formula:C21H15F3N4O3Molecular weight:428.36N-Stearoyltyrosine
CAS:N-Stearoyltyrosine (N-(1-Oxooctadecyl)-L-tyrosine) is an analog of Anandamide. It exhibits neuroprotective effects by safeguarding the CA1 region of the hippocampus in a gerbil ischemia-reperfusion model. Additionally, N-Stearoyltyrosine inhibits free radical generation, enhances antioxidant capacity, and reduces IR-induced apoptosis (cell apoptosis).Formula:C27H45NO4Color and Shape:SolidMolecular weight:447.65BM-962
CAS:BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.Formula:C53H58ClF3N6O7S3Color and Shape:SolidMolecular weight:1079.71HLDA-212
CAS:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Formula:C70H90BrFN8O19SColor and Shape:SolidMolecular weight:1478.4784-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Formula:C25H22F3NO5Purity:99.76%Color and Shape:SolidMolecular weight:473.44Ref: TM-T75268
1mg47.00€5mg92.00€10mg152.00€25mg289.00€50mg447.00€100mg670.00€200mg888.00€1mL*10mM (DMSO)92.00€2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc
2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc is the PD-L1 ligand-linker polymer of AUTACPD-L1degrader-3. It can be utilized in the synthesis of AUTAC.Formula:C35H45N5O6Color and Shape:SolidMolecular weight:631.765-HT1AR agonist 2
5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.Formula:C31H31N5O3Color and Shape:SolidMolecular weight:521.61Biguanidinium-porphyrin free TFA
Biguanidinium-porphyrin free TFA is a mitochondrial-targeting photosensitiser exhibiting low dark toxicity towards human hepatocellular carcinoma HEp2 cells.Formula:C48H36F3N9O2Purity:98.69%Color and Shape:SolidMolecular weight:827.85NFh-NMe-2
NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.
Formula:C32H33IN2OColor and Shape:SolidMolecular weight:588.522Human membrane-bound PD-L1 polypeptide
CAS:Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formula:C85H140N26O36SPurity:98%Color and Shape:SolidMolecular weight:2134.24MDM2 ligand 4
MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].Formula:C31H33Cl2FN2O4Color and Shape:SolidMolecular weight:587.509EGFR-IN-143
EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.Formula:C20H21ClN6O3Color and Shape:SolidMolecular weight:428.872Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formula:C18H15Cl2F2N5O3SPurity:98.68% - 99.85%Color and Shape:SolidMolecular weight:490.31PZ703b
CAS:PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Formula:C80H102ClF3N10O11S4Color and Shape:SolidMolecular weight:1600.44PROTAC LZK-IN-1
CAS:PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Formula:C51H64F2N10O5SColor and Shape:SolidMolecular weight:967.18Echitamine chloride
CAS:Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).Formula:C22H29ClN2O4Color and Shape:SolidMolecular weight:420.93Oxythiamine
CAS:Oxythiamine (Hydroxythiamin) is a TK inhibitor that inhibits cancer cell proliferation, induces cell cycle arrest, and induces apoptosis.
Formula:C12H16N3O2SPurity:96.14% - 99.51%Color and Shape:SolidMolecular weight:266.34TRF2-IN-1
TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.Formula:C18H17BrO4Color and Shape:SolidMolecular weight:377.229Tubulin-IN-53
Tubulin-IN-53 is a potent inhibitor of microtubulin (Tubulin) with an IC50 of 6.06 μM. By targeting the colchicine binding site on tubulin, Tubulin-IN-53 hinders tubulin polymerization, disrupting the microtubule network. It induces cell cycle arrest at the G2/M phase and apoptosis (apoptosis) in MCF-7 cells, while inhibiting cell migration. This compound also leads to a reduction in mitochondrial membrane potential and an increase in reactive oxygen species (ROS) accumulation. Additionally, Tubulin-IN-53 disrupts angiogenesis in human umbilical vein endothelial cells and is applicable in research on cancers such as breast and lung cancer.Color and Shape:Odour SolidTAT-GluN2BCTM
CAS:TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, therebyFormula:C224H374N86O54Purity:98%Color and Shape:SolidMolecular weight:5135.91
