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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 6038 products of "Apoptosis"

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  • Maceneolignan A
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    Maceneolignan A

    CAS:
    Maceneolignan A, a natural product isolated from the aril of Myristica fragrans (Myristicaceae), inhibits β-hexosaminidase release in RBL-2H3 cells, exhibiting
    Formula:C21H24O5
    Color and Shape:Solid
    Molecular weight:356.41

    Ref: TM-T79977

  • 2,2'-Dihydroxy chalcone
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    2,2'-Dihydroxy chalcone

    CAS:
    2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.
    Formula:C15H12O3
    Purity:99.70%
    Color and Shape:Solid
    Molecular weight:240.25

    Ref: TM-TN7224

  • Mechercharmycin A
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    Mechercharmycin A

    CAS:
    Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.
    Formula:C35H32N8O7S
    Color and Shape:Solid
    Molecular weight:708.75

    Ref: TM-T40929

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    Balstilimab

    CAS:
    Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .
    Color and Shape:Liquid

    Ref: TM-T76917

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    RET Ligand-Linker Conjugate-1

    RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.
    Formula:C40H44N10O
    Color and Shape:Solid
    Molecular weight:680.84

    Ref: TM-T205264

  • PROTAC CDK4/6 degrader 1
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    PROTAC CDK4/6 degrader 1

    CAS:
    PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis).
    Formula:C41H47N11O6
    Color and Shape:Solid
    Molecular weight:789.88

    Ref: TM-T88727

  • β-Apopicropodophyllin
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    β-Apopicropodophyllin

    CAS:
    β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,
    Formula:C22H20O7
    Color and Shape:Solid
    Molecular weight:396.39

    Ref: TM-T75622

  • Thalidomide-NH-PEG7
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    Thalidomide-NH-PEG7

    Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.
    Formula:C27H39N3O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:581.61

    Ref: TM-T18814

  • APG-1387
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    APG-1387

    CAS:
    APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.
    Formula:C60H72N10O10S2
    Color and Shape:Solid
    Molecular weight:1157.41

    Ref: TM-T30095

  • Ac-Pro-Gly-Pro-OH
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    Ac-Pro-Gly-Pro-OH

    CAS:
    Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.
    Formula:C14H21N3O5
    Purity:98.32%
    Color and Shape:Solid
    Molecular weight:311.33

    Ref: TM-T76662

  • USP7-IN-9
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    USP7-IN-9

    USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.
    Formula:C32H33ClF6N6O8
    Color and Shape:Solid
    Molecular weight:779.08

    Ref: TM-T73257

  • Tubulin polymerization-IN-73
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    Tubulin polymerization-IN-73

    Tubulin polymerization-IN-73 (Compound 37) is an inhibitor of microtubule polymerization with an IC50 of 1.8 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in A549 cells. The compound inhibits the proliferation of both A549 WT and A549/T resistant cells with IC50 values of 0.023 μM and 0.057 μM, respectively. Additionally, Tubulin polymerization-IN-73 demonstrates antitumor activity in mouse models.
    Formula:C23H23N3O4
    Color and Shape:Solid
    Molecular weight:405.446

    Ref: TM-T204211

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    PROTAC NCOA4 degrader-1

    PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.
    Color and Shape:Odour Solid

    Ref: TM-T89280

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    EGFR-IN-151

    EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.
    Color and Shape:Odour Solid

    Ref: TM-T206456

  • PROTAC Mcl1 degrader-1
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    PROTAC Mcl1 degrader-1

    CAS:
    <p>PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.</p>
    Formula:C45H45BrN6O8S
    Purity:98.74%
    Color and Shape:Solid
    Molecular weight:909.84

    Ref: TM-T11975

  • IC 86621
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    IC 86621

    CAS:
    IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.
    Formula:C12H15NO3
    Purity:99.68%
    Color and Shape:Solid
    Molecular weight:221.25

    Ref: TM-T9760

  • Uvarigrin
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    Uvarigrin

    CAS:
    <p>Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.</p>
    Formula:C37H68O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:608.93

    Ref: TM-T13956

  • 10-SLF
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    10-SLF

    CAS:
    <p>10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.</p>
    Formula:C59H76Cl2N4O13
    Color and Shape:Solid
    Molecular weight:1120.16

    Ref: TM-T205612

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    NecroIr2

    NecroIr2, an iridium(III) compound, induces necroptosis in Cisplatin-resistant A549R lung cancer cells and disrupts mitochondria.
    Formula:C46H30ClIrN6O2
    Color and Shape:Solid
    Molecular weight:926.44

    Ref: TM-T74681

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    Necroptosis-IN-4

    Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.
    Color and Shape:Odour Solid

    Ref: TM-T89380