Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(91 products)
- c-RET(61 products)
- p53(63 products)
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Found 6170 products of "Apoptosis"
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Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
Thalidomide-PEG conjugate for E3 ligase in PROTACs; has cereblon ligand and 3-unit PEG linker.Formula:C27H35F3N4O11Purity:98%Color and Shape:SolidMolecular weight:648.58TNF-α Antagonist
CAS:TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction withFormula:C58H71N11O15S2Color and Shape:SolidMolecular weight:1226.39Ac-LEVD-CHO
CAS:Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Formula:C22H36N4O9Color and Shape:SolidMolecular weight:500.54IDH1/2-IN-1
IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.Color and Shape:Odour SolidVinepidine sulfate
CAS:Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .Formula:C46H58N4O13SColor and Shape:SolidMolecular weight:907.04Antitumor agent-150
Antitumor agent-150 (V10) is a breast cancer treatment that functions as a PROTAC degrader of MDM2.Formula:C70H106N8O14SMolecular weight:1314.75492PD-1/PD-L1-IN-39
PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with an IC50 value of 15.73 nM. It exhibits strong binding affinity to human and mouse PD-L1, with KD values of 14.62 and 392 nM, respectively. PD-1/PD-L1-IN-39 also demonstrates antitumor activity.Formula:C23H20ClFN2O3Molecular weight:426.11465PROTAC EGFR degrader 9
CAS:PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.
Formula:C45H48F3N9O6SMolecular weight:899.98NAE-IN-1
NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.Formula:C29H30N4O2SMolecular weight:498.20895Ru-Poma
Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.Formula:C89H75Cl2N11O11Ru·7H2OOPBP-1
OPBP-1 is a D-peptide developed through phage display screening, molecular docking, and molecular dynamics simulations. It exhibits high stability, strong antitumor activity, and oral bioavailability. OPBP-1 selectively binds to the PD-L1 protein, significantly blocking the interaction between PD-1 and PD-L1, which helps restore and enhance T lymphocyte function while reducing the proportion of myeloid-derived suppressor cells (MDSCs), counteracting tumor-induced immune evasion. OPBP-1 is applicable for research in cancer immunotherapy.Formula:C64H92N20O19SMolecular weight:1476.65683RIP1 kinase inhibitor 9
RIP1 kinase inhibitor 9 (compound SY-1) is a selective inhibitor of RIP kinase. It effectively reduces central inflammatory responses caused by seizures. RIP1 kinase inhibitor 9 also obstructs Z-VAD-FMK-induced necroptosis in HT-29 cells, with an EC50 of 7.04 nM.Formula:C25H21N3O3Molecular weight:411.15829PROTAC PD-L1 degrader-1
PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.Anticancer agent 204
Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.Formula:C26H18FN5O3SMolecular weight:499.11144Necrosis inhibitor 2 (hydrocholide)
Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.Formula:C24H26ClN5O5Molecular weight:499.16225Anticancer agent 178
Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.Formula:C32H30ClFeN2O6Molecular weight:629.11418RIPK2-IN-4
RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.Formula:C16H10N6S2Molecular weight:350.04084Cu(I) chelator 1
Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.Formula:C16H27NO4S3Molecular weight:393.11022P-gp inhibitor 16
P-gp inhibitor 16 (compound 14) is an inhibitor of p-glycoprotein. It significantly enhances apoptosis induced by doxorubicin and displays anticancer properties.Formula:C35H35N5O4Molecular weight:589.2689Camrelizumab
CAS:Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up
Purity:95% - 98.6%Color and Shape:LiquidMolecular weight:143.7 kDaLw13
Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.Formula:C46H55F3N8O8Molecular weight:904.4095SB 699551
CAS:SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.Formula:C34H45N3OPurity:99.83%Color and Shape:SoildMolecular weight:511.74Ref: TM-T23325L
1mg190.00€5mg471.00€10mg662.00€25mg1,036.00€50mg1,429.00€100mg1,821.00€200mg2,489.00€4-Nitro-3-cresol
CAS:4-Nitro-3-cresol exhibits ciliate toxicity against Tetrahymena pyriformis and is widely used in biochemical experiments and drug synthesis research.Formula:C7H7NO3Purity:99.87%Color and Shape:Beige PowderMolecular weight:153.14Pro-GA
CAS:Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.Formula:C12H19NO7Color and Shape:SolidMolecular weight:289.28Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formula:C18H15Cl2F2N5O3SPurity:98.68% - 99.85%Color and Shape:SolidMolecular weight:490.31FOXJ1 agonist 1
FOXJ1 agonist 1 (compound 16c), an orally effective small molecule, effectively enhances FOXJ1 expression and acts on multiciliated cells (MCC) in the mammalian airway system to prevent chronic obstructive pulmonary disease (COPD). Foxj1-IN-1 induces motile cilia production in the respiratory system of both zebrafish and mammals and inhibits elastase-induced COPD in mouse models. Additionally, Foxj1-IN-1 demonstrates good liver microsomal stability and favorable in vivo pharmacokinetic (PK) curves and area under the curve (AUC). It exhibits negligible inhibition of CYP and hERG and lacks significant cytotoxicity.Formula:C24H27N5O3Color and Shape:SolidMolecular weight:433.5Antitumor photosensitizer-7
Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.Formula:C23H20N2O3Color and Shape:SolidMolecular weight:372.42Linsidomine hydrochloride
CAS:SIN-1 chloride is a moxidomine metabolite with vasodilatory, anti-platelet, and antianginal effects, reducing myocardial ischemia-related damage.Formula:C6H11ClN4O2Purity:99.27% - 99.67%Color and Shape:White Solid CrystallineMolecular weight:206.63Isomahanine
Isomahanine is a useful organic compound for research related to life sciences and the catalog number is T125848.Formula:C23H25NO2Color and Shape:SolidMolecular weight:347.458Phosphocreatine dipotassium
CAS:Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives.Formula:C4H8K2N3O5PPurity:98%Color and Shape:SolidMolecular weight:287.29Verproside
CAS:Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.Formula:C22H26O13Color and Shape:SolidMolecular weight:498.437HTR2A antagonist 1
HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.Formula:C35H43Cl2F2N5O4Color and Shape:SolidMolecular weight:706.65Verdinexor
CAS:Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.Formula:C18H12F6N6OPurity:98% - 99.68%Color and Shape:SolidMolecular weight:442.32Ref: TM-T6123
1mg35.00€5mg111.00€10mg187.00€25mg341.00€50mg567.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)123.00€WKYMVM
CAS:WKYMVM is a N-formyl peptide receptor (FPR1) agonist.Formula:C41H61N9O7S2Purity:98%Color and Shape:SolidMolecular weight:856.11Spexin TFA
Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.Formula:C76H115F3N20O21SColor and Shape:SolidMolecular weight:1733.9Z-Ala-Ala-Asp-CMK
CAS:Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.Formula:C19H24ClN3O7Purity:99.967%Color and Shape:SolidMolecular weight:441.86RMC-9805
CAS:RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.Formula:C63H88F3N11O7Purity:98.10% - 99.92%Color and Shape:SolidMolecular weight:1168.44Ref: TM-T78212
1mg127.00€5mg311.00€10mg485.00€25mg795.00€50mg1,159.00€100mg1,710.00€1mL*10mM (DMSO)687.00€ChoKα inhibitor-4
ChoKα Inhibitor-4 is a bioisosteric agent that effectively inhibits human choline kinase α1 (HChoK α1) with an IC50 of 0.66 μM.Color and Shape:Odour SolidS-Adenosyl-L-methionine iodide
CAS:S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].Formula:C15H23IN6O5SColor and Shape:SolidMolecular weight:526.35Syringolin A
CAS:Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.
Formula:C24H39N5O6Color and Shape:SolidMolecular weight:493.605AVJ16
CAS:AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation.Formula:C28H27N3O4Purity:98.87% - 99.72%Color and Shape:SolidMolecular weight:469.53Ref: TM-T9980
1mg130.00€5mg313.00€10mg500.00€25mg807.00€50mg1,108.00€100mg1,485.00€200mg1,998.00€1mL*10mM (DMSO)323.00€DC-Y13-27
Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM).
Formula:C14H10N2O2SPurity:99.75%Color and Shape:SoildMolecular weight:270.31Chloranil
CAS:Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.Formula:C6Cl4O2Purity:98.03%Color and Shape:SolidMolecular weight:245.88Z-DQMD-FMK
CAS:Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Formula:C29H40FN5O11SPurity:98%Color and Shape:SolidMolecular weight:685.72ALK/ROS1 inhibitor 2e HCL
(R)-1-(2-((2-MeO-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(CF3O)benzyl)piperidine-3-carboxamide HCl is anti-apoptotic and anti-cancer.Formula:C30H36ClF3N6O3Purity:98.66%Color and Shape:SoildMolecular weight:621.09Human membrane-bound PD-L1 polypeptide
CAS:Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formula:C85H140N26O36SPurity:98%Color and Shape:SolidMolecular weight:2134.24H-20
CAS:H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.Formula:C44H64N10O15Color and Shape:SolidMolecular weight:973.037TNF-α (46-65), human
CAS:Human TNF alpha (46-65) peptide.Formula:C110H172N24O30Purity:98%Color and Shape:SolidMolecular weight:2310.69AZD5153
CAS:AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formula:C25H33N7O3Purity:99.25%Color and Shape:SolidMolecular weight:479.57NSD-IN-4
NSD-IN-4 (Compound A8) is a potent and orally active inhibitor of NSD3, inducing apoptosis in a dose-dependent manner. It demonstrates significant antitumor activity against lung squamous cell carcinoma.Formula:C17H12ClFN2O2Color and Shape:SolidMolecular weight:330.741
