
Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(91 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Anticancer agent 136
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM), exhibits an IC50 value of 3.38 μM against human dermal fibroblasts (HDF) andFormula:C40H50N6O8Purity:98%Color and Shape:SolidMolecular weight:742.86RMC-9805
CAS:RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.Formula:C63H88F3N11O7Purity:98.10% - 99.92%Color and Shape:SolidMolecular weight:1168.44Ref: TM-T78212
1mg127.00€5mg311.00€10mg485.00€25mg795.00€50mg1,159.00€100mg1,710.00€1mL*10mM (DMSO)687.00€Lon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Formula:C24H28Cl2N2O3S2Color and Shape:SolidMolecular weight:527.53DMUP
CAS:DMUP inhibits CD47-SIRPα, induces apoptosis, boosts macrophage activity in A549 cells, and has antitumor properties.Formula:C24H24Cl2N2O10PtColor and Shape:SolidMolecular weight:766.45ChoKα inhibitor-4
ChoKα Inhibitor-4 is a bioisosteric agent that effectively inhibits human choline kinase α1 (HChoK α1) with an IC50 of 0.66 μM.Color and Shape:Odour Solid2-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS:2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formula:C22H17N3O2Color and Shape:SolidMolecular weight:355.39R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formula:C54H70N8O7S2Color and Shape:SolidMolecular weight:1007.31Thalidomide-5-propargyne-NH2 hydrochloride
CAS:Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.Formula:C16H14ClN3O4Color and Shape:SolidMolecular weight:347.753Ecdysone
CAS:Ecdysone is a major steroid hormone in insects and herbs.Formula:C27H44O6Purity:99.22%Color and Shape:PowderMolecular weight:464.63Bcl-2-IN-21
Bcl-2-IN-21 (compound C1), an iridium-based anticancer agent, effectively targets and inhibits Bcl-2, thereby impeding cancer cell colony formation and promoting increased levels of Bax and caspase 3.Formula:C45H33F6IrN5PMolecular weight:980.96Xylopine
CAS:Xylopine: an aporphine alkaloid, cytotoxic to cancer cells, induces oxidative stress, G2/M arrest, and apoptosis.Formula:C18H17NO3Color and Shape:SolidMolecular weight:295.33[Au(L4)(CyJohnPhos)]SbF6
[Au(L4)(CyJohnPhos)]SbF6 is a gold-containing compound that exhibits inhibitory effects on cyclooxygenase-1/2 (COX-1/2), suppresses the proliferation of colon cancer cells Caco2-/TC7 with an IC50 of 0.98 μM, and induces cell apoptosis (apoptosis). Additionally, [Au(L4)(CyJohnPhos)]SbF6 acts as an inhibitor of thioredoxin reductase (TrxR) and demonstrates antioxidative activity by modulating ROS levels.Formula:C44H56AuF6NO4PSSbColor and Shape:SolidMolecular weight:1158.68ECDD-S18
ECDD-S18 (compound ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targeting the vacuolar ATPase (V-ATPase) and impairing lysosomal acidification.Formula:C35H31BrO12Color and Shape:SolidMolecular weight:723.52Golimumab
CAS:Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.Color and Shape:LiquidMolecular weight:146.93 kDaBromoiodoacetamide
CAS:Bromoiodoacetamide (I-HAcAm): cytotoxic, induces ROS & apoptosis in HepG-2 cells.Formula:C2H3BrINOColor and Shape:SolidMolecular weight:263.86Etanercept
CAS:Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.
Purity:98%Color and Shape:LiquidKP1019
CAS:KP1019 is now discontinued.Formula:C21H19Cl4N6RuColor and Shape:SolidMolecular weight:598.30Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Formula:C36H48N6O7Purity:98%Color and Shape:SolidMolecular weight:676.8Tubulin polymerization-IN-70
Tubulin polymerization-IN-70 (compound Q19) is an effective inhibitor of tubulin polymerization. This compound exerts antiproliferative properties by targeting the colchicine binding site on tubulin, thereby inhibiting its polymerization. Tubulin polymerization-IN-70 also induces apoptosis and cell cycle arrest at the G2/M phase. Additionally, it triggers a decrease in mitochondrial membrane potential and elevates levels of reactive oxygen species (ROS). Moreover, Tubulin polymerization-IN-70 possesses anti-angiogenic and anticancer activities.Formula:C25H23N3O2Color and Shape:SolidMolecular weight:397.47eIF4A3-IN-7
CAS:eIF4A3-IN-7: Potent eIF4A3 inhibitor, potential cancer/dysproliferation research (WO2019161345A1, Compound 8).Formula:C26H25NO7Color and Shape:SolidMolecular weight:463.486Liensinine Perchlorate
CAS:Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
Formula:C37H43ClN2O10Purity:99.80%Color and Shape:SolidMolecular weight:711.2Apoptosis inducer 30
Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.Formula:C52H69BrNO4PColor and Shape:SolidMolecular weight:882.99PI3Kδ-IN-16
CAS:PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.Formula:C22H26N6O2Purity:99.68%Color and Shape:SoildMolecular weight:406.48Psalmotoxin 1
CAS:Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.Formula:C200H312N62O57S6Purity:98%Color and Shape:SolidMolecular weight:4689.41Antitumor photosensitizer-7
Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.Formula:C23H20N2O3Color and Shape:SolidMolecular weight:372.42GLP-2(rat)
CAS:intestinal epithelium-specific growth factorFormula:C166H256N44O56SPurity:98%Color and Shape:SolidMolecular weight:3796.17Linsidomine hydrochloride
CAS:SIN-1 chloride is a moxidomine metabolite with vasodilatory, anti-platelet, and antianginal effects, reducing myocardial ischemia-related damage.Formula:C6H11ClN4O2Purity:99.27% - 99.67%Color and Shape:White Solid CrystallineMolecular weight:206.63SSE1806
SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer andFormula:C21H18N2O5Color and Shape:SolidMolecular weight:378.38Quercetin-d3
Quercetin-d3 hydrate, a deuterated form of Quercetin hydrate, acts as a flavonoid that stimulates recombinant SIRT1 and serves as a PI3K inhibitor. The compound specifically exhibits IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM against PI3Kγ, PI3Kδ, and PI3Kβ, respectively.Formula:C15H9D3O8Color and Shape:SolidMolecular weight:323.275-LOX-IN-2
CAS:5-LOX-in-2: a 5-lipoxygenase inhibitor with IC50 of 0.33 μM, reduces kidney cancer cell activity, induces apoptosis.Formula:C17H16O4Purity:98.74%Color and Shape:SoildMolecular weight:284.31CAY10678
CAS:CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPSFormula:C23H34N4OPurity:99.66%Color and Shape:SolidMolecular weight:382.54hCAIX-IN-13
CAS:hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.Formula:C37H33F3N6O7PtS2Color and Shape:SolidMolecular weight:989.9Spiroplatin
CAS:Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.Formula:C8H18N2O4PtSPurity:≥98%Color and Shape:SolidMolecular weight:433.39PIM-1/CK2-IN-2
PIM-1/CK2-IN-2 (compound 3aA) is an inhibitor of the PIM-1/CK2 enzymes. This compound can induce the mitochondrial apoptosis pathway in CCRF-CEM cells and is utilized in cancer research.Formula:C15H8Br4N2OColor and Shape:SolidMolecular weight:551.85Cytostatin
CAS:Cytostatin: Natural antitumor, inhibits cell adhesion, blocks B16 melanoma, induces apoptosis, selectively targets PP2A (IC50 = 29 nM).Formula:C21H33O7PColor and Shape:SolidMolecular weight:428.462Tyroserleutide hydrochloride
CAS:Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.Formula:C18H28ClN3O6Purity:98%Color and Shape:SolidMolecular weight:417.88Sodium propionate
CAS:Sodium propionate (Propionic acid sodium salt) has potential anti-inflammatory and anti-apoptotic activities, inhibiting certain signaling pathways.Formula:C3H5NaO2Color and Shape:SoildMolecular weight:96.06eIF4E-IN-5
eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].Formula:C30H39Cl2N6O8PColor and Shape:SolidMolecular weight:713.55Silicon naphthalocyanine dichloride
CAS:Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. This compound is employed in photodynamic therapy to inhibit cancer by effectively absorbing specific wavelengths of light, thereby generating oxygen radicals that aid in the destruction of cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride demonstrates promising prospects for medical applications.Formula:C48H24Cl2N8SiColor and Shape:SolidMolecular weight:811.75BCL-XL-IN-1
BCL-XL-IN-1 (Compound 11) is a selective inhibitor of BCL-XL, exhibiting a Ki of less than 0.01 nM against BCL-XLTR-FERT. It is primarily used in cancer research.Formula:C46H55N7O6SColor and Shape:SolidMolecular weight:834.04A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormula:C27H28N6OPurity:98%Color and Shape:SolidMolecular weight:452.55Giloralimab
CAS:Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.Purity:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Color and Shape:LiquidMolecular weight:146.34 kDaBMS-986156
BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody that targets the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR). It binds to GITR and enhances the activation of T effector cells while deactivating T regulatory cells. BMS-986156 is applicable for research in advanced solid tumors.Zigakibart
CAS:Zigakibart (BION-1301) is a humanized monoclonal antibody targeting TNFSF13 with anti-inflammatory activity for the study of immunoglobulin A nephropathy (IgAN)Purity:95.8% (SDS-PAGE); 99.8% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.8% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.03 kDaTulinercept
CAS:Tulinercept (OPRX-106), a monoclonal antibody, may be utilized in a range of biochemical research applications [1].Color and Shape:LiquidMcl-1 inhibitor 15
Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].Formula:C40H42ClFN6O4SColor and Shape:SolidMolecular weight:757.32CYP51/PD-L1-IN-3
CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μMFormula:C27H28N6O2Color and Shape:SolidMolecular weight:468.55Lipustobart
CAS:Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticPurity:98%Color and Shape:LiquidMG-C-30
CAS:MG-C-30 is an orally active CD27 agonist with an EC50 of 0.84 μM. It activates co-stimulatory signaling in NK cells and T cells, thereby enhancing the immune response. In the EG7-OVA mouse model, MG-C-30 demonstrates antitumor activity.Formula:C24H26N4O3SColor and Shape:SolidMolecular weight:450.55N-Acetylpsychosine
CAS:N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties.
Formula:C26H49NO8Color and Shape:SolidMolecular weight:503.67

