Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(11 products)
- Caspase(141 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(138 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(14 products)
- Survivin(14 products)
- TNF(92 products)
- c-RET(55 products)
- p53(63 products)
Show 6 more subcategories
Found 5865 products of "Apoptosis"
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BTK-IN-37
<p>BTK-IN-37 (compound 8d), a BTK inhibitor, demonstrates potent apoptotic effects on cancer cells by targeting BTK with K_i and IC_50 values of 5.07 nM and 3.6 nM, respectively. Additionally, this compound selectively promotes the enrichment of genes associated with necroptosis and pyroptosis.</p>Formula:C29H29N9O4SColor and Shape:SolidMolecular weight:599.66Nur77 modulator 4
<p>Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. It significantly promotes Nur77 expression and apoptosis, exhibiting excellent growth inhibitory effects on HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, leading to apoptosis. This compound is applicable in cancer research.</p>Formula:C26H28ClN5O2Color and Shape:SolidMolecular weight:477.99Rasagiline
CAS:<p>Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons</p>Formula:C12H13NPurity:98% - 99.87%Color and Shape:SolidMolecular weight:171.24hCAIX/XII-IN-13
<p>hCAIX/XII-IN-13 functions as an inhibitor targeting specific human carbonic anhydrases (hCA) IX and XII, crucial in tumor-related processes. Demonstrating efficacy, this compound offers inhibitory K i values of 0.08 µM for IX and 0.06 µM for XII. Additionally, under hypoxic conditions, hCAIX/XII-IN-13 enhances the effectiveness of Doxorubicin on MCF-7 cells by promoting G2/M phase cell cycle arrest and increasing apoptosis.</p>Formula:C25H16N6O6SColor and Shape:SolidMolecular weight:528.5FC-116
CAS:<p>FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.</p>Formula:C21H20FNO4Purity:98.18%Color and Shape:SoildMolecular weight:369.39Stem bromelain
CAS:<p>Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.</p>Color and Shape:SolidFKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Formula:C63H79N5O19Purity:98%Color and Shape:SolidMolecular weight:1210.32MC-25B
<p>MC-25B is a selective FKBP12 PROTAC degrader. It effectively degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a mechanism dependent on DCAF16.</p>Formula:C65H92ClN7O14Color and Shape:SolidMolecular weight:1230.921-Methyl-1H-pyrrolo[2,3-b]pyridine
CAS:<p>1-Methyl-1H-pyrrolo[2,3-b]pyridine exhibits cytotoxicity against MCF-7 cells and can be used in related research in the field of life sciences.</p>Formula:C8H8N2Purity:98.89%Color and Shape:SolidMolecular weight:132.16Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formula:C8H15NaO2Purity:98% - 99.78%Color and Shape:White PowderMolecular weight:166.2GL392
<p>GL392 is a senolytic agent that delivers the potent senescence-clearing compound Dasatinib specifically to senescent cells. By targeting the LBD domain, it binds lipofuscin in these cells and releases Dasatinib via an ester linkage, inducing apoptosis (Apoptosis) in senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL microcapsules to ensure efficient intracellular delivery while minimizing systemic toxicity. GL392 is applicable in cancer research.</p>Formula:C55H52ClN13O5SColor and Shape:SolidMolecular weight:1042.610-SLF
CAS:<p>10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.</p>Formula:C59H76Cl2N4O13Color and Shape:SolidMolecular weight:1120.16KT5823
CAS:<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>Formula:C29H25N3O5Purity:95%Color and Shape:SolidMolecular weight:495.53C-Met/Axl-IN-1
C-Met/Axl-IN-1 (Compound 22a) is an oral, selective type II c-Met/Axl inhibitor with IC50 values of 1 nM and 10 nM, respectively. It effectively suppresses tumor cell proliferation, induces cell cycle arrest, and apoptosis (apoptosis), showcasing potent anti-tumor activity.Formula:C25H18F2N6O2Color and Shape:SolidMolecular weight:472.45RMC-4998 formic
<p>RMC-4998 formic is an orally active inhibitor targeting the GTP-bound state of the KRASG12C mutant. It forms a trimeric complex with intracellular CYPA and the activated KRASG12C mutant, displaying an IC50 value of 28 nM. This compound inhibits ERK signaling and induces apoptosis in KRASG12C mutant cancer cells and is utilized in tumor research.</p>Color and Shape:Odour SolidZ-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Formula:C37H42FN7O10Purity:98%Color and Shape:SolidMolecular weight:763.78Diethanolamine hydrochloride
CAS:Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.Formula:C4H12ClNO2Purity:99.69%Color and Shape:SolidMolecular weight:141.6Hypoxia inducer-1
<p>Hypoxia inducer-1 (Compound N6) is a NO donor compound that is orally active and activated under hypoxic conditions. It exhibits high selectivity in releasing NO, inhibiting apoptosis, necrosis, and elevated levels of reactive oxygen species (ROS) associated with hypoxia. It modulates vasodilation and shows protective effects in a mouse model of myocardial hypoxic injury, making it useful for coronary heart disease research.</p>Formula:C14H12FN3O4Color and Shape:SolidMolecular weight:305.261BT44
CAS:<p>BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.</p>Formula:C28H27F4N3O4SPurity:99.87%Color and Shape:SoildMolecular weight:577.59RIPK1-IN-30
RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. It demonstrates a protective effect in the HT-29 cell model of TSZ-induced necroptosis, with an EC50 of 6.77 μM.Formula:C27H25FN2O4Color and Shape:SolidMolecular weight:460.17984PD-L1/VISTA-IN-2
<p>PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.</p>Formula:C22H22N2O3Color and Shape:SolidMolecular weight:362.42Src Inhibitor 4
<p>Src Inhibitor4 (Compound 18) is a derivative of KX-01 and functions as a Src inhibitor. It effectively disrupts tumor cells, damages microtubules, and induces cell cycle arrest, apoptosis, and immunogenic cell death. After introducing phenol or aniline functional groups, Src Inhibitor4 serves as a payload conjugation site for antibody-drug conjugates, showcasing antitumor activity.</p>Formula:C33H34N4O3Color and Shape:SolidMolecular weight:534.648Giloralimab
CAS:Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.Purity:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Color and Shape:LiquidCOG-1410 acetate
<p>COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.</p>Formula:C66H125N21O16Purity:99.61%Color and Shape:SolidMolecular weight:1468.83ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Formula:C110H210N52O26Purity:99.55%Color and Shape:SolidMolecular weight:2677.18Thalidomide-O-C7-NH2
CAS:Thalidomide-O-C7-NH2 is a cereblon ligand-linked E3 ligase for PROTAC use.Formula:C20H25N3O5Color and Shape:SolidMolecular weight:387.436p53-Mdm2 inhibitor 4
CAS:<p>p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.</p>Formula:C23H20FN3O3Purity:98.66%Color and Shape:SoildMolecular weight:405.42Cuprichydroxide
CAS:<p>Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.</p>Formula:CuH2O2Color and Shape:SolidMolecular weight:97.56P1D-34
<p>P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS).</p>Color and Shape:Odour SolidLisaftoclax
CAS:Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Formula:C45H48ClN7O8SPurity:97.14% - 99.66%Color and Shape:SolidMolecular weight:882.422-deoxy-D-Glucose-13C6
CAS:2-deoxy-D-Glucose-13C6 is an internal standard for GC/LC-MS, a glycolysis inhibitor, and induces apoptosis in certain cells at 2 mg/ml.Formula:C5CH12O5Color and Shape:SoildMolecular weight:165.15FW-1
<p>FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.</p>Formula:C24H27N7OColor and Shape:SolidMolecular weight:429.517Obexelimab
CAS:<p>ACBI3 is a pan-KRAS degrader with anticancer activity, degrading oncogenic KRAS.</p>Purity:98% (SDS-PAGE); 100% (SEC-HPLC) - 98% (SDS-PAGE); 100% (SEC-HPLC)Color and Shape:LiquidEciskafusp alfa
CAS:<p>Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specific</p>Purity:98%Color and Shape:SolidThalidomide-NH-(CH2)2-NH2 TFA
CAS:Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified derivative of Thalidomide serving as a Cereblon ligand to recruit CRBN proteins and a pivotal intermediate inFormula:C17H17F3N4O6Color and Shape:SolidMolecular weight:430.34Thalidomide-NH-C4-NH2 TFA
CAS:<p>Compound 29c, a Thalidomide-linker conjugate for potent PROTAC BRD2/BRD4 degrader-1, targets BET proteins.</p>Formula:C19H21F3N4O6Purity:98%Color and Shape:SolidMolecular weight:458.39MS78
MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP.Formula:C57H66FN9O6SColor and Shape:SolidMolecular weight:1024.25AZD5582 TFA
<p>AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA</p>Formula:C60H79F3N8O10Purity:99.89%Color and Shape:SoildMolecular weight:1129.31MEK/PI3K-IN-2
CAS:<p>MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.</p>Formula:C38H41F5IN9O7Color and Shape:SolidMolecular weight:957.68GGTI298 Trifluoroacetate
CAS:<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Formula:C27H33N3O3S·C2HF3O2Purity:98.07% - >99.99%Color and Shape:SolidMolecular weight:593.66Moracin N
CAS:<p>Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].</p>Formula:C19H18O4Purity:98%Color and Shape:SolidMolecular weight:310.34Thalidomide-O-PEG2-propargyl
CAS:<p>Thalidomide-O-PEG2-propargyl is a cereblon-based E3 ligase ligand with a PEG linker for PROTAC-induced protein degradation.</p>Formula:C20H20N2O7Purity:98%Color and Shape:SolidMolecular weight:400.38Asparanin A
CAS:<p>Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.</p>Formula:C39H64O13Purity:98%Color and Shape:SolidMolecular weight:740.92Narasin (sodium salt)
CAS:<p>Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and</p>Formula:C43H71NaO11Purity:98%Color and Shape:SolidMolecular weight:787.01DB2313
CAS:<p>DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.</p>Formula:C42H41FN8O2Purity:98.63% - 99.29%Color and Shape:SolidMolecular weight:708.83Anticancer agent 130
<p>Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].</p>Formula:C38H46FN5O5Purity:98%Color and Shape:SolidMolecular weight:671.8Thalidomide-O-C8-COOH
CAS:Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitmentFormula:C22H26N2O7Color and Shape:SolidMolecular weight:430.45Oligomycin B
CAS:Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Formula:C45H72O12Purity:98%Color and Shape:SolidMolecular weight:805.05Thymidine 3',5'-disphosphate
CAS:<p>pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.</p>Formula:C10H16N2O11P2Color and Shape:SolidMolecular weight:402.19Salinomycin sodium salt
CAS:<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Formula:C42H69NaO11Purity:98.76% - 99.11%Color and Shape:White Or Light Yellow Crystalline Powder With Special SmelMolecular weight:772.98
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