Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(127 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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Fascaplysin chloride
CAS:Fascaplysin inhibits CDK4/D1 (IC50=0.35μM), triggers caspase-activated autophagy-apoptosis crosstalk, and blocks PI3K/AKT/mTOR in HL-60 cells.Formula:C18H11ClN2OColor and Shape:SolidMolecular weight:306.75Boc-AEVD-CHO
CAS:Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].Formula:C22H36N4O10Purity:98%Color and Shape:SolidMolecular weight:516.54Ganoderic acid Mk
CAS:GA-Mk is a triterpenoid from Ganoderma lucidum mycelia, inhibits HeLa cell growth, and induces apoptosis via mitochondria; used in cervical cancer studies.Formula:C34H50O7Color and Shape:SolidMolecular weight:570.76PB28
CAS:PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.Formula:C24H38N2OColor and Shape:SolidMolecular weight:370.581Anticancer agent 52
CAS:Anticancer agent 52 exhibits potent cytotoxicity, induces apoptosis, and has potential in bladder cancer research.Formula:C50H43Br2N2PColor and Shape:SolidMolecular weight:862.67SHOC2-RAS PPI-IN-1
SHOC2–RAS PPI-IN-1 (compound 6) is a non-covalent competitive inhibitor that targets the interaction between SHOC2 and RAS proteins. It exhibits an IC50 of 0.048 μM and a KD of 0.065 μM against NRASQ61R. This compound inhibits SMP phosphatase-complex activity, increasing CRAFS259 phosphorylation levels and thus blocking the MAPK signaling pathway (by reducing pMEK and pERK levels). It induces cell cycle arrest and apoptosis in tumor cells. SHOC2–RAS PPI-IN-1 is used in targeting studies for malignancies, such as NRASQ61R-mutant melanoma and colorectal cancer.Color and Shape:Odour SolidEnpp/Carbonic anhydrase-IN-1
CAS:Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.Formula:C23H25NO4SPurity:99.96%Color and Shape:SoildMolecular weight:411.51PROTAC MNK1 degrader-1
ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.Formula:C35H38N6O6SColor and Shape:SolidMolecular weight:670.78XIAP ligand-Linker Conjugate 2
XIAPligand-Linker Conjugate 2 is an E3 ubiquitin ligase ligand-linker conjugate (E3 ligase Ligand-linker conjugate) that includes the XIAPBIR2 ligand XB2M54 and a linker. It is utilized in the synthesis of PROTACGNE-1567.Color and Shape:Odour SolidLY3415244
LY3415244 is a human bispecific antibody (bsAb) that targets B7-H1/PD-L1/CD274 and TIM-3/HAVCR2/CD366. This compound is applicable in the study of advanced solid tumors.Color and Shape:Odour LiquidS-Adenosyl-L-methionine
CAS:S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formula:C15H22N6O5SPurity:99.08%Color and Shape:SolidMolecular weight:398.44Thalidomide-NH-C8-NH2
CAS:Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.Formula:C21H28N4O4Color and Shape:SolidMolecular weight:400.479Apo A-I mimetic 5A peptide
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). It facilitates the efflux of cholesterol from inside cells, helping to reduce intracellular cholesterol accumulation. Additionally, Apo A-I mimetic 5A peptide exhibits anti-inflammatory properties, lowering inflammatory markers in blood and tissues. This peptide is used in cardiovascular disease research.Formula:C197H295N47O56Molecular weight:4215.16808Anti-inflammatory agent 42
CAS:Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.Formula:C20H12N2OSPurity:99.47%Color and Shape:SolidMolecular weight:328.39Thalidomide-O-amido-C6-NH2
CAS:Thalidomide-O-amido-C6-NH2 is a synthetic E3 ligase used for PROTAC creation, containing cereblon ligand and linker.Formula:C21H26N4O6Color and Shape:SolidMolecular weight:430.45PD-1/PD-L1-IN-40
PD-1/PD-L1-IN-40 (Compound EP16) is a PD-1/PD-L1 inhibitor. It effectively suppresses the production of exosomal PD-L1 with an IC50 of 0.108 μM. PD-1/PD-L1-IN-40 serves as a lead compound for the elimination of exosomal PD-L1 and is applicable in cancer research.Formula:C20H22N4O2Molecular weight:350.17428BCL6-IN-6
CAS:BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma.Formula:C27H31FN6O2SPurity:98.90%Color and Shape:SolidMolecular weight:522.64Oxybenzone-d3
Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.Formula:C14H9D3O3Color and Shape:SolidMolecular weight:231.26Furazolidone
CAS:Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Formula:C8H7N3O5Purity:99.96%Color and Shape:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidMolecular weight:225.16XZ739
CAS:XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.Formula:C65H76ClF3N8O12S3Color and Shape:SolidMolecular weight:1349.99Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formula:C32H46FN5O11Color and Shape:SolidMolecular weight:695.742m7GpppAmpG
CAS:M7GpppAmpG is a trinucleotide 5′ cap analog, exhibiting capping efficiencies of 90% for the produced RNAs [1].Formula:C32H43N15O24P4Color and Shape:SolidMolecular weight:1145.66Chetomin
CAS:Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar
Formula:C31H30N6O6S4Purity:98%Color and Shape:Off-White To Fawn SolidMolecular weight:710.87INF 195
CAS:INF 195 is an inflammasome NLRP3 inhibitor that can be used to study myocardial ischemia and myocardial infarction.Formula:C17H22ClNO3Purity:99.78%Color and Shape:SoildMolecular weight:323.81Apoptolidin
CAS:Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.Formula:C58H96O21Color and Shape:SolidMolecular weight:1129.385PROTAC LZK-IN-1
CAS:PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Formula:C51H64F2N10O5SColor and Shape:SolidMolecular weight:967.18Mitochondria modulator-2
Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.Formula:C63H50F12IrN6OP3Color and Shape:SolidMolecular weight:1420.23Topoisomerase IIα-IN-10
TopoisomeraseIIα-IN-10 (Compound 13r) is a topoisomerase IIα inhibitor that binds to the active site of DNA when complexed with topoisomerase IIα. This binding is stabilized through interactions with DNA base pairs and amino acid residues. By intercalating into DNA, TopoisomeraseIIα-IN-10 induces apoptosis and disrupts the mitochondrial membrane potential in HCT116 cells, effectively inhibiting their growth with an IC50 of 4.37 μM. It is applicable for cancer research studies.Formula:C32H27N3O3Color and Shape:SolidMolecular weight:501.575Lacto-N-fucopentaose I
CAS:Lacto-N-fucopentaose I is a milk oligosaccharide.Formula:C32H55NO25Color and Shape:SolidMolecular weight:853.774HDAC3-IN-6
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.Formula:C23H23N5O3Color and Shape:SolidMolecular weight:417.46PZ671
PZ671 is a potent PROTAC degrader targeting Bcl-xL, exhibiting an IC50 of 1.3 nM in MOLT-4 cells and a DC50 of 0.9 nM for Bcl-xL. It induces apoptosis in MOLT-4 cells and effectively inhibits tumor growth in MOLT-4 xenograft mice, while quickly restoring transiently reduced platelet counts. PZ671 is applicable in cancer research, including studies on small cell lung cancer.Color and Shape:Odour SolidCYP51/PD-L1-IN-1
CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).Formula:C20H15N5O2Color and Shape:SolidMolecular weight:357.37Bcl-2-IN-14
Bcl-2-IN-14 (Compound 13c), a BCL-2 inhibitor, exhibits an inhibitory concentration (IC 50) of 0.471 μM, and is applicable in cancer research [1].Color and Shape:Odour SolidABBV-167
CAS:ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.Formula:C46H53ClN7O11PSColor and Shape:SolidMolecular weight:978.45Thymidine 3',5'-disphosphate
CAS:pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Formula:C10H16N2O11P2Color and Shape:SolidMolecular weight:402.19Eciskafusp alfa
CAS:Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specificPurity:98%Color and Shape:SolidPROTAC PI3K/110β degrader-2
CAS:PROTACPI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. It effectively degrades the 110β protein and inhibits the expression of P-glycoprotein. Additionally, it increases reactive oxygen species (ROS) levels. PROTACPI3K/110β degrader-2 exerts antitumor effects by activating the endoplasmic reticulum stress (ERS) mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. This compound is applicable in cancer research.Formula:C51H65N9O7SColor and Shape:SolidMolecular weight:948.18Anticancer agent 102
CAS:Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].Formula:C20H19F6N3OColor and Shape:SolidMolecular weight:431.37YTHu78
YTHu78 is a KDM5B PROTAC-based degrader. It induces the degradation of KDM5B through the ubiquitin-proteasome system and triggers apoptosis in MV-4-11 and MM.1S cell lines. YTHu78 demonstrates significant antiproliferative activity against various hematologic tumor cell lines and is useful for studying hematological malignancies.Color and Shape:Odour SolidEmavusertib Tosylate
CAS:Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.Formula:C31H33N7O8SMolecular weight:663.7TNF/IFNγ-IN-1
CAS:TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formula:C20H23N3O6Purity:99.39%Color and Shape:SoildMolecular weight:401.41Disitertide diammonium
Disitertide (P144) is a TGF-β1 receptor blocker, PI3K inhibitor, and apoptosis inducer.Formula:C68H115N19O22S2Color and Shape:SolidMolecular weight:1614.88Z-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Formula:C37H42FN7O10Purity:98%Color and Shape:SolidMolecular weight:763.78LWY713
LWY713 is a PROTAC-based FLT3 degrader (DC50=0.64 nM) that selectively induces FLT3 degradation through a cereblon and proteasome-dependent mechanism. It inhibits cell proliferation and causes G0/G1 phase arrest and apoptosis (apoptosis) in MV4-11 cells. In MV4-11 xenograft models, LWY713 demonstrates significant in vivo antitumor activity. The E3 ligase ligand and linker consist of Lenalidomide-Glycolic acid, while the target protein ligand's active control is NaproxenGilteritinib.Formula:C43H54N10O8Molecular weight:838.41261TS-24
CAS:TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Formula:C20H15NO2Purity:99.41%Color and Shape:SoildMolecular weight:301.34PAA5
PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.Formula:C14H8Au5B2F8N2Color and Shape:SolidMolecular weight:1348.66Triphenyl phosphate
CAS:Triphenyl phosphate is an flame retardant and endocrine disruptor that activates MAO-A/ROS/NF-κB pathways, disrupting placental tryptophan metabolism.Formula:C18H15O4PPurity:99.94%Molecular weight:326.288Bcl-2/Mcl-1-IN-4
Bcl-2/Mcl-1-IN-4 (compound 20) acts as a dual inhibitor targeting Bcl-2 (Ki=0.49 μM) and Mcl-1 (Ki=0.51 μM). This compound effectively suppresses cancer cell proliferation and induces apoptosis in U937 cells. It is utilized in cancer research.Color and Shape:Odour SolideIF4E-IN-1
CAS:eIF4E-IN-1 inhibits eIF4E and boosts immunity by targeting PD-1, PD-L1, LAG3, TIM3, IDO, aiding cancer and infection treatment.Formula:C33H28ClF3N6O4SColor and Shape:SolidMolecular weight:697.13Thyrotropin
CAS:Thyrotropin (TSH), a thyroid-stimulating hormone, is synthesized by thyrotrope cells in the anterior pituitary gland and modulates the endocrine activity of theColor and Shape:Solid
