Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(109 products)
- CDK(522 products)
- Cell Cycle Arrest(4 products)
- Chk(46 products)
- DYRK(49 products)
- Dynamin(26 products)
- Ferroptosis(223 products)
- HSP(179 products)
- Integrin(256 products)
- Kinesin(83 products)
- LIM Kinase(19 products)
- Microtubule Associated(284 products)
- PKC(111 products)
- PLK(25 products)
- ROCK(67 products)
- Rho(2 products)
- Wee1(14 products)
- c-Myc(74 products)
Show 10 more subcategories
Found 3730 products of "Cell Cycle/Checkpoint"
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Aplidine
CAS:Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM).Formula:C57H87N7O15Purity:99.86%Color and Shape:SolidMolecular weight:1110.34MLN8054 sodium
CAS:MLN8054 sodium is an Aurora A inhibitor.Formula:C25H14ClF2N4NaO2Color and Shape:SolidMolecular weight:498.84Piritrexim isethionate
CAS:Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.Formula:C19H25N5O6SColor and Shape:SolidMolecular weight:451.49MTOB
CAS:MTOB, a CtBP substrate, inhibits CtBP-linked cancer activity in cells/mice and regulates TCF-4, affecting CSC proliferation.Formula:C5H7NaO3SPurity:98.23%Color and Shape:SolidMolecular weight:170.16Ganciclovir sodium
CAS:Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.Formula:C9H13N5NaO4Purity:99.93%Color and Shape:SolidMolecular weight:278.22ML-7 hydrochloride
CAS:ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM);Formula:C15H18ClIN2O2SPurity:99% - 99.26%Color and Shape:White PowderMolecular weight:452.74Nemorubicin HCL
CAS:Nemorubicin HCL, a PNU152243A salt, acts on resistant tumors via topoisomerase I inhibition and targets NER pathway upregulated cells.Formula:C32H38ClNO13Color and Shape:SolidMolecular weight:680.1Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Formula:C18H24N6OPurity:99.09% - 99.53%Color and Shape:SolidMolecular weight:340.42GS-441524 HCl
CAS:GS-441524: Inhibits FIP virus, EC50 at 0.78 μM, precursor to active triphosphate, non-toxic up to 100 μM, works at ≥1 μM, metabolite of Remdesivir.Formula:C12H14ClN5O4Color and Shape:SolidMolecular weight:327.72CWHM-12
CAS:<p>CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).</p>Formula:C26H32BrN5O6Purity:98.05% - 99.83%Color and Shape:SolidMolecular weight:590.47Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Formula:C14H19Cl2N3O2SPurity:99.86%Color and Shape:SolidMolecular weight:364.29BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Formula:C20H27N5O3Purity:99.85%Color and Shape:SolidMolecular weight:385.461,7-Diaminoheptane
CAS:1,7-Diaminoheptane, an aliphatic amine, is used in peptide synthesis and as a substrate, ligand, or reagent.Formula:C7H18N2Purity:99.97%Color and Shape:White To Light Yellow Crystalline ChunksMolecular weight:130.23Preq1-Dihydrochloride
CAS:Preq1-Dihydrochloride, a queuosine pathway intermediate, binds strongly to PreQ1 riboswitch aptamer, suppressing protein expression.Formula:C7H11Cl2N5OPurity:99.46%Color and Shape:SolidMolecular weight:252.1Cdk5 Substrate acetate
<p>Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.</p>Formula:C55H103N15O14Purity:96.21%Color and Shape:SolidMolecular weight:1198.5Poloxin
CAS:<p>Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).</p>Formula:C18H19NO3Purity:99.19%Color and Shape:SolidMolecular weight:297.35M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Formula:C19H24N4O4SPurity:99.02% - >99.99%Color and Shape:SolidMolecular weight:404.48NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.29ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purity:99.39%Color and Shape:SolidMolecular weight:334.32GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Formula:C24H16Cl2F2N6OPurity:98.59%Color and Shape:SolidMolecular weight:513.33A-674563 2HCl(552325-73-2(fb-2hcl))
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.Formula:C22H24Cl2N4OPurity:94.66%Color and Shape:SolidMolecular weight:431.36Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formula:C24H29N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:447.53IMP-1088
CAS:IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.Formula:C25H29F2N5OPurity:98.48% - 99.52%Color and Shape:SolidMolecular weight:453.53BTYNB
CAS:BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.Formula:C12H9BrN2OSPurity:≥95%Color and Shape:SolidMolecular weight:309.186-Thio-2'-Deoxyguanosine
CAS:6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.Formula:C10H13N5O3SPurity:97.52%Color and Shape:SolidMolecular weight:283.31SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Formula:C16H12F3N3SPurity:97.98% - >99.99%Color and Shape:SolidMolecular weight:335.35GDC-0575
CAS:<p>GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).</p>Formula:C16H20BrN5OPurity:≥95%Color and Shape:SolidMolecular weight:378.27AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43Tegafur-Uracil
CAS:Tegafur-Uracil, an oral anticancer agent for solid tumor research, inhibits thymidylate synthase.Formula:C12H13FN4O5Color and Shape:SolidMolecular weight:312.257Levoleucovorin Calcium
CAS:Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.Formula:C20H21N7O7·CaPurity:99.07% - ≥98%Color and Shape:White Crystalline PowderMolecular weight:511.5Afuresertib
CAS:Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFormula:C18H17Cl2FN4OSPurity:97.51% - 99.51%Color and Shape:SolidMolecular weight:427.32Danofloxacin
CAS:<p>Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine.</p>Formula:C19H20FN3O3Purity:99.77% - 99.8%Color and Shape:SolidMolecular weight:357.38CC-671
CAS:<p>CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.</p>Formula:C28H28N6O4Purity:98.66% - 98.8%Color and Shape:SolidMolecular weight:512.56Calcium N5-methyltetrahydrofolate
CAS:<p>Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and</p>Formula:C20H23CaN7O6Purity:99.41%Color and Shape:SolidMolecular weight:497.51Bractoppin
CAS:Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibitsFormula:C25H23FN4OPurity:98.38%Color and Shape:SolidMolecular weight:414.47FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formula:C17H18FN3SPurity:98.61%Color and Shape:SolidMolecular weight:315.41IRE1α kinase-IN-1
CAS:<p>IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM.</p>Formula:C26H26ClFN8Purity:99.18%Color and Shape:SolidMolecular weight:504.99Datelliptium chloride hydrochloride
CAS:<p>Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.</p>Formula:C23H29Cl2N3OPurity:99.46%Color and Shape:SolidMolecular weight:434.4MLS000532223
CAS:<p>MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).</p>Formula:C15H9NO3Purity:98.6%Color and Shape:SolidMolecular weight:251.24Hesperadin
CAS:Hesperadin(IC50=250 nM) effectively inhibits Aurora B.Formula:C29H32N4O3SPurity:98.04% - 99.44%Color and Shape:SolidMolecular weight:516.65Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.45%Color and Shape:SolidMolecular weight:393.49SB-743921 hydrochloride
CAS:SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).Formula:C31H34Cl2N2O3Purity:95.58% - 99.70%Color and Shape:SolidMolecular weight:553.52BCH001
CAS:BCH001 is a specific small-molecule inhibitor of PAPD5.Formula:C20H15F3N2O5Purity:99.06%Color and Shape:SolidMolecular weight:420.34R-IMPP
CAS:<p>R-IMPP is an inhibitor of PCSK9 translation.</p>Formula:C24H27N3O2Purity:99.47% - 99.85%Color and Shape:SolidMolecular weight:389.49EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formula:C25H28Cl2N4O3Purity:99.6%Color and Shape:SolidMolecular weight:503.42Trifluridine/tipiracil hydrochloride mixture
CAS:Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in aFormula:C29H34Cl2F6N8O12Purity:98% - 99.79%Color and Shape:SolidMolecular weight:871.53Arg-Gly-Asp TFA (99896-85-2(free base))
Arg-Gly-Asp TFA (RGD, 99896-85-2) is a tripeptide that promotes cell adhesion and integrin binding.Formula:C14H23F3N6O8Purity:99.2% - ≥98%Color and Shape:SolidMolecular weight:460.36Tempo
CAS:Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as aFormula:C9H18NOPurity:98.35%Color and Shape:Orange Crystals Or PowderMolecular weight:156.25BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purity:97.13% - 97.54%Color and Shape:SolidMolecular weight:464.56GDC0575 monohydrochloride
CAS:<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Formula:C16H21BrClN5OPurity:97.85%Color and Shape:SolidMolecular weight:414.73
