Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3756 products of "Cell Cycle/Checkpoint"

Purity (%)

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CDK6/9-IN-1
CAS:
- 2414373-55-8
CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).
Formula:C₂₂H₂₅ClN₈O
Color and Shape:Solid
Molecular weight:452.95
Ref: TM-T40047
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PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.
Color and Shape:Odour Solid
Ref: TM-T200724
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Dihydro-5-azacytidine
CAS:
- 62488-57-7
Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.
Formula:C₈H₁₄N₄O₅
Purity:>99.99%
Color and Shape:Solid
Molecular weight:246.22
Ref: TM-T40713
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5'-O-DMT-ibu-dC
CAS:
- 100898-62-2
5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.
Formula:C₃₄H₃₇N₃O₇
Color and Shape:Solid
Molecular weight:599.67
Ref: TM-T38405
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Carboxy-pyridostatin
CAS:
- 1417638-60-8
Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
Formula:C₃₅H₃₄N₁₀O₇
Color and Shape:Solid
Molecular weight:706.71
Ref: TM-T30745
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Isocytosine
CAS:
- 108-53-2
Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.
Formula:C₄H₅N₃O
Color and Shape:White To Off-White Solid
Molecular weight:111.1
Ref: TM-PDK0016
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Biotin-PEG7-C2-S-Vidarabine
Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.
Formula:C₃₆H₆₀N₈O₁₂S₂
Color and Shape:Solid
Molecular weight:861.04
Ref: TM-T74385
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PP-C8
PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.
Formula:C₄₃H₅₁FN₁₂O₇
Color and Shape:Solid
Molecular weight:866.94
Ref: TM-T74359
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Uridine triphosphate 13C9,15N2 sodium
CAS:
- 285978-18-9
Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.
Formula:C₉H₁₄₁₅N₂NaO₁₅P₃
Color and Shape:Solid
Molecular weight:517.04
Ref: TM-T36299
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PLK1-IN-2
CAS:
- 2640254-52-8
PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.
Formula:C₂₄H₂₇FN₈OS
Color and Shape:Solid
Molecular weight:494.59
Ref: TM-T40265
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Garenoxacin
CAS:
- 194804-75-6
Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.
Formula:C₂₃H₂₀F₂N₂O₄
Purity:98%
Color and Shape:Solid
Molecular weight:426.41
Ref: TM-T7179
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Xylocytidine
CAS:
- 3530-56-1
Xylocytidine is a biochemical.
Formula:C₉H₁₃N₃O₅
Color and Shape:Solid
Molecular weight:243.22
Ref: TM-T35201
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Nocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.
Formula:C₂₉H₄₂N₆O₉
Color and Shape:Odour Solid
Molecular weight:618.68
Ref: TM-TN9153
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Ficellomycin
CAS:
- 59458-27-4
Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.
Formula:C₁₃H₂₄N₆O₃
Color and Shape:Solid
Molecular weight:312.37
Ref: TM-T24063
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Anti-MRSA agent 7
Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.
Formula:C₂₂H₂₀BrF₂N₃O₄
Color and Shape:Solid
Molecular weight:508.31
Ref: TM-T74810
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Endo-1,4-β-xylanase
CAS:
- 9025-57-4
Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.
Color and Shape:Solid
Ref: TM-T76179
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Eesperamicin A1
CAS:
- 99674-26-7
Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.
Formula:C₅₉H₈₀N₄O₂₂S₄
Color and Shape:Solid
Molecular weight:1325.54
Ref: TM-T41140
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CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.
Color and Shape:Solid
Ref: TM-T36932
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RA-V
RA-V is a natural product that can be used as a reference standard.
Formula:C₁₆₀H₂₀₂N₂₄O₄₁
Color and Shape:Solid
Molecular weight:3117.5
Ref: TM-T124482
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BSJ-03-204
CAS:
- 2349356-09-6
BSJ-03-204 is a selective Cdk4/6 degrader.
Formula:C₄₃H₄₈N₁₀O₈
Color and Shape:Solid
Molecular weight:832.9
Ref: TM-T30600