HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 169 products of "HSP"
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GRP78-IN-3
CAS:<p>GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.</p>Formula:C17H18N4O2SPurity:99.11%Color and Shape:SoildMolecular weight:342.42CC-99677
CAS:<p>CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.</p>Formula:C22H20ClN5O3SPurity:99.59%Color and Shape:SolidMolecular weight:469.94Novobiocin Sodium
CAS:<p>Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.</p>Formula:C31H35N2NaO11Purity:99% - 99.28%Color and Shape:SolidMolecular weight:634.61IPI-493
CAS:<p>IPI-493 is a bioactive chemical.</p>Formula:C28H39N3O8Purity:>99.99%Color and Shape:SolidMolecular weight:545.62Ethoxyquin
CAS:<p>Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.</p>Formula:C14H19NOPurity:97.15% - 98.73%Color and Shape:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Molecular weight:217.31Arimoclomol maleate
CAS:<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Formula:C18H24ClN3O7Purity:99.44% - 99.98%Color and Shape:SolidMolecular weight:429.85Rifabutin
CAS:<p>Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.</p>Formula:C46H62N4O11Purity:98.87% - 99.7%Color and Shape:Red-Violet Crystalline PowderMolecular weight:847Col003
CAS:<p>Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).</p>Formula:C14H11NO4Purity:98.67% - 99.03%Color and Shape:SolidMolecular weight:257.24PU-H71 HCl
CAS:<p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>Formula:C18H22ClIN6O2SPurity:98.95%Color and Shape:SoildMolecular weight:548.83Gamitrinib TPP
CAS:<p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>Formula:C52H65N3O8PPurity:98%Color and Shape:SolidMolecular weight:891.078NMS-E973
CAS:<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>Formula:C22H22N4O7Purity:99.84%Color and Shape:SolidMolecular weight:454.43HEMTAC WEE1 degrader-1
CAS:<p>HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.</p>Formula:C57H71N15O6Color and Shape:SolidMolecular weight:1062.273-Phenyltoxoflavin
CAS:<p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>Formula:C13H11N5O2Purity:99.88%Color and Shape:SolidMolecular weight:269.266BrCaQ-C10-TPP
<p>6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.</p>Formula:C45H47Br2N2O3PColor and Shape:SolidMolecular weight:854.65Shepherdin (79-87)
CAS:<p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>Formula:C41H64N12O12SPurity:98%Color and Shape:SolidMolecular weight:949.09JG-258
CAS:<p>JG-258 is an inactive negative control for Hsp70 inhibitors [1] .</p>Formula:C20H22ClN3OS3Color and Shape:SolidMolecular weight:452.06trans-Dehydrocurvularin
CAS:<p>trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.</p>Formula:C16H18O5Color and Shape:SolidMolecular weight:290.315HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purity:98%Color and Shape:Odour SolidAlvespimycin TFA
<p>Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.</p>Formula:C34H49F3N4O10Color and Shape:SolidMolecular weight:730.34008Myrtucommulone
CAS:<p>Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.</p>Formula:C38H52O10Purity:98%Color and Shape:SolidMolecular weight:668.81p5 Ligand for Dnak and DnaJ
CAS:<p>P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.</p>Formula:C44H81N15O11SPurity:98%Color and Shape:SolidMolecular weight:1028.27PROTAC HSP90 degrader BP3
CAS:<p>PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.</p>Formula:C32H29ClN8O5Color and Shape:SolidMolecular weight:641.08MAL3-101
CAS:<p>MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).</p>Formula:C54H66N4O10Color and Shape:SolidMolecular weight:931.12HA15-Biotin
CAS:<p>HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.</p>Formula:C37H45N7O5S3Color and Shape:SolidMolecular weight:763.99MPC-0767
CAS:<p>MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.</p>Formula:C26H36BrN7O9S2Color and Shape:SolidMolecular weight:734.64Hsp70-derived octapeptide
CAS:<p>TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.</p>Formula:C36H58N8O16Purity:98%Color and Shape:SolidMolecular weight:858.89Arimoclomol citrate
CAS:<p>Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.</p>Formula:C20H28ClN3O10Color and Shape:SolidMolecular weight:505.9117-DMAP-GA
CAS:<p>17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities.</p>Formula:C33H50N4O8Color and Shape:SolidMolecular weight:630.783Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Formula:C31H30N6O6S4Purity:98%Color and Shape:Off-White To Fawn SolidMolecular weight:710.87TRAP1-IN-1
CAS:<p>TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.</p>Formula:C45H39F7N2O4P2Purity:98%Color and Shape:SolidMolecular weight:866.74Grp94 Inhibitor-3
<p>Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.</p>Formula:C24H20ClNO4Color and Shape:SolidMolecular weight:421.87Hsp90-IN-36
<p>Hsp90-IN-36 (compound 5) is an Hsp90 inhibitor with anticancer properties and exhibits an IC50 value of 14.74 μM against MCF-7 cells.</p>Formula:C20H13F4N3O4Color and Shape:SolidMolecular weight:435.328HS-27
CAS:<p>HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.</p>Formula:C52H60N6O12SPurity:97.09%Color and Shape:SolidMolecular weight:993.13Hsp110-STAT3 interaction-IN-2
<p>Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).</p>Formula:C24H18F3N5O3Color and Shape:SolidMolecular weight:481.43NPX800
CAS:<p>NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.</p>Formula:C32H32FN5O4Purity:99.29%Color and Shape:SolidMolecular weight:569.63HSP90-IN-35
CAS:<p>HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.</p>Formula:C27H33N5O5Color and Shape:SolidMolecular weight:507.58DN401
CAS:<p>DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.</p>Formula:C13H9BrClN5O2Purity:99.63%Color and Shape:SolidMolecular weight:382.6Zelavespib hydrochloride
<p>Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.</p>Purity:98%Color and Shape:Odour SolidNDNA4
<p>NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.</p>Formula:C31H35F3N2O5SPurity:98%Color and Shape:SolidMolecular weight:604.68TRAP1-IN-2
CAS:<p>TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.</p>Formula:C46H42F6N2O5P2Purity:98%Color and Shape:SolidMolecular weight:878.77HSP90-IN-25
<p>HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].</p>Formula:C29H48O10Purity:98%Color and Shape:SolidMolecular weight:556.69PROTAC Hsp90α degrader 1
<p>Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.</p>Formula:C43H50N6O7Purity:98%Color and Shape:SolidMolecular weight:762.89NDNA3
<p>NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A</p>Formula:C28H32N2O3SPurity:98%Color and Shape:SolidMolecular weight:476.63HSP90-IN-23
<p>HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.</p>Formula:C22H24N2O6SPurity:98%Color and Shape:SolidMolecular weight:444.5Palmitic acid-1-13C
CAS:<p>Palmitic acid-13C, a 16-C saturated fatty acid internal standard for GC/LC-MS, is prevalent in plasma lipids and influences protein acylation and COX-2 levels.</p>Formula:C16H32O2Color and Shape:SolidMolecular weight:257.422CCT245232
CAS:<p>CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.</p>Formula:C27H23N3O4Color and Shape:SolidMolecular weight:453.49PU-H71
CAS:<p>PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.</p>Formula:C18H21IN6O2SPurity:98.31% - 99.937%Color and Shape:SolidMolecular weight:512.37Debio 0932
CAS:<p>Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.</p>Formula:C22H30N6O2SPurity:98.98%Color and Shape:SolidMolecular weight:442.58Dihydroberberine
CAS:<p>Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.</p>Formula:C20H19NO4Purity:93.77%Color and Shape:SolidMolecular weight:337.37Pifithrin-μ
CAS:<p>Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.</p>Formula:C8H7NO2SPurity:99.33% - 99.79%Color and Shape:SolidMolecular weight:181.21MK2-IN-1 hydrochloride
CAS:<p>MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.</p>Formula:C27H26Cl2N4O2Purity:97.32%Color and Shape:SolidMolecular weight:509.43XL888
CAS:<p>XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.</p>Formula:C29H37N5O3Purity:99.18%Color and Shape:SolidMolecular weight:503.64HM03 trihydrochloride
CAS:<p>HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.</p>Formula:C26H30Cl4N4O2Color and Shape:SolidMolecular weight:572.35Tanespimycin
CAS:<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Formula:C31H43N3O8Purity:99.07% - 99.83%Color and Shape:Dark Purple SolidMolecular weight:585.69VER49009
CAS:<p>VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).</p>Formula:C19H18ClN3O4Purity:98.95% - >99.99%Color and Shape:SolidMolecular weight:387.82MitoBloCK-10
CAS:<p>MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.</p>Formula:C12H8FN3O3SPurity:99.51%Color and Shape:SolidMolecular weight:293.27HSP70-IN-1
CAS:<p>HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).</p>Formula:C24H28N6O2SPurity:99.91%Color and Shape:SolidMolecular weight:464.58HM03
CAS:<p>HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.</p>Formula:C26H27ClN4O2Purity:97.15%Color and Shape:SolidMolecular weight:462.97VER-50589
CAS:<p>VER-50589 is a potent HSP90 inhibitor.</p>Formula:C19H17ClN2O5Purity:99.96% - >99.99%Color and Shape:SolidMolecular weight:388.8MK2-IN-1
CAS:<p>MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.</p>Formula:C27H25ClN4O2Color and Shape:SolidMolecular weight:472.97MKT-077
CAS:<p>MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.</p>Formula:C21H22ClN3OS2Purity:98.2%Color and Shape:SolidMolecular weight:432HSP27 inhibitor J2
CAS:<p>HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of</p>Formula:C13H12O4SPurity:99.51%Color and Shape:SolidMolecular weight:264.3ML346
CAS:<p>ML346 is a novel activator of Hsp70.</p>Formula:C14H12N2O4Purity:97.32% - 99.36%Color and Shape:SolidMolecular weight:272.262-hexyl-4-Pentynoic Acid
CAS:<p>2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.</p>Formula:C11H18O2Purity:98%Color and Shape:SolidMolecular weight:182.26Luminespib
CAS:<p>Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C26H31N3O5Purity:98% - 99.25%Color and Shape:SolidMolecular weight:465.54Onalespib
CAS:<p>Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.</p>Formula:C24H31N3O3Purity:98.05% - 99.66%Color and Shape:SolidMolecular weight:409.52Rocaglamide
CAS:<p>Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.</p>Formula:C29H31NO7Purity:95.32% - 99.67%Color and Shape:SolidMolecular weight:505.56Alvespimycin hydrochloride
CAS:<p>Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.</p>Formula:C32H48N4O8·HClPurity:99.94%Color and Shape:SolidMolecular weight:653.21PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Formula:C26H34F3N5O7SPurity:99% - 99.46%Color and Shape:SolidMolecular weight:617.63JG-98
CAS:<p>JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).</p>Formula:C24H21Cl2N3OS3Purity:99.13%Color and Shape:SolidMolecular weight:534.53Teprenone
CAS:<p>Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).</p>Formula:C23H38OPurity:99.1% - 99.96%Color and Shape:SolidMolecular weight:330.55DDO-5936
CAS:<p>DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.</p>Formula:C25H29N5O4SPurity:99.81%Color and Shape:SolidMolecular weight:495.59NVP-HSP990
CAS:<p>NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).</p>Formula:C20H18FN5O2Purity:98.03% - 99.32%Color and Shape:SolidMolecular weight:379.39L-Alanyl-L-glutamine
CAS:<p>L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.</p>Formula:C8H15N3O4Purity:99.71% - 99.97%Color and Shape:SolidMolecular weight:217.22PF04929113
CAS:<p>PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.</p>Formula:C25H30F3N5O4Purity:99.04%Color and Shape:SolidMolecular weight:521.53Eupalinolide A
CAS:<p>Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.</p>Formula:C24H30O9Purity:98.82% - 99.22%Color and Shape:SolidMolecular weight:462.49Grp94 Inhibitor-1
CAS:<p>Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).</p>Formula:C22H28N2O2Purity:97.02%Color and Shape:SolidMolecular weight:352.47Paeoniflorin
CAS:<p>Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.</p>Formula:C23H28O11Purity:96.9% - 97.43%Color and Shape:White Fine PowderMolecular weight:480.46Gedunin
CAS:<p>Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.</p>Formula:C28H34O7Purity:99.64% - 99.68%Color and Shape:SolidMolecular weight:482.57Ganetespib
CAS:<p>Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.</p>Formula:C20H20N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:364.4TRC051384
CAS:<p>TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.</p>Formula:C25H31N5O4Purity:98.79%Color and Shape:SolidMolecular weight:465.54KRIBB11
CAS:<p>KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.</p>Formula:C13H12N6O2Purity:97.25% - 99.91%Color and Shape:SolidMolecular weight:284.27Pimitespib
CAS:<p>Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).</p>Formula:C25H26N8OPurity:99.22% - 99.49%Color and Shape:SolidMolecular weight:454.53VER-49009
CAS:<p>VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).</p>Formula:C19H18ClN3O4Purity:99.36% - 99.99%Color and Shape:SolidMolecular weight:387.82TRC051384 HCl
CAS:<p>TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.</p>Formula:C25H32ClN5O4Purity:97.55%Color and Shape:SolidMolecular weight:502.01BIIB021
CAS:<p>BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).</p>Formula:C14H15ClN6OPurity:98% - 99.82%Color and Shape:SolidMolecular weight:318.76Geldanamycin
CAS:<p>Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.</p>Formula:C29H40N2O9Purity:97.59% - 99.27%Color and Shape:Yellow To Orange PowderMolecular weight:560.64Feretoside
CAS:<p>Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).</p>Formula:C17H24O11Purity:99.85%Color and Shape:SolidMolecular weight:404.37HA15
CAS:<p>HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.</p>Formula:C23H22N4O3S2Purity:99.77% - 99.86%Color and Shape:SolidMolecular weight:466.58Palmitic acid
CAS:<p>Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.</p>Formula:C16H32O2Purity:99.17% - 99.67%Color and Shape:White Crystalline Scales SolidMolecular weight:256.42KNK437
CAS:<p>KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).</p>Formula:C13H11NO4Purity:98.90%Color and Shape:SolidMolecular weight:245.23DTHIB
CAS:<p>DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.</p>Formula:C13H9ClFN3O3Purity:98.86% - 99.29%Color and Shape:SolidMolecular weight:309.68Apoptozole
CAS:<p>Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.</p>Formula:C33H25F6N3O3Purity:99.75%Color and Shape:SolidMolecular weight:625.56Azadiradione
CAS:<p>Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica</p>Formula:C28H34O5Purity:99.52%Color and Shape:SolidMolecular weight:450.57HSF1A
CAS:<p>HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.</p>Formula:C21H19N3O2S2Purity:98.89%Color and Shape:SolidMolecular weight:409.52YUM70
CAS:<p>YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.</p>Formula:C21H19ClN2O4Purity:97.25%Color and Shape:SolidMolecular weight:398.84KBU2046
CAS:<p>KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.</p>Formula:C15H11FO2Purity:99.89%Color and Shape:SolidMolecular weight:242.24VER-82576
CAS:<p>VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.</p>Formula:C21H23Cl2N5O2SPurity:97.31% - 99.85%Color and Shape:SolidMolecular weight:480.41VER-155008
CAS:<p>VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.</p>Formula:C25H23Cl2N7O4Purity:97.03% - 99.55%Color and Shape:SolidMolecular weight:556.4PU-H54
CAS:<p>PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.</p>Formula:C18H19N5SPurity:99.13%Color and Shape:SolidMolecular weight:337.44KW-2478
CAS:<p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>Formula:C30H42N2O9Purity:98.68% - 99.52%Color and Shape:SolidMolecular weight:574.66Alvespimycin
CAS:<p>Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.</p>Formula:C32H48N4O8Purity:99.88%Color and Shape:SolidMolecular weight:616.75Calenduloside E
CAS:<p>Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by</p>Formula:C36H56O9Purity:96.16% - 98.99%Color and Shape:SolidMolecular weight:632.8217-AEP-GA
CAS:<p>17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.</p>Formula:C34H50N4O8Purity:97.77% - 99.56%Color and Shape:SolidMolecular weight:642.78Retaspimycin Hydrochloride
CAS:<p>Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).</p>Formula:C31H46ClN3O8Purity:98%Color and Shape:SolidMolecular weight:624.17Bimoclomol
CAS:<p>Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.</p>Formula:C14H20ClN3O2Color and Shape:SolidMolecular weight:297.78CH5138303
CAS:<p>CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.</p>Formula:C19H18ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:415.9AMP-PCP
CAS:<p>AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.</p>Formula:C11H18N5O12P3Purity:98%Color and Shape:SolidMolecular weight:505.21JG-48
CAS:<p>JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.</p>Formula:C20H16F3N3OS2Color and Shape:SolidMolecular weight:435.49Hsp90-IN-15
CAS:<p>Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.</p>Formula:C23H27F3N4Color and Shape:SolidMolecular weight:416.48CCT251236
CAS:<p>CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.</p>Formula:C32H32N4O5Purity:98.82% - 99.89%Color and Shape:SolidMolecular weight:552.62HSP90-IN-12
CAS:<p>VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.</p>Formula:C25H36O4Color and Shape:SolidMolecular weight:400.55YM-01 Tosylate
CAS:<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Formula:C27H27N3O4S3Color and Shape:SolidMolecular weight:553.72Displurigen
CAS:<p>Displurigen is an inhibitor of ATPase activity of HSP70.</p>Formula:C15H10O4SPurity:98%Color and Shape:SolidMolecular weight:286.3Malonganenone A
CAS:<p>Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.</p>Formula:C26H38N4O2Color and Shape:SolidMolecular weight:438.616BrCaQ
CAS:<p>6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.</p>Formula:C18H15BrN2O3Color and Shape:SolidMolecular weight:387.23HSP90-IN-22
CAS:<p>HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in</p>Formula:C25H30N4O3Purity:98%Color and Shape:SolidMolecular weight:434.53PU3
CAS:<p>PU3 is an inhibitor of Hsp90.</p>Formula:C19H25N5O3Purity:98%Color and Shape:SolidMolecular weight:371.43SEW84
CAS:<p>SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.</p>Formula:C19H14F4N4OSColor and Shape:SolidMolecular weight:422.4HSP90-IN-14
CAS:<p>HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.</p>Formula:C14H8Cl2N4O4SColor and Shape:SolidMolecular weight:399.21CH5164840
CAS:<p>CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.</p>Formula:C19H23N5O2SColor and Shape:SolidMolecular weight:385.48Hsp90-Cdc37-IN-1
CAS:<p>Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.</p>Formula:C43H57FN2O6SPurity:98%Color and Shape:SolidMolecular weight:748.99Vibsanin A
CAS:<p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>Formula:C25H38O4Color and Shape:SolidMolecular weight:402.57YM-1
CAS:<p>YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.</p>Formula:C20H20ClN3OS2Color and Shape:SolidMolecular weight:417.98BIIB028
CAS:<p>BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.</p>Formula:C19H21ClN5O5PColor and Shape:SolidMolecular weight:465.83Retaspimycin
CAS:<p>Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).</p>Formula:C31H45N3O8Purity:98%Color and Shape:SolidMolecular weight:587.7KUNB31
CAS:<p>KUNB31 is a potent and selective inhibitor of Hsp90β.</p>Formula:C19H18N2O3Color and Shape:SolidMolecular weight:322.36HSP90-IN-20
CAS:<p>HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.</p>Formula:C26H32N4O4Color and Shape:SolidMolecular weight:464.56Hsp90-IN-17
CAS:<p>Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.</p>Formula:C21H20N4O7Color and Shape:SolidMolecular weight:440.41Heat Shock Protein Inhibitor II
CAS:<p>Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.</p>Formula:C12H11NO3Color and Shape:SolidMolecular weight:217.22SW02
CAS:<p>SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).</p>Formula:C19H23BrN2O5Color and Shape:SolidMolecular weight:439.3PU24FCl
CAS:<p>PU24FCl is a specific inhibitor of tumor Hsp90.</p>Formula:C20H21ClFN5O3Color and Shape:SolidMolecular weight:433.86BMS-358233
CAS:<p>BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.</p>Formula:C25H25ClN6O2SColor and Shape:SolidMolecular weight:509.02EC 144
CAS:<p>EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.</p>Formula:C21H24ClN5O2Color and Shape:SolidMolecular weight:413.9MPC-3100
CAS:<p>MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].</p>Formula:C22H25BrN6O4SColor and Shape:SolidMolecular weight:549.44Iroxanadine
CAS:<p>Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in</p>Formula:C14H20N4OPurity:98.04% - 99.04%Color and Shape:SolidMolecular weight:260.33AMP-PCP disodium
CAS:<p>AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.</p>Formula:C11H16N5Na2O12P3Purity:99.32%Color and Shape:SolidMolecular weight:549.17SNX0723
CAS:<p>SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.</p>Formula:C22H26FN3O3Purity:99.85%Color and Shape:SolidMolecular weight:399.46Arimoclomol
CAS:<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Formula:C14H20ClN3O3Purity:99.15%Color and Shape:SolidMolecular weight:313.78JG-231
CAS:<p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>Formula:C22H18BrCl2N3OS4Purity:99.79%Color and Shape:SolidMolecular weight:619.47KU-177
CAS:<p>KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.</p>Formula:C27H23NO8Purity:96.92% - 98.54%Color and Shape:SolidMolecular weight:489.47HSP90-IN-29
CAS:<p>HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].</p>Formula:C19H20ClN3O4Color and Shape:SolidMolecular weight:389.83GRP78-IN-2
CAS:<p>GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.</p>Formula:C29H29NO6Color and Shape:SolidMolecular weight:487.54HSP90-IN-27
CAS:<p>HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].</p>Formula:C18H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:343.44Flavokawain 1i
CAS:<p>Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.</p>Formula:C21H18O4Color and Shape:SolidMolecular weight:334.37MAO A/HSP90-IN-2
CAS:<p>MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.</p>Formula:C25H31ClN2O4Purity:98%Color and Shape:SolidMolecular weight:458.98HSP70/SIRT2-IN-2
CAS:<p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>Formula:C17H13N3S3Purity:98%Color and Shape:SolidMolecular weight:355.5Colletofragarone A2
CAS:<p>Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.</p>Formula:C22H26O6Color and Shape:SolidMolecular weight:386.44YM-08
CAS:<p>YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].</p>Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49HSP90-IN-19
CAS:<p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>Formula:C29H38O7Purity:98%Color and Shape:SolidMolecular weight:498.61MAO A/HSP90-IN-1
CAS:<p>MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.</p>Formula:C24H29ClN2O4Purity:98%Color and Shape:SolidMolecular weight:444.95Iroxanadine sulfate
CAS:<p>Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.</p>Formula:C14H22N4O5SColor and Shape:SolidMolecular weight:358.41BX-2819
CAS:<p>BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .</p>Formula:C21H24N4O4SPurity:98%Color and Shape:SolidMolecular weight:428.51EV206
CAS:<p>EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.</p>Formula:C21H19N3OColor and Shape:SolidMolecular weight:329.40DDO-6691
CAS:<p>DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.</p>Formula:C22H17N3O2SColor and Shape:SolidMolecular weight:387.45Onalespib lactate
CAS:<p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>Formula:C27H37N3O6Color and Shape:SolidMolecular weight:499.6Cemdomespib
CAS:<p>Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.</p>Formula:C24H30FNO6Color and Shape:SolidMolecular weight:447.5Hsp90-IN-37
CAS:<p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>Formula:C12H15N3O2Color and Shape:SolidMolecular weight:233.266ETB
CAS:<p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>Formula:C24H33NO6Molecular weight:431.52Hsp110-STAT3 interaction-IN-1
CAS:<p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>Formula:C23H31N3O4SColor and Shape:SolidMolecular weight:445.58DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Formula:C22H23N3O2SColor and Shape:SolidMolecular weight:393.50KUNG65
CAS:<p>KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.</p>Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85KU-32
CAS:<p>KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.</p>Formula:C20H25NO8Purity:98%Color and Shape:SolidMolecular weight:407.41Macbecin I
CAS:<p>Hsp90 inhibitor</p>Formula:C30H42N2O8Purity:98%Color and Shape:SolidMolecular weight:558.66C086
CAS:<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Formula:C29H28O8Color and Shape:SolidMolecular weight:504.53Hsp90-IN-34
CAS:<p>Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.</p>Formula:C22H14F2N6OColor and Shape:SolidMolecular weight:416.38HSP90-IN-11
<p>HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.</p>Formula:C27H30FN3O6Color and Shape:SolidMolecular weight:511.54HSP90-IN-32
CAS:<p>HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.</p>Formula:C33H40N2O4Color and Shape:SolidMolecular weight:528.68HSP90α-IN-1
CAS:<p>HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.</p>Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.356
