DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(71 products)
- DNA Alkylation(11 products)
- DNA Methyltransferase(422 products)
- DNA gyrase(11 products)
- DNA-PK(51 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,388 products)
- Reverse Transcriptase(43 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(136 products)
Show 3 more subcategories
Found 959 products of "DNA Damage/DNA Repair"
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Palifosfamide
CAS:<p>Palifosfamide lysine (ZIO-201) stable, effective vs. sarcomas in vitro. IC50: 2.25-6.75 μM, except OS222 at 31.5 μM.</p>Formula:C4H11Cl2N2O2PPurity:99.72%Color and Shape:SolidMolecular weight:221.02360A
CAS:<p>360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).</p>Formula:C27H23N5O2Purity:98.68%Color and Shape:SolidMolecular weight:449.5Lomeguatrib
CAS:<p>Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .</p>Formula:C10H8BrN5OSPurity:99.26% - >99.99%Color and Shape:SolidMolecular weight:326.17Nexturastat A
CAS:<p>Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.</p>Formula:C19H23N3O3Purity:99.40% - 99.57%Color and Shape:SolidMolecular weight:341.4ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Formula:C16H17N5O2Purity:99.14%Color and Shape:SolidMolecular weight:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54Pimelic diphenylamide 106
CAS:<p>Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC, showing no activity against class II HDACs.</p>Formula:C20H25N3O2Purity:95.25% - 99.28%Color and Shape:SolidMolecular weight:339.43TMP269
CAS:<p>TMP269: Class IIa HDAC inhibitor; HDAC4 IC50=157 nM, HDAC5 IC50=97 nM, HDAC7 IC50=43 nM, HDAC9 IC50=23 nM.</p>Formula:C25H21F3N4O3SPurity:98% - 99.72%Color and Shape:SolidMolecular weight:514.52Amonafide
CAS:<p>Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.</p>Formula:C16H17N3O2Purity:99.39%Color and Shape:SolidMolecular weight:283.33A-966492
CAS:<p>A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.</p>Formula:C18H17FN4OPurity:98.53% - 99.27%Color and Shape:SolidMolecular weight:324.356-AZATHYMINE
CAS:<p>6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.</p>Formula:C4H5N3O2Purity:99.47%Color and Shape:SolidMolecular weight:127.1ACY-775
CAS:<p>ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).</p>Formula:C17H19FN4O2Purity:97.67% - 98.83%Color and Shape:SolidMolecular weight:330.36Satraplatin
CAS:<p>Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical</p>Formula:C10H22Cl2N2O4PtPurity:98.25%Color and Shape:SolidMolecular weight:500.28CRT0044876
CAS:<p>CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.</p>Formula:C9H6N2O4Purity:98.27% - 98.98%Color and Shape:Brown PowderMolecular weight:206.15azd1390
CAS:<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Formula:C27H32FN5O2Purity:97.41% - 99.72%Color and Shape:SolidMolecular weight:477.57RGFP966
CAS:<p>RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 μM.</p>Formula:C21H19FN4OPurity:99.2% - 99.88%Color and Shape:SolidMolecular weight:362.4RG2833
CAS:<p>RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.</p>Formula:C20H25N3O2Purity:99% - 99.50%Color and Shape:SolidMolecular weight:339.433,4-Dicaffeoylquinic acid
CAS:<p>3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity.</p>Formula:C25H24O12Purity:96.33% - 98.82%Color and Shape:SolidMolecular weight:516.45Seclidemstat
CAS:<p>Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.</p>Formula:C20H23ClN4O4SPurity:98.28% - 99.76%Color and Shape:SolidMolecular weight:450.94Veliparib dihydrochloride
CAS:<p>Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.</p>Formula:C13H18Cl2N4OPurity:98% - 99.81%Color and Shape:SolidMolecular weight:317.21Prexasertib dihydrochloride
CAS:<p>Prexasertib dihydrochloride (LY2606368) inhibits CHK1 (Ki: 0.9 nM); IC50: CHK2 8 nM, RSK 9 nM.</p>Formula:C18H21Cl2N7O2Purity:98.46% - 99.82%Color and Shape:SolidMolecular weight:438.316-Thioguanine
CAS:<p>6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.</p>Formula:C5H5N5SPurity:98.34% - >99.99%Color and Shape:Odorless Or Almost Odorless Pale Yellow Crystalline PowderMolecular weight:167.19SIS17
CAS:<p>SIS17: Potent, selective HDAC11 inhibitor (IC50: 0.83 μM), blocks serine hydroxymethyl transferase 2 demyristoylation, spares other HDACs.</p>Formula:C21H38N2OSPurity:98.22%Color and Shape:SolidMolecular weight:366.6CC-115
CAS:<p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>Formula:C16H16N8OPurity:86.79% - 99.01%Color and Shape:SolidMolecular weight:336.35SRT 1460
CAS:<p>SRT 1460 is a SIRT1 activator.</p>Formula:C26H29N5O4SPurity:98.25%Color and Shape:SolidMolecular weight:507.6Venadaparib
CAS:<p>Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.</p>Formula:C23H23FN4O2Purity:99.86%Color and Shape:SolidMolecular weight:406.45Ochromycinone
CAS:<p>Ochromycinone (STA 21) is a selective STAT3 inhibitor.</p>Formula:C19H14O4Purity:99.21%Color and Shape:SolidMolecular weight:306.315-Methyl-2'-deoxycytidine
CAS:<p>5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.</p>Formula:C10H15N3O4Purity:99.18% - 99.69%Color and Shape:SolidMolecular weight:241.245-Fluoro-2'-deoxycytidine
CAS:<p>5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .</p>Formula:C9H12FN3O4Purity:97.91%Color and Shape:Fine White PowderMolecular weight:245.21Bimolane
CAS:<p>Bimolane is a topoisomerase II inhibitor.</p>Formula:C20H32N6O6Purity:99.13% - 99.29%Color and Shape:SolidMolecular weight:452.5Amsacrine hydrochloride
CAS:<p>Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.</p>Formula:C21H20ClN3O3SPurity:99.05% - 99.92%Color and Shape:SolidMolecular weight:429.92Levofloxacin
CAS:<p>Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.</p>Formula:C18H20FN3O4Purity:98.14% - 99.80%Color and Shape:Off-White To Yellow CrystalsMolecular weight:361.37ACY-738
CAS:<p>ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.</p>Formula:C14H14N4O2Purity:98.85% - 99.89%Color and Shape:SolidMolecular weight:270.29YU238259
CAS:<p>YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.</p>Formula:C22H22ClN3O4SPurity:99.28% - 99.56%Color and Shape:SolidMolecular weight:459.95GeA-69
CAS:<p>GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).</p>Formula:C20H16N2OPurity:99.85%Color and Shape:SolidMolecular weight:300.35Talazoparib
CAS:<p>Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).</p>Formula:C19H14F2N6OPurity:97.02% - 99.92%Color and Shape:SolidMolecular weight:380.35Tunicamycin
CAS:<p>Tunicamycin is a mixture of antibiotics that inhibit N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT).</p>Formula:C39H64N4O16Purity:98.77%Color and Shape:White Crystalline SolidMolecular weight:844.94 (n=10)LY-294002 hydrochloride
CAS:<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Formula:C19H17NO3·HClPurity:99.95%Color and Shape:SolidMolecular weight:343.81HDAC8-IN-1
CAS:<p>MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.</p>Formula:C22H19NO3Purity:97.13% - 99.19%Color and Shape:SolidMolecular weight:345.39Belinostat
CAS:<p>Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.</p>Formula:C15H14N2O4SPurity:99.75% - >99.99%Color and Shape:SolidMolecular weight:318.35Veliparib
CAS:<p>Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.</p>Formula:C13H16N4OPurity:98.66% - 99%Color and Shape:SolidMolecular weight:244.29SF2523
CAS:<p>SF2523 is a highly selective and potent inhibitor.</p>Formula:C19H17NO5SPurity:99.1% - 99.51%Color and Shape:SolidMolecular weight:371.41SGI-1027
CAS:<p>SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).</p>Formula:C27H23N7OPurity:99.45% - 99.78%Color and Shape:SolidMolecular weight:461.523-Methoxybenzamide
CAS:<p>3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.</p>Formula:C8H9NO2Purity:98.52%Color and Shape:SolidMolecular weight:151.16HDAC-IN-7
CAS:<p>HDAC-IN-7 (HBI-8000) (Chidamide impurity) is an impurity of Chidamide.</p>Formula:C22H19FN4O2Purity:97.64% - 98.45%Color and Shape:SolidMolecular weight:390.41Pirarubicin
CAS:<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Formula:C32H37NO12Purity:97.80% - 99.15%Color and Shape:Red Crystalline PowderMolecular weight:627.64Potassium acetate
CAS:<p>Potassium acetate (Diuretic salt) with antibacterial and antifungal properties.</p>Formula:C2H3KO2Purity:≥98%Color and Shape:Colorless Lustrous Rapidly Deliquescent Crystals Or White Crystal Powder Or Flakes Solid Repidly Deliquescent Crystals Or White Crystal Powder Or FlakesMolecular weight:98.14TAS-103 dihydrochloride
CAS:<p>TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.</p>Formula:C20H21Cl2N3O2Purity:97.78%Color and Shape:SolidMolecular weight:406.31KU-0060648
CAS:<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Formula:C33H34N4O4SPurity:98.75%Color and Shape:SolidMolecular weight:582.71Hypericin
CAS:<p>Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.</p>Formula:C30H16O8Purity:99.05% - ≥98%Color and Shape:Red-Coloured Anthraquinone-DerivativeMolecular weight:504.44
