Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(136 products)
- CXCR(149 products)
- Cell wall(5 products)
- IL Receptor(112 products)
- IκB/IKK(59 products)
- LTR(3 products)
- MALT(23 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(443 products)
- NOD(18 products)
- NOS(62 products)
- Nrf2(78 products)
- PGE Synthase(31 products)
- ROS(69 products)
- TGF-beta/Smad(58 products)
- TLR(66 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3055 products of "Immunology and Inflammation"
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TLR7/8 antagonist 2
<p>TLR7/8 antagonist 2: potent, orally active, IC50: 4.9 nM (TLR7), 0.6 nM (TLR8); potential for lupus therapy research.</p>Formula:C22H26FN5Color and Shape:SolidMolecular weight:379.47TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53IRAK4 modulator-1
CAS:<p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>Formula:C19H13ClN4O2Color and Shape:SolidMolecular weight:364.79IKZF1-degrader-2
CAS:<p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>Formula:C33H30FN5O5Color and Shape:SolidMolecular weight:595.62SB24011
CAS:<p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>Formula:C34H38N4O7Color and Shape:SolidMolecular weight:614.69TE-11
CAS:<p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>Formula:C16H13NOColor and Shape:SolidMolecular weight:235.28IRAK4-IN-11
<p>IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].</p>Formula:C16H19N7OColor and Shape:SolidMolecular weight:325.37BMS-986458
CAS:<p>BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.</p>Formula:C32H34ClN9O3Color and Shape:SolidMolecular weight:628.124ALR-27
CAS:<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Formula:C19H22O3Color and Shape:SolidMolecular weight:298.38STING agonist-21
CAS:<p>STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].</p>Formula:C17H11F6N5O2Color and Shape:SolidMolecular weight:431.29IL-17 modulator 5
CAS:<p>IL-17 modulator 5 is a IL-17 inhibitor, with an IC 50 of 1 nM .</p>Formula:C28H23F6N9O2Color and Shape:SolidMolecular weight:631.53(S,R,S)-AHPC-Boc derivative 1
CAS:<p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>Formula:C28H40N4O6SColor and Shape:SolidMolecular weight:560.705Galectin-3-IN-3
CAS:<p>Galectin-3-IN-3 (Compound 4) serves as a selective and orally active inhibitor targeting Gal-3. It exhibits IC50 values of 11 nM for mGal-3 and 84 nM for hGal-3 [1].</p>Formula:C25H22ClF2N7O4SColor and Shape:SolidMolecular weight:590.00UBS109
CAS:<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Formula:C18H17N3OPurity:99.48%Color and Shape:SolidMolecular weight:291.35KI696
CAS:<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Formula:C28H30N4O6SPurity:99.74%Color and Shape:SolidMolecular weight:550.63Dazostinag disodium
CAS:<p>Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.</p>Formula:C21H20F2N8Na2O10P2S2Purity:98.84% - 99.96%Color and Shape:SolidMolecular weight:754.48Zharp1-211
CAS:<p>Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.</p>Formula:C24H25N5O4Purity:99.71%Color and Shape:SolidMolecular weight:447.49Evixapodlin
CAS:<p>Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.</p>Formula:C34H36Cl2N8O4Purity:99.07%Color and Shape:SolidMolecular weight:691.61Antiproliferative agent-22
CAS:<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Formula:C17H13N3O3Purity:99.20% - 99.27%Color and Shape:SolidMolecular weight:307.3AM103
CAS:AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).Formula:C36H38N3NaO4SPurity:99.75%Color and Shape:SolidMolecular weight:631.76VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formula:C17H17ClN4O2Purity:99.01% - 99.92%Color and Shape:SolidMolecular weight:344.8HOIPIN-8 sodium
CAS:<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Formula:C23H15F2N4NaO3Purity:97.34%Color and Shape:SolidMolecular weight:456.382-Selenouracil
CAS:<p>2-Selenouracil is a specialized photosensitizer for photodynamical therapy.</p>Formula:C4H4N2OSeColor and Shape:SolidMolecular weight:175.05NSC23925
CAS:NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formula:C22H26Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:421.36Veledimex
CAS:<p>Veledimex is an oral activator ligand for a proprietary gene therapy promoter system. It is also a moderate inhibitor of and substrate for CYP3A4/5.</p>Formula:C27H38N2O3Purity:98%Color and Shape:SolidMolecular weight:438.6PSB-12379
CAS:<p>PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).</p>Formula:C18H23N5O9P2Purity:98%Color and Shape:SolidMolecular weight:515.359a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
CAS:Formula:C22H29FO5Purity:99%Color and Shape:SolidMolecular weight:392.4611α-Terpineol
CAS:<p>Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.</p>Formula:C10H18OPurity:97.55%Color and Shape:Colorless LiquidMolecular weight:154.25(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
CAS:Formula:C24H31FO6Purity:99%Color and Shape:SolidMolecular weight:434.4977Ref: IN-DA0039HQ
Discontinued product11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
CAS:Formula:C21H28O5Purity:98%Color and Shape:SolidMolecular weight:360.4440Ref: IN-DA0034OW
Discontinued product11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
CAS:Formula:C21H30O5Purity:98%Color and Shape:SolidMolecular weight:362.4599Ref: IN-DA003AAY
Discontinued productRacemic Naproxen
CAS:<p>Racemic Naproxen is a biochemical substance.</p>Formula:C14H14O3Purity:98%Color and Shape:Crystals From Acetone-Hexane White SolidMolecular weight:230.26JH-X-119-01 hydrochloride
CAS:<p>JH-X-119-01 hydrochloride is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 1 (IRAK1) that effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.</p>Formula:C25H21ClN6O3Color and Shape:SolidMolecular weight:488.93STING agonist-22
CAS:<p>STING agonist-22 (CF501) boosts vaccines by activating STING, inducing IFN-I and cytokines, aiding in SARS-CoV-2 research.</p>Formula:C40H48N14O6Color and Shape:SolidMolecular weight:820.92,3-Bis(3-indolylmethyl)indole
CAS:<p>2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.</p>Formula:C26H21N3Color and Shape:SolidMolecular weight:375.475Tacalcitol
CAS:<p>Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes.</p>Formula:C27H44O3Purity:98%Color and Shape:SolidMolecular weight:416.64Icatolimab
<p>Icatolimab (JS-004) is a humanized antibody targeting BTLA/CD272 for the study of lymphomas and solid tumors.</p>Purity:98.7% (SDS-PAGE); 95.6% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.6% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.5 kDaRef: TM-T77490
Discontinued productPam2CSK4 TFA
<p>Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.</p>Formula:C67H127F3N10O14SPurity:99.90%Color and Shape:SoildMolecular weight:1385.84TLQP-21 TFA
<p>TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.</p>Purity:98%Color and Shape:LiquidXibornol
CAS:<p>Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性，可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。</p>Formula:C18H26OColor and Shape:SolidMolecular weight:258.4Ref: TM-T35177
Discontinued productMagnesium citrate
CAS:<p>Magnesium citrate is a useful organic compound for research related to life sciences. The catalog number is T64455 and the CAS number is 3344-18-1.</p>Formula:C12H10Mg3O14Color and Shape:SolidMolecular weight:451.113Elamipretide acetate
<p>Elamipretide acetate (MTP 131), a small tetrapeptide, targets mitochondria to reduce toxic species and stabilize cardiolipin.</p>Formula:C34H53N9O7Purity:99.76%Color and Shape:SoildMolecular weight:699.84Ref: TM-TP1095L
Discontinued productgp91ds-tat
<p>gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.</p>Purity:98%Color and Shape:SolidAurothioglucose
CAS:<p>Aurothioglucose is a active-site TrxR1 inhibitor.</p>Formula:C6H11AuO5SPurity:98%Color and Shape:Yellow Crystals SolidMolecular weight:392.18RIDR-PI-103
CAS:<p>RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug featuring an autocyclized portion connected to the pan-PI3K inhibitor (PI-103). In MDA-MB-361 and MDA-MB-231 cells, Doxorubicin and RIDR-PI-103 exhibited synergistic inhibition of cancer cell proliferation.</p>Formula:C27H25N7O4Color and Shape:SolidMolecular weight:511.53TLR7/8/9 antagonist 2
CAS:<p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>Formula:C23H31N7Purity:98%Color and Shape:SoildMolecular weight:405.54TLQP-21 TFA
<p>TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。</p>Purity:98%Di-O-methyldemethoxycurcumin
CAS:<p>Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL.</p>Formula:C22H22O5Purity:98%Color and Shape:SolidMolecular weight:366.41Tripeptide-41
CAS:<p>Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.</p>Formula:C29H30N4O5Purity:98%Color and Shape:SolidMolecular weight:514.57ARGX-112
CAS:<p>Temtokibart is a humanized IgG1 λ2 antibody that specifically targets IL22RA1, and is expressed by cells that are deficient in the glutamine synthetase gene.</p>Color and Shape:Odour LiquidALPK1-IN-1
CAS:<p>ALPK1-IN-1 (A001) strongly inhibits ALPK1, key for innate immunity & NF-κB signaling via TIFA/TRAF.</p>Formula:C25H32N6O2SColor and Shape:SolidMolecular weight:480.63L-NIO dihydrochloride
CAS:<p>L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively.</p>Formula:C7H16ClN3O2Purity:98%Color and Shape:SolidMolecular weight:209.67ALPK1-IN-2
CAS:<p>ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).</p>Formula:C20H18F2N4O2SColor and Shape:SolidMolecular weight:416.44ALPK1-IN-3
CAS:<p>ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced</p>Formula:C20H16F2N4OSPurity:98%Color and Shape:SolidMolecular weight:398.43
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