Immunology and Inflammation

<p>Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody against IL-33, which can be used to study chronic obstructive pulmonary disease.</p>

<p>MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively).</p>

Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Satralizumab (SA-237) is a humanized antibody targeting interleukin-6 (IL-6), used in research on neuromyelitis optica spectrum disorder (NMOSD).</p>

<p>MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).</p>

<p>GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.</p>

<p>Benzobicyclon is a 4-HPPD) inhibitor and herbicide that is spectrally active against annual grasses, sedges, and broadleaf weeds without toxicity to rice.</p>

<p>NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.</p>

<p>L-Cystine dihydrochloride, a sulfur-based glutathione precursor, maintains GSH balance, used in cell culture.</p>

<p>L-Kynurenine-d4 is a deuterated isotope compound of L-Kynurenine. L-Kynurenine is a metabolite of tryptophan and an endogenous agonist of the AHR.</p>

<p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>

<p>Bempikibart (ADX-914) is a fully humanised monoclonal antibody targeting IL-7Rα, inhibiting IL-17 and TSLP (Thymic stromal lymphopoietin), inflammation.</p>

<p>Anrukinzumab (IMA-638) is an anti-IL-13 mAb with anti-inflammatory effects, in development for ulcerative colitis and asthma.</p>

<p>Manfidokimab is an anti-IL-4Rα mAb that blocks IL-4/IL-13 signaling, in trials for atopic dermatitis.</p>

<p>Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.</p>

<p>Casdozokitug is a human IgG1κ anti-IL-27 antibody that blocks immunosuppressive activity, relevant in tumor immunology and immune checkpoint therapy research.</p>

<p>Dazukibart (anti-IFNB1 mAb) is a potential treatment for dermatomyositis, an autoimmune disorder with pronounced interferon overexpression.</p>

<p>Bimekizumab is a humanised monoclonal antibody targeting IL17A/IL17F, blocking inflammation-driven osteoblast differentiation.</p>

<p>Anti-Mouse CD8α Antibody (2.43) is a mouse-derived IgG2b kappa antibody targeting CD8α in mice,,flow cytometry.</p>

<p>Camoteskimab (AVTX-007) is a human anti-IL-18 antibody for autoinflammatory diseases like AOSD research.</p>

<p>Minretumomab (CC-49) is a mouse monoclonal antibody targeting TAG-72 breast cancer, colon cancer, lung cancer, and pancreatic cancer.</p>

<p>Tositumomab is a murine IgG2a lambda antibody targeting CD20 on B cells, used in B cell therapy, immunology studies, and radioimmunoconjugate development.</p>

<p>Divozilimab (BCD-132), a humanized monoclonal antibody targeting CD20 (CD20), is utilized in multiple sclerosis research [1].</p>

<p>Samalizumab (anti-CD200 mAb) is an immune checkpoint inhibitor under investigation for treating myeloma and B-cell CLL.</p>

<p>Anti-Mouse IL-1R Antibody is an IgG2b subclass inhibitor targeting the mouse IL-1 receptor, sourced from Armenian hamsters.</p>

<p>Argininosuccinic acid can be obtained during the urea cycle from citrulline, aspartate, and ATP by argininosuccinic acid synthetase.</p>

<p>Faralimomab (64G12) is an immunomodulator, and a murine anti- IFNA1 IgG1 mAb [1] .</p>

<p>Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin.</p>

<p>Sonelokimab (ALX 0761; M 1095), a trivalent nanobody targeting IL-17A, IL-17F, and serum albumin, may aid in psoriasis research.</p>

<p>Depemokimab (GSK-3511294) is a long-acting monoclonal antibody targeting IL-15, utilized in asthma research [1] [2].</p>

<p>Zanolimumab is a humanised monoclonal antibody targeting CD4, blocking TCR signalling, autoimmune diseases such as rheumatoid arthritisa.</p>

<p>CTX-471, a human monoclonal antibody, targets CD137 with Kd 50-748 nM, for immunomodulation and cancer research.</p>

<p>CC-90002: humanized anti-CD47 mAb, high affinity, subnanomolar Kd. For hematologic and solid tumor research.</p>

<p>Dargistotug (M-6223), a human IgG1 antibody targeting TIGIT, enhances NK and T-cell activity, cytokine secretion, Treg function for immune checkpoint studies.</p>

<p>Photosensitizer-1 (Compound CLB-13) hydrochloride is a photosensitizer [1] .</p>

<p>Tegoprubart (anti-CD40L mAb) inhibits the CD40-CD40L pathway, reducing immune responses and promoting tolerance in transplant models.</p>

<p>Lutikizumab (ABT-981) is a dual-action antibody blocking IL-1α/β, potential osteoarthritis research drug.</p>

<p>Gevokizumab (S-78989) is a humanised monoclonal antibody targeting IL-1β, allosteric regulation, diabetes, cancer, inflammation, and cardiovascular diseases.</p>

<p>Ocaratuzumab, an Fc-engineered humanized IgG1 anti-CD20 antibody with ~100 pM affinity, enhances ADCC.</p>

<p>Tebotelimab is a human IgG4κ DART antibody targeting PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM, blocking their interactions and signaling.</p>

<p>Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.</p>

<p>Avizakimab (BOS161721) is a humanized lgG1 monoclonal antibody IL-21, with potential for the treatment of systemic lupus erythematosus (SLE).</p>

<p>Imalumab (BAX69), a human IgG1 antibody, targets MIF for ovarian cancer, recurrent ascites, and cancer research.</p>

<p>Ifinatamab is a humanised monoclonal immunoglobulin,B7-H3 protein.ADC drug Ifinatamab deruxtecan,small cell lung cancer (SCLC).</p>

<p>Favezelimab (MK-4280) blocks LAG-3/MHC II interaction, restoring T-cell function, studied in colorectal cancer research and with PD-L1 inhibitors.</p>

NSC 31156 is a bioactive chemical.

<p>BMS-986449 is a CELMoD-type molecular gel that enhances anti-tumor by directing the E3 ubiquitin ligase, Cereblon, to degrade IKZF2 (Helios) and IKZF4 (Eos).</p>

<p>Vamikibart is a chimeric, humanized IgG2κ antibody that targets IL6 [1].</p>

<p>Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression</p>