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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3054 products of "Immunology and Inflammation"

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  • (S,R,S)-AHPC-Boc derivative 1
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    (S,R,S)-AHPC-Boc derivative 1

    CAS:
    <p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>
    Formula:C28H40N4O6S
    Color and Shape:Solid
    Molecular weight:560.705

    Ref: TM-T206790

  • Galectin-3-IN-4
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    Galectin-3-IN-4

    CAS:
    <p>Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].</p>
    Formula:C24H22ClF2N5O5S
    Color and Shape:Solid
    Molecular weight:565.98

    Ref: TM-T86487

  • IKZF1-degrader-1
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    IKZF1-degrader-1

    CAS:
    IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].
    Formula:C35H29F2N5O3
    Color and Shape:Solid
    Molecular weight:605.63

    Ref: TM-T86707

  • Factor B-IN-3
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    Factor B-IN-3

    CAS:
    <p>Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.</p>
    Formula:C24H29N3O4
    Color and Shape:Solid
    Molecular weight:423.5

    Ref: TM-T62276

  • COX-2-IN-51
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    COX-2-IN-51

    CAS:
    <p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>
    Formula:C23H18F4O3S
    Color and Shape:Solid
    Molecular weight:450.446

    Ref: TM-T204857

  • VISTA-IN-3
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    VISTA-IN-3

    CAS:
    <p>VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].</p>
    Formula:C14H18N4O3
    Color and Shape:Solid
    Molecular weight:290.32

    Ref: TM-T87620

  • NLRP3-IN-69
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    NLRP3-IN-69

    CAS:
    <p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>
    Formula:C25H24O7
    Color and Shape:Solid
    Molecular weight:436.454

    Ref: TM-T205524

  • G108
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    G108

    CAS:
    <p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>
    Formula:C16H14Cl2N4O2
    Purity:99.13% - 99.75%
    Color and Shape:Solid
    Molecular weight:365.21

    Ref: TM-T69663

  • Pelecopan
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    Pelecopan

    CAS:
    <p>Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).</p>
    Formula:C23H19FN2O4
    Color and Shape:Solid
    Molecular weight:406.41

    Ref: TM-T62020

  • NLRP3-IN-29
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    NLRP3-IN-29

    CAS:
    <p>NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].</p>
    Formula:C21H22N2O3S
    Color and Shape:Solid
    Molecular weight:382.48

    Ref: TM-T87020

  • Glutathione monoethyl ester
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    Glutathione monoethyl ester

    CAS:
    <p>Glutathione monoethyl ester, a derivative of glutathione, can protect motor neuron cells (NSC-34) from TDP-43 pathology caused by mutations, which includes reducing aggregate formation, nuclear clearance, reactive oxygen species (ROS) production, and cell death.</p>
    Formula:C12H21N3O6S
    Color and Shape:Solid
    Molecular weight:335.377

    Ref: TM-T204308

  • HEI3090
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    HEI3090

    CAS:
    <p>HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).</p>
    Formula:C18H15Cl3N4O3
    Color and Shape:Solid
    Molecular weight:441.70

    Ref: TM-T89862

  • cGAS-IN-2
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    cGAS-IN-2

    CAS:
    <p>cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].</p>
    Formula:C16H18Cl2N2O2
    Color and Shape:Solid
    Molecular weight:341.23

    Ref: TM-T86042

  • Carazostatin
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    Carazostatin

    CAS:
    <p>Carazostatin is an antioxidant, free radical scavenger, and potent lipid peroxidation inhibitor.</p>
    Formula:C20H25NO
    Purity:98%
    Color and Shape:Pale Yellow Solid
    Molecular weight:295.42

    Ref: TM-T23853

  • BIO-8169
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    BIO-8169

    CAS:
    <p>BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.</p>
    Formula:C24H27N5O4
    Color and Shape:Solid
    Molecular weight:449.50

    Ref: TM-T87972

  • Factor B-IN-4
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    Factor B-IN-4

    CAS:
    <p>Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.</p>
    Formula:C27H32N2O4
    Color and Shape:Solid
    Molecular weight:448.55

    Ref: TM-T62688

  • CymitQuimica logo
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    COX-2/PI3K-IN-2

    <p>COX-2/PI3K-IN-2 (5f): anti-inflammatory &amp; anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>
    Formula:C16H17N5O2
    Color and Shape:Solid
    Molecular weight:311.34

    Ref: TM-T60769

  • NP3-146 sodium
    Targetmol
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    NP3-146 sodium

    CAS:
    <p>NP3-146 sodium is an inhibitor of the NLRP3 inflammasome.</p>
    Formula:C20H26ClN2NaO5S
    Color and Shape:Solid
    Molecular weight:464.94

    Ref: TM-T200987

  • NLRP3-IN-58
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    NLRP3-IN-58

    CAS:
    <p>NLRP3-IN-58 (Compound DS15) acts as an inhibitor of NLRP3 inflammasome activation, with an IC50 value of 3.85 μM, and is capable of inhibiting 33% of IL-1β release at a concentration of 10 μM.</p>
    Formula:C22H18ClN3O3S
    Color and Shape:Solid
    Molecular weight:439.92

    Ref: TM-T200969

  • Ocadusertib
    Targetmol
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    Ocadusertib

    CAS:
    <p>Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).</p>
    Formula:C25H25N5O4
    Color and Shape:Solid
    Molecular weight:459.50

    Ref: TM-T201183