JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
Subcategories of "JAK/STAT signaling"
Found 361 products of "JAK/STAT signaling"
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Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formula:C15H12O5Purity:99.42% - 99.82%Color and Shape:SolidMolecular weight:272.25Ref: TM-TJS1779
1mg88.00€5mg195.00€10mg318.00€25mg523.00€50mg743.00€100mg999.00€1mL*10mM (DMSO)178.00€Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formula:C20H27N7O3SPurity:98.74% - 99.49%Color and Shape:SolidMolecular weight:445.54Ref: TM-T2487
1mg42.00€2mg52.00€5mg74.00€10mg101.00€25mg175.00€50mg268.00€100mg409.00€200mg573.00€500mg888.00€1mL*10mM (DMSO)81.00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.85%Color and Shape:Yellow SolidMolecular weight:294.3SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurity:99.56%Color and Shape:SolidMolecular weight:336.15Ref: TM-T8719
1mg43.00€5mg87.00€10mg133.00€25mg227.00€50mg344.00€100mg429.00€200mg597.00€1mL*10mM (DMSO)94.00€NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Formula:C16H14BrNO5SPurity:99.64%Color and Shape:SolidMolecular weight:412.26Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurity:97.31% - 99.96%Color and Shape:SolidMolecular weight:524.68Ref: TM-T1995
1g592.00€5mg50.00€10mg65.00€50mg107.00€100mg127.00€200mg205.00€500mg447.00€1mL*10mM (DMSO)54.00€Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purity:97.55% - 99.92%Color and Shape:SolidMolecular weight:230.30Thymidylate Kinase Inhibitor, YMU1
CAS:YMU1 inhibits hTMPK, stabilizes its LID region, and blocks the catalytic/ATP-binding site.Formula:C17H22N4O4SPurity:98.06%Color and Shape:SolidMolecular weight:378.45HODHBt
CAS:HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Formula:C7H5N3O2Purity:99.45% - 99.95%Color and Shape:Off-White To Yellow SolidMolecular weight:163.13Cucurbitacin I
CAS:Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formula:C30H42O7Purity:96.69% - 99.8%Color and Shape:SolidMolecular weight:514.65Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Formula:C15H10O8Purity:99.65% - 99.91%Color and Shape:SolidMolecular weight:318.24Ref: TM-T8114
1mg94.00€5mg192.00€10mg286.00€25mg482.00€50mg695.00€100mg945.00€500mg1,882.00€1mL*10mM (DMSO)202.00€HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Formula:C14H11NO2Purity:98.92%Color and Shape:SolidMolecular weight:225.24Ref: TM-T9583
1mg34.00€5mg75.00€10mg110.00€25mg245.00€50mg363.00€100mg515.00€200mg700.00€1mL*10mM (DMSO)73.00€Ruxolitinib phosphate
CAS:Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formula:C17H21N6O4PPurity:98% - >99.99%Color and Shape:SolidMolecular weight:404.36Ref: TM-T3043
1g583.00€5mg49.00€10mg62.00€25mg78.00€50mg92.00€100mg138.00€200mg215.00€500mg395.00€1mL*10mM (DMSO)56.00€Pacritinib hydrochloride
CAS:Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formula:C28H32N4O3·xClHColor and Shape:SolidNapabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Formula:C14H8O4Purity:98.43% - 99.85%Color and Shape:SolidMolecular weight:240.21AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formula:C18H22N4O2Purity:98.67% - 99.4%Color and Shape:SolidMolecular weight:326.39Ref: TM-T6933
2mg38.00€5mg63.00€10mg99.00€25mg172.00€50mg268.00€100mg416.00€200mg610.00€1mL*10mM (DMSO)70.00€Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formula:C14H21N5O2SPurity:99.09% - 99.91%Color and Shape:SolidMolecular weight:323.41TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formula:C22H25F3N4OPurity:99.8% - 99.95%Color and Shape:SolidMolecular weight:418.46Delgocitinib EtOH
CAS:Delgocitinib (LEO-124249/JTE052) is a selective JAK inhibitor used for reducing skin inflammation and treating chronic dermatitis.Formula:C18H24N6O2Color and Shape:SolidMolecular weight:356.43
