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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • Fedratinib
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    Fedratinib

    CAS:
    <p>Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.</p>
    Formula:C27H36N6O3S
    Purity:97.31% - 99.96%
    Color and Shape:Solid
    Molecular weight:524.68

    Ref: TM-T1995

  • TP-3654
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    TP-3654

    CAS:
    <p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>
    Formula:C22H25F3N4O
    Purity:99.8% - 99.95%
    Color and Shape:Solid
    Molecular weight:418.46

    Ref: TM-T4523

  • HODHBt
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    HODHBt

    CAS:
    <p>HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.</p>
    Formula:C7H5N3O2
    Purity:99.45% - 99.95%
    Color and Shape:Off-White To Yellow Solid
    Molecular weight:163.13

    Ref: TM-T21267

  • Pacritinib hydrochloride
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    Pacritinib hydrochloride

    CAS:
    <p>Pacritinib HCl: strong JAK2/Wild-type &amp; JAK2V617F inhibitor (IC50: 23/19 nM), used in AML &amp; MF research.</p>
    Formula:C28H32N4O3·xClH
    Color and Shape:Solid

    Ref: TM-T64283

  • HJ-PI01
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    HJ-PI01

    CAS:
    <p>HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.</p>
    Formula:C14H11NO2
    Purity:98.92%
    Color and Shape:Solid
    Molecular weight:225.24

    Ref: TM-T9583

  • AZD1208
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    AZD1208

    CAS:
    <p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>
    Formula:C21H21N3O2S
    Purity:97.24% - 99.83%
    Color and Shape:Solid
    Molecular weight:379.48

    Ref: TM-T2300

  • Cucurbitacin I
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    Cucurbitacin I

    CAS:
    <p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>
    Formula:C30H42O7
    Purity:96.69% - 99.8%
    Color and Shape:Solid
    Molecular weight:514.65

    Ref: TM-TQ0196

  • Baricitinib phosphate
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    Baricitinib phosphate

    CAS:
    <p>Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.</p>
    Formula:C16H20N7O6PS
    Purity:99.4% - 99.82%
    Color and Shape:Solid
    Molecular weight:469.41

    Ref: TM-T2360

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Formula:C23H25NO·HCl
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:367.91

    Ref: TM-T6145

  • Napabucasin
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    Napabucasin

    CAS:
    <p>Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.</p>
    Formula:C14H8O4
    Purity:98.43% - 99.85%
    Color and Shape:Solid
    Molecular weight:240.21

    Ref: TM-T3218

  • Quercetagetin
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    Quercetagetin

    CAS:
    <p>Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.</p>
    Formula:C15H10O8
    Purity:99.65% - 99.91%
    Color and Shape:Solid
    Molecular weight:318.24

    Ref: TM-T8114

  • Abrocitinib
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    Abrocitinib

    CAS:
    <p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>
    Formula:C14H21N5O2S
    Purity:99.09% - 99.91%
    Color and Shape:Solid
    Molecular weight:323.41

    Ref: TM-TQ0037

  • AT9283
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    AT9283

    CAS:
    <p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>
    Formula:C19H23N7O2
    Purity:99.83% - 99.98%
    Color and Shape:Solid
    Molecular weight:381.43

    Ref: TM-T3068

  • Curculigoside
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    Curculigoside

    CAS:
    <p>1.</p>
    Formula:C22H26O11
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:466.44

    Ref: TM-T6S1966

  • Pim1/AKK1-IN-1
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    Pim1/AKK1-IN-1

    CAS:
    <p>Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.</p>
    Formula:C20H13N5O
    Purity:97.03% - 98.69%
    Color and Shape:Solid
    Molecular weight:339.35

    Ref: TM-T5093

  • WHI-P154
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    WHI-P154

    CAS:
    <p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>
    Formula:C16H14BrN3O3
    Purity:98% - 99.67%
    Color and Shape:Solid
    Molecular weight:376.2

    Ref: TM-T1985

  • Niclosamide sodium
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    Niclosamide sodium

    CAS:
    <p>Niclosamide (BAY2353) sodium: oral antihelminthic, STAT3 inhibitor (IC50 0.25 μM), anti-cancer, and DNA replication blocker.</p>
    Formula:C13H7Cl2N2NaO4
    Color and Shape:Solid
    Molecular weight:349.1

    Ref: TM-T72519

  • CEP-33779
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    CEP-33779

    CAS:
    <p>CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.</p>
    Formula:C24H26N6O2S
    Purity:98.24% - ≥95%
    Color and Shape:Solid
    Molecular weight:462.57

    Ref: TM-T6122

  • JANEX-1
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    JANEX-1

    CAS:
    <p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>
    Formula:C16H15N3O3
    Purity:98% - 99.81%
    Color and Shape:Solid
    Molecular weight:297.31

    Ref: TM-T2045

  • Pacritinib
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    Pacritinib

    CAS:
    <p>Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).</p>
    Formula:C28H32N4O3
    Purity:99.25% - 99.49%
    Color and Shape:Solid
    Molecular weight:472.58

    Ref: TM-T6020