STAT
STAT proteins are critical components of the JAK/STAT signaling pathway, which transmits extracellular signals from cytokines and growth factors to the cell nucleus, influencing gene expression. STAT proteins are involved in regulating immune responses, cell growth, differentiation, and survival. Dysregulation of STAT signaling is implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammation. At CymitQuimica, we provide a comprehensive range of STAT pathway modulators to support your research in signal transduction, immunology, and therapeutic development.
Found 98 products of "STAT"
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L002
CAS:L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Formula:C15H15NO5SPurity:98.59%Color and Shape:SolidMolecular weight:321.35UC-514321
CAS:UC-514321 directly targets STAT3/5 and represses TET1 expression.Formula:C26H35NO5Purity:98.50%Color and Shape:SolidMolecular weight:441.56Ref: TM-T13950
1mg71.00€5mg152.00€10mg236.00€25mg477.00€50mg713.00€100mg1,071.00€200mg1,468.00€1mL*10mM (DMSO)167.00€Fludarabine
CAS:Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.
Formula:C10H12FN5O4Purity:99.65% - 99.89%Color and Shape:White SolidMolecular weight:285.23Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Formula:C12H9N3O5Purity:99.79% - 99.95%Color and Shape:Yellow SolidMolecular weight:275.22Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purity:99.13% - 99.92%Color and Shape:SolidMolecular weight:414.45Niclosamide
CAS:Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.Formula:C13H8Cl2N2O4Purity:98.47% - 99.1%Color and Shape:Pale Yellow Crystals SolidMolecular weight:327.12STAT3-IN-1
CAS:STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumorFormula:C28H29NO6Purity:95.89% - 95.89%Color and Shape:SolidMolecular weight:475.53Ref: TM-T13009
1mg60.00€2mg88.00€5mg131.00€10mg192.00€25mg349.00€50mg523.00€100mg753.00€500mg1,549.00€1mL*10mM (DMSO)137.00€Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formula:C19H28O8Purity:97.67% - 99.9%Color and Shape:White Crystalline PowderMolecular weight:384.42Niclosamide olamine
CAS:Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.
Formula:C15H15Cl2N3O5Purity:99.89%Color and Shape:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Molecular weight:388.20Diosgenin
CAS:Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Formula:C27H42O3Purity:99.87%Color and Shape:Flaky Or Needle CrystalMolecular weight:414.62Ac-GpYLPQTV-NH2 acetate
Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. It also exhibits antitumor properties.Formula:C38H60N9O14P·xC2H4O2Color and Shape:SolidMolecular weight:897.91 (free base)STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Color and Shape:Odour SolidSTAT3-IN-41
STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.Formula:C22H30F3NO7Color and Shape:SolidMolecular weight:477.471STAT3-IN-23
CAS:STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Formula:C36H61N8O12PColor and Shape:SolidMolecular weight:828.89MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purity:99.74%Color and Shape:SolidMolecular weight:252.27CMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Formula:C46H59N9O7Purity:98%Color and Shape:SolidMolecular weight:850.03STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Formula:C25H27N5OColor and Shape:SolidMolecular weight:413.51STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Formula:C19H16N2O4SColor and Shape:SolidMolecular weight:368.41STAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formula:C16H15NO3SColor and Shape:SolidMolecular weight:301.36JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Color and Shape:Odour SolidRef: TM-L3700
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