Neuroscience

<p>S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2</p>

(S)-Mirtazapine ((S)-Org3770) is a 5-HT2 receptor antagonist with pro-nociceptive effects that can be used to study depression.

<p>Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.</p>

Pipecuronium bromide (RGH-1106) is an nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker that causes muscle relaxation.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BNP, and the Human BNP standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human BNP. After TMB substrate solution is added, only those wells that contain Human BNP and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BNP in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PSA, and the Human PSA standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human PSA. After TMB substrate solution is added, only those wells that contain Human PSA and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PSA in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GH, and the Human GH standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human GH. After TMB substrate solution is added, only those wells that contain Human GH and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GH in the samples is then determined by comparing the OD of the samples to the standard curve.

<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>

Rotigotine (1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-) is an antiparkinson agent and dopamine receptor agonist.

<p>Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).</p>

<p>Chlorpyrifos (diethyl-d10) is a deuterated compound of Chlorpyrifos. Chlorpyrifos has a CAS number of 2921-88-2. Chlorpyrifos is an organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.</p>

Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].

Donepezil-d5 is a deuterated compound of Donepezil. Donepezil has a CAS number of 120014-06-4. Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alzheimer's type.

<p>Fenitrothion-d6 (O,O-dimethyl-d6) is a deuterated compound of Fenitrothion. Fenitrothion has a CAS number of 122-14-5. Fenitrothion is an organothiophosphate cholinesterase inhibitor. Fenitrothion is used as an insecticide.</p>

Pyridostigmine D6 bromide is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible inhibitor of cholinesterase.

<p>Acephate-d3 (acetyl-d3) is a deuterated compound of Acephate. Acephate has a CAS number of 30560-19-1. Acephate is an anticholinesterase insecticide with a weak inhibitory effect on AChE in rats, but it can effectively inhibit AChE in cockroaches.</p>

<p>R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.</p>

<p>Gefapixant citrate is an orally active P2X3R blocker used for chronic cough and knee osteoarthritis. IC50: ~30 nM (hP2X3), 100-200 nM (hP2X2/3).</p>

Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.

<p>Cyproheptadine hydrochloride (Periactin hydrochloride) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.</p>